PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PSE1 MND2 10688190 biogrid,i2d,mint,intact,dip exp MND2 GIS2 21232131 biogrid exp NAB2 MND2 19840948 biogrid exp SSA3 MND2 19536198 intact exp MND2 MND2 12477395 biogrid exp MND2 BIT61 18719252, 23023127 biogrid,intact exp, pred MND2 CTF19 17634282, 23023127 biogrid exp, pred CDC27 MND2 12477395,17459880,12609981,12574115, 23023127 biogrid,intact exp, pred MND2 APC2 12477395,15060174,12609981,15797379, 23023127 biogrid,intact exp, pred MND2 SWM1 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred MND2 APC11 12477395, 23023127 biogrid,intact exp, pred MND2 APC5 12477395,16429126,12609981,12574115, 23023127 biogrid,intact exp, pred RPN3 MND2 18467557, 23023127 biogrid,i2d,mint,intact exp, pred CDC16 MND2 12477395,21186364,16364911,15649358,15060174,16275330,17406682,12609981,12574115,15797379, 23023127 biogrid,i2d,intact,dip exp, pred MND2 APC4 12477395,15060174,12609981,21186364,12574115, 23023127 biogrid,intact exp, pred CDC26 MND2 12477395, 23023127 biogrid,intact exp, pred MND2 APC1 12477395,12609981,12574115, 23023127 biogrid,intact exp, pred SPC25 MND2 17634282, 23023127 biogrid exp, pred MND2 JSN1 11283351, 23023127 i2d,mint,intact,dip exp, pred MND2 DOC1 12477395,12609981,16554755, 23023127 biogrid,i2d,mint,intact exp, pred MND2 APC9 12477395,12609981, 23023127 biogrid,intact exp, pred CDC23 MND2 12477395,12609981, 23023127 biogrid,intact exp, pred PDS1 MND2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40577 - 15797379 - C 13 P40577 - 15649358 - C 13 P47135 P40577 - 11283351 - X 2 P40577 P32337 - 10688190 - X 2 Q12440 P40577 affinity chromatography technology 12609981 physical association X 2 Q12440 P40577 affinity chromatography technology 15060174 physical association X 2 Q12440 P40577 affinity chromatography technology 12477395 physical association X 2 Q12440 P40577 affinity chromatography technology 15797379 physical association X 2 Q12157 P40577 affinity chromatography technology 12477395 physical association X 2 P16522 P40577 affinity chromatography technology 12609981 physical association X 2 P16522 P40577 affinity chromatography technology 12477395 physical association X 2 P16522 P40577 affinity chromatography technology 12609981 physical association X 2 P09798 P40577 affinity chromatography technology 12609981 physical association X 2 P09798 P40577 affinity chromatography technology 12574115 physical association X 2 P09798 P40577 affinity chromatography technology 15060174 physical association X 2 P09798 P40577 affinity chromatography technology 12477395 physical association X 2 P09798 P40577 affinity chromatography technology 15649358 physical association X 2 P09798 P40577 affinity chromatography technology 16275330 physical association X 2 P09798 P40577 affinity chromatography technology 17406682 physical association X 2 P09798 P40577 affinity chromatography technology 15797379 physical association X 2 P09798 P40577 affinity chromatography technology 21186364 physical association X 2 P09798 P40577 affinity chromatography technology 16364911 physical association X 2 P40577 P40577 affinity chromatography technology 12477395 physical association X 2 Q08683 P40577 affinity chromatography technology 12609981 physical association X 2 Q08683 P40577 affinity chromatography technology 12574115 physical association X 2 Q08683 P40577 affinity chromatography technology 12477395 physical association X 2 Q08683 P40577 affinity chromatography technology 12609981 physical association X 2 Q08683 P40577 affinity chromatography technology 17200106 physical association X 2 Q12107 P40577 affinity chromatography technology 12609981 physical association X 2 Q12107 P40577 affinity chromatography technology 12477395 physical association X 2 P40014 P40577 two hybrid 17634282 direct interaction X 2 P53068 P40577 affinity chromatography technology 12609981 physical association X 2 P53068 P40577 affinity chromatography technology 12477395 physical association X 2 P53068 P40577 affinity chromatography technology 16554755 physical association X 2 P47041 P40577 two hybrid 18719252 direct interaction X 2 P0CG63 P40577 biochemical 23583075 association X 2 P53886 P40577 affinity chromatography technology 12609981 physical association X 2 P53886 P40577 affinity chromatography technology 12574115 physical association X 2 P53886 P40577 affinity chromatography technology 12477395 physical association X 2 P53886 P40577 affinity chromatography technology 12609981 physical association X 2 P38042 P40577 affinity chromatography technology 12609981 physical association X 2 P38042 P40577 affinity chromatography technology 12609981 physical association X 2 P38042 P40577 affinity chromatography technology 12574115 physical association X 2 P38042 P40577 affinity chromatography technology 12477395 physical association X 2 P38042 P40577 affinity chromatography technology 17459880 physical association X 2 P38042 P40577 affinity chromatography technology 17459880 physical association X 2 P40016 P40577 protein complementation assay 18467557 direct interaction X 2 P40577 P32337 two hybrid 10688190 direct interaction X 2 Q12379 P40577 affinity chromatography technology 12609981 physical association X 2 Q12379 P40577 affinity chromatography technology 12609981 physical association X 2 Q12379 P40577 affinity chromatography technology 12574115 physical association X 2 Q12379 P40577 affinity chromatography technology 15060174 physical association X 2 Q12379 P40577 affinity chromatography technology 12477395 physical association X 2 Q12379 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12609981 physical association X 2 Q04601 P40577 affinity chromatography technology 12574115 physical association X 2 Q04601 P40577 affinity chromatography technology 15060174 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 12477395 physical association X 2 Q04601 P40577 affinity chromatography technology 21186364 physical association X 2 P14724 P40577 affinity chromatography technology 12477395 physical association X 2 Q02732 P40577 two hybrid 17634282 direct interaction X 2 P40577 pull down 21107322 - C 13 P40577 tandem affinity purification 21107322 - C 12 P40577 tandem affinity purification 21107322 - C 13 P09798 P40577 tandem affinity purification 21107322 physical association X 2 P09798 P40577 pull down 21107322 physical association X 2 P09798 P40577 pull down 21107322 physical association X 2 P09798 P40577 tandem affinity purification 21107322 physical association X 2 P09798 P40577 tandem affinity purification 21186364 physical association X 2 P47135 P40577 two hybrid pooling approach 11283351 physical association X 2 P40577 tandem affinity purification 21186364 physical association C 11 P40577 electron tomography 21186364 physical association C 11 P40577 pull down 21107322 - C 14 P40577 P32337 two hybrid 10688190 physical association X 2 P40577 affinity chromatography technology 12609981 association C 11 P40577 affinity chromatography technology 12609981 association C 11 P40577 inferred by author 16554755 association C 12 P40577 tandem affinity purification 12477395 association C 13 P40577 tandem affinity purification 12477395 association C 13 P40577 tandem affinity purification 12477395 association C 13 P40577 affinity chromatography technology 12609981 association C 13 P40577 affinity chromatography technology 12609981 association C 3 Q12440 P40577 anti tag coimmunoprecipitation 12609981 physical association X 2 P16522 P40577 anti tag coimmunoprecipitation 12609981 physical association X 2 P47135 P40577 two hybrid fragment pooling approach 11283351 physical association X 2 Q08683 P40577 anti tag coimmunoprecipitation 12609981 physical association X 2 P53068 P40577 tandem affinity purification 16554755 physical association X 2 P53068 P40577 tandem affinity purification 16554755 physical association X 2 P40577 tandem affinity purification 16429126 association C 19 P47041 P40577 two hybrid 18719252 physical association X 2 P53886 P40577 anti tag coimmunoprecipitation 12609981 physical association X 2 P40577 P32337 two hybrid 10688190 physical association X 2 P40016 P40577 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40577 P09435 tandem affinity purification 19536198 association X 2 Q04601 P40577 anti tag coimmunoprecipitation 12477395 physical association X 2 Q04601 P40577 anti tag coimmunoprecipitation 12477395 physical association X 2 P47135 P40577 two hybrid 11283351 - X 2 P40577 P32337 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PSE1 MND2 10688190,10688190 0397,0018 HT SPC25 MND2 17634282 0018 HT RPN3 MND2 18467557,18467557 0111,0090 HT PDS1 MND2 16364911 0415 LC MND2 BIT61 18719252 0018 HT MND2 JSN1 11283351,11283351,11283351 0018,0399,0398 HT MND2 CTF19 17634282 0018 HT SSA3 MND2 19536198 0676 HT CDC16 MND2 12477395,12609981,12477395,17406682,16364911,15060174,21186364,21186364,21107322,21107322,15649358,12574115,16275330,15797379 0676,0004,0004,0004,0004,0004,0004,0676,0096,0676,0004,0004,0004,0004 LC CDC26 MND2 12477395,12477395 0676,0004 LC CDC23 MND2 12477395,12609981,12609981,12477395 0004,0007,0004,0676 LC NAB2 MND2 19840948 0004 LC CDC27 MND2 12477395,12609981,12477395,17459880,12574115 0676,0004,0004,0004,0004 LC MND2 MND2 12477395 0004 LC MND2 DOC1 12477395,12609981,16554755,16554755,12477395,16554755 0676,0004,0363,0004,0004,0676 LC,HT MND2 CDH1 21107322 0004 LC MND2 APC1 12477395,12609981,12477395,12574115,12609981 0676,0004,0004,0004,0007 LC MND2 APC4 12477395,12609981,12477395,12477395,15060174,21186364,12574115 0676,0004,0007,0004,0004,0004,0004 LC MND2 APC5 12477395,12609981,12477395,16429126,12574115,12609981,17200106 0676,0004,0004,0676,0004,0007,0004 LC,HT MND2 APC9 12477395,12609981,12477395 0004,0004,0676 LC MND2 APC11 12477395,12477395 0004,0676 LC MND2 SWM1 12477395,15060174,12477395,12609981,12574115 0676,0004,0004,0004,0004 LC MND2 APC2 12477395,12609981,12477395,15060174,12609981,15797379 0676,0004,0004,0004,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12440 P40577 APC2 MND2 0.396 15797379,12477395 P40577 P09435 MND2 SSA3 0.126 19536198 Q08683 P40577 APC5 MND2 0.472 12477395,16429126,12609981 Q12379 P40577 SWM1 MND2 0.416 12477395 P53068 P40577 DOC1 MND2 0.49 16554755,12477395 P40577 P09798 MND2 CDC16 0.814 16275330,17406682,15649358,12477395,15797379,21186364,16364911 P40577 P14724 MND2 CDC26 0.236 12477395 Q12107 P40577 APC9 MND2 0.236 12477395 Q12157 P40577 APC11 MND2 0.236 12477395 P40577 P40016 MND2 RPN3 0.286 18467557 Q04601 P40577 APC4 MND2 0.597 21186364,12477395 P40577 P38042 MND2 CDC27 0.396 12477395,17459880 P40577 P32337 MND2 PSE1 0.332 10688190 P40577 P32505 MND2 NAB2 0.126 19840948 P40577 P40014 MND2 SPC25 0.183 17634282 P47041 P40577 BIT61 MND2 0.332 18719252 P40577 P40577 MND2 MND2 0.155 12477395 P47135 P40577 JSN1 MND2 0.21 11283351 P40577 P16522 MND2 CDC23 0.396 12609981,12477395 Q02732 P40577 CTF19 MND2 0.183 17634282 P53849 P40577 GIS2 MND2 0.126 21232131 P53886 P40577 APC1 MND2 0.396 12609981,12477395