PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBP7 UBC7 14690591 intact exp UBP7 ACC1 i2d exp UBP7 TOS3 16319894 biogrid,i2d exp UBP7 LAP3 i2d exp KGD1 UBP7 i2d exp UBP7 BCK1 i2d exp GDH2 UBP7 i2d exp RVS167 UBP7 19841731,11805837 biogrid,i2d,mint,intact,dip exp UBP7 PEX13 19841731 biogrid,mint,intact exp PPR1 UBP7 16554755 biogrid,i2d,mint,intact exp UBP7 VAM6 25026036 biogrid exp YCK1 UBP7 16319894 biogrid exp UBP7 LSB3 19841731,14737190 biogrid,i2d,mint,intact exp UBP7 Uncharacterized protein YGL081W i2d exp UBP7 MLP1 24152732 biogrid exp UBP7 LAS17 21035341 biogrid exp UBP7 HMS2 i2d exp BZZ1 UBP7 19841731,11743162 biogrid,i2d,mint,intact,dip exp UBP7 SKY1 16319894 biogrid,i2d exp UBP7 ATG1 16319894 biogrid,i2d exp PDS1 UBP7 22072716 biogrid exp UBP7 PTK2 16319894 biogrid,i2d exp SHO1 UBP7 19841731 biogrid,mint,intact exp RPN1 UBP7 i2d exp CDC24 UBP7 i2d exp UBP7 LSB1 11743162,19841731 mint,intact exp CRM1 UBP7 26673895 biogrid exp SWE1 UBP7 i2d exp STT3 UBP7 i2d exp UBP7 SCS7 i2d exp YSC84 UBP7 19841731 biogrid,mint,intact exp UBP7 VHS1 21460040 biogrid exp UBP7 MYO5 19841731,11743162,14737190 biogrid,i2d,mint,intact,dip exp UBP7 BBC1 16554755 biogrid,i2d,mint,intact exp KSP1 UBP7 i2d exp SIS1 UBP7 19536198 intact exp HSE1 UBP7 19841731,11743162,17079730 biogrid,i2d,mint,intact,dip exp HSP82 UBP7 19536198 intact exp HSP60 UBP7 19536198 intact exp SNF1 UBP7 16319894 biogrid,i2d exp UBP7 KAP95 i2d exp IPL1 UBP7 16319894 biogrid,i2d exp TPK1 UBP7 16319894 biogrid,i2d exp UBP7 PIN3 19841731 biogrid,mint,intact exp SSE1 UBP7 19536198 intact exp HEK2 UBP7 18805955 biogrid exp UBP7 MON2 i2d exp CCL1 UBP7 i2d exp UBP7 PUF3 23409723 biogrid exp NDT80 UBP7 16554755 biogrid,i2d,mint,intact exp UBP7 AIM21 i2d exp PHO85 UBP7 16319894 biogrid,i2d exp GLC3 UBP7 i2d exp UBP7 STE20 16319894 biogrid,i2d exp SSB1 UBP7 19536198 intact exp ECM10 UBP7 19536198 intact exp MYO3 UBP7 19841731,11743162,11901111 biogrid,i2d,mint,intact,dip exp UBP7 HOF1 19841731 biogrid,mint,intact exp SSA1 UBP7 19536198 intact exp YCK2 UBP7 16319894 biogrid,i2d exp UBP7 NBP2 19841731, 23023127 mint,intact exp, pred UBP7 UBP2 23023127 i2d exp, pred SLA1 UBP7 19841731, 23023127 biogrid,mint,intact exp, pred UBP7 CYK3 19841731, 23023127 mint,intact exp, pred BEM1 UBP7 19841731, 23023127 mint,intact exp, pred UBP7 UBP16 23023127 pred DOA4 UBP7 23023127 pred UBP7 UBI4 23023127 pred UBP11 UBP7 23023127 pred UBP7 UBP10 23023127 pred RPN3 UBP7 23023127 pred UBX7 UBP7 23023127 pred UBP7 UBP15 23023127 pred UBP7 UBP3 23023127 pred UBP7 UBX5 23023127 pred UBP5 UBP7 23023127 pred UBP7 UBP6 23023127 pred UBP7 UBP8 23023127 pred UBP7 UBX6 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40453 - 11805837 - C 7 P40453 Q04439 - 11743162 - X 2 P40453 Q04439 - 14737190 - X 2 P40453 Q04439 - 14737190 - X 2 P40453 - 14737190 - X 2 P40453 - 14737190 - X 2 P40453 P38753 - 11743162 - X 2 P40453 P38822 - 11743162 - X 2 P40453 - 11743162 - X 2 P40453 P36006 two hybrid 11901111 direct interaction X 2 P40453 P38822 two hybrid 11743162 direct interaction X 2 P40453 P36006 two hybrid 11743162 direct interaction X 2 P40453 Q04439 two hybrid 11743162 direct interaction X 2 P40453 P38753 two hybrid 11743162 direct interaction X 2 P40453 P40316 enzymatic study 22072716 direct interaction X 2 P40453 P07272 affinity chromatography technology 16554755 physical association X 2 P40453 P53104 enzymatic study 16319894 direct interaction X 2 P40453 P47116 enzymatic study 16319894 direct interaction X 2 P40453 Q03656 enzymatic study 16319894 direct interaction X 2 P40453 P43637 enzymatic study 16319894 direct interaction X 2 P40453 P23291 enzymatic study 16319894 direct interaction X 2 P40453 P38753 affinity chromatography technology 17079730 physical association X 2 P40453 P38753 affinity chromatography technology 17079730 physical association X 2 P40453 P38753 pull down 17079730 direct interaction X 2 P40453 P38822 two hybrid 19841731 direct interaction X 2 P40453 Q05080 two hybrid 19841731 direct interaction X 2 P40453 P38753 two hybrid 19841731 direct interaction X 2 P40453 P43603 two hybrid 19841731 direct interaction X 2 P40453 P36006 two hybrid 19841731 direct interaction X 2 P40453 Q04439 two hybrid 19841731 direct interaction X 2 P40453 P17157 enzymatic study 16319894 direct interaction X 2 P06782 P40453 enzymatic study 16319894 direct interaction X 2 Q06449 P40453 two hybrid 19841731 direct interaction X 2 P23292 P40453 enzymatic study 16319894 direct interaction X 2 P0CG63 P40453 affinity chromatography technology 23749301 physical association X 2 P0CG63 P40453 biochemical 23583075 association X 2 P0CG63 P40453 affinity chromatography technology 23793018 physical association X 2 P0CG63 P40453 affinity chromatography technology 21427232 physical association X 2 P40453 W4YHN9 enzymatic study 22072716 direct interaction X 2 P40453 P38830 affinity chromatography technology 16554755 physical association X 2 P40453 P38991 enzymatic study 16319894 direct interaction X 2 P40453 Q03497 enzymatic study 16319894 direct interaction X 2 P40453 P06244 enzymatic study 16319894 direct interaction X 2 P40453 P32793 two hybrid 19841731 direct interaction X 2 P40453 P80667 two hybrid 19841731 direct interaction X 2 P40453 P39743 two hybrid 19841731 direct interaction X 2 P40453 P32790 two hybrid 19841731 direct interaction X 2 P40453 Q12446 affinity chromatography technology 21035341 physical association X 2 P40453 P39743 affinity chromatography technology 11805837 physical association X 2 Q03785 P40453 pull down 21460040 direct interaction X 2 Q03785 P40453 affinity chromatography technology 21460040 physical association X 2 P40073 P40453 two hybrid 19841731 direct interaction X 2 P47068 P40453 affinity chromatography technology 16554755 physical association X 2 P40453 anti tag coimmunoprecipitation 11805837 - C 11 P40453 anti tag coimmunoprecipitation 11805837 - C 7 P40453 P38822 two hybrid 11743162 physical association X 2 P40453 P36006 two hybrid 11743162 physical association X 2 P40453 Q04439 two hybrid 11743162 physical association X 2 P40453 P38753 two hybrid 11743162 physical association X 2 P40453 P39743 anti tag coimmunoprecipitation 11805837 physical association X 2 P40453 anti tag coimmunoprecipitation 11805837 association C 15 P11484 P40453 tandem affinity purification 19536198 association X 2 P29366 P40453 inferred by author 19841731 direct interaction X 2 Q02159 P40453 two hybrid array 14690591 physical association X 2 P02829 P40453 tandem affinity purification 19536198 association X 2 Q07533 P40453 inferred by author 19841731 direct interaction X 2 P40453 Q04439 two hybrid 11743162 physical association X 2 P40453 P38822 two hybrid 11743162 physical association X 2 P40453 P38753 two hybrid array 11743162 physical association X 2 P40453 P36006 two hybrid 11743162 physical association X 2 P40453 P43603 peptide array 14737190 direct interaction X 2 P40453 Q04439 peptide array 14737190 direct interaction X 2 P40453 P07272 tandem affinity purification 16554755 physical association X 2 P40453 P07272 tandem affinity purification 16554755 physical association X 2 P40453 P25294 tandem affinity purification 19536198 association X 2 P40453 P43603 inferred by author 19841731 direct interaction X 2 P40453 P53281 inferred by author 19841731 direct interaction X 2 P40453 P53281 inferred by author 19841731 direct interaction X 2 P40453 P38753 inferred by author 19841731 direct interaction X 2 P40453 P38822 inferred by author 19841731 direct interaction X 2 P40453 P38822 inferred by author 19841731 direct interaction X 2 P40453 P38822 two hybrid pooling approach 19841731 physical association X 2 P40453 Q05080 peptide array 19841731 direct interaction X 2 P40453 P38753 peptide array 19841731 direct interaction X 2 P40453 P38822 two hybrid pooling approach 19841731 physical association X 2 P40453 P38753 two hybrid array 19841731 physical association X 2 P40453 P36006 two hybrid array 19841731 physical association X 2 P40453 Q04439 two hybrid array 19841731 physical association X 2 P40453 Q05080 two hybrid pooling approach 19841731 physical association X 2 P40453 P38753 two hybrid pooling approach 19841731 physical association X 2 P40453 P43603 two hybrid pooling approach 19841731 physical association X 2 P40453 P36006 two hybrid pooling approach 19841731 physical association X 2 P40453 Q04439 two hybrid pooling approach 19841731 physical association X 2 P10591 P40453 tandem affinity purification 19536198 association X 2 P40453 inferred by author 16554755 association C 4 P19882 P40453 tandem affinity purification 19536198 association X 2 P32589 P40453 tandem affinity purification 19536198 association X 2 Q06449 P40453 two hybrid pooling approach 19841731 physical association X 2 P40453 P38830 tandem affinity purification 16554755 physical association X 2 P40453 P39987 tandem affinity purification 19536198 association X 2 P40453 P32790 two hybrid pooling approach 19841731 physical association X 2 P40453 Q12163 inferred by author 19841731 direct interaction X 2 P40453 P39743 inferred by author 19841731 direct interaction X 2 P40453 P39743 inferred by author 19841731 direct interaction X 2 P40453 P32793 inferred by author 19841731 direct interaction X 2 P40453 P80667 peptide array 19841731 direct interaction X 2 P40453 P32793 two hybrid pooling approach 19841731 physical association X 2 P40453 P80667 two hybrid pooling approach 19841731 physical association X 2 P40453 P39743 two hybrid pooling approach 19841731 physical association X 2 P40073 P40453 two hybrid pooling approach 19841731 physical association X 2 P47068 P40453 tandem affinity purification 16554755 physical association X 2 P47068 P40453 tandem affinity purification 16554755 physical association X 2 P40453 P38822 two hybrid 11743162 - X 2 P40453 P36006 two hybrid 11743162 - X 2 P40453 Q04439 two hybrid 11743162 - X 2 P40453 P38753 two hybrid 11743162 - X 2 P40453 mass spectrometry studies of complexes 11805837 - C 8

PPI - HINT Gene A Gene B PMID Method Quality TPK1 UBP7 16319894 0415 LC SNF1 UBP7 16319894 0415 LC PHO85 UBP7 16319894 0415 LC YCK1 UBP7 16319894 0415 LC YCK2 UBP7 16319894 0415 LC SLA1 UBP7 19841731,19841731 0398,0018 HT YSC84 UBP7 19841731,19841731,19841731 0398,0363,0018 HT MYO3 UBP7 19841731,11743162,11743162,11901111,19841731,19841731 0018,0397,0018,0018,0397,0398 HT,LC HSE1 UBP7 19841731,11743162,19841731,11743162,19841731,19841731,19841731 0018,0397,0363,0018,0397,0398,0081 HT BZZ1 UBP7 19841731,11743162,19841731,11743162,19841731 0018,0397,0363,0018,0398 HT IPL1 UBP7 16319894 0415 LC RVS167 UBP7 19841731,19841731,19841731 0018,0363,0398 HT SHO1 UBP7 19841731,19841731 0398,0018 HT PDS1 UBP7 22072716 0415 LC UBP7 LSB3 14737190,19841731,19841731,14737190,19841731 0081,0398,0363,0045,0018 HT UBP7 TOS3 16319894 0415 LC UBP7 PTK2 16319894 0415 LC UBP7 ATG1 16319894 0415 LC UBP7 PEX13 19841731,19841731,19841731 0398,0081,0018 HT UBP7 UBC7 14690591 0397 LC UBP7 STE20 16319894 0415 LC UBP7 SKY1 16319894 0415 LC UBP7 MYO5 19841731,11743162,19841731,11743162,14737190,19841731,14737190 0018,0397,0397,0018,0081,0398,0045 HT UBP7 HOF1 19841731,19841731,19841731 0398,0081,0018 HT UBP7 PIN3 19841731,19841731 0398,0018 HT HSP82 UBP7 19536198 0676 HT PPR1 UBP7 16554755,16554755 0676,0004 HT SSA1 UBP7 19536198 0676 HT SSB1 UBP7 19536198 0676 HT HSP60 UBP7 19536198 0676 HT SIS1 UBP7 19536198 0676 HT BEM1 UBP7 19841731 0363 LC CRM1 UBP7 26673895,26673895 0096,0004 LC SSE1 UBP7 19536198 0676 HT YSC84 UBP7 19841731,19841731,19841731 0398,0363,0018 LC HSE1 UBP7 17079730,19841731,19841731,19841731,17079730,19841731,19841731 0004,0018,0363,0397,0096,0398,0081 LC BZZ1 UBP7 19841731,19841731,19841731 0018,0363,0398 LC NDT80 UBP7 16554755,16554755 0676,0004 HT RVS167 UBP7 11805837,19841731,19841731,19841731,11805837 0004,0018,0363,0398,0007 HT,LC ECM10 UBP7 19536198 0676 HT UBP7 LSB3 19841731,19841731,19841731 0398,0363,0018 LC UBP7 BBC1 16554755,16554755,16554755 0363,0676,0004 HT UBP7 LSB1 19841731 0363 LC UBP7 MLP1 24152732 0004 LC UBP7 VHS1 21460040,21460040 0096,0004 LC UBP7 CYK3 19841731 0363 LC UBP7 NBP2 19841731 0363 LC UBP7 LAS17 21035341 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53104 P40453 ATG1 UBP7 0.183 16319894 P40453 P23291 UBP7 YCK1 0.183 16319894 P40453 P23292 UBP7 YCK2 0.183 16319894 P40453 P17157 UBP7 PHO85 0.183 16319894 Q12163 P40453 NBP2 UBP7 0.183 19841731 Q12221 P40453 PUF2 UBP7 0.126 26668354 Q12446 P40453 LAS17 UBP7 0.126 21035341 P40453 P06244 UBP7 TPK1 0.183 16319894 P40453 P06782 UBP7 SNF1 0.183 16319894 P43603 P40453 LSB3 UBP7 0.523 14737190,19841731 P47068 P40453 BBC1 UBP7 0.416 16554755 P40453 P38830 UBP7 NDT80 0.236 16554755 P80667 P40453 PEX13 UBP7 0.583 19841731 P40453 P38753 UBP7 HSE1 0.765 11743162,19841731 P40453 P29366 UBP7 BEM1 0.183 19841731 P40453 P30822 UBP7 CRM1 0.126 26673895 P40453 P38199 UBP7 HEK2 0.126 18805955 P40453 P32589 UBP7 SSE1 0.126 19536198 P40453 P38991 UBP7 IPL1 0.183 16319894 P40453 P32790 UBP7 SLA1 0.286 19841731 P40453 P32793 UBP7 YSC84 0.554 19841731 P40453 P39987 UBP7 ECM10 0.126 19536198 P40453 P40073 UBP7 SHO1 0.286 19841731 P40453 P36006 UBP7 MYO3 0.539 11743162,19841731 P40453 P02829 UBP7 HSP82 0.126 19536198 P40453 P07272 UBP7 PPR1 0.236 16554755 P40453 P10591 UBP7 SSA1 0.126 19536198 P40453 P11484 UBP7 SSB1 0.126 19536198 P40453 P19882 UBP7 HSP60 0.126 19536198 P40453 P25294 UBP7 SIS1 0.126 19536198 P40453 P38822 UBP7 BZZ1 0.583 11743162,19841731 P40453 P39743 UBP7 RVS167 0.61 11805837,19841731 P40453 P40316 UBP7 PDS1 0.309 22072716 P53281 P40453 LSB1 UBP7 0.332 19841731 Q02159 P40453 UBC7 UBP7 0.126 14690591 Q03785 P40453 VHS1 UBP7 0.286 21460040 Q04439 P40453 MYO5 UBP7 0.623 19841731,11743162,14737190 Q05080 P40453 HOF1 UBP7 0.507 19841731 Q06449 P40453 PIN3 UBP7 0.376 19841731 Q07533 P40453 CYK3 UBP7 0.183 19841731 P43637 P40453 TOS3 UBP7 0.183 16319894 P47116 P40453 PTK2 UBP7 0.183 16319894 Q02455 P40453 MLP1 UBP7 0.126 24152732 Q03656 P40453 SKY1 UBP7 0.183 16319894 Q03497 P40453 STE20 UBP7 0.183 16319894 Q07468 P40453 VAM6 UBP7 0.126 25026036 Q07807 P40453 PUF3 UBP7 0.126 23409723