PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CDC37 SKI8 16429126 intact exp ADE17 SKI8 18467557 biogrid,i2d,mint,intact exp KRI1 SKI8 16554755 biogrid,i2d,mint,intact exp TEF1, TEF2 SKI8 16429126 intact exp RPO26 SKI8 18467557 biogrid,i2d,mint,intact exp NUG1 SKI8 16554755 biogrid,i2d,mint,intact exp PUT3 SKI8 16554755 biogrid,i2d,mint,intact exp SKI8 HRK1 18467557 biogrid,i2d,mint,intact exp CRM1 SKI8 26673895 biogrid exp MYO4 SKI8 16554755 biogrid,i2d,mint,intact exp FRM2 SKI8 11283351 i2d,mint,intact,dip exp AKL1 SKI8 11283351,21460040,11805837 biogrid,i2d,mint,intact,dip exp SKI8 ENT5 16554755 biogrid,i2d,mint,intact exp SKI8 ESA1 19303850 biogrid exp TUB2 SKI8 11805837 dip exp SKI8 RRS1 16554755 biogrid,i2d,mint,intact exp AMN1 SKI8 16429126 intact exp STF2 SKI8 18467557 biogrid,i2d,mint,intact exp SKI8 YRA1 16554755 biogrid,mint,intact exp COX4 SKI8 11283351 biogrid,i2d,mint,intact,dip exp Uncharacterized protein YKL023W SKI8 16554755 biogrid,i2d,mint,intact exp SKI8 DCP1 i2d exp AIM46 SKI8 11805837 dip exp SPB4 SKI8 21825077 biogrid exp NOP1 SKI8 16554755 biogrid,i2d,mint,intact exp SSB2 SKI8 23332755 biogrid exp ASC1 SKI8 16429126, 23023127 biogrid,intact exp, pred RDH54 SKI8 11283351, 23023127 i2d,mint,intact,dip exp, pred REC104 SKI8 17558514, 23023127 biogrid exp, pred XRN1 SKI8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred SSB1 SKI8 19536198,11805837, 23023127 intact,dip exp, pred CSL4 SKI8 16429126, 23023127 intact exp, pred SKI8 Uncharacterized protein YML108W 18719252, 23023127 biogrid,intact exp, pred SKI8 SKI7 23953113,11532933,22114319,16043509, 23023127 biogrid,intact,dip exp, pred RRP4 SKI8 18467557, 23023127 biogrid,i2d,mint,intact exp, pred SKI2 SKI8 23953113,16429126,18042677,16043509,16554755,10744028,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPF2 SKI8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred BCY1 SKI8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred SKI3 SKI8 16429126,15340168,18042677,16043509,16554755,10744028,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred SKI8 SKI8 18467557, 23023127 biogrid,i2d,mint,intact exp, pred STM1 SKI8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred SPO11 SKI8 15340168,10688190,14992724, 23023127 biogrid,i2d,mint,intact,dip exp, pred Uncharacterized protein YCR016W SKI8 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RAD54 SKI8 23023127 pred SWI6 SKI8 23023127 pred SKI8 UME1 23023127 pred CDC5 SKI8 23023127 pred SKI8 CAC2 23023127 pred GPA1 SKI8 23023127 pred XRS2 SKI8 23023127 pred REC107 SKI8 23023127 pred BUB3 SKI8 23023127 pred SIR3 SKI8 23023127 pred MMS4 SKI8 23023127 pred SPS1 SKI8 23023127 pred UBC5 SKI8 23023127 pred SLH1 SKI8 23023127 pred CDC55 SKI8 23023127 pred PAT1 SKI8 23023127 pred HIR1 SKI8 23023127 pred MER1 SKI8 23023127 pred SGS1 SKI8 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q02793 - 11805837 - C 4 Q02793 - 15044803 - C 3 Q02793 P35207 - 11805837 - X 2 Q02793 P23179 - 10688190 - X 2 Q02793 P37261 - 11283351 - X 2 Q02793 - 11283351 - X 2 Q02793 P35207 - 10744028 - X 2 Q02793 P17883 - 10744028 - X 2 Q02793 P04037 - 11283351 - X 2 Q02793 P38080 - 11283351 - X 2 Q02793 P35207 affinity chromatography technology 10744028 physical association X 2 Q02793 P35207 affinity chromatography technology 10744028 physical association X 2 Q02793 P17883 affinity chromatography technology 10744028 physical association X 2 Q02793 P23179 two hybrid 14992724 direct interaction X 2 Q02793 P23179 two hybrid 14992724 direct interaction X 2 Q02793 P17883 two hybrid 15340168 direct interaction X 2 Q02793 P23179 two hybrid 15340168 direct interaction X 2 Q02793 P17883 two hybrid 16043509 direct interaction X 2 Q02793 P17883 affinity chromatography technology 16043509 physical association X 2 Q02793 P40150 biochemical 23332755 association X 2 Q02793 Q03769 affinity chromatography technology 16554755 physical association X 2 Q02793 P32492 affinity chromatography technology 16554755 physical association X 2 Q02793 P25617 affinity chromatography technology 16554755 physical association X 2 Q02793 P15646 affinity chromatography technology 16554755 physical association X 2 Q02793 Q12159 affinity chromatography technology 16554755 physical association X 2 Q02793 P40010 affinity chromatography technology 16554755 physical association X 2 Q02793 P07278 affinity chromatography technology 16554755 physical association X 2 Q02793 P25502 affinity chromatography technology 16554755 physical association X 2 Q02793 P39015 affinity chromatography technology 16554755 physical association X 2 Q02793 P35207 affinity chromatography technology 16554755 physical association X 2 Q02793 P42846 affinity chromatography technology 16554755 physical association X 2 Q02793 Q08746 affinity chromatography technology 16554755 physical association X 2 Q02793 P17883 affinity chromatography technology 16554755 physical association X 2 Q02793 P38011 affinity chromatography technology 16429126 physical association X 2 Q02793 P35207 affinity chromatography technology 16429126 physical association X 2 Q02793 P17883 affinity chromatography technology 16429126 physical association X 2 Q02793 P35207 affinity chromatography technology 16429126 physical association X 2 Q02793 P17883 affinity chromatography technology 16429126 physical association X 2 Q02793 P35207 affinity chromatography technology 17200106 physical association X 2 Q02793 P17883 affinity chromatography technology 17200106 physical association X 2 Q02793 P17883 affinity chromatography technology 18042677 physical association X 2 Q02793 P35207 affinity chromatography technology 18042677 physical association X 2 Q02793 P35207 affinity chromatography technology 18042677 physical association X 2 Q02793 P17883 affinity chromatography technology 18042677 physical association X 2 Q02793 P38009 protein complementation assay 18467557 direct interaction X 2 Q02793 P38792 protein complementation assay 18467557 direct interaction X 2 Q02793 Q08732 protein complementation assay 18467557 direct interaction X 2 Q02793 P16965 protein complementation assay 18467557 direct interaction X 2 Q02793 Q03759 two hybrid 18719252 direct interaction X 2 Q02793 P35207 affinity chromatography technology 11805837 physical association X 2 Q02793 P17883 affinity chromatography technology 11805837 physical association X 2 Q02793 P23179 two hybrid 10688190 direct interaction X 2 P25808 Q02793 affinity chromatography technology 21825077 physical association X 2 P0CG63 Q02793 affinity chromatography technology 23749301 physical association X 2 P36103 Q02793 affinity chromatography technology 16554755 physical association X 2 Q02793 Q08491 affinity chromatography technology 11532933 physical association X 2 Q02793 Q08491 affinity chromatography technology 16043509 physical association X 2 Q02793 Q08491 pull down 23953113 direct interaction X 2 Q02793 P22147 affinity chromatography technology 16554755 physical association X 2 Q02793 P04037 two hybrid 11283351 direct interaction X 2 Q02793 P38080 two hybrid 11283351 direct interaction X 2 Q02793 P33323 two hybrid 17558514 direct interaction X 2 Q02793 Q02793 protein complementation assay 18467557 direct interaction X 2 Q02793 Q08649 enzymatic study 19303850 direct interaction X 2 Q02793 P38080 pull down 21460040 direct interaction X 2 Q02793 P38080 affinity chromatography technology 11805837 physical association X 2 Q02793 Q08491 pull down 22114319 direct interaction X 2 P36160 Q02793 affinity chromatography technology 16554755 physical association X 2 P20435 Q02793 protein complementation assay 18467557 direct interaction X 2 Q02793 anti tag coimmunoprecipitation 11805837 - C 4 Q02793 P02557 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 P38885 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 two hybrid pooling approach 11283351 physical association X 2 Q02793 P37261 two hybrid pooling approach 11283351 physical association X 2 Q02793 P35207 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 P17883 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 P23179 two hybrid 10688190 physical association X 2 Q02793 anti tag coimmunoprecipitation 11805837 - C 7 Q02793 P11484 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 P04037 two hybrid pooling approach 11283351 physical association X 2 Q02793 P38080 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 P38080 two hybrid pooling approach 11283351 physical association X 2 Q02793 Q08491 coimmunoprecipitation 11532933 physical association X 2 Q02793 pull down 23953113 association C 4 Q02793 anti tag coimmunoprecipitation 11805837 association C 4 Q02793 inferred by author 16554755 association C 5 Q02793 anti tag coimmunoprecipitation 10744028 association C 3 Q02793 anti tag coimmunoprecipitation 10744028 association C 3 Q02793 pull down 16043509 association C 3 Q02793 cosedimentation through density gradient 16043509 physical association C 3 Q02793 x-ray crystallography 23953113 physical association C 3 Q02793 comigration in sds page 23953113 physical association C 3 Q02793 pull down 23953113 association C 3 Q02793 tandem affinity purification 16429126 association C 30 Q02793 inferred by author 16429126 physical association C 23 Q02793 P23179 two hybrid 10688190 physical association X 2 Q02793 P35207 anti tag coimmunoprecipitation 10744028 physical association X 2 Q02793 P17883 anti tag coimmunoprecipitation 10744028 physical association X 2 Q02793 P37261 two hybrid fragment pooling approach 11283351 physical association X 2 Q02793 P35207 anti tag coimmunoprecipitation 11805837 physical association X 2 Q02793 P17883 two hybrid 16043509 physical association X 2 Q02793 P17883 pull down 16043509 physical association X 2 Q02793 P35207 two hybrid 16043509 physical association X 2 Q02793 P35207 tandem affinity purification 16554755 physical association X 2 Q02793 P35207 tandem affinity purification 16554755 physical association X 2 Q02793 P35207 tandem affinity purification 16554755 physical association X 2 Q02793 P35207 tandem affinity purification 16554755 physical association X 2 Q02793 P25502 tandem affinity purification 16554755 physical association X 2 Q02793 P39015 tandem affinity purification 16554755 physical association X 2 Q02793 P07278 tandem affinity purification 16554755 physical association X 2 Q02793 P25617 tandem affinity purification 16554755 physical association X 2 Q02793 P35207 tandem affinity purification 16554755 physical association X 2 Q02793 Q12159 tandem affinity purification 16554755 physical association X 2 Q02793 P17883 tandem affinity purification 16554755 physical association X 2 Q02793 Q08746 tandem affinity purification 16554755 physical association X 2 Q02793 P32492 tandem affinity purification 16554755 physical association X 2 Q02793 P15646 tandem affinity purification 16554755 physical association X 2 Q02793 P42846 tandem affinity purification 16554755 physical association X 2 Q02793 P40010 tandem affinity purification 16554755 physical association X 2 Q02793 Q03769 tandem affinity purification 16554755 physical association X 2 Q02793 P38792 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02793 P16965 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02793 P38009 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02793 Q08732 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02793 Q03759 two hybrid 18719252 physical association X 2 P38086 Q02793 two hybrid fragment pooling approach 11283351 physical association X 2 Q02793 inferred by author 16429126 physical association C 41 Q02793 tandem affinity purification 16429126 association C 5 Q02793 inferred by author 16429126 physical association C 20 Q02793 tandem affinity purification 16429126 association C 10 P36103 Q02793 tandem affinity purification 16554755 physical association X 2 Q02793 P04037 two hybrid fragment pooling approach 11283351 physical association X 2 Q02793 P38080 two hybrid fragment pooling approach 11283351 physical association X 2 Q02793 Q08491 anti tag coimmunoprecipitation 16043509 physical association X 2 Q02793 P22147 tandem affinity purification 16554755 physical association X 2 Q02793 Q02793 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02793 P11484 tandem affinity purification 19536198 association X 2 P36160 Q02793 tandem affinity purification 16554755 physical association X 2 P20435 Q02793 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q02793 P37261 two hybrid 11283351 - X 2 Q02793 P23179 two hybrid 10688190 - X 2 P38086 Q02793 two hybrid 11283351 - X 2 Q02793 mass spectrometry studies of complexes 11805837 - C 5 Q02793 mass spectrometry studies of complexes 11805837 - C 5 Q02793 P22147 interaction detection method 9482746 - X 2 Q02793 P04037 two hybrid 11283351 - X 2 Q02793 P38080 two hybrid 11283351 - X 2 Q02793 Q12517 interaction detection method 9482746 - X 2

PPI - HINT Gene A Gene B PMID Method Quality COX4 SKI8 11283351,11283351,11283351 0018,0399,0398 HT STF2 SKI8 18467557,18467557 0111,0090 HT SKI3 SKI8 16043509,15340168,16043509,16043509 0096,0018,0018,0004 LC RPO26 SKI8 18467557,18467557 0111,0090 HT SPO11 SKI8 15340168,14992724,10688190,10688190 0018,0018,0397,0018 LC,HT REC104 SKI8 17558514 0018 LC SKI2 SKI8 23953113,16043509,16043509,23953113,16043509 0808,0096,0029,0114,0018 LC FRM2 SKI8 11283351,11283351,11283351 0018,0399,0398 HT ADE17 SKI8 18467557,18467557 0111,0090 HT AKL1 SKI8 11283351,11283351,11283351 0018,0398,0399 HT RDH54 SKI8 11283351,11283351,11283351 0018,0399,0398 HT RRP4 SKI8 18467557,18467557 0111,0090 HT SSB2 SKI8 23332755 0401 LC SKI8 SKI8 18467557,18467557 0111,0090 HT SKI8 Q03759 18719252 0018 HT SKI8 SKI7 11532933,11532933 0004,0019 LC SKI8 ESA1 19303850 0415 LC SKI8 HRK1 18467557,18467557 0111,0090 HT TUB2 SKI8 11805837 0007 HT TEF1|TEF2 SKI8 16429126 0676 HT CDC37 SKI8 16429126 0363 HT BCY1 SKI8 16554755,16554755 0676,0004 HT SSB1 SKI8 19536198,11805837 0676,0007 HT NOP1 SKI8 16554755,16554755 0676,0004 HT SKI3 SKI8 11805837,16043509,10744028,16554755,16429126,18042677,10744028,16043509,17200106,16043509,16429126,11805837,16554755 0004,0096,0004,0676,0004,0004,0007,0018,0004,0004,0676,0007,0004 HT,LC XRN1 SKI8 16554755,16554755 0004,0676 HT PUT3 SKI8 16554755,16554755 0676,0004 HT P25617 SKI8 16554755,16554755 0676,0004 HT SPB4 SKI8 21825077 0004 LC CRM1 SKI8 26673895,26673895 0096,0004 LC MYO4 SKI8 16554755,16554755 0676,0004 HT SKI2 SKI8 11805837,18042677,16554755,16429126,16429126,10744028,16043509,16043509,16043509,17200106,10744028,11805837,16554755 0004,0004,0676,0004,0676,0007,0096,0029,0018,0004,0004,0007,0004 HT,LC P36103 SKI8 16554755,16554755 0676,0004 HT RPF2 SKI8 16554755,16554755 0676,0004 HT ASC1 SKI8 16429126,16429126 0676,0004 HT AKL1 SKI8 11805837,21460040,11805837 0004,0096,0007 HT,LC AMN1 SKI8 16429126 0363 HT AIM46 SKI8 11805837 0007 HT STM1 SKI8 16554755,16554755 0676,0004 HT NUG1 SKI8 16554755,16554755 0676,0004 HT SSB2 SKI8 23332755 0401 LC KRI1 SKI8 16554755,16554755 0676,0004 HT ENT3 SKI8 25512335 0096 LC CSL4 SKI8 16429126 0363 HT SKI8 ENT5 16554755,16554755,16554755 0363,0676,0004 HT SKI8 SKI7 11532933,11532933,22114319,23953113,16043509,16043509 0004,0019,0096,0096,0007,0004 LC SKI8 RRS1 16554755,16554755 0676,0004 HT SKI8 YRA1 16554755,16554755 0676,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5D1E8 Q02793 ZC3H12A SKI8 0.332 27107014 Q02793 P23179 SKI8 SPO11 0.772 10688190,14992724,15340168 Q02793 P02557 SKI8 TUB2 0.126 11805837 Q02793 P06101 SKI8 CDC37 0.126 16429126 Q02793 P39015 SKI8 STM1 0.236 16554755 Q02793 P22147 SKI8 XRN1 0.236 16554755 Q02793 P15646 SKI8 NOP1 0.236 16554755 Q02793 P32492 SKI8 MYO4 0.236 16554755 Q02793 P25502 SKI8 PUT3 0.236 16554755 Q02793 P25617 SKI8 P25617 0.236 16554755 Q02793 P38080 SKI8 AKL1 0.623 11805837,11283351,21460040 Q02793 P40010 SKI8 NUG1 0.236 16554755 Q02793 P38432 SKI8 COIL 0.332 27107014 Q02793 P37261 SKI8 FRM2 0.236 11283351 Q02793 P25808 SKI8 SPB4 0.126 21825077 Q02793 P38009 SKI8 ADE17 0.126 18467557 Q02793 P38086 SKI8 RDH54 0.21 11283351 Q02793 P30822 SKI8 CRM1 0.126 26673895 Q02793 P38285 SKI8 AMN1 0.126 16429126 Q02793 P38792 SKI8 RRP4 0.126 18467557 Q02793 P36103 SKI8 P36103 0.236 16554755 Q02793 P38885 SKI8 AIM46 0.126 11805837 Q02793 P36160 SKI8 RPF2 0.236 16554755 Q02793 P40150 SKI8 SSB2 0.126 23332755 Q02793 P47160 SKI8 ENT3 0.183 25512335 Q02793 P17883 SKI8 SKI3 0.914 15340168,16429126,16043509,16554755,11805837,18042677 Q02793 P42846 SKI8 KRI1 0.236 16554755 Q02793 O00444 SKI8 PLK4 0.332 27107014 Q02793 P02994 SKI8 TEF2 0.126 16429126 Q02793 P04037 SKI8 COX4 0.354 11283351 Q02793 P07278 SKI8 BCY1 0.236 16554755 Q02793 P11484 SKI8 SSB1 0.21 11805837,19536198 Q02793 P16965 SKI8 STF2 0.126 18467557 Q02793 P35207 SKI8 SKI2 0.934 23953113,16429126,16043509,16554755,11805837,18042677 Q02793 P38011 SKI8 ASC1 0.126 16429126 Q02793 Q02793 SKI8 SKI8 0.155 18467557 Q03759 Q02793 Q03759 SKI8 0.332 18719252 Q03769 Q02793 ENT5 SKI8 0.332 16554755 Q08491 Q02793 SKI7 SKI8 0.702 23953113,11532933,22114319,16043509 Q08746 Q02793 RRS1 SKI8 0.236 16554755 Q12159 Q02793 YRA1 SKI8 0.236 16554755 Q02793 P20435 SKI8 RPO26 0.126 18467557 Q02793 P53859 SKI8 CSL4 0.126 16429126 Q08649 Q02793 ESA1 SKI8 0.183 19303850 Q08732 Q02793 HRK1 SKI8 0.126 18467557