PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSE1 URM1 19536198 intact exp URM1 MEC3 11283351 i2d,mint,intact,dip exp URM1 GIS2 21232131 biogrid exp URM1 URM1 18260097 biogrid exp URM1 SLF1 22271760 biogrid exp URM1 LGE1 i2d exp ILV2 URM1 i2d exp URM1 LSM8 i2d exp SSA1 URM1 19536198 intact exp AHP1 URM1 14555475 biogrid exp BMH2 URM1 i2d exp URM1 COP1 i2d exp URM1 SRP1 11283351 i2d,mint,intact,dip exp URM1 PUF3 23409723 biogrid exp NAB2 URM1 19840948 biogrid exp URM1 UPF3 11283351, 23023127 i2d,mint,intact,dip exp, pred BZZ1 URM1 11283351, 23023127 i2d,mint,intact,dip exp, pred URM1 NOP56 11283351, 23023127 i2d,mint,intact,dip exp, pred UBA4 URM1 10688190,19145231,11283351,10713047,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred URM1 ULP1 23403034, 23023127 biogrid exp, pred URM1 NCS2 19145231, 23023127 biogrid,dip exp, pred URM1 NCS6 19145231, 23023127 biogrid,dip exp, pred SLA1 URM1 23023127 pred UBC1 URM1 23023127 pred SEC4 URM1 23023127 pred CUE2 URM1 23023127 pred URM1 RUB1 23023127 pred URM1 UBC12 23023127 pred UBP14 URM1 23023127 pred SHO1 URM1 23023127 pred URM1 UBI4 23023127 pred UBA1 URM1 23023127 pred CDC34 URM1 23023127 pred URM1 UBC11 23023127 pred RSR1 URM1 23023127 pred RAD6 URM1 23023127 pred URM1 OTU1 23023127 pred URM1 ELP2 23023127 pred UBC4 URM1 23023127 pred CDC24 URM1 23023127 pred UBC5 URM1 23023127 pred MYO3 URM1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40554 P38822 - 11283351 - X 2 P40554 Q02574 - 11283351 - X 2 P40554 P48412 - 11283351 - X 2 P40554 Q02821 - 11283351 - X 2 P40554 P38820 - 11283351 - X 2 P40554 P38820 - 10688190 - X 2 P40554 Q12460 - 11283351 - X 2 P40554 P40554 x-ray crystallography 18260097 association X 2 P40554 P53923 two hybrid 19145231 direct interaction X 2 P40554 P53923 affinity chromatography technology 19145231 physical association X 2 Q02724 P40554 protein complementation assay 23403034 direct interaction X 2 P40554 P38013 affinity chromatography technology 14555475 physical association X 2 P40554 Q12306 protein complementation assay 23403034 direct interaction X 2 P40554 P38820 two hybrid 10713047 direct interaction X 2 P40554 P38820 affinity chromatography technology 10713047 physical association X 2 P40554 P38820 two hybrid 11283351 direct interaction X 2 P40554 P38820 two hybrid 18719252 direct interaction X 2 P40554 P38820 two hybrid 19145231 direct interaction X 2 P40554 P53088 two hybrid 19145231 direct interaction X 2 P40554 P38820 two hybrid 19145231 direct interaction X 2 P40554 P38820 affinity chromatography technology 19145231 physical association X 2 P40554 P53088 affinity chromatography technology 19145231 physical association X 2 P40554 P38820 affinity chromatography technology 19145231 physical association X 2 P40554 P53088 affinity chromatography technology 19145231 physical association X 2 P40554 P38820 enzymatic study 19145231 direct interaction X 2 P40554 P38820 two hybrid 11283351 direct interaction X 2 P40554 P38820 two hybrid 10688190 direct interaction X 2 P40554 anti tag coimmunoprecipitation 19145231 - C 4 P40554 tandem affinity purification 19145231 - C 5 P40554 Q02574 two hybrid pooling approach 11283351 physical association X 2 P40554 P53923 two hybrid 19145231 physical association X 2 P40554 P53923 anti tag coimmunoprecipitation 19145231 physical association X 2 P40554 P38822 two hybrid pooling approach 11283351 physical association X 2 P40554 tandem affinity purification 19145231 - C 4 P40554 Q02821 two hybrid pooling approach 11283351 physical association X 2 P40554 P53088 anti tag coimmunoprecipitation 19145231 physical association X 2 P40554 P53088 tandem affinity purification 19145231 physical association X 2 P40554 P53088 two hybrid 19145231 physical association X 2 P40554 P48412 two hybrid pooling approach 11283351 physical association X 2 P40554 Q12460 two hybrid pooling approach 11283351 physical association X 2 P40554 P38820 two hybrid 10688190 direct interaction X 2 P40554 P38820 two hybrid 19145231 direct interaction X 2 P40554 P38820 two hybrid pooling approach 11283351 direct interaction X 2 P40554 P38820 two hybrid pooling approach 11283351 direct interaction X 2 P40554 P38820 two hybrid 19145231 direct interaction X 2 P40554 P38820 tandem affinity purification 19145231 direct interaction X 2 P40554 P38820 enzymatic study 19145231 direct interaction X 2 P40554 P38820 anti tag coimmunoprecipitation 19145231 direct interaction X 2 P32589 P40554 tandem affinity purification 19536198 association X 2 P40554 P38822 two hybrid fragment pooling approach 11283351 physical association X 2 P40554 Q02574 two hybrid fragment pooling approach 11283351 physical association X 2 P10591 P40554 tandem affinity purification 19536198 association X 2 P40554 P38820 two hybrid 10688190 physical association X 2 P40554 P48412 two hybrid fragment pooling approach 11283351 physical association X 2 P40554 P38820 two hybrid fragment pooling approach 11283351 physical association X 2 P40554 P38820 two hybrid fragment pooling approach 11283351 physical association X 2 P40554 Q12460 two hybrid fragment pooling approach 11283351 physical association X 2 P40554 Q02821 two hybrid fragment pooling approach 11283351 physical association X 2 P40554 P38820 two hybrid 18719252 physical association X 2 P40554 P38822 two hybrid 11283351 - X 2 P40554 Q02574 two hybrid 11283351 - X 2 Q04493 P40554 interaction detection method 14764870 - X 2 P40554 P38820 two hybrid 10688190 - X 2 P40554 P38820 two hybrid 11283351 - X 2 P40554 P38820 two hybrid 11283351 - X 2 P40554 Q12460 two hybrid 11283351 - X 2 P40554 Q02821 two hybrid 11283351 - X 2 P40554 P48363 interaction detection method 14764870 - X 2 P40554 P52553 interaction detection method 14764870 - X 2 P40554 P19524 interaction detection method 14764870 - X 2 P40554 P48412 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBA4 URM1 18719252,10713047,19145231,19145231,11283351,10713047,11283351,19145231,10713047,19145231,19145231,10688190,11283351,10688190 0018,0415,0018,0007,0018,0004,0398,0004,0018,0415,0676,0397,0399,0018 HT,LC BZZ1 URM1 11283351,11283351,11283351 0018,0399,0398 HT URM1 URM1 18260097 0114 LC URM1 UPF3 11283351,11283351,11283351 0018,0399,0398 HT URM1 NCS6 19145231,19145231,19145231,19145231 0004,0018,0007,0676 LC URM1 NCS2 19145231,19145231,19145231 0018,0007,0004 LC URM1 MEC3 11283351,11283351,11283351 0018,0399,0398 HT URM1 ULP1 23403034 0090 HT URM1 SRP1 11283351,11283351,11283351 0018,0399,0398 HT URM1 NOP56 11283351,11283351,11283351 0018,0399,0398 HT SSA1 URM1 19536198 0676 HT NAB2 URM1 19840948 0004 LC SSE1 URM1 19536198 0676 HT AHP1 URM1 14555475 0004 LC UBA4 URM1 10713047,19145231,19145231,10713047,19145231,10713047,19145231,19145231 0415,0018,0007,0004,0004,0018,0415,0676 LC URM1 NCS6 19145231,19145231,19145231,19145231 0004,0018,0007,0676 LC URM1 NCS2 19145231,19145231,19145231 0018,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12221 P40554 PUF2 URM1 0.126 26668354 Q12460 P40554 NOP56 URM1 0.21 11283351 P40554 P38820 URM1 UBA4 0.963 10688190,19145231,18719252,11283351,10713047 P40554 P32505 URM1 NAB2 0.126 19840948 P40554 P32589 URM1 SSE1 0.126 19536198 P40554 P10591 URM1 SSA1 0.126 19536198 P40554 P38822 URM1 BZZ1 0.21 11283351 P40554 P40554 URM1 URM1 0.332 18260097 P48412 P40554 UPF3 URM1 0.236 11283351 P53088 P40554 NCS6 URM1 0.569 19145231 P53923 P40554 NCS2 URM1 0.454 19145231 Q02574 P40554 MEC3 URM1 0.21 11283351 Q02821 P40554 SRP1 URM1 0.21 11283351 Q02724 P40554 ULP1 URM1 0.183 23403034 P53849 P40554 GIS2 URM1 0.126 21232131 Q07807 P40554 PUF3 URM1 0.126 23409723