PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SIS1 FOL2 19536198 intact exp FOL2 BTS1 i2d exp RTS1 FOL2 20489023 intact exp HAP2 FOL2 11805837 biogrid,mint,intact,dip exp ERG20 FOL2 i2d exp FOL2 SRP1 11283351,18719252 biogrid,i2d,mint,intact,dip exp FOL2 VAM6 25026036 biogrid exp SSA2 FOL2 19536198 intact exp FOL2 SLT2 11805837 biogrid,mint,intact,dip exp TAE1 FOL2 18719252 biogrid,intact exp DFR1 FOL2 i2d exp FOL2 MET7 i2d exp HSP82 FOL2 19536198,26217697 biogrid,intact exp UBA1 FOL2 11805837 biogrid,mint,intact,dip exp GRR1 FOL2 11805837 biogrid,intact,dip exp GCD7 FOL2 18719252 biogrid,intact exp PTK2 FOL2 16319894 biogrid,i2d exp RMA1 FOL2 i2d exp FOL2 PKP2 16319894 biogrid,i2d exp COQ1 FOL2 i2d exp SSB2 FOL2 23332755,19536198 biogrid,intact exp QCR2 FOL2 i2d exp FOL2 PIL1 16554755 biogrid,i2d,mint,intact exp YAK1 FOL2 16319894 biogrid,i2d exp PSE1 FOL2 18719252 biogrid,intact exp TEM1 FOL2 11283351 i2d,mint,intact,dip exp YCK1 FOL2 11805837 biogrid,intact,dip exp SSA3 FOL2 19536198 intact exp FOL2 Uncharacterized WD repeat-containing protein YOL087C 11805837 biogrid,mint,intact,dip exp SSE1 FOL2 19536198 intact exp FOL2 Putative uncharacterized protein YPL251W 18719252 intact exp FOL2 AEP3 16554755 intact exp CPA2 FOL2 i2d exp NAB2 FOL2 19840948 biogrid exp FOL2 ULA1 11283351 i2d,mint,intact,dip exp TPK1 FOL2 16319894 biogrid,i2d exp FOL2 USB1 18719252 biogrid,intact exp SSA1 FOL2 26217697 biogrid exp SSB1 FOL2 19536198 biogrid,intact exp FOL2 KAP95 11283351 i2d,mint,intact,dip exp FOL2 YKU80 11805837 biogrid,mint,intact,dip exp CCT7 FOL2 19536198 intact exp FOL2 FOL2 10688190,11283351, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred FOL2 FOL1 23023127 i2d exp, pred RIO2 FOL2 20489023, 23023127 biogrid,mint exp, pred LYS1 FOL2 11805837, 23023127 biogrid,mint,intact,dip exp, pred FOL2 FOL3 23023127 i2d exp, pred BCY1 FOL2 ortho CKA2 FOL2 ortho CKB2 FOL2 ortho FOL2 AHA1 ortho PDX3 FOL2 23023127 pred ADE3 FOL2 23023127 pred RIB1 FOL2 23023127 pred Putative pterin-4-alpha-carbinolamine dehydratase, PHS FOL2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P51601 - 11805837 - C 17 P51601 - 11805837 - C 34 P51601 - 11805837 - C 23 P51601 - 11805837 - C 30 Q12059 P51601 - 11283351 - X 2 P51601 Q06142 - 11283351 - X 2 P51601 P51601 - 10688190 - X 2 P51601 P51601 - 10655498 - X 2 P51601 P51601 - 11283351 - X 2 P51601 - 11805837 - C 4 P51601 - 11805837 - C 13 P51601 - 11805837 - C 4 P51601 - 11805837 - C 16 P38987 P51601 - 11283351 - X 2 Q02821 P51601 - 11283351 - X 2 P53252 P51601 affinity chromatography technology 16554755 physical association X 2 P0CG63 P51601 affinity chromatography technology 23749301 physical association X 2 P0CG63 P51601 affinity chromatography technology 23793018 physical association X 2 P0CG63 P51601 affinity chromatography technology 12872131 physical association X 2 P38998 P51601 affinity chromatography technology 11805837 physical association X 2 P51601 P47116 enzymatic study 16319894 direct interaction X 2 P51601 P38340 two hybrid 18719252 direct interaction X 2 P51601 Q12208 two hybrid 18719252 direct interaction X 2 P51601 P06774 affinity chromatography technology 11805837 physical association X 2 P51601 P23291 affinity chromatography technology 11805837 physical association X 2 P51601 Q99247 affinity chromatography technology 11805837 physical association X 2 P51601 P51601 two hybrid 10688190 direct interaction X 2 Q00772 P51601 affinity chromatography technology 11805837 physical association X 2 P40150 P51601 biochemical 23332755 association X 2 P24814 P51601 affinity chromatography technology 11805837 physical association X 2 Q04437 P51601 affinity chromatography technology 11805837 physical association X 2 P53170 P51601 enzymatic study 16319894 direct interaction X 2 P22515 P51601 affinity chromatography technology 11805837 physical association X 2 P11484 P51601 affinity chromatography technology 19536198 physical association X 2 P11484 P51601 affinity chromatography technology 19536198 physical association X 2 P51601 P06244 enzymatic study 16319894 direct interaction X 2 P51601 P32502 two hybrid 18719252 direct interaction X 2 P51601 P32337 two hybrid 18719252 direct interaction X 2 P40160 P51601 affinity chromatography technology 20489023 physical association X 2 Q02821 P51601 two hybrid 11283351 direct interaction X 2 Q02821 P51601 two hybrid 18719252 direct interaction X 2 P14680 P51601 enzymatic study 16319894 direct interaction X 2 P51601 anti tag coimmunoprecipitation 11805837 - C 50 P51601 anti tag coimmunoprecipitation 11805837 - C 5 P51601 anti tag coimmunoprecipitation 11805837 - C 45 P51601 anti tag coimmunoprecipitation 11805837 - C 23 P51601 anti tag coimmunoprecipitation 11805837 - C 60 P51601 anti tag coimmunoprecipitation 11805837 - C 37 P51601 anti tag coimmunoprecipitation 11805837 - C 76 P51601 anti tag coimmunoprecipitation 11805837 - C 30 P51601 anti tag coimmunoprecipitation 11805837 - C 16 P51601 anti tag coimmunoprecipitation 11805837 - C 22 P38998 P51601 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12059 P51601 two hybrid pooling approach 11283351 physical association X 2 P51601 Q06142 two hybrid pooling approach 11283351 physical association X 2 P51601 P06774 anti tag coimmunoprecipitation 11805837 physical association X 2 P51601 P23291 anti tag coimmunoprecipitation 11805837 physical association X 2 P51601 Q99247 anti tag coimmunoprecipitation 11805837 physical association X 2 Q00772 P51601 anti tag coimmunoprecipitation 11805837 physical association X 2 P24814 P51601 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04437 P51601 anti tag coimmunoprecipitation 11805837 physical association X 2 P51601 anti tag coimmunoprecipitation 11805837 - C 4 P51601 anti tag coimmunoprecipitation 11805837 - C 71 P51601 anti tag coimmunoprecipitation 11805837 - C 34 P51601 anti tag coimmunoprecipitation 11805837 - C 5 P51601 anti tag coimmunoprecipitation 11805837 - C 13 P51601 anti tag coimmunoprecipitation 11805837 - C 4 P22515 P51601 anti tag coimmunoprecipitation 11805837 physical association X 2 P38987 P51601 two hybrid pooling approach 11283351 physical association X 2 P51601 P51601 two hybrid 10688190 physical association Y 1 P51601 P51601 two hybrid 10655498 physical association Y 1 P51601 P51601 two hybrid pooling approach 11283351 physical association Y 1 Q02821 P51601 two hybrid pooling approach 11283351 physical association X 2 P51601 anti tag coimmunoprecipitation 11805837 association C 34 P51601 anti tag coimmunoprecipitation 11805837 association C 30 P51601 anti tag coimmunoprecipitation 11805837 association C 16 P32589 P51601 tandem affinity purification 19536198 association X 2 P53252 P51601 tandem affinity purification 16554755 physical association X 2 P53252 P51601 tandem affinity purification 16554755 physical association X 2 P02829 P51601 tandem affinity purification 19536198 association X 2 Q12059 P51601 two hybrid fragment pooling approach 11283351 physical association X 2 P51601 P51601 two hybrid 10688190 physical association X 2 P51601 P51601 two hybrid fragment pooling approach 11283351 physical association X 2 P51601 Q06142 two hybrid fragment pooling approach 11283351 physical association X 2 P51601 P38340 two hybrid 18719252 physical association X 2 P51601 Q12208 two hybrid 18719252 physical association X 2 P51601 P42943 tandem affinity purification 19536198 association X 2 P51601 P25294 tandem affinity purification 19536198 association X 2 P40150 P51601 tandem affinity purification 19536198 association X 2 P51601 anti tag coimmunoprecipitation 11805837 association C 4 P51601 anti tag coimmunoprecipitation 11805837 association C 17 P51601 anti tag coimmunoprecipitation 11805837 association C 49 P51601 anti tag coimmunoprecipitation 11805837 association C 13 P51601 anti tag coimmunoprecipitation 11805837 association C 4 P51601 anti tag coimmunoprecipitation 20489023 association C 28 P51601 inferred by author 16554755 association C 16 P10592 P51601 tandem affinity purification 19536198 association X 2 P11484 P51601 tandem affinity purification 19536198 association X 2 P11484 P51601 tandem affinity purification 19536198 association X 2 P38987 P51601 two hybrid fragment pooling approach 11283351 physical association X 2 P51601 P32502 two hybrid 18719252 physical association X 2 P51601 P32337 two hybrid 18719252 physical association X 2 P51601 P09435 tandem affinity purification 19536198 association X 2 Q12058 P51601 two hybrid 18719252 physical association X 2 Q02821 P51601 two hybrid fragment pooling approach 11283351 physical association X 2 Q02821 P51601 two hybrid 18719252 physical association X 2 P51601 mass spectrometry studies of complexes 11805837 - C 5 P51601 mass spectrometry studies of complexes 11805837 - C 35 Q12059 P51601 two hybrid 11283351 - X 2 P51601 Q06142 two hybrid 11283351 - X 2 P51601 P51601 two hybrid 10688190 - X 2 P51601 P51601 two hybrid 11283351 - X 2 P51601 mass spectrometry studies of complexes 11805837 - C 46 P51601 mass spectrometry studies of complexes 11805837 - C 31 P51601 mass spectrometry studies of complexes 11805837 - C 38 P51601 mass spectrometry studies of complexes 11805837 - C 17 P51601 mass spectrometry studies of complexes 11805837 - C 5 P51601 mass spectrometry studies of complexes 11805837 - C 14 P38987 P51601 two hybrid 11283351 - X 2 Q02821 P51601 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality TPK1 FOL2 16319894 0415 LC YAK1 FOL2 16319894 0415 LC PSE1 FOL2 18719252 0018 HT GCD7 FOL2 18719252 0018 HT TAE1 FOL2 18719252 0018 HT TEM1 FOL2 11283351,11283351,11283351 0018,0399,0398 HT SSB2 FOL2 23332755 0401 LC PTK2 FOL2 16319894 0415 LC FOL2 FOL2 11283351,11283351,11283351,10688190,10655498,10688190 0018,0399,0398,0397,0018,0018 HT,LC FOL2 PKP2 16319894 0415 LC FOL2 SRP1 11283351,18719252,11283351,11283351 0018,0018,0399,0398 HT FOL2 KAP95 11283351,11283351,11283351 0018,0399,0398 HT FOL2 Q12058 18719252 0018 HT FOL2 ULA1 11283351,11283351,11283351 0018,0399,0398 HT FOL2 USB1 18719252 0018 HT HSP82 FOL2 19536198,26217697 0676,0004 HT,LC HAP2 FOL2 11805837,11805837 0004,0007 HT SSA3 FOL2 19536198 0676 HT SSA1 FOL2 26217697 0004 LC SSA2 FOL2 19536198 0676 HT SSB1 FOL2 19536198,19536198 0004,0676 HT UBA1 FOL2 11805837,11805837 0004,0007 HT YCK1 FOL2 11805837,11805837 0004,0007 HT GRR1 FOL2 11805837,11805837 0004,0007 HT SIS1 FOL2 19536198 0676 HT NAB2 FOL2 19840948 0004 LC SSE1 FOL2 19536198 0676 HT RTS1 FOL2 20489023 0007 HT LYS1 FOL2 11805837,11805837 0004,0007 HT SSB2 FOL2 19536198,23332755 0676,0401 HT,LC RIO2 FOL2 20489023,20489023 0007,0004 HT CCT7 FOL2 19536198 0676 HT FOL2 PIL1 16554755,16554755 0676,0004 HT FOL2 SLT2 11805837,11805837 0004,0007 HT FOL2 YKU80 11805837,11805837 0004,0007 HT FOL2 AEP3 16554755 0363 HT FOL2 Q99247 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04437 P51601 YKU80 FOL2 0.21 11805837 P51601 P22515 FOL2 UBA1 0.21 11805837 P53170 P51601 PKP2 FOL2 0.183 16319894 P51601 P23291 FOL2 YCK1 0.21 11805837 Q12089 P51601 AEP3 FOL2 0.126 16554755 Q12221 P51601 PUF2 FOL2 0.126 26668354 P51601 P10592 FOL2 SSA2 0.126 19536198 P51601 P11484 FOL2 SSB1 0.332 19536198 P51601 P09435 FOL2 SSA3 0.126 19536198 P51601 P06244 FOL2 TPK1 0.183 16319894 P51601 P06774 FOL2 HAP2 0.21 11805837 P51601 P02829 FOL2 HSP82 0.236 19536198,26217697 Q12208 P51601 USB1 FOL2 0.332 18719252 P51601 P32337 FOL2 PSE1 0.332 18719252 P51601 P51601 FOL2 FOL2 0.523 10688190,11283351,10655498 P51601 P38340 FOL2 TAE1 0.332 18719252 P51601 P32502 FOL2 GCD7 0.332 18719252 P51601 P32505 FOL2 NAB2 0.126 19840948 Q99247 P51601 Q99247 FOL2 0.236 11805837 P51601 P38903 FOL2 RTS1 0.236 20489023 P51601 P32589 FOL2 SSE1 0.126 19536198 P51601 P38998 FOL2 LYS1 0.236 11805837 P51601 P40150 FOL2 SSB2 0.236 23332755,19536198 P51601 P40160 FOL2 RIO2 0.126 20489023 P51601 P47116 FOL2 PTK2 0.183 16319894 P51601 P14680 FOL2 YAK1 0.183 16319894 Q00772 P51601 SLT2 FOL2 0.21 11805837 P51601 P24814 FOL2 GRR1 0.332 11805837 P51601 P25294 FOL2 SIS1 0.126 19536198 P51601 P38987 FOL2 TEM1 0.21 11283351 P51601 P42943 FOL2 CCT7 0.126 19536198 P53252 P51601 PIL1 FOL2 0.236 16554755 Q02821 P51601 SRP1 FOL2 0.472 11283351,18719252 Q06142 P51601 KAP95 FOL2 0.21 11283351 Q12058 P51601 Q12058 FOL2 0.183 18719252 Q12059 P51601 ULA1 FOL2 0.236 11283351