PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSB1 CUL3 19536198 intact exp CUL3 ATG33 16554755 intact exp RPF2 CUL3 i2d exp MYO2 CUL3 16554755 biogrid,i2d,mint,intact exp MYO4 CUL3 i2d exp Ankyrin repeat-containing protein YIL001W CUL3 16429126 intact exp CUL3 HSP42 19536198 intact exp SSA2 CUL3 19536198 intact exp CMD1 CUL3 i2d exp MLC1 CUL3 i2d exp CUL3 RMD5 i2d exp SSA1 CUL3 19536198 intact exp CUL3 HRT1 19882662,18719252,12676951, 23023127 biogrid,intact,dip exp, pred RAD16 CUL3 16675952, 23023127 biogrid exp, pred CUL3 Uncharacterized vacuolar protein YLR297W 11283351, 23023127 i2d,mint,intact,dip exp, pred CUL3 RUB1 14519104, 23023127 dip exp, pred CUL3 UBX5 21211725, 23023127 biogrid exp, pred RAD7 CUL3 16675952, 23023127 biogrid,mint,intact exp, pred CUL3 ELC1 19920177, 23023127 biogrid exp, pred PRP19 CUL3 23023127 pred CUL3 ELA1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q08273 P53202 - 10230407 - X 2 Q05899 P53202 - 11283351 - X 2 Q08273 P53202 two hybrid 12676951 direct interaction X 2 Q08273 P53202 two hybrid 18719252 direct interaction X 2 P0CG63 P53202 affinity chromatography technology 23749301 physical association X 2 P53202 P06779 affinity chromatography technology 16675952 physical association X 2 P53202 P06779 biochemical 16675952 association X 2 P53202 Q03071 affinity chromatography technology 19920177 physical association X 2 Q06682 P53202 affinity chromatography technology 21211725 physical association X 2 P31244 P53202 biochemical 16675952 association X 2 P53202 P62837 pull down 16675952 direct interaction X 2 P53202 P19524 affinity chromatography technology 16554755 physical association X 2 Q08273 P53202 two hybrid 12676951 physical association X 2 P53202 Q03919 comigration in sds page 14519104 physical association X 2 Q05899 P53202 two hybrid pooling approach 11283351 physical association X 2 P53202 pull down 19882662 association C 41 P53202 inferred by author 16554755 association C 22 Q08273 P53202 two hybrid 18719252 physical association X 2 P53202 P40560 tandem affinity purification 16429126 physical association X 2 P53202 P06779 anti bait coimmunoprecipitation 16675952 physical association X 2 P10592 P53202 tandem affinity purification 19536198 association X 2 Q05899 P53202 two hybrid fragment pooling approach 11283351 physical association X 2 P53202 P19524 tandem affinity purification 16554755 physical association X 2 P53202 P19524 tandem affinity purification 16554755 physical association X 2 P53202 P19524 tandem affinity purification 16554755 physical association X 2 P53202 P11484 tandem affinity purification 19536198 association X 2 P53202 Q12329 tandem affinity purification 19536198 association X 2 P10591 P53202 tandem affinity purification 19536198 association X 2 Q05899 P53202 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RPO21 CUL3 19920177 0415 LC RAD7 CUL3 16675952,16675952,16675952 0401,0004,0006 LC RAD16 CUL3 16675952 0401 LC CUL3 RUB1 14519104,14519104 0808,0415 LC CUL3 Q05899 11283351,11283351,11283351 0018,0399,0398 HT CUL3 HRT1 18719252,12676951 0018,0018 HT,LC RAD7 CUL3 16675952,16675952,16675952 0401,0004,0006 LC SSA1 CUL3 19536198 0676 HT SSA2 CUL3 19536198 0676 HT SSB1 CUL3 19536198 0676 HT MYO2 CUL3 16554755,16554755 0676,0004 HT RAD16 CUL3 16675952 0401 LC P40560 CUL3 16429126 0676 HT CUL3 ELC1 19920177 0004 LC CUL3 ATG33 16554755 0363 HT CUL3 UBX5 21211725 0004 LC CUL3 HRT1 19882662 0096 LC CUL3 HSP42 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53202 P10591 CUL3 SSA1 0.126 19536198 P53202 O95198 CUL3 KLHL2 0.332 27107014 P53202 O43791 CUL3 SPOP 0.332 27107014 Q05899 P53202 Q05899 CUL3 0.236 11283351 P53202 P11484 CUL3 SSB1 0.126 19536198 P62837 P53202 UBE2D2 CUL3 0.309 16675952 Q12329 P53202 HSP42 CUL3 0.126 19536198 Q9H898 P53202 ZMAT4 CUL3 0.332 27107014 P53202 P10592 CUL3 SSA2 0.126 19536198 P53202 P06779 CUL3 RAD7 0.21 16675952 Q08273 P53202 HRT1 CUL3 0.636 19882662,12676951,18719252 Q96IK5 P53202 GMCL1 CUL3 0.332 27107014 P53202 P40560 CUL3 P40560 0.126 16429126 P53202 P19524 CUL3 MYO2 0.332 16554755 Q06485 P53202 ATG33 CUL3 0.126 16554755 Q03071 P53202 ELC1 CUL3 0.21 19920177 Q06682 P53202 UBX5 CUL3 0.21 21211725 Q03919 P53202 RUB1 CUL3 0.033 14519104