PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FMP52 DOC1 16554755 intact exp DOC1 Uncharacterized protein YNL193W 17634282 biogrid exp HAP4 DOC1 17634282 biogrid exp SSA1 DOC1 19536198 intact exp HSP78 DOC1 19536198 intact exp HMT1 DOC1 17634282 biogrid exp CLB2 DOC1 21107322 biogrid,dip exp DOC1 SSP2 16554755 intact exp CCT4 DOC1 19536198 intact exp DOC1 DOC1 i2d exp RPO26 DOC1 17634282 biogrid exp YTA7 DOC1 18467557 biogrid,i2d,mint,intact exp DOC1 SSQ1 19536198 intact exp SSN8 DOC1 17634282 biogrid exp DOC1 HAP5 17634282 biogrid exp SSB2 DOC1 19536198 intact exp ECM13 DOC1 17634282 biogrid exp RAD27 DOC1 i2d exp DOC1 APC5 10318877,16429126,16554755,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC27 DOC1 10318877,12609981,9348530,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred DOC1 APC2 11805826,10318877,16429126,15060174,17634282,16554755,9469814,15797379, 23023127 biogrid,i2d,mint,intact,dip exp, pred DOC1 APC11 9469814, 23023127 biogrid,i2d,intact,dip exp, pred DOC1 APC4 12477395,10318877,15060174,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred DOC1 APC9 10318877,17634282, 23023127 biogrid,i2d exp, pred DOC1 SWM1 12477395,15060174,12609981, 23023127 biogrid,intact exp, pred CDC26 DOC1 9348530,16554755,9469814, 23023127 biogrid,i2d,intact,dip exp, pred DOC1 ACT1 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred DOC1 APC1 10318877,15060174,16481473,17634282,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred NAP1 DOC1 18719252, 23023127 biogrid,intact exp, pred CDC16 DOC1 16429126,10318877,23267104,12402045,21186364,16554755,9469814,16364911,15649358,11805826,16275330,15060174,17406682,12574115,12887895,15797379, 23023127 biogrid,i2d,mint,intact,dip exp, pred MND2 DOC1 12477395,12609981,16554755, 23023127 biogrid,i2d,mint,intact exp, pred DOC1 CDH1 21107322,19362536, 23023127 biogrid,dip exp, pred CDC23 DOC1 11805826,16429126,10318877,16481473,17634282,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred UBC9 DOC1 23023127 pred PDS1 DOC1 23023127 pred RSP5 DOC1 23023127 pred CDC34 DOC1 23023127 pred UBA1 DOC1 23023127 pred CDC20 DOC1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53068 - 15916960 - C 3 P53068 - 15797379 - C 13 P53068 - 15649358 - C 13 P53068 - 9469814 - C 12 Q12157 P53068 - 9469814 - X 2 Q12107 P53068 - 9469814 - X 2 P53068 - 9469814 - X 2 P53068 P16522 - 9469814 - X 2 P14724 P53068 - 9348530 - X 2 P14724 P53068 - 9469814 - X 2 P53068 - 15797379 - C 6 P53068 P53068 - 11884135 - X 2 P53068 P53068 - 11884135 - X 2 Q04601 P53068 - 9469814 - X 2 P53068 Q08683 - 9469814 - X 2 P53068 Q12440 - 9469814 - X 2 P53068 P09798 - 9469814 - X 2 Q12157 P53068 affinity chromatography technology 9469814 physical association X 2 P10815 P53068 unspecified method 21107322 direct interaction X 2 P53197 P53068 affinity chromatography technology 19362536 physical association X 2 P20435 P53068 two hybrid 17634282 direct interaction X 2 Q12107 P53068 affinity chromatography technology 10318877 physical association X 2 Q12107 P53068 two hybrid 17634282 direct interaction X 2 P53068 P38042 affinity chromatography technology 12609981 physical association X 2 P53068 P16522 affinity chromatography technology 10318877 physical association X 2 P53068 P38042 affinity chromatography technology 10318877 physical association X 2 P53068 P40577 affinity chromatography technology 12609981 physical association X 2 P53068 Q12379 affinity chromatography technology 12609981 physical association X 2 P53068 Q12379 affinity chromatography technology 15060174 physical association X 2 P53068 P40577 affinity chromatography technology 12477395 physical association X 2 P53068 P16522 affinity chromatography technology 16481473 physical association X 2 P53068 P24869 unspecified method 21107322 direct interaction X 2 P53068 P38042 affinity chromatography technology 16554755 physical association X 2 P53068 P16522 affinity chromatography technology 16554755 physical association X 2 P53068 P40577 affinity chromatography technology 16554755 physical association X 2 P53068 P16522 affinity chromatography technology 17200106 physical association X 2 P53068 P38195 two hybrid 17634282 direct interaction X 2 P53068 P16522 two hybrid 17634282 direct interaction X 2 P53068 P47821 two hybrid 17634282 direct interaction X 2 P53068 P53870 two hybrid 17634282 direct interaction X 2 P53068 P38042 pull down 21186364 direct interaction X 2 P53068 P60010 affinity chromatography technology 11805826 physical association X 2 P53068 P16522 affinity chromatography technology 11805826 physical association X 2 P14724 P53068 affinity chromatography technology 9348530 physical association X 2 P53068 P09798 affinity chromatography technology 12574115 physical association X 2 P53068 P09798 affinity chromatography technology 10318877 physical association X 2 P53068 P09798 affinity chromatography technology 10318877 physical association X 2 P53068 P53886 affinity chromatography technology 10318877 physical association X 2 P53068 Q12440 affinity chromatography technology 10318877 physical association X 2 Q04601 P53068 affinity chromatography technology 10318877 physical association X 2 P53068 Q08683 affinity chromatography technology 10318877 physical association X 2 P53068 P09798 affinity chromatography technology 12887895 physical association X 2 P53068 P09798 affinity chromatography technology 12402045 physical association X 2 P53068 P09798 affinity chromatography technology 15649358 physical association X 2 P53068 P09798 affinity chromatography technology 15060174 physical association X 2 P53068 Q12440 affinity chromatography technology 15060174 physical association X 2 Q04601 P53068 affinity chromatography technology 15060174 physical association X 2 P53068 P09798 affinity chromatography technology 9469814 physical association X 2 Q04601 P53068 affinity chromatography technology 12477395 physical association X 2 P53068 Q12440 affinity chromatography technology 9469814 physical association X 2 P53068 Q08683 affinity chromatography technology 9469814 physical association X 2 Q04601 P53068 affinity chromatography technology 9469814 physical association X 2 P53068 P53886 biochemical 15060174 colocalization X 2 P53068 P53886 affinity chromatography technology 16481473 physical association X 2 Q04601 P53068 affinity chromatography technology 16554755 physical association X 2 P53068 P09798 affinity chromatography technology 16554755 physical association X 2 P53068 Q12440 affinity chromatography technology 16554755 physical association X 2 P53068 P53886 affinity chromatography technology 16554755 physical association X 2 P53068 P09798 affinity chromatography technology 16275330 physical association X 2 P53068 P53886 affinity chromatography technology 16481473 physical association X 2 P53068 P09798 affinity chromatography technology 17200106 physical association X 2 P53068 Q12440 affinity chromatography technology 17200106 physical association X 2 P53068 P38074 two hybrid 17634282 direct interaction X 2 P53068 P14064 two hybrid 17634282 direct interaction X 2 P53068 Q12440 two hybrid 17634282 direct interaction X 2 P53068 P53886 two hybrid 17634282 direct interaction X 2 P53068 Q02516 two hybrid 17634282 direct interaction X 2 P53068 P40340 protein complementation assay 18467557 direct interaction X 2 P53068 P25293 two hybrid 18719252 direct interaction X 2 P53068 P09798 affinity chromatography technology 17406682 physical association X 2 P53068 Q12440 affinity chromatography technology 15797379 physical association X 2 P53068 P09798 affinity chromatography technology 15797379 physical association X 2 Q04601 P53068 affinity chromatography technology 21186364 physical association X 2 P53068 P09798 pull down 21186364 direct interaction X 2 P53068 P53886 pull down 21186364 direct interaction X 2 P53068 P09798 affinity chromatography technology 21186364 physical association X 2 P53068 Q12440 affinity chromatography technology 11805826 physical association X 2 P53068 P09798 affinity chromatography technology 11805826 physical association X 2 P53068 P09798 affinity chromatography technology 16364911 physical association X 2 P53068 anti tag coimmunoprecipitation 9469814 association C 9 P53068 anti tag coimmunoprecipitation 9469814 association C 9 P53068 anti tag coimmunoprecipitation 9469814 association C 9 P53068 anti tag coimmunoprecipitation 9469814 association C 9 P53068 anti tag coimmunoprecipitation 9469814 association C 9 P53068 affinity chromatography technology 12609981 association C 11 P53068 affinity chromatography technology 12609981 association C 11 P53068 inferred by author 16554755 association C 12 P53068 tandem affinity purification 12477395 association C 13 P53068 tandem affinity purification 12477395 association C 13 P53068 tandem affinity purification 12477395 association C 13 P53068 affinity chromatography technology 12609981 association C 13 P53068 tandem affinity purification 11805826 association C 5 P53068 tandem affinity purification 16429126 association C 5 P53068 anti tag coimmunoprecipitation 9469814 association C 10 P53068 anti tag coimmunoprecipitation 9469814 association C 10 P53068 anti tag coimmunoprecipitation 9469814 association C 10 P53068 anti tag coimmunoprecipitation 9469814 association C 12 P53068 anti tag coimmunoprecipitation 9469814 association C 12 P53068 anti tag coimmunoprecipitation 9469814 association C 12 P53068 anti tag coimmunoprecipitation 9469814 association C 12 P53068 anti tag coimmunoprecipitation 9469814 association C 12 P53068 P40577 tandem affinity purification 16554755 physical association X 2 P53068 P16522 tandem affinity purification 16554755 physical association X 2 P53068 P38042 tandem affinity purification 16554755 physical association X 2 P53068 P40577 tandem affinity purification 16554755 physical association X 2 P53068 P16522 tandem affinity purification 16554755 physical association X 2 P53068 P38042 tandem affinity purification 16554755 physical association X 2 P53068 Q05931 tandem affinity purification 19536198 association X 2 P53068 P33416 tandem affinity purification 19536198 association X 2 P53068 tandem affinity purification 16429126 association C 19 P53068 anti tag coimmunoprecipitation 9469814 association C 8 P53068 anti tag coimmunoprecipitation 9469814 association C 8 P53068 anti tag coimmunoprecipitation 9469814 association C 7 P53068 anti tag coimmunoprecipitation 9469814 association C 7 P10591 P53068 tandem affinity purification 19536198 association X 2 P53068 Q12440 tandem affinity purification 16554755 physical association X 2 P53068 P53886 tandem affinity purification 16554755 physical association X 2 P53068 P09798 tandem affinity purification 16554755 physical association X 2 Q04601 P53068 tandem affinity purification 16554755 physical association X 2 P53068 P53886 tandem affinity purification 16554755 physical association X 2 P53068 P09798 tandem affinity purification 16554755 physical association X 2 P53068 P09798 tandem affinity purification 16554755 physical association X 2 P53068 Q12440 tandem affinity purification 16554755 physical association X 2 P53068 P53886 tandem affinity purification 16554755 physical association X 2 P53068 Q12440 tandem affinity purification 16554755 physical association X 2 Q04601 P53068 tandem affinity purification 16554755 physical association X 2 P53068 P09798 tandem affinity purification 16554755 physical association X 2 P53068 P40340 dihydrofolate reductase reconstruction 18467557 physical association X 2 P53068 P25293 two hybrid 18719252 physical association X 2 P53068 P39078 tandem affinity purification 19536198 association X 2 P53068 P40150 tandem affinity purification 19536198 association X 2 P53068 P09798 miniaturized immunoprecipitation 23267104 direct interaction X 2 P53068 mass spectrometry studies of complexes 11805826 - C 8 Q12157 P53068 coimmunoprecipitation 9469814 - X 2 Q12107 P53068 coimmunoprecipitation 9469814 - X 2 P53068 P29465 interaction detection method 14764870 - X 2 P53068 P32566 interaction detection method 14764870 - X 2 P53068 P38042 coimmunoprecipitation 9469814 - X 2 P53068 P16522 coimmunoprecipitation 9469814 - X 2 P14724 P53068 interaction detection method - - X 2 P14724 P53068 interaction detection method 9348530 - X 2 P14724 P53068 coimmunoprecipitation 9348530,9469814 - X 2 P14724 P53068 coimmunoprecipitation 9469814 - X 2 P53068 confirmational text mining - - C 11 P53068 P26793 interaction detection method 11743205 - X 2 P53068 P26793 interaction detection method 11743205 - X 2 P53068 P38631 interaction detection method 14764870 - X 2 Q04601 P53068 coimmunoprecipitation 9469814 - X 2 P53068 P09798 coimmunoprecipitation 9469814 - X 2 P53068 Q12440 coimmunoprecipitation 9469814 - X 2 P53068 P53886 coimmunoprecipitation 9469814 - X 2 P53068 Q08683 coimmunoprecipitation 9469814 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC16 DOC1 21186364,21186364,9469814,9469814,10318877,23267104,10318877,21186364,21186364,9469814 0096,0676,0004,0019,0019,0946,0004,0004,0030,0007 LC HAP4 DOC1 17634282 0018 HT CDC26 DOC1 9348530,9348530,9469814,9469814 0004,0019,0019,0007 LC CDC23 DOC1 17634282,10318877,9469814,10318877,9469814 0018,0004,0019,0019,0007 HT,LC RPO26 DOC1 17634282 0018 HT CLB2 DOC1 21107322 0077 LC NAP1 DOC1 18719252 0018 HT CDC27 DOC1 21186364,9348530,21186364,9469814,9469814 0030,0029,0096,0019,0007 LC HMT1 DOC1 17634282 0018 HT ECM13 DOC1 17634282 0018 HT PDS1 DOC1 16364911 0415 LC YTA7 DOC1 18467557,18467557 0111,0090 HT SSN8 DOC1 17634282 0018 HT DOC1 DOC1 11884135 0114 LC DOC1 CDH1 21107322,21107322,21107322 0004,0114,0020 LC DOC1 NRM1 21562221 0415 LC DOC1 P53870 17634282 0018 HT DOC1 APC1 15060174,21186364,21186364,17634282,10318877,9469814,10318877,9469814 0401,0030,0096,0018,0004,0019,0019,0007 LC,HT DOC1 HAP5 17634282 0018 HT DOC1 YHP1 21562221 0415 LC DOC1 APC4 9469814,9469814,9469814 0004,0019,0007 LC DOC1 APC5 9469814,9469814,9469814 0004,0019,0007 LC DOC1 APC9 17634282,9469814 0018,0019 HT,LC DOC1 APC11 9469814,9469814,9469814 0019,0007,0004 LC DOC1 APC2 9469814,21107322,17634282,10318877,9469814,10318877,9469814 0004,0114,0018,0004,0019,0019,0007 LC,HT CDC16 DOC1 17406682,21186364,21186364,21107322,12574115,17200106,9469814,12887895,12402045,9469814,10318877,15797379,16554755,16554755,21107322,16429126,11805826,10318877,15649358,16554755,15060174,16364911,11805826,21186364,16275330,11805826,21186364,9469814 0004,0096,0676,0096,0004,0004,0004,0004,0004,0019,0019,0004,0363,0676,0676,0676,0004,0004,0004,0004,0004,0004,0676,0004,0004,0007,0030,0007 LC,HT SSA1 DOC1 19536198 0676 HT CDC26 DOC1 9348530,9348530,16554755,9469814,9469814 0004,0019,0363,0019,0007 LC,HT CDC23 DOC1 11805826,16554755,16554755,16429126,11805826,11805826,10318877,16481473,9469814,10318877,17200106,9469814,16554755 0007,0363,0676,0676,0004,0676,0004,0004,0019,0019,0004,0007,0004 HT,LC HSP78 DOC1 19536198 0676 HT CDC27 DOC1 12609981,16554755,16554755,21186364,21186364,10318877,9469814,9469814,16554755 0004,0363,0676,0030,0096,0004,0019,0007,0004 LC,HT CCT4 DOC1 19536198 0676 HT FMP52 DOC1 16554755 0363 HT SSB2 DOC1 19536198 0676 HT MND2 DOC1 12477395,12609981,16554755,16554755,12477395,16554755 0676,0004,0363,0004,0004,0676 LC,HT DOC1 CDH1 21107322,19362536,21107322,21107322 0004,0004,0114,0020 LC DOC1 APC1 15060174,16554755,16554755,21186364,21186364,10318877,16481473,9469814,10318877,9469814,16554755 0401,0363,0676,0030,0096,0004,0004,0019,0019,0007,0004 LC,HT DOC1 ACT1 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT DOC1 APC4 12477395,16554755,16554755,9469814,15060174,12477395,21186364,10318877,21186364,9469814,9469814,16554755 0676,0363,0676,0004,0004,0004,0004,0004,0676,0019,0007,0004 LC,HT DOC1 SSQ1 19536198 0676 HT DOC1 SSP2 16554755 0363 HT DOC1 APC5 16554755,9469814,16429126,10318877,9469814,9469814 0363,0004,0676,0004,0019,0007 HT,LC DOC1 APC9 10318877 0004 LC DOC1 APC11 9469814,9469814,9469814 0019,0007,0004 LC DOC1 SWM1 12477395,15060174,12609981 0676,0004,0004 LC DOC1 APC2 11805826,16554755,16554755,9469814,16429126,11805826,11805826,15060174,10318877,16554755,9469814,10318877,17200106,9469814,15797379 0007,0363,0676,0004,0676,0004,0676,0004,0004,0004,0019,0019,0004,0007,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04601 P53068 APC4 DOC1 0.731 10318877,12477395,16554755,9469814,21186364 Q02516 P53068 HAP5 DOC1 0.183 17634282 P53068 P14064 DOC1 HAP4 0.183 17634282 P53068 P10591 DOC1 SSA1 0.126 19536198 P53068 P10815 DOC1 CDC13 0.309 21107322 P53068 P24869 DOC1 CLB2 0.309 21107322 P53068 P20435 DOC1 RPO26 0.183 17634282 P53068 P38074 DOC1 HMT1 0.183 17634282 P53068 P25293 DOC1 NAP1 0.332 18719252 P53068 P33416 DOC1 HSP78 0.126 19536198 P53870 P53068 P53870 DOC1 0.183 17634282 P53068 P38195 DOC1 ECM13 0.183 17634282 P53197 P53068 CDH1 DOC1 0.21 19362536 P53068 P40008 DOC1 FMP52 0.126 16554755 P53068 P47821 DOC1 SSN8 0.183 17634282 Q12157 P53068 APC11 DOC1 0.261 9469814 P60010 P53068 ACT1 DOC1 0.332 11805826,16429126 Q12379 P53068 SWM1 DOC1 0.126 12477395 P53068 P16522 DOC1 CDC23 0.787 11805826,16429126,17634282,16554755,9469814,16481473,10318877 P53068 P40577 DOC1 MND2 0.49 16554755,12477395 Q12107 P53068 APC9 DOC1 0.354 10318877,17634282 P53068 P09798 DOC1 CDC16 0.934 16275330,23267104,17406682,16554755,9469814,15797379,21186364,16364911,10318877,11805826,16429126 Q12440 P53068 APC2 DOC1 0.837 11805826,16429126,16554755,9469814,15797379,10318877,17634282 P53068 P38042 DOC1 CDC27 0.659 10318877,9348530,16554755,9469814,21186364 P53068 P39078 DOC1 CCT4 0.126 19536198 P53068 P40150 DOC1 SSB2 0.126 19536198 P53068 P40340 DOC1 YTA7 0.126 18467557 P53068 P14724 DOC1 CDC26 0.236 16554755,9469814,9348530 P53886 P53068 APC1 DOC1 0.826 17634282,16554755,9469814,16481473,21186364,10318877,15060174 Q08683 P53068 APC5 DOC1 0.523 16429126,10318877,16554755,9469814 Q08646 P53068 SSP2 DOC1 0.126 16554755 Q05931 P53068 SSQ1 DOC1 0.126 19536198