PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBR1 PUF3 26493364 biogrid exp UBR1 LSB1 11743162 mint exp UBR1 BBC1 11743162 mint exp SSB1 UBR1 19536198 intact exp UBR1 MCD1 18566452 biogrid exp KIN2 UBR1 i2d exp UBR1 PIN3 11743162 mint exp DFR1 UBR1 23530227 biogrid exp UBR1 MCK1 19033468 biogrid,dip exp UBR1 UBP8 21734642 intact exp UBR1 NAB2 19840948 biogrid exp UBR1 IDH2 i2d exp STE6 UBR1 23988329 biogrid exp SRS2 UBR1 15964827 biogrid exp SSA1 UBR1 23341891,19536198,23217712 biogrid,intact exp UBR1 YCK1 19033468 dip exp UBR1 BRE1 i2d exp FAS2 UBR1 25564609 biogrid exp UBR1 SIS1 23341891,19536198 biogrid,intact exp UBR1 CDH1 22189709 biogrid exp UBR1 SPT7 21734642 biogrid,intact exp UBR1 CSE4 21070971 biogrid exp UBR1 SSE1 19536198 intact exp UBR1 SIT4 20489023 biogrid,mint,intact exp UBR1 CCT7 19536198 intact exp UBR1 TAH18 19194512 biogrid exp UBR1 MGT1 21076411,19164530,11805837 biogrid,mint,intact,dip exp UBR1 ADA2 21734642 intact exp SBP1 UBR1 23222640 biogrid exp SSC1 UBR1 19536198 intact exp UBR1 SSB2 19536198 intact exp UBR1 VAM6 25026036 biogrid exp UBR1 PMT1 21147851 biogrid exp GAL80 UBR1 12706896 biogrid exp UBR1 GND1 20080635 biogrid exp UBR1 UBR1 12391316 biogrid exp UBR1 CUP9 18162538,18566452,12391316,10850718 biogrid,dip exp UBR1 RPT1 10688918, 23023127 biogrid,intact,dip exp, pred UBR1 RPN2 10688918, 23023127 biogrid,intact,dip exp, pred UBR1 UFD4 21076411, 23023127 biogrid exp, pred UBR1 PRE2 8628401, 23023127 biogrid exp, pred UBR1 CCR4 11805837, 23023127 biogrid,mint,intact,dip exp, pred YAK1 UBR1 11805837, 23023127 biogrid,mint,intact,dip exp, pred RAD6 UBR1 21076411,21179020,12391316,8436296,12535539,8505328,10850718,1651502,19164530,10581257,7926769, 23023127 biogrid,i2d,intact,dip exp, pred UBR1 PRE6 10688918, 23023127 biogrid,intact exp, pred UBR1 PEX7 11805837, 23023127 biogrid,intact,dip exp, pred UBR1 Uncharacterized protein YGL081W 11805837, 23023127 biogrid,mint,intact,dip exp, pred UBR1 RPT6 10688918, 23023127 biogrid,intact,dip exp, pred UBR1 UBI4 23023127 pred UBR1 PIM1 23023127 pred UBR1 DER1 23023127 pred UBR1 RSP5 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P19812 - 11805837 - C 16 P19812 - 11805837 - C 10 P19812 - 11805837 - C 10 P19812 - 11805837 - C 9 P19812 - 11805837 - C 13 P19812 P06104 - 7926769 - X 2 P19812 P06104 - 8505328 - X 2 P19812 P06104 - 8982460 - X 2 P19812 P06104 - 10581257 - X 2 P19812 P06104 - 7926769 - X 2 P19812 P40303 affinity chromatography technology 10688918 physical association X 2 P19812 Q01939 affinity chromatography technology 10688918 physical association X 2 P19812 Q01939 affinity chromatography technology 10688918 physical association X 2 P19812 P04387 unspecified method 12706896 direct interaction X 2 P19812 P32565 pull down 10688918 direct interaction X 2 P19812 Q01939 pull down 10688918 direct interaction X 2 P19812 P12866 affinity chromatography technology 23988329 physical association X 2 P19812 P12866 affinity chromatography technology 23988329 physical association X 2 P19812 P19812 pull down 12391316 direct interaction X 2 P19812 Q12158 pull down 18566452 direct interaction X 2 P19812 P21965 affinity chromatography technology 19033468 physical association X 2 P19812 P38720 enzymatic study 20080635 direct interaction X 2 P19812 P20604 affinity chromatography technology 20489023 physical association X 2 P19812 P36012 affinity chromatography technology 21070971 physical association X 2 P19812 P33202 affinity chromatography technology 21076411 physical association X 2 P19812 P33202 affinity chromatography technology 21076411 physical association X 2 P19812 P33202 pull down 21076411 direct interaction X 2 P19812 P39108 affinity chromatography technology 11805837 physical association X 2 P19812 P14680 affinity chromatography technology 11805837 physical association X 2 P19812 P31384 affinity chromatography technology 11805837 physical association X 2 P19812 P33202 protein complementation assay 21076411 direct interaction X 2 P0CG63 P19812 affinity chromatography technology 23749301 physical association X 2 P0CG63 P19812 biochemical 23583075 association X 2 P0CG63 P19812 affinity chromatography technology 17644757 physical association X 2 P0CG63 P19812 affinity chromatography technology 23793018 physical association X 2 P0CG63 P19812 affinity chromatography technology 12872131 physical association X 2 P0CG63 P19812 affinity chromatography technology 21427232 physical association X 2 P0CG63 P19812 affinity chromatography technology 14557538 physical association X 2 P53197 P19812 affinity chromatography technology 22189709 physical association X 2 P19812 P06104 affinity chromatography technology 7926769 physical association X 2 P19812 P06104 affinity chromatography technology 7926769 physical association X 2 P19812 P06104 pull down 21076411 direct interaction X 2 P19812 P06104 affinity chromatography technology 1651502 physical association X 2 P19812 P33299 pull down 10688918 direct interaction X 2 P19812 P06104 pull down 10581257 direct interaction X 2 P19812 P06104 two hybrid 8505328 direct interaction X 2 P19812 P06104 two hybrid 10581257 direct interaction X 2 P19812 P06104 two hybrid 10581257 direct interaction X 2 P19812 P06104 affinity chromatography technology 12535539 physical association X 2 P19812 P25294 affinity chromatography technology 23341891 physical association X 2 P19812 P07807 affinity chromatography technology 23530227 physical association X 2 P19812 P12954 two hybrid 15964827 direct interaction X 2 P19812 P30656 biochemical 8628401 association X 2 P19812 P06104 pull down 8436296 direct interaction X 2 P19812 P06104 affinity chromatography technology 10581257 physical association X 2 P19812 P41817 enzymatic study 10850718 direct interaction X 2 P19812 P06104 pull down 10850718 direct interaction X 2 P19812 P41817 pull down 12391316 direct interaction X 2 P19812 P06104 pull down 12391316 direct interaction X 2 P19812 P41817 pull down 18162538 direct interaction X 2 P19812 P41817 pull down 18566452 direct interaction X 2 P19812 P41817 pull down 18566452 direct interaction X 2 P19812 Q12181 affinity chromatography technology 19194512 physical association X 2 P19812 P26188 pull down 19164530 direct interaction X 2 P19812 P35177 affinity chromatography technology 21734642 physical association X 2 P19812 P53156 affinity chromatography technology 11805837 physical association X 2 P19812 P26188 affinity chromatography technology 11805837 physical association X 2 P19812 P26188 enzymatic study 21076411 direct interaction X 2 P10591 P19812 affinity chromatography technology 23341891 physical association X 2 P33775 P19812 affinity chromatography technology 21147851 physical association X 2 P19812 anti tag coimmunoprecipitation 11805837 - C 14 P19812 anti tag coimmunoprecipitation 11805837 - C 16 P19812 anti tag coimmunoprecipitation 11805837 - C 27 P19812 anti tag coimmunoprecipitation 11805837 - C 10 P19812 anti tag coimmunoprecipitation 11805837 - C 22 P19812 anti tag coimmunoprecipitation 11805837 - C 13 P19812 anti tag coimmunoprecipitation 11805837 - C 44 P19812 anti tag coimmunoprecipitation 11805837 - C 46 P19812 P21965 anti tag coimmunoprecipitation 19033468 direct interaction X 2 P19812 P21965 protein kinase assay 19033468 direct interaction X 2 P19812 P21965 anti tag coimmunoprecipitation 19033468 direct interaction X 2 P19812 Q01939 affinity chromatography technology 10688918 physical association X 2 P19812 P32565 affinity chromatography technology 10688918 physical association X 2 P19812 P31384 anti tag coimmunoprecipitation 11805837 physical association X 2 P19812 P39108 anti tag coimmunoprecipitation 11805837 physical association X 2 P19812 P14680 anti tag coimmunoprecipitation 11805837 physical association X 2 P19812 anti tag coimmunoprecipitation 11805837 - C 11 P19812 anti tag coimmunoprecipitation 11805837 - C 24 P19812 anti tag coimmunoprecipitation 11805837 physical association X 2 P19812 pull down 19164530 physical association X 2 P19812 P23291 anti bait coimmunoprecipitation 19033468 physical association X 2 P19812 P23291 anti tag coimmunoprecipitation 19033468 physical association X 2 P19812 P33299 affinity chromatography technology 10688918 physical association X 2 P19812 P53156 anti tag coimmunoprecipitation 11805837 physical association X 2 P19812 P41817 affinity chromatography technology 12391316 physical association X 2 P19812 P41817 pull down 19164530 physical association X 2 P19812 P06104 two hybrid 10581257 physical association X 2 P19812 P06104 pull down 19164530 physical association X 2 P19812 P06104 two hybrid 8505328 physical association X 2 P19812 P06104 affinity chromatography technology 10581257 physical association X 2 P19812 P06104 coimmunoprecipitation 10581257 physical association X 2 P19812 tandem affinity purification 21179020 association C 10 P19812 tandem affinity purification 21734642 association C 124 P19812 pull down 23217712 association C 317 P19812 anti tag coimmunoprecipitation 11805837 association C 13 P19812 anti tag coimmunoprecipitation 11805837 association C 10 P19812 anti tag coimmunoprecipitation 11805837 association C 19 P19812 anti tag coimmunoprecipitation 11805837 association C 10 P19812 tandem affinity purification 21734642 association C 66 P19812 Q01939 anti tag coimmunoprecipitation 10688918 physical association X 2 P19812 P32565 pull down 10688918 physical association X 2 P19812 Q01939 pull down 10688918 physical association X 2 P19812 P32565 pull down 10688918 physical association X 2 P19812 Q01939 anti tag coimmunoprecipitation 10688918 physical association X 2 P19812 Q01939 pull down 10688918 physical association X 2 P19812 P40303 anti tag coimmunoprecipitation 10688918 physical association X 2 P19812 P42943 tandem affinity purification 19536198 association X 2 P19812 P40150 tandem affinity purification 19536198 association X 2 P19812 tandem affinity purification 21734642 association C 77 P19812 anti tag coimmunoprecipitation 11805837 association C 9 P19812 anti tag coimmunoprecipitation 20489023 association C 8 P19812 tandem affinity purification 21179020 association C 8 P19812 tandem affinity purification 21734642 association C 53 P32589 P19812 tandem affinity purification 19536198 association X 2 P19812 P33299 pull down 10688918 physical association X 2 P19812 P33299 pull down 10688918 physical association X 2 P19812 P06104 anti tag coimmunoprecipitation 1651502 physical association X 2 P19812 P25294 tandem affinity purification 19536198 association X 2 P19812 P11484 tandem affinity purification 19536198 association X 2 P19812 P0CS90 tandem affinity purification 19536198 association X 2 P10591 P19812 tandem affinity purification 19536198 association X 2 P19812 mass spectrometry studies of complexes 11805837 - C 14 P19812 mass spectrometry studies of complexes 11805837 - C 11 P19812 mass spectrometry studies of complexes 11805837 - C 12 P19812 mass spectrometry studies of complexes 11805837 - C 15 P19812 Q06683 interaction detection method 14764870 - X 2 P19812 Q01454 interaction detection method 14764870 - X 2 P19812 mass spectrometry studies of complexes 11805837 - C 17 P19812 P25559 interaction detection method 14764870 - X 2 P19812 P38877 interaction detection method 14764870 - X 2 P19812 P06104 coimmunoprecipitation 10581257,7926769,8505328 - X 2 P19812 P06104 two hybrid 20050578,7926769,8505328 - X 2 P19812 P06104 interaction detection method 8982460 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RAD6 UBR1 7926769,10581257,7926769,10581257,10581257,8505328,8505328,10581257,20050578,7926769 0018,0019,0004,0004,0018,0018,0019,0096,0018,0019 LC SRS2 UBR1 15964827 0018 LC UBR1 UBR1 20835240 0114 LC UBR1 MCK1 19033468,19033468,19033468 0004,0007,0424 LC UBR1 MGT1 21076411 0415 LC UBR1 PRE2 8628401 0401 LC UBR1 UFD4 21076411,21076411,21076411 0096,0090,0004 LC UBR1 GND1 20080635 0415 LC UBR1 CUP9 10850718 0415 LC RAD6 UBR1 21179020,1651502,19164530,7926769,10581257,10850718,8436296,7926769,21076411,1651502,10581257,12391316,10581257,10581257,12391316,12535539,7926769 0676,0004,0096,0018,0019,0096,0096,0004,0096,0007,0004,0096,0018,0096,0004,0004,0019 HT,LC DFR1 UBR1 23530227 0004 LC UBI4 UBR1 14557538 0004 LC SSC1 UBR1 19536198 0676 HT SSA1 UBR1 19536198,23217712,23341891 0676,0096,0004 HT,LC SSB1 UBR1 19536198 0676 HT STE6 UBR1 23988329 0004 LC YAK1 UBR1 11805837,11805837 0004,0007 HT FAS2 UBR1 25564609 0004 LC UBR1 UBR1 12391316,12391316 0004,0096 LC UBR1 SIT4 20489023,20489023 0007,0004 HT UBR1 MCK1 19033468,19033468,19033468 0004,0007,0424 LC UBR1 YCK1 19033468,19033468 0007,0006 LC UBR1 SIS1 19536198,23341891 0676,0004 HT,LC UBR1 MGT1 11805837,19164530,11805837 0004,0096,0007 HT,LC UBR1 PRE2 8628401 0401 LC UBR1 CCR4 11805837,11805837 0004,0007 HT UBR1 NAB2 19840948 0004 LC UBR1 RPN2 10688918,10688918 0004,0096 LC UBR1 SSE1 19536198 0676 HT UBR1 UFD4 21076411,21076411,21076411 0096,0090,0004 LC UBR1 RPT1 10688918,10688918 0004,0096 LC UBR1 PMT1 21147851 0004 LC UBR1 SPT7 21734642,21734642 0676,0004 LC UBR1 CSE4 21070971 0004 LC UBR1 PEX7 11805837,11805837 0004,0007 HT UBR1 SSB2 19536198 0676 HT UBR1 PRE6 10688918,10688918 0004,0007 LC UBR1 CUP9 18566452,12391316,19164530,18162538,12391316,18162538 0096,0004,0096,0096,0096,0004 LC UBR1 CCT7 19536198 0676 HT UBR1 UBP8 21734642 0676 LC UBR1 P53156 11805837,11805837 0004,0007 HT UBR1 CDH1 22189709 0004 LC UBR1 RPT6 10688918,10688918,10688918 0004,0096,0007 LC UBR1 ADA2 21734642 0676 LC UBR1 MCD1 18566452 0096 LC UBR1 TAH18 19194512 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53156 P19812 P53156 UBR1 0.286 11805837 P53197 P19812 CDH1 UBR1 0.21 22189709 Q12158 P19812 MCD1 UBR1 0.309 18566452 P19812 P0CS90 UBR1 SSC1 0.126 19536198 P19812 P10080 UBR1 SBP1 0.126 23222640 P19812 P12954 UBR1 SRS2 0.183 15964827 P19812 P07807 UBR1 DFR1 0.21 23530227 P41817 P19812 CUP9 UBR1 0.872 18566452,12391316,19164530,18162538,10850718 P25294 P19812 SIS1 UBR1 0.309 23341891,19536198 P23291 P19812 YCK1 UBR1 0.376 19033468 P35177 P19812 SPT7 UBR1 0.236 21734642 P19812 P06104 UBR1 RAD6 0.98 21076411,8436296,21179020,8505328,10581257,19164530,12391316,7926769,10850718 P31384 P19812 CCR4 UBR1 0.286 11805837 P32505 P19812 NAB2 UBR1 0.126 19840948 P32565 P19812 RPN2 UBR1 0.033 10688918 P33202 P19812 UFD4 UBR1 0.702 21076411 P40150 P19812 SSB2 UBR1 0.126 19536198 P36012 P19812 CSE4 UBR1 0.126 21070971 P19812 P14680 UBR1 YAK1 0.236 11805837 P19812 P19097 UBR1 FAS2 0.21 25564609 P50102 P19812 UBP8 UBR1 0.126 21734642 P42943 P19812 CCT7 UBR1 0.126 19536198 P19812 P10591 UBR1 SSA1 0.396 23217712,19536198,23341891 P19812 P11484 UBR1 SSB1 0.126 19536198 P19812 P12866 UBR1 STE6 0.376 23988329 P19812 P19812 UBR1 UBR1 0.332 12391316 P26188 P19812 MGT1 UBR1 0.692 11805837,19164530,21076411 P32589 P19812 SSE1 UBR1 0.126 19536198 P33299 P19812 RPT1 UBR1 0.033 10688918 P38720 P19812 GND1 UBR1 0.309 20080635 P39108 P19812 PEX7 UBR1 0.332 11805837 Q01939 P19812 RPT6 UBR1 0.033 10688918 Q12181 P19812 TAH18 UBR1 0.21 19194512 Q02336 P19812 ADA2 UBR1 0.126 21734642 P20604 P19812 SIT4 UBR1 0.286 20489023 Q07468 P19812 VAM6 UBR1 0.126 25026036 Q07807 P19812 PUF3 UBR1 0.126 P21965 P19812 MCK1 UBR1 0.354 19033468