PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSA2 HUL5 19536198 intact exp SSB1 HUL5 19536198 intact exp CCT4 HUL5 19536198 intact exp NUF2 HUL5 18467557 biogrid,i2d,mint,intact exp SSZ1 HUL5 19536198 intact exp SSA1 HUL5 19536198 intact exp MAK11 HUL5 11805837 biogrid,mint,intact,dip exp PRE1 HUL5 21878652 biogrid exp HUL5 UBP10 i2d exp UBC4 HUL5 21983566 biogrid exp SSE1 HUL5 19536198 intact exp RPN10 HUL5 17190603 biogrid exp OAF3 HUL5 18719252 biogrid,intact exp HUL5 CSI1 16554755 intact exp CCT8 HUL5 19536198 intact exp UBC5 HUL5 21983566 biogrid exp PTK2 HUL5 16319894 biogrid,i2d exp SSB2 HUL5 23332755 biogrid exp RPN11 HUL5 21878652 biogrid exp NAB2 HUL5 19840948 biogrid exp CMD1 HUL5 11805837, 23023127 biogrid,intact,dip exp, pred HUL5 HUL5 11805826, 23023127 mint,intact exp, pred UBP6 HUL5 12408819, 23023127 biogrid exp, pred HUL5 RPN5 21289098, 23023127 biogrid exp, pred HUL5 RPT6 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RPN2 HUL5 17190603, 23023127 biogrid exp, pred HUL5 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53119 - 15044803 - C 22 P53119 - 11805837 - C 6 P53119 - 11805837 - C 10 P15731 P53119 affinity chromatography technology 21983566 physical association X 2 P20484 P53119 affinity chromatography technology 11805837 physical association X 2 P32565 P53119 pull down 17190603 direct interaction X 2 P06787 P53119 affinity chromatography technology 11805837 physical association X 2 P22141 P53119 affinity chromatography technology 21878652 physical association X 2 Q01939 P53119 affinity chromatography technology 16554755 physical association X 2 P47116 P53119 enzymatic study 16319894 direct interaction X 2 Q12250 P53119 affinity chromatography technology 21289098 physical association X 2 P15732 P53119 affinity chromatography technology 21983566 physical association X 2 P33895 P53119 protein complementation assay 18467557 direct interaction X 2 P43588 P53119 affinity chromatography technology 21878652 physical association X 2 P38886 P53119 pull down 17190603 direct interaction X 2 P0CG63 P53119 biochemical 23583075 association X 2 P0CG63 P53119 affinity chromatography technology 17644757 physical association X 2 P0CG63 P53119 affinity chromatography technology 23793018 physical association X 2 P0CG63 P53119 affinity chromatography technology 12872131 physical association X 2 P43593 P53119 biochemical 12408819 association X 2 P40150 P53119 biochemical 23332755 association X 2 P36023 P53119 two hybrid 18719252 direct interaction X 2 P53119 anti tag coimmunoprecipitation 11805837 - C 8 P20484 P53119 anti tag coimmunoprecipitation 11805837 physical association X 2 P06787 P53119 anti tag coimmunoprecipitation 11805837 physical association X 2 P53119 anti tag coimmunoprecipitation 11805837 - C 6 P53119 anti tag coimmunoprecipitation 11805837 - C 41 P53119 anti tag coimmunoprecipitation 11805837 - C 26 P53119 inferred by author 16554755 association C 52 P32589 P53119 tandem affinity purification 19536198 association X 2 P11484 P53119 tandem affinity purification 19536198 association X 2 P53119 P53119 tandem affinity purification 11805826 physical association X 2 Q01939 P53119 tandem affinity purification 16554755 physical association X 2 Q01939 P53119 tandem affinity purification 16554755 physical association X 2 Q01939 P53119 tandem affinity purification 16554755 physical association X 2 P10591 P53119 tandem affinity purification 19536198 association X 2 P53119 anti tag coimmunoprecipitation 11805837 association C 6 P53119 anti tag coimmunoprecipitation 11805837 association C 10 P10592 P53119 tandem affinity purification 19536198 association X 2 P33895 P53119 dihydrofolate reductase reconstruction 18467557 physical association X 2 P53119 P47079 tandem affinity purification 19536198 association X 2 P39078 P53119 tandem affinity purification 19536198 association X 2 P38788 P53119 tandem affinity purification 19536198 association X 2 P36023 P53119 two hybrid 18719252 physical association X 2 P53119 mass spectrometry studies of complexes 11805837 - C 27 P53119 mass spectrometry studies of complexes 11805837 - C 7

PPI - HINT Gene A Gene B PMID Method Quality NUF2 HUL5 18467557,18467557 0111,0090 HT OAF3 HUL5 18719252 0018 HT SSB2 HUL5 23332755 0401 LC UBP6 HUL5 12408819 0401 LC PTK2 HUL5 16319894 0415 LC CMD1 HUL5 11805837,11805837 0004,0007 HT SSA1 HUL5 19536198 0676 HT SSA2 HUL5 19536198 0676 HT SSB1 HUL5 19536198 0676 HT UBC4 HUL5 21983566 0004 LC UBC5 HUL5 21983566 0004 LC MAK11 HUL5 11805837,11805837 0004,0007 HT PRE1 HUL5 21878652 0004 LC NAB2 HUL5 19840948 0004 LC RPN2 HUL5 17190603 0096 LC SSE1 HUL5 19536198 0676 HT SSZ1 HUL5 19536198 0676 HT RPN10 HUL5 17190603 0096 LC CCT4 HUL5 19536198 0676 HT SSB2 HUL5 23332755 0401 LC RPN11 HUL5 21878652 0004 LC UBP6 HUL5 12408819 0401 LC CCT8 HUL5 19536198 0676 HT HUL5 HUL5 11805826,11805826 0676,0007 HT HUL5 RPT6 16554755,16554755 0676,0004 HT HUL5 CSI1 16554755 0363 HT HUL5 RPN5 21289098 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53119 P15732 HUL5 UBC5 0.21 21983566 P53119 P15731 HUL5 UBC4 0.21 21983566 P53119 P06787 HUL5 CMD1 0.236 11805837 P53119 P32589 HUL5 SSE1 0.126 19536198 P53119 P10591 HUL5 SSA1 0.126 19536198 P53119 P53119 HUL5 HUL5 0.155 11805826 P53119 P38788 HUL5 SSZ1 0.126 19536198 P53119 P47079 HUL5 CCT8 0.126 19536198 P53119 P39078 HUL5 CCT4 0.126 19536198 Q12250 P53119 RPN5 HUL5 0.126 21289098 P53119 P10592 HUL5 SSA2 0.126 19536198 P53119 P11484 HUL5 SSB1 0.126 19536198 Q01939 P53119 RPT6 HUL5 0.236 16554755 P53119 P36023 HUL5 OAF3 0.332 18719252 P53119 P32505 HUL5 NAB2 0.126 19840948 P53119 P33895 HUL5 NUF2 0.126 18467557 P53119 P40150 HUL5 SSB2 0.126 23332755 P53119 P43588 HUL5 RPN11 0.21 21878652 P53119 P43593 HUL5 UBP6 0.21 12408819 P53119 P47116 HUL5 PTK2 0.183 16319894 P53119 P20484 HUL5 MAK11 0.236 11805837 P53119 P22141 HUL5 PRE1 0.21 21878652 Q04368 P53119 CSI1 HUL5 0.126 16554755