PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus OTU2 NOP53 22875988 biogrid exp SSB1 OTU2 19536198 intact exp PRT1 OTU2 i2d exp YCK1 OTU2 16319894 biogrid exp OTU2 TSR1 i2d exp OTU2 ESA1 19303850 biogrid exp OTU2 IPL1 16319894 biogrid exp OTU2 SCC4 i2d exp CRM1 OTU2 26673895 biogrid exp NAB2 OTU2 19840948 biogrid exp OTU2 GIS2 21232131 biogrid exp SSA1 OTU2 19536198 intact exp OTU2 ATG1 16319894 biogrid exp OTU2 SWA2 19536198 intact exp SSE1 OTU2 19536198 intact exp TPK1 OTU2 16319894 biogrid exp

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38747 W4YHN9 enzymatic study 22072716 direct interaction X 2 P38747 P53104 enzymatic study 16319894 direct interaction X 2 Q12080 P38747 two hybrid 22875988 direct interaction X 2 P0CG63 P38747 affinity chromatography technology 23749301 physical association X 2 P38747 P38991 enzymatic study 16319894 direct interaction X 2 P38747 P06244 enzymatic study 16319894 direct interaction X 2 P38747 P23291 enzymatic study 16319894 direct interaction X 2 P38747 Q08649 enzymatic study 19303850 direct interaction X 2 P32589 P38747 tandem affinity purification 19536198 association X 2 P38747 Q06677 tandem affinity purification 19536198 association X 2 P38747 P11484 tandem affinity purification 19536198 association X 2 P10591 P38747 tandem affinity purification 19536198 association X 2

PPI - HINT Gene A Gene B PMID Method Quality TPK1 OTU2 16319894 0415 LC YCK1 OTU2 16319894 0415 LC OTU2 IPL1 16319894 0415 LC OTU2 ATG1 16319894 0415 LC OTU2 ESA1 19303850 0415 LC OTU2 NOP53 22875988 0018 HT SSA1 OTU2 19536198 0676 HT SSB1 OTU2 19536198 0676 HT CRM1 OTU2 26673895,26673895 0096,0004 LC NAB2 OTU2 19840948 0004 LC SSE1 OTU2 19536198 0676 HT OTU2 ENT5 25512335 0096 LC OTU2 SWA2 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53104 P38747 ATG1 OTU2 0.183 16319894 P38747 P23291 OTU2 YCK1 0.183 16319894 Q12080 P38747 NOP53 OTU2 0.183 22875988 P38747 P10591 OTU2 SSA1 0.126 19536198 P38747 P11484 OTU2 SSB1 0.126 19536198 P38747 P30822 OTU2 CRM1 0.236 26673895 Q06677 P38747 SWA2 OTU2 0.126 19536198 P38747 P32505 OTU2 NAB2 0.126 19840948 P38747 P32589 OTU2 SSE1 0.126 19536198 P38991 P38747 IPL1 OTU2 0.183 16319894 Q03769 P38747 ENT5 OTU2 0.183 25512335 P53849 P38747 GIS2 OTU2 0.126 21232131 Q08649 P38747 ESA1 OTU2 0.183 19303850