PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GGA2 MON2 18418388 biogrid,mint,intact exp UBI4 GGA2 19574226,15039776 biogrid exp HTB2 GGA2 22199229 biogrid exp URA2 GGA2 16429126 intact exp SBP1 GGA2 23222640 biogrid exp FAS1 GGA2 16429126 intact exp GGA2 TAF9 21734642 biogrid,intact exp GGA2 CMR1 22199229 biogrid exp SSB1 GGA2 16429126,22940862,19536198 biogrid,intact exp HTB1 GGA2 22199229 biogrid exp TEF1, TEF2 GGA2 16429126 intact exp HHF1, HHF2 GGA2 22199229 biogrid exp GGA2 ULP1 23712011 biogrid exp GGA2 ECM10 19536198 intact exp KEX2 GGA2 23408788 biogrid exp GGA2 PSA1 16429126 intact exp GGA2 FRQ1 22344030 biogrid exp GGA2 NOP53 22875988 biogrid exp GGA2 PIK1 22344030 biogrid exp ADE5,7 GGA2 i2d exp RPL4A GGA2 22940862 biogrid exp GGA2 SSB2 23332755 biogrid exp GGA2 LYS12 11805826,16429126 biogrid,mint,intact,dip exp GGA2 HHT1, HHT2 22199229 biogrid exp SSA2 GGA2 19536198, 23023127 intact exp, pred APS1 GGA2 17344475, 23023127 biogrid exp, pred SSA3 GGA2 19536198, 23023127 intact exp, pred GGA2 ENT5 12483220,17344475,20704189,16687571, 23023127 biogrid exp, pred SSE2 GGA2 19536198, 23023127 intact exp, pred GGA2 LAA1 16687571, 23023127 biogrid exp, pred SSA1 GGA2 16429126,22940862,19536198, 23023127 biogrid,intact exp, pred GGA2 ENT3 12483220,17344475,22940862,20704189, 23023127 biogrid exp, pred PEP1 GGA2 23408788,18467557, 23023127 biogrid,i2d,mint,intact exp, pred APL2 GGA2 11408593, 23023127 biogrid exp, pred SLA1 GGA2 20150898, 23023127 biogrid,mint,intact exp, pred ARF2 GGA2 11124697,12221117, 23023127 biogrid,i2d exp, pred ARF1 GGA2 11124697,12221117, 23023127 biogrid,i2d exp, pred GGA2 RPN11 20170199,18757749, 23023127 biogrid exp, pred SSE1 GGA2 19536198, 23023127 intact exp, pred GGA2 INP53 18467557, 23023127 biogrid,i2d,mint,intact exp, pred CLC1 GGA2 22457357,11408593, 23023127 biogrid exp, pred ARL1 GGA2 18418388, 23023127 mint,intact exp, pred GGA2 GGA2 11805826,18418388,22940862, 23023127 biogrid,mint,intact exp, pred TAF5 GGA2 21734642, 23023127 biogrid,intact exp, pred CRM1 GGA2 11027275,26673895, 23023127 biogrid,dip exp, pred CHC1 GGA2 11805826,16429126,22457357,11689690,11408593, 23023127 biogrid,mint,intact,dip exp, pred GGA2 APL4 18467557, 23023127 biogrid,i2d,mint,intact exp, pred GCN1 GGA2 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred SMI1 GGA2 18467557, 23023127 biogrid,i2d,mint,intact exp, pred GGA2 DID2 23023127 pred GGA2 GGA1 23023127 pred GGA2 MVB12 23023127 pred VPS24 GGA2 23023127 pred RAD23 GGA2 23023127 pred GGA2 EAR1 23023127 pred GGA2 UBI4 23023127 pred GGA2 GEA2 23023127 pred GGA2 UBX5 23023127 pred GGA2 VPS4 23023127 pred PEP12 GGA2 23023127 pred GGA2 UBX6 23023127 pred GGA2 VPS27 23023127 pred GGA2 VPS20 23023127 pred GGA2 SNF7 23023127 pred TUL1 GGA2 23023127 pred UBX7 GGA2 23023127 pred GGA2 VPS60 23023127 pred GGA2 RSP5 23023127 pred UBC4 GGA2 23023127 pred GGA2 TLG2 23023127 pred SHP1 GGA2 23023127 pred GGA2 HUB1 23023127 pred ATG8 GGA2 23023127 pred GGA2 VAM3 23023127 pred STP22 GGA2 23023127 pred DSS4 GGA2 23023127 pred KAR2 GGA2 23023127 pred DID4 GGA2 23023127 pred GGA2 DSK2 23023127 pred GGA2 APM1 23023127 pred HSE1 GGA2 23023127 pred GGA2 UBX4 23023127 pred GOS1 GGA2 23023127 pred GGA2 BRO1 23023127 pred GGA2 IST1 23023127 pred GGA2 SSO2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P19146 P38817 - 11124697 - X 2 P47160 P38817 - 12483220 - X 2 P11076 P38817 - 11124697 - X 2 P38817 - 11805826 - C 4 P11484 P38817 affinity chromatography technology 22940862 physical association X 2 P02294 P38817 affinity chromatography technology 22199229 physical association X 2 P19146 P38817 two hybrid 11124697 direct interaction X 2 P19146 P38817 affinity chromatography technology 11124697 physical association X 2 P19146 P38817 two hybrid 12221117 direct interaction X 2 Q02724 P38817 affinity chromatography technology 23712011 physical association X 2 Q06389 P38817 pull down 22344030 direct interaction X 2 P32566 P38817 protein complementation assay 18467557 direct interaction X 2 P47160 P38817 affinity chromatography technology 22940862 physical association X 2 P47160 P38817 two hybrid 12483220 direct interaction X 2 P47160 P38817 pull down 12483220 direct interaction X 2 P47160 P38817 affinity chromatography technology 12483220 physical association X 2 P47160 P38817 affinity chromatography technology 17344475 physical association X 2 P47160 P38817 pull down 20704189 direct interaction X 2 P38129 P38817 affinity chromatography technology 21734642 physical association X 2 Q12271 P38817 protein complementation assay 18467557 direct interaction X 2 P39104 P38817 pull down 22344030 direct interaction X 2 P39526 P38817 biochemical 16687571 association X 2 P13134 P38817 two hybrid 23408788 direct interaction X 2 P13134 P38817 two hybrid 23408788 direct interaction X 2 P13134 P38817 affinity chromatography technology 23408788 physical association X 2 P40150 P38817 biochemical 23332755 association X 2 P33892 P38817 affinity chromatography technology 11805826 physical association X 2 P38817 P38817 affinity chromatography technology 22940862 physical association X 2 P38817 Q03769 two hybrid 12483220 direct interaction X 2 P38817 Q03769 pull down 12483220 direct interaction X 2 P38817 Q03769 affinity chromatography technology 16687571 physical association X 2 P38817 Q03769 affinity chromatography technology 17344475 physical association X 2 P38817 P32790 pull down 20150898 direct interaction X 2 P38817 Q03769 pull down 20704189 direct interaction X 2 P38817 P02293 affinity chromatography technology 22199229 physical association X 2 Q12510 P38817 affinity chromatography technology 22199229 physical association X 2 Q12028 P38817 protein complementation assay 18467557 direct interaction X 2 P48563 P38817 affinity chromatography technology 18418388 physical association X 2 P10664 P38817 affinity chromatography technology 22940862 physical association X 2 P35181 P38817 affinity chromatography technology 17344475 physical association X 2 P11076 P38817 two hybrid 11124697 direct interaction X 2 P11076 P38817 affinity chromatography technology 11124697 physical association X 2 P11076 P38817 biochemical 12221117 association X 2 P22137 P38817 pull down 22457357 direct interaction X 2 P22137 P38817 affinity chromatography technology 11408593 physical association X 2 P22137 P38817 pull down 11689690 direct interaction X 2 P22137 P38817 affinity chromatography technology 11805826 physical association X 2 P43588 P38817 affinity chromatography technology 18757749 physical association X 2 P43588 P38817 affinity chromatography technology 20170199 physical association X 2 P36000 P38817 affinity chromatography technology 11408593 physical association X 2 P32319 P38817 two hybrid 23408788 direct interaction X 2 P32319 P38817 protein complementation assay 18467557 direct interaction X 2 Q05027 P38817 affinity chromatography technology 21734642 physical association X 2 P17891 P38817 affinity chromatography technology 22457357 physical association X 2 P17891 P38817 affinity chromatography technology 11408593 physical association X 2 P0CG63 P38817 affinity chromatography technology 15039776 physical association X 2 P0CG63 P38817 two hybrid 15039776 direct interaction X 2 P0CG63 P38817 affinity chromatography technology 23749301 physical association X 2 P0CG63 P38817 two hybrid 15039776 direct interaction X 2 P0CG63 P38817 affinity chromatography technology 17644757 physical association X 2 P0CG63 P38817 affinity chromatography technology 23793018 physical association X 2 P0CG63 P38817 pull down 19574226 direct interaction X 2 P0CG63 P38817 affinity chromatography technology 12872131 physical association X 2 P0CG63 P38817 two hybrid 19574226 direct interaction X 2 P0CG63 P38817 affinity chromatography technology 21427232 physical association X 2 P0CG63 P38817 affinity chromatography technology 14557538 physical association X 2 P0CG63 P38817 affinity chromatography technology 22106047 physical association X 2 Q12080 P38817 two hybrid 22875988 direct interaction X 2 P40495 P38817 affinity chromatography technology 11805826 physical association X 2 P61830 P38817 affinity chromatography technology 22199229 physical association X 2 P61830 P38817 affinity chromatography technology 22199229 physical association X 2 P38817 P02309 affinity chromatography technology 22199229 physical association X 2 P38817 P02309 affinity chromatography technology 22199229 physical association X 2 P10591 P38817 affinity chromatography technology 22940862 physical association X 2 P30822 P38817 two hybrid 11027275 direct interaction X 2 P33892 P38817 tandem affinity purification 11805826 physical association X 2 P22137 P38817 tandem affinity purification 11805826 physical association X 2 P38817 inferred by author 11805826 physical association C 4 P38817 tandem affinity purification 11805826 physical association C 4 P40495 P38817 tandem affinity purification 11805826 physical association X 2 P30822 P38817 two hybrid 11027275 physical association X 2 P38817 tandem affinity purification 21734642 association C 76 P38817 tandem affinity purification 21734642 association C 113 P38817 pull down 18418388 association C 3 P38817 tandem affinity purification 11805826 association C 5 P38817 tandem affinity purification 11805826 association C 5 P38817 tandem affinity purification 21734642 association C 60 P11484 P38817 tandem affinity purification 19536198 association X 2 P32566 P38817 dihydrofolate reductase reconstruction 18467557 physical association X 2 P32590 P38817 tandem affinity purification 19536198 association X 2 Q12271 P38817 dihydrofolate reductase reconstruction 18467557 physical association X 2 P38817 P38817 pull down 18418388 physical association X 2 P38817 P32790 pull down 20150898 direct interaction X 2 Q12028 P38817 dihydrofolate reductase reconstruction 18467557 physical association X 2 P48563 P38817 pull down 18418388 physical association X 2 P48563 P38817 pull down 18418388 direct interaction X 2 P39987 P38817 tandem affinity purification 19536198 association X 2 P38817 tandem affinity purification 16429126 association C 10 P10592 P38817 tandem affinity purification 19536198 association X 2 P32589 P38817 tandem affinity purification 19536198 association X 2 Q7Z3U7 P38817 pull down 18418388 physical association X 2 P32319 P38817 dihydrofolate reductase reconstruction 18467557 physical association X 2 P38817 P38116 pull down 18418388 physical association X 2 P38817 P09435 tandem affinity purification 19536198 association X 2 P10591 P38817 tandem affinity purification 19536198 association X 2 P38817 mass spectrometry studies of complexes 11805826 - C 5 P38817 mass spectrometry studies of complexes 11805826 - C 5 P38138 P38817 interaction detection method 14764870 - X 2 Q00772 P38817 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality RPS31 GGA2 15039776 0018 LC UBI4 GGA2 19574226,19574226,15039776,15039776,19574226 0018,0004,0004,0018,0096 LC RPL40A GGA2 15039776 0018 LC ARF1 GGA2 11124697,12221117,11124697 0004,0401,0018 LC KEX2 GGA2 23408788,23408788 0004,0018 LC ARF2 GGA2 11124697,11124697,12221117 0004,0018,0018 LC CRM1 GGA2 11027275 0018 LC PEP1 GGA2 23408788,18467557,18467557 0018,0111,0090 LC,HT SMI1 GGA2 18467557,18467557 0111,0090 HT GGA2 GGA2 20704189 0114 LC GGA2 LAA1 16687571 0401 LC GGA2 SSB2 23332755 0401 LC GGA2 ENT3 12483220,12483220,12483220 0096,0018,0004 LC GGA2 ENT5 12483220,12483220 0096,0018 LC GGA2 APL4 18467557,18467557 0111,0090 HT GGA2 NOP53 22875988 0018 HT GGA2 INP53 18467557,18467557 0090,0111 HT HTB1 GGA2 22199229 0004 HT HTB2 GGA2 22199229 0004 HT HHF1|HHF2 GGA2 22199229 0004 HT TEF1|TEF2 GGA2 16429126 0676 HT FAS1 GGA2 16429126 0676 HT URA2 GGA2 16429126 0676 HT SSA3 GGA2 19536198 0676 HT UBI4 GGA2 14557538,19574226,19574226,15039776,15039776,19574226,22106047 0004,0018,0004,0004,0018,0096,0004 LC SSA1 GGA2 22940862,19536198,16429126 0004,0676,0676 HT SSA2 GGA2 19536198 0676 HT RPL4A GGA2 22940862 0004 HT ARF1 GGA2 11124697,12221117,11124697 0004,0401,0018 LC SSB1 GGA2 22940862,19536198,16429126 0004,0676,0676 HT KEX2 GGA2 23408788,23408788 0004,0018 LC CLC1 GGA2 11408593,22457357,26842894 0004,0004,0004 LC ARF2 GGA2 11124697,11124697 0004,0018 LC CHC1 GGA2 22457357,16429126,11408593,11805826,11805826,11689690,11805826 0096,0676,0004,0004,0676,0096,0007 LC,HT CRM1 GGA2 26673895,26673895 0096,0004 LC SSE1 GGA2 19536198 0676 HT SSE2 GGA2 19536198 0676 HT SLA1 GGA2 20150898 0096 LC GCN1 GGA2 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT APS1 GGA2 17344475 0004 LC APL2 GGA2 11408593 0004 LC ARL1 GGA2 18418388 0096 LC TAF5 GGA2 21734642,21734642 0676,0004 LC GGA2 GGA2 22940862,11805826,11805826,18418388 0004,0676,0007,0096 HT,LC GGA2 PIK1 22344030 0096 LC GGA2 LAA1 16687571 0401 LC GGA2 ECM10 19536198 0676 HT GGA2 SSB2 23332755 0401 LC GGA2 LYS12 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT GGA2 PSA1 16429126 0676 HT GGA2 RPN11 20170199,18757749 0004,0004 LC,HT GGA2 ENT3 12483220,22940862,12483220,20704189,17344475,12483220 0096,0004,0018,0096,0004,0004 LC,HT GGA2 MON2 18418388,18418388 0004,0096 LC GGA2 HHT1|HHT2 22199229 0004 HT GGA2 ULP1 23712011 0004 LC GGA2 ENT5 12483220,26842894,20704189,12483220,16687571,17344475 0096,0004,0096,0018,0004,0004 LC GGA2 TAF9 21734642,21734642 0676,0004 LC GGA2 FRQ1 22344030 0096 LC GGA2 CMR1 22199229 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12080 P38817 NOP53 GGA2 0.183 22875988 Q12221 P38817 PUF2 GGA2 0.126 26668354 Q7Z3U7 P38817 MON2 GGA2 0.21 18418388 P38817 P10080 GGA2 SBP1 0.126 23222640 P38817 P0CG63 GGA2 UBI4 0.82 19574226,15039776 Q03769 P38817 ENT5 GGA2 0.74 20704189,12483220,26842894 Q05027 P38817 TAF9 GGA2 0.236 21734642 P43588 P38817 RPN11 GGA2 0.236 20170199,18757749 P47160 P38817 ENT3 GGA2 0.74 20704189,12483220 P48563 P38817 MON2 GGA2 0.659 18418388 P38817 P32566 GGA2 SMI1 0.286 18467557 P38817 P19146 GGA2 ARF2 0.454 11124697 P38817 P11484 GGA2 SSB1 0.236 16429126,19536198 P38817 P38817 GGA2 GGA2 0.354 11805826,18418388 Q12028 P38817 APL4 GGA2 0.286 18467557 P38817 P38116 GGA2 ARL1 0.21 18418388 P38817 P38129 GGA2 TAF5 0.126 21734642 P38817 P32319 GGA2 PEP1 0.507 18467557,23408788 P38817 P02994 GGA2 TEF2 0.126 16429126 P38817 P07149 GGA2 FAS1 0.126 16429126 P38817 P07259 GGA2 URA2 0.126 16429126 P38817 P09435 GGA2 SSA3 0.126 19536198 P38817 P10591 GGA2 SSA1 0.236 16429126,19536198 P38817 P10592 GGA2 SSA2 0.126 19536198 P38817 P11076 GGA2 ARF1 0.454 11124697 P38817 P13134 GGA2 KEX2 0.623 23408788 P38817 P17891 GGA2 CLC1 0.507 26842894,22457357,11408593 P38817 P22137 GGA2 CHC1 0.583 11805826,16429126,11408593,22457357 P38817 P30822 GGA2 CRM1 0.261 26673895,11027275 P38817 P32790 GGA2 SLA1 0.523 20150898 P38817 P36000 GGA2 APL2 0.21 11408593 P39104 P38817 PIK1 GGA2 0.309 22344030 P40495 P38817 LYS12 GGA2 0.286 11805826,16429126 P41940 P38817 PSA1 GGA2 0.126 16429126 Q06389 P38817 FRQ1 GGA2 0.309 22344030 Q12271 P38817 INP53 GGA2 0.286 18467557 P38817 P32589 GGA2 SSE1 0.126 19536198 P38817 P32590 GGA2 SSE2 0.126 19536198 P39987 P38817 ECM10 GGA2 0.126 19536198 P38817 P33892 GGA2 GCN1 0.332 11805826,16429126 Q02724 P38817 ULP1 GGA2 0.126 23712011