PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TOP1 WSS1 24998930 biogrid exp KAR9 WSS1 18832349 biogrid exp RPT1 WSS1 20516210 biogrid exp WSS1 PAC1 23034179 biogrid exp SGS1 WSS1 i2d exp WSS1 FIN1 11929974 dip exp EBP2 WSS1 18603780 biogrid exp HEK2 WSS1 18805955 biogrid exp SSZ1 WSS1 19536198 intact exp HMG1 WSS1 24998930 biogrid exp WSS1 BIM1 18832349 biogrid exp PRE1 WSS1 20516210 biogrid exp WSS1 SNO1 18719252 biogrid,intact exp CDC48 WSS1 24998930 biogrid exp WSS1 PSY2 15598824 biogrid,i2d exp UBI4 WSS1 20516210 biogrid exp WSS1 HHO1 24998930 biogrid exp WSS1 RTA1 10688190 biogrid,i2d,mint,intact,dip exp RAD23 WSS1 20516210 biogrid exp BIK1 WSS1 23034179 biogrid exp WSS1 WSS1 24998930 biogrid exp WSS1 TOF1 15598824 biogrid,i2d exp WSS1 SLX8 20516210, 23023127 biogrid exp, pred SLX5 WSS1 20516210, 23023127 biogrid exp, pred WSS1 SMT3 24998930,20516210,15590687,18719252, 23023127 biogrid,intact exp, pred WSS1 LIN1 12402242, 23023127 biogrid,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53840 P38838 - 15598824 - X 2 P40164 P38838 - 15598824 - X 2 P38838 P38852 - 12402242 - X 2 Q03898 P38838 - 11929974 - X 2 P53047 P38838 - 10688190 - X 2 P53840 P38838 two hybrid 15598824 direct interaction X 2 Q03144 P38838 two hybrid 18719252 direct interaction X 2 P40164 P38838 two hybrid 15598824 direct interaction X 2 P32828 P38838 two hybrid 20516210 direct interaction X 2 P32828 P38838 two hybrid 20516210 direct interaction X 2 P38838 P38852 two hybrid 12402242 direct interaction X 2 P38838 P38838 enzymatic study 24998930 direct interaction X 2 P38838 P22141 affinity chromatography technology 20516210 physical association X 2 P38838 P22141 affinity chromatography technology 20516210 physical association X 2 P12683 P38838 enzymatic study 24998930 direct interaction X 2 P40013 P38838 two hybrid 18832349 direct interaction X 2 P40072 P38838 two hybrid 20516210 direct interaction X 2 P04786 P38838 enzymatic study 24998930 direct interaction X 2 P0CG63 P38838 enzymatic study 20516210 direct interaction X 2 P32628 P38838 affinity chromatography technology 20516210 physical association X 2 P53047 P38838 two hybrid 10688190 direct interaction X 2 P32526 P38838 two hybrid 18832349 direct interaction X 2 P36049 P38838 two hybrid 18603780 direct interaction X 2 P33299 P38838 affinity chromatography technology 20516210 physical association X 2 P53551 P38838 enzymatic study 24998930 direct interaction X 2 P11709 P38838 two hybrid 23034179 direct interaction X 2 P38838 P39946 two hybrid 23034179 direct interaction X 2 P38838 Q12306 two hybrid 15590687 direct interaction X 2 P38838 Q12306 enzymatic study 20516210 direct interaction X 2 P38838 P25694 pull down 24998930 direct interaction X 2 P38838 Q12306 pull down 24998930 direct interaction X 2 P38838 Q12306 enzymatic study 20516210 direct interaction X 2 P38838 Q12306 two hybrid 18719252 direct interaction X 2 Q03898 P38838 two hybrid 11929974 physical association X 2 P53047 P38838 two hybrid 10688190 physical association X 2 Q03144 P38838 two hybrid 18719252 physical association X 2 P38788 P38838 tandem affinity purification 19536198 association X 2 P38838 P38852 two hybrid 12402242 physical association X 2 P53047 P38838 two hybrid 10688190 physical association X 2 P38838 Q12306 two hybrid 18719252 physical association X 2 P48363 P38838 interaction detection method 14764870 - X 2 Q04493 P38838 interaction detection method 14764870 - X 2 P35187 P38838 interaction detection method 11743205 - X 2 P35187 P38838 interaction detection method 11743205 - X 2 P53047 P38838 two hybrid 10688190 - X 2 Q06340 P38838 interaction detection method 14764870 - X 2 P52553 P38838 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality TOP1 WSS1 24998930 0415 LC UBI4 WSS1 20516210 0415 LC BIK1 WSS1 23034179 0018 LC HMG1 WSS1 24998930 0415 LC CDC48 WSS1 26349035,26349035,26349035 0415,0096,0004 LC KAR9 WSS1 18832349 0018 LC SLX5 WSS1 20516210 0018 LC EBP2 WSS1 18603780 0018 LC WSS1 WSS1 26349035,24998930 0415,0415 LC WSS1 LIN1 12402242 0018 LC WSS1 PAC1 23034179 0018 LC WSS1 BIM1 18832349 0018 LC WSS1 SLX8 20516210 0018 LC WSS1 PSY2 15598824 0018 LC WSS1 RTA1 10688190,10688190 0397,0018 HT WSS1 HHO1 24998930 0415 LC WSS1 TOF1 15598824 0018 LC WSS1 SNO1 18719252 0018 HT WSS1 FIN1 11929974 0018 LC WSS1 SMT3 20516210,18719252,26349035,26349035,15590687,20516210 0004,0018,0096,0415,0018,0415 LC,HT RPL17A WSS1 26349035 0004 LC RAD10 WSS1 26349035 0004 LC RAD2 WSS1 26349035 0004 LC MYO1 WSS1 26349035 0004 LC HEM13 WSS1 26349035 0004 LC ERD1 WSS1 26349035 0004 LC SCL1 WSS1 26349035 0004 LC PRE1 WSS1 20516210 0004 LC RET1 WSS1 26349035 0004 LC URE2 WSS1 26349035 0004 LC CLB1 WSS1 26349035 0004 LC P25361 WSS1 26349035 0004 LC RSA4 WSS1 26349035 0004 LC USO1 WSS1 26349035 0004 LC DCC1 WSS1 26349035 0004 LC CDC48 WSS1 26349035,26349035,26349035,24998930 0415,0096,0004,0096 LC CPR3 WSS1 26349035 0004 LC PEP3 WSS1 26349035 0004 LC PRP45 WSS1 26349035 0004 LC PRR1 WSS1 26349035 0004 LC PAP1 WSS1 26349035 0004 LC DGR2 WSS1 26349035 0004 LC RAD23 WSS1 20516210 0004 LC SSO1 WSS1 26349035 0004 LC RPC34 WSS1 26349035 0004 LC RPT1 WSS1 20516210 0004 LC DOA1 WSS1 26349035,26349035 0096,0004 LC PXL1 WSS1 26349035 0004 LC PHO88 WSS1 26349035 0004 LC RRM3 WSS1 26349035 0004 LC SSZ1 WSS1 19536198 0676 HT TRA1 WSS1 26349035 0004 LC WSS1 CHL4 26349035 0004 LC WSS1 SEC72 26349035 0004 LC WSS1 PAC2 26349035 0004 LC WSS1 FIR1 26349035 0004 LC WSS1 UBP6 26349035 0004 LC WSS1 SMC3 26349035 0004 LC WSS1 P47072 26349035 0004 LC WSS1 POL32 26349035 0004 LC WSS1 ARP3 26349035 0004 LC WSS1 MSN5 26349035 0004 LC WSS1 RPN14 26349035 0004 LC WSS1 SEN1 26349035 0004 LC WSS1 RSC4 26349035 0004 LC WSS1 RAT1 26349035 0004 LC WSS1 MSH6 26349035 0004 LC WSS1 SCC2 26349035 0004 LC WSS1 EMI2 26349035 0004 LC WSS1 Q06640 26349035 0004 LC WSS1 IMH1 26349035 0004 LC WSS1 Q06833 26349035 0004 LC WSS1 TRM3 26349035 0004 LC WSS1 PPM2 26349035 0004 LC WSS1 DIA2 26349035 0004 LC WSS1 ENV7 26349035 0004 LC WSS1 THP3 26349035 0004 LC WSS1 CSF1 26349035 0004 LC WSS1 SMT3 20516210,24998930,26349035,26349035,20516210 0004,0096,0096,0415,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P38838 P25694 WSS1 CDC48 0.671 26349035,24998930 P38838 P11709 WSS1 BIK1 0.309 23034179 P38838 P38838 WSS1 WSS1 0.472 24998930,26349035 Q03144 P38838 SNO1 WSS1 0.332 18719252 Q12306 P38838 SMT3 WSS1 0.826 26349035,24998930,20516210,18719252,15590687 P38838 P38199 WSS1 HEK2 0.126 18805955 P38838 P04786 WSS1 TOP1 0.309 24998930 P38838 P05740 WSS1 RPL17A 0.126 26349035 P38838 P06838 WSS1 RAD10 0.126 26349035 P38838 P07276 WSS1 RAD2 0.126 26349035 P38838 P08964 WSS1 MYO1 0.126 26349035 P38838 P0CG63 WSS1 UBI4 0.309 20516210 P38838 P11353 WSS1 HEM13 0.126 26349035 P38838 P12683 WSS1 HMG1 0.309 24998930 P38838 P16151 WSS1 ERD1 0.126 26349035 P38838 P21243 WSS1 SCL1 0.126 26349035 P38838 P22141 WSS1 PRE1 0.376 20516210 P38838 P22276 WSS1 RET1 0.126 26349035 P38838 P23202 WSS1 URE2 0.126 26349035 P38838 P24868 WSS1 CLB1 0.126 26349035 P38838 P25361 WSS1 P25361 0.126 26349035 P38838 P25382 WSS1 RSA4 0.126 26349035 P38838 P25386 WSS1 USO1 0.126 26349035 P38838 P25559 WSS1 DCC1 0.126 26349035 P38838 P25719 WSS1 CPR3 0.126 26349035 P38838 P27801 WSS1 PEP3 0.126 26349035 P38838 P28004 WSS1 PRP45 0.126 26349035 P38838 P28708 WSS1 PRR1 0.126 26349035 P38838 P29468 WSS1 PAP1 0.126 26349035 P38838 P32330 WSS1 DGR2 0.126 26349035 P38838 P32828 WSS1 SLX5 0.523 20516210 P38838 P32867 WSS1 SSO1 0.126 26349035 P38838 P32910 WSS1 RPC34 0.126 26349035 P38838 P36166 WSS1 PXL1 0.126 26349035 P38838 P38264 WSS1 PHO88 0.126 26349035 P38838 P38766 WSS1 RRM3 0.126 26349035 P38838 P38788 WSS1 SSZ1 0.126 19536198 P38838 P38811 WSS1 TRA1 0.126 26349035 P38907 P38838 CHL4 WSS1 0.126 26349035 P39742 P38838 SEC72 WSS1 0.126 26349035 P39937 P38838 PAC2 WSS1 0.126 26349035 P40020 P38838 FIR1 WSS1 0.126 26349035 P40164 P38838 PSY2 WSS1 0.309 15598824 P43593 P38838 UBP6 WSS1 0.126 26349035 P47037 P38838 SMC3 WSS1 0.126 26349035 P47072 P38838 P47072 WSS1 0.126 26349035 P47110 P38838 POL32 WSS1 0.126 26349035 P47117 P38838 ARP3 WSS1 0.126 26349035 P52918 P38838 MSN5 WSS1 0.126 26349035 P53047 P38838 RTA1 WSS1 0.332 10688190 P53196 P38838 RPN14 WSS1 0.126 26349035 P53551 P38838 HHO1 WSS1 0.309 24998930 P53840 P38838 TOF1 WSS1 0.309 15598824 Q00416 P38838 SEN1 WSS1 0.126 26349035 Q02206 P38838 RSC4 WSS1 0.126 26349035 Q02792 P38838 RAT1 WSS1 0.126 26349035 Q03834 P38838 MSH6 WSS1 0.126 26349035 Q03898 P38838 FIN1 WSS1 0.033 11929974 Q04002 P38838 SCC2 WSS1 0.126 26349035 Q04409 P38838 EMI2 WSS1 0.126 26349035 Q06640 P38838 Q06640 WSS1 0.126 26349035 Q06704 P38838 IMH1 WSS1 0.126 26349035 Q06833 P38838 Q06833 WSS1 0.126 26349035 Q07527 P38838 TRM3 WSS1 0.126 26349035 Q08282 P38838 PPM2 WSS1 0.126 26349035 Q08496 P38838 DIA2 WSS1 0.126 26349035 Q12003 P38838 ENV7 WSS1 0.126 26349035 Q12049 P38838 THP3 WSS1 0.126 26349035 Q12150 P38838 CSF1 WSS1 0.126 26349035 P38852 P38838 LIN1 WSS1 0.309 12402242 P38838 P32526 WSS1 KAR9 0.309 18832349 P38838 P32628 WSS1 RAD23 0.21 20516210 P38838 P33299 WSS1 RPT1 0.21 20516210 P39946 P38838 PAC1 WSS1 0.309 23034179 P40013 P38838 BIM1 WSS1 0.309 18832349 P40072 P38838 SLX8 WSS1 0.309 20516210 P38838 P36037 WSS1 DOA1 0.376 26349035 P38838 P36049 WSS1 EBP2 0.309 18603780 P63279 P38838 UBE2I WSS1 0.332 27107014