PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ATG7 GIS2 10688190 dip exp OCT1 ATG7 10688190 dip exp ATG7 PUF3 26493364 biogrid exp ATG7 SSB2 23332755,19536198 biogrid,intact exp ATG7 ULS1 11805837 biogrid,mint,intact,dip exp WHI3 ATG7 24386330 biogrid exp ATG7 ATG7 11139573,21193819,12965207, 23023127 biogrid,i2d,intact,dip exp, ortho, pred ATG8 ATG7 22325599,11139573,22056771,22055191,12965207,19398890,18719252,10688190,11100732,25042851, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred ATG7 VID27 11283351, 23023127 i2d,mint,intact,dip exp, pred ATG7 Putative magnesium-dependent phosphatase YER134C 18719252, 23023127 biogrid,intact exp, pred ATG7 ATG10 22056771,23142976,10508157,18719252, 23023127 biogrid,intact,dip exp, pred ATG7 ATG5 23023127 i2d exp, pred ATG7 SSO2 10688190,11489916, 23023127 biogrid,i2d,mint,intact,dip exp, pred ATG12 ATG7 11139573,10233150,10688190,12965207,11283351, 23023127 biogrid,i2d,mint,intact,dip exp, pred ATG7 ATG3 22325599,11139573,17986448,22056771,23142976,22055191,12965207,11283351,18719252,10688190,17227760, 23023127 biogrid,i2d,mint,intact,dip exp, pred ATG7 VPS36 ortho ATG7 YHC3 ortho SES1 ATG7 ortho PRE10 ATG7 ortho SHM1 ATG7 ortho SUP35 ATG7 ortho CMP2 ATG7 ortho VMA5 ATG7 ortho SEC17 ATG7 23023127 pred PEP4 ATG7 23023127 pred PRB1 ATG7 23023127 pred ATG7 PPM1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38862 - 11805837 - C 4 P38862 P40157 - 11283351 - X 2 P38182 P38862 - 10688190 - X 2 P40344 P38862 - 10688190 - X 2 P40344 P38862 - 11283351 - X 2 P39926 P38862 - 11489916 - X 2 P38316 P38862 - 10688190 - X 2 P38316 P38862 - 11283351 - X 2 P38862 P38862 two hybrid 12965207 direct interaction X 2 P38862 P38862 two hybrid 11139573 direct interaction X 2 P38862 P38862 affinity chromatography technology 11139573 physical association X 2 P38862 P38862 pull down 21193819 direct interaction X 2 P38862 Q08562 affinity chromatography technology 11805837 physical association X 2 P38182 P38862 two hybrid 12965207 direct interaction X 2 P38182 P38862 affinity chromatography technology 11100732 physical association X 2 P38182 P38862 two hybrid 11139573 direct interaction X 2 P38182 P38862 affinity chromatography technology 11139573 physical association X 2 P38182 P38862 pull down 22325599 direct interaction X 2 P38182 P38862 affinity chromatography technology 25042851 physical association X 2 P38182 P38862 two hybrid 18719252 direct interaction X 2 P38182 P38862 affinity chromatography technology 19398890 physical association X 2 P38182 P38862 two hybrid 19398890 direct interaction X 2 P38182 P38862 pull down 22055191 direct interaction X 2 P38182 P38862 x-ray crystallography 22055191 association X 2 P38182 P38862 pull down 22056771 direct interaction X 2 P38182 P38862 x-ray crystallography 22056771 association X 2 P38182 P38862 two hybrid 10688190 direct interaction X 2 P40150 P38862 biochemical 23332755 association X 2 P40344 P38862 x-ray crystallography 23142976 association X 2 P40344 P38862 two hybrid 12965207 direct interaction X 2 P40344 P38862 two hybrid 11139573 direct interaction X 2 P40344 P38862 affinity chromatography technology 11139573 physical association X 2 P40344 P38862 pull down 17986448 direct interaction X 2 P40344 P38862 pull down 22325599 direct interaction X 2 P40344 P38862 two hybrid 11283351 direct interaction X 2 P40344 P38862 pull down 17227760 direct interaction X 2 P40344 P38862 two hybrid 18719252 direct interaction X 2 P40344 P38862 two hybrid 11283351 direct interaction X 2 P40344 P38862 pull down 22055191 direct interaction X 2 P40344 P38862 x-ray crystallography 22055191 association X 2 P40344 P38862 pull down 22056771 direct interaction X 2 P40344 P38862 two hybrid 10688190 direct interaction X 2 P39926 P38862 two hybrid 11489916 direct interaction X 2 P38316 P38862 two hybrid 12965207 direct interaction X 2 P38316 P38862 affinity chromatography technology 10233150 physical association X 2 P38316 P38862 two hybrid 10233150 direct interaction X 2 P38316 P38862 two hybrid 11139573 direct interaction X 2 P38316 P38862 two hybrid 11283351 direct interaction X 2 P38316 P38862 two hybrid 10688190 direct interaction X 2 Q07879 P38862 x-ray crystallography 23142976 association X 2 Q07879 P38862 two hybrid 10508157 direct interaction X 2 Q07879 P38862 two hybrid 18719252 direct interaction X 2 Q07879 P38862 pull down 22056771 direct interaction X 2 P40081 P38862 two hybrid 18719252 direct interaction X 2 P38862 anti tag coimmunoprecipitation 11805837 - C 4 P38862 molecular sieving 22056771 physical association C 3 P38862 molecular sieving 22056771 physical association C 3 P38862 P40157 two hybrid pooling approach 11283351 physical association X 2 P38862 Q658J6 molecular sieving 22056771 direct interaction X 2 P38862 Q658J6 comigration in sds page 22056771 direct interaction X 2 P38862 Q08562 anti tag coimmunoprecipitation 11805837 physical association X 2 P38182 P38862 comigration in sds page 22056771 covalent binding X 2 P38182 P38862 x-ray crystallography 22056771 covalent binding X 2 P38182 P38862 comigration in sds page 22056771 covalent binding X 2 P38182 P38862 coimmunoprecipitation 11100732 covalent binding X 2 P38182 P38862 two hybrid 11139573 covalent binding X 2 P38182 P38862 molecular sieving 22056771 covalent binding X 2 P38182 P38862 molecular sieving 22056771 covalent binding X 2 P38182 P38862 comigration in sds page 23142976 covalent binding X 2 P38182 P38862 two hybrid 10688190 covalent binding X 2 P38182 P38862 coimmunoprecipitation 11139573 covalent binding X 2 P40344 P38862 two hybrid pooling approach 11283351 direct interaction X 2 P40344 P38862 two hybrid 10688190 direct interaction X 2 P40344 P38862 molecular sieving 22056771 direct interaction X 2 P40344 P38862 two hybrid pooling approach 11283351 direct interaction X 2 P40344 P38862 light scattering 22056771 direct interaction X 2 P40344 P38862 cross-linking study 23142976 direct interaction X 2 P40344 P38862 coimmunoprecipitation 11139573 direct interaction X 2 P40344 P38862 molecular sieving 22056771 direct interaction X 2 P40344 P38862 cross-linking study 23142976 direct interaction X 2 P40344 P38862 two hybrid 11139573 direct interaction X 2 P39926 P38862 two hybrid 10688190 physical association X 2 P39926 P38862 two hybrid 11489916 physical association X 2 P38862 P38862 two hybrid 11139573 direct interaction Y 1 P38862 P38862 biochemical 11139573 direct interaction Y 1 P38862 P38862 light scattering 22056771 direct interaction Y 1 P38862 P38862 cross-linking study 11139573 direct interaction Y 1 P38862 P38862 coimmunoprecipitation 11139573 direct interaction Y 1 P38862 P38862 molecular sieving 22056771 direct interaction Y 1 P38862 P53849 two hybrid 10688190 physical association X 2 P38862 two hybrid 10688190 physical association X 2 P38316 P38862 two hybrid 11139573 physical association X 2 P38316 P38862 coimmunoprecipitation 10233150 physical association X 2 P38316 P38862 two hybrid 10688190 physical association X 2 P38316 P38862 two hybrid 10233150 physical association X 2 P38316 P38862 two hybrid pooling approach 11283351 physical association X 2 Q07879 P38862 cross-linking study 23142976 direct interaction X 2 Q07879 P38862 light scattering 22056771 direct interaction X 2 Q07879 P38862 cross-linking study 23142976 direct interaction X 2 Q07879 P38862 cross-linking study 23142976 direct interaction X 2 Q07879 P38862 molecular sieving 22056771 direct interaction X 2 Q07879 P38862 molecular sieving 22056771 direct interaction X 2 P38862 anti tag coimmunoprecipitation 25042851 association C 4 P38862 anti tag coimmunoprecipitation 11805837 association C 4 P38862 P40157 two hybrid fragment pooling approach 11283351 physical association X 2 P38862 P38862 cross-linking study 12965207 physical association X 2 P38182 P38862 two hybrid 10688190 physical association X 2 P38182 P38862 two hybrid 12965207 physical association X 2 P38182 P38862 two hybrid 18719252 physical association X 2 P40150 P38862 tandem affinity purification 19536198 association X 2 P40344 P38862 two hybrid 10688190 physical association X 2 P40344 P38862 two hybrid fragment pooling approach 11283351 physical association X 2 P40344 P38862 two hybrid fragment pooling approach 11283351 physical association X 2 P40344 P38862 two hybrid 12965207 physical association X 2 P40344 P38862 two hybrid 18719252 physical association X 2 P39926 P38862 two hybrid 10688190 physical association X 2 P38316 P38862 two hybrid 10688190 physical association X 2 P38316 P38862 two hybrid fragment pooling approach 11283351 physical association X 2 P38316 P38862 two hybrid 12965207 physical association X 2 Q07879 P38862 two hybrid 18719252 physical association X 2 P40081 P38862 two hybrid 18719252 physical association X 2 P38862 P40157 two hybrid 11283351 - X 2 P38182 P38862 two hybrid 10688190 - X 2 P40344 P38862 two hybrid 10688190 - X 2 P40344 P38862 two hybrid 11283351 - X 2 P40344 P38862 two hybrid 11283351 - X 2 P39926 P38862 two hybrid 11489916 - X 2 P39926 P38862 two hybrid 11489916 - X 2 P38862 mass spectrometry studies of complexes 11805837 - C 5 P38316 P38862 two hybrid 11283351 - X 2 P38316 P38862 interaction detection method - - X 2 P38316 P38862 two hybrid 10688190 - X 2 Q12380 P38862 interaction detection method - - X 2

PPI - HINT Gene A Gene B PMID Method Quality OCT1 ATG7 10688190 0018 HT ATG8 ATG7 19398890,18719252,11139573,12965207,22055191,11100732,11100732,11139573,22055191,11139573,23142976,22056771,10688190,22056771,22056771,10688190,22056771,19398890 0018,0018,0004,0018,0114,0004,0019,0019,0096,0018,0808,0071,0018,0808,0114,0397,0096,0004 LC,HT ATG12 ATG7 10233150,10688190,12965207,11283351,11283351,10233150,11283351,10233150,11139573,10688190 0004,0397,0018,0018,0399,0018,0398,0019,0018,0018 LC,HT ATG7 ATG7 11139573,11139573,12965207,12965207,11139573,22056771,11139573,22056771,23142976,22055190,11139573 0030,0401,0018,0030,0019,0067,0018,0071,0114,0114,0004 LC ATG7 SSO2 11489916,10688190 0018,0018 HT ATG7 P40081 18719252 0018 HT ATG7 SSB2 23332755 0401 LC ATG7 VID27 11283351,11283351,11283351 0018,0399,0398 HT ATG7 ATG3 22055190,17986448,11139573,22055191,11139573,12965207,22055191,11139573,11283351,10688190,10688190,11283351,17986448,18719252,23142976,22056771,11283351,22056771,22056771,23142976 0114,0415,0018,0096,0004,0018,0114,0019,0398,0397,0018,0399,0096,0018,0030,0067,0018,0096,0071,0114 LC,HT ATG7 GIS2 10688190 0018 HT ATG7 ATG10 18719252,22056771,22056771,22056771,23142976,10508157,23142976 0018,0067,0096,0071,0114,0018,0030 HT,LC WHI3 ATG7 24386330 0004 LC ATG8 ATG7 22325599,19398890,11139573,22055191,11100732,11100732,11139573,22055191,11139573,25042851,22056771,25042851,22056771,22056771,22056771,19398890 0096,0018,0004,0114,0004,0019,0019,0096,0018,0004,0071,0007,0808,0114,0096,0004 LC ATG12 ATG7 10233150,10233150,10233150 0004,0018,0019 LC ATG7 ATG7 11139573,21193819,11139573,11139573,11139573,11139573 0030,0096,0401,0019,0018,0004 LC ATG7 SSB2 19536198,23332755 0676,0401 HT,LC ATG7 ATG3 17986448,11139573,22055191,11139573,22055191,11139573,17986448,22325599,22056771,22056771,22056771,17227760 0415,0018,0096,0004,0114,0019,0096,0096,0067,0096,0071,0096 LC ATG7 ATG10 22056771,22056771,22056771 0067,0096,0071 LC ATG7 ULS1 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P38862 P38862 ATG7 ATG7 0.636 12965207,11139573,21193819 P38862 P38316 ATG7 ATG12 0.702 10688190,10233150,11283351,12965207,11139573 P40150 P38862 SSB2 ATG7 0.236 23332755,19536198 P38862 P38182 ATG7 ATG8 0.977 10688190,25042851,22056771,12965207,11100732,11139573,22325599,18719252,22055191,19398890 P40344 P38862 ATG3 ATG7 0.974 10688190,22056771,17986448,11283351,12965207,23142976,11139573,22325599,18719252,22055191 P38862 P35999 ATG7 OCT1 0.033 10688190 P39926 P38862 SSO2 ATG7 0.332 10688190,11489916 P40081 P38862 P40081 ATG7 0.332 18719252 P40157 P38862 VID27 ATG7 0.236 11283351 Q07879 P38862 ATG10 ATG7 0.78 10508157,23142976,18719252,22056771 Q08562 P38862 ULS1 ATG7 0.332 11805837 P38862 P34761 ATG7 WHI3 0.126 24386330 P53849 P38862 GIS2 ATG7 0.033 10688190 Q07807 P38862 PUF3 ATG7 0.126 26493364