PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RTT101 F-box protein YDR306C i2d exp NAB2 RTT101 19840948 biogrid exp YEL1 RTT101 16554755 biogrid,i2d,mint,intact exp RTT101 HMO1 i2d exp BZZ1 RTT101 11283351 i2d,mint,intact,dip exp SSA1 RTT101 19536198 intact exp HSP26 RTT101 19536198,16554755 biogrid,i2d,mint,intact exp SSB2 RTT101 23332755 biogrid exp OPI3 RTT101 10688190 mint,intact,dip exp HTA1 RTT101 i2d exp RPS10B RTT101 i2d exp SNZ3 RTT101 11283351 i2d,mint,intact,dip exp REF2 RTT101 i2d exp IPP1 RTT101 i2d exp HTA2 RTT101 16554755 biogrid,mint,intact exp RTT101 LAG2 19942853 biogrid exp SPT16 RTT101 20634314 biogrid exp CRM1 RTT101 26673895 biogrid exp SSC1 RTT101 19536198 i2d,intact exp BFR1 RTT101 i2d exp SSA3 RTT101 19536198 i2d,intact exp RTT101 SOL1 16429126 intact exp NHP6A RTT101 i2d exp RTT101 ABF2 i2d exp PFD1 RTT101 19536198 intact exp TEL1 RTT101 i2d exp ECM10 RTT101 19536198 intact exp RTT101 RUB1 14519104 dip exp HHF1, HHF2 RTT101 24209620,16554755 biogrid,i2d,mint,intact exp EFT1, EFT2 RTT101 i2d exp CDC27 RTT101 i2d exp TDH2 RTT101 i2d exp SBA1 RTT101 i2d exp SSB1 RTT101 19536198 intact exp TRX2 RTT101 i2d exp CAK1 RTT101 16554755 intact exp HSP60 RTT101 19536198 i2d,intact exp RTT107 RTT101 17978089,20670896,20139071, 23023127 biogrid exp, pred RTT101 Putative ISWI chromatin-remodeling complex subunit YPL216W 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RTT101 ORC5 20139071, 23023127 biogrid exp, pred CDC34 RTT101 16554755,18704118, 23023127 biogrid,i2d,mint,intact exp, pred PRE4 RTT101 11595789, 23023127 biogrid,i2d,intact,dip exp, pred RTT101 HHT1, HHT2 24209620,16554755, 23023127 biogrid,i2d,mint,intact exp, pred UBC4 RTT101 18704118, 23023127 mint,intact exp, pred RAD6 RTT101 18704118, 23023127 mint,intact exp, pred RTT101 ESC2 20139071, 23023127 biogrid exp, pred RTT101 MMS1 25534857,24209620,20139071,18704118, 23023127 biogrid,mint,intact exp, pred FUS1 RTT101 19841731, 23023127 mint,intact exp, pred RTT101 MMS22 20174551,20139071,18704118,11805837, 23023127 biogrid,mint,intact,dip exp, pred RTT101 CTF4 20139071, 23023127 biogrid exp, pred RTT101 CRT10 25534857,18704118, 23023127 biogrid,mint,intact exp, pred RTT101 JSN1 11283351, 23023127 i2d,mint,intact,dip exp, pred RTT101 HRT1 19882662,18719252,11805837,12676951, 23023127 biogrid,mint,intact,dip exp, pred STM1 RTT101 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RTT101 CDC53 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P47050 - 11805837 - C 4 Q08273 P47050 - 12676951 - X 2 Q08273 P47050 - 10230407 - X 2 P47050 P47135 - 11283351 - X 2 P47050 P38822 - 11283351 - X 2 P47050 - 11283351 - X 2 P47050 - 11805837 - C 3 P47050 - 11805837 - C 8 P47050 P30657 - 11595789 - X 2 Q08273 P47050 two hybrid 12676951 direct interaction X 2 Q08273 P47050 affinity chromatography technology 12676951 physical association X 2 Q08273 P47050 two hybrid 18719252 direct interaction X 2 Q08273 P47050 affinity chromatography technology 11805837 physical association X 2 P32558 P47050 affinity chromatography technology 20634314 physical association X 2 P32558 P47050 pull down 20634314 direct interaction X 2 P32558 P47050 enzymatic study 20634314 direct interaction X 2 P47050 P40150 biochemical 23332755 association X 2 P47050 P15992 affinity chromatography technology 16554755 physical association X 2 P47050 P34225 affinity chromatography technology 16554755 physical association X 2 P47050 P39015 affinity chromatography technology 16554755 physical association X 2 P47050 Q08964 affinity chromatography technology 16554755 physical association X 2 P47050 Q12018 affinity chromatography technology 17200106 physical association X 2 P47050 Q06340 affinity chromatography technology 20139071 physical association X 2 P47050 P50874 affinity chromatography technology 20139071 physical association X 2 P47050 Q06340 affinity chromatography technology 20139071 physical association X 2 P47050 Q92325 pull down 19942853 direct interaction X 2 P14682 P47050 pull down 24209620 direct interaction X 2 P14682 P47050 affinity chromatography technology 16554755 physical association X 2 P14682 P47050 affinity chromatography technology 17200106 physical association X 2 P14682 P47050 pull down 18704118 direct interaction X 2 P0CG63 P47050 affinity chromatography technology 23793018 physical association X 2 Q06211 P47050 affinity chromatography technology 18704118 physical association X 2 Q06211 P47050 affinity chromatography technology 20139071 physical association X 2 Q06211 P47050 affinity chromatography technology 20139071 physical association X 2 P04912 P47050 affinity chromatography technology 16554755 physical association X 2 P47050 P30657 two hybrid 11595789 direct interaction X 2 P47050 P61830 affinity chromatography technology 24209620 physical association X 2 P47050 P02309 affinity chromatography technology 24209620 physical association X 2 P47050 P02309 enzymatic study 24209620 direct interaction X 2 P47050 P02309 affinity chromatography technology 16554755 physical association X 2 P47050 P61830 affinity chromatography technology 16554755 physical association X 2 P47050 Q06164 affinity chromatography technology 18704118 physical association X 2 P47050 Q06164 affinity chromatography technology 20139071 physical association X 2 P47050 Q06164 affinity chromatography technology 20139071 physical association X 2 P47050 P38850 affinity chromatography technology 20139071 physical association X 2 P47050 P38850 affinity chromatography technology 20139071 physical association X 2 P47050 Q01454 affinity chromatography technology 20139071 physical association X 2 P47050 Q06164 affinity chromatography technology 20174551 physical association X 2 P47050 P38850 affinity chromatography technology 20670896 physical association X 2 P47050 P38850 affinity chromatography technology 17978089 physical association X 2 P47050 Q06164 affinity chromatography technology 11805837 physical association X 2 Q08226 P47050 affinity chromatography technology 17200106 physical association X 2 Q08226 P47050 affinity chromatography technology 18704118 physical association X 2 P47050 anti tag coimmunoprecipitation 11805837 - C 4 P47050 anti tag coimmunoprecipitation 11805837 - C 9 P47050 anti tag coimmunoprecipitation 11805837 - C 32 Q08273 P47050 anti tag coimmunoprecipitation 11805837 physical association X 2 Q08273 P47050 two hybrid 12676951 physical association X 2 Q08273 P47050 coimmunoprecipitation 12676951 physical association X 2 P47050 P47135 two hybrid pooling approach 11283351 physical association X 2 P47050 P38822 two hybrid pooling approach 11283351 physical association X 2 P47050 P43545 two hybrid pooling approach 11283351 physical association X 2 P05375 P47050 two hybrid 10688190 physical association X 2 P47050 anti tag coimmunoprecipitation 11805837 - C 60 P47050 anti tag coimmunoprecipitation 11805837 - C 3 P47050 anti tag coimmunoprecipitation 11805837 - C 6 P47050 P30657 two hybrid 11595789 physical association X 2 P47050 Q06164 anti tag coimmunoprecipitation 11805837 physical association X 2 P47050 Q06164 anti tag coimmunoprecipitation 11805837 physical association X 2 P47050 Q03919 comigration in sds page 14519104 physical association X 2 P47050 pull down 19882662 association C 41 P47050 anti tag coimmunoprecipitation 11805837 association C 4 P47050 inferred by author 16554755 association C 12 P47050 pull down 24209620 physical association C 3 P19882 P47050 tandem affinity purification 19536198 association X 2 Q08273 P47050 two hybrid 18719252 physical association X 2 P47050 P38822 two hybrid fragment pooling approach 11283351 physical association X 2 P47050 P43545 two hybrid fragment pooling approach 11283351 physical association X 2 P47050 P47135 two hybrid fragment pooling approach 11283351 physical association X 2 P47050 P34225 tandem affinity purification 16554755 physical association X 2 P47050 P39015 tandem affinity purification 16554755 physical association X 2 P47050 P39015 tandem affinity purification 16554755 physical association X 2 P47050 Q08964 tandem affinity purification 16554755 physical association X 2 P47050 P15992 tandem affinity purification 16554755 physical association X 2 P47050 P15731 pull down 18704118 physical association X 2 P47050 P09435 tandem affinity purification 19536198 association X 2 P47050 P15992 tandem affinity purification 19536198 association X 2 P05375 P47050 two hybrid 10688190 physical association X 2 P47050 tandem affinity purification 16429126 association C 16 P47050 anti tag coimmunoprecipitation 11805837 association C 8 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 tandem affinity purification 16554755 physical association X 2 P14682 P47050 pull down 18704118 physical association X 2 P46988 P47050 tandem affinity purification 19536198 association X 2 Q06211 P47050 pull down 18704118 physical association X 2 P04912 P47050 tandem affinity purification 16554755 physical association X 2 P47050 P30657 two hybrid array 11595789 physical association X 2 P47050 P61830 tandem affinity purification 16554755 physical association X 2 P47050 P02309 tandem affinity purification 16554755 physical association X 2 P47050 Q06164 pull down 18704118 physical association X 2 P47050 P06104 pull down 18704118 physical association X 2 P47050 P11484 tandem affinity purification 19536198 association X 2 P47050 P0CS90 tandem affinity purification 19536198 association X 2 P47050 P39987 tandem affinity purification 19536198 association X 2 P47050 P11710 inferred by author 19841731 direct interaction X 2 P47050 P61830 anti tag coimmunoprecipitation 24209620 physical association X 2 P47050 P02309 anti tag coimmunoprecipitation 24209620 physical association X 2 P10591 P47050 tandem affinity purification 19536198 association X 2 Q08226 P47050 pull down 18704118 physical association X 2 P12753 P47050 interaction detection method 14764870 - X 2 P47050 P38822 two hybrid 11283351 - X 2 P47050 P43545 two hybrid 11283351 - X 2 P47050 P47135 two hybrid 11283351 - X 2 P47050 P38766 interaction detection method 14764870 - X 2 P47050 P48562 interaction detection method 12686605 - X 2 P47050 mass spectrometry studies of complexes 11805837 - C 4 P47050 mass spectrometry studies of complexes 11805837 - C 5

PPI - HINT Gene A Gene B PMID Method Quality OPI3 RTT101 10688190 0018 HT PRE4 RTT101 11595789,11595789 0018,0397 LC SPT16 RTT101 20634314,20634314,20634314 0004,0096,0415 LC BZZ1 RTT101 11283351,11283351,11283351 0018,0399,0398 HT RTT107 RTT101 26439300 0018 LC SSB2 RTT101 23332755 0401 LC SNZ3 RTT101 11283351,11283351,11283351 0018,0399,0398 HT RTT101 JSN1 11283351,11283351,11283351 0018,0399,0398 HT RTT101 RUB1 14519104,14519104 0808,0415 LC RTT101 MMS22 20174551,20174551 0018,0004 LC RTT101 HRT1 18719252,12676951,12676951,12676951 0018,0019,0018,0004 HT,LC HHF1|HHF2 RTT101 24209620,24209620,16554755,16554755 0007,0004,0676,0004 LC,HT HTA2 RTT101 16554755,16554755 0676,0004 HT RAD6 RTT101 18704118 0096 LC SSA3 RTT101 19536198 0676 HT SSC1 RTT101 19536198 0676 HT SSA1 RTT101 19536198 0676 HT SSB1 RTT101 19536198 0676 HT FUS1 RTT101 19841731 0363 LC CDC34 RTT101 16554755,17200106,16554755,18704118 0004,0004,0676,0096 HT,LC UBC4 RTT101 18704118 0096 LC HSP26 RTT101 19536198,16554755,16554755 0676,0676,0004 HT HSP60 RTT101 19536198 0676 HT CRM1 RTT101 26673895,26673895 0096,0004 LC NAB2 RTT101 19840948 0004 LC SPT16 RTT101 20634314,20634314,20634314 0004,0096,0415 LC SAS3 RTT101 16554755,16554755 0676,0004 HT RTT107 RTT101 20670896,20139071,17978089 0004,0004,0004 LC STM1 RTT101 16554755,16554755 0676,0004 HT ECM10 RTT101 19536198 0676 HT SSB2 RTT101 23332755 0401 LC CAK1 RTT101 16554755 0363 HT PFD1 RTT101 19536198 0676 HT RTT101 SOL1 16429126 0676 HT RTT101 ORC5 20139071 0004 LC RTT101 HHT1|HHT2 24209620,24209620,16554755,16554755 0007,0004,0676,0004 LC,HT RTT101 CTF4 20139071 0004 LC RTT101 SLD5 26849847 0004 LC RTT101 MMS22 11805837,18704118,26849847,20139071,20174551,18704118,20174551,11805837 0004,0096,0004,0004,0018,0004,0004,0007 HT,LC RTT101 MMS1 18704118,25534857,20139071,24209620,18704118 0096,0004,0004,0096,0004 LC RTT101 ESC2 20139071 0004 LC RTT101 CRT10 17200106,18704118,25534857,18704118 0004,0004,0004,0096 HT,LC RTT101 HRT1 11805837,12676951,19882662,12676951,12676951,11805837 0004,0019,0096,0018,0004,0007 HT,LC RTT101 Q08964 16554755,16554755 0676,0004 HT RTT101 CDC53 17200106 0004 HT RTT101 LAG2 19942853 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61830 P47050 HHT2 RTT101 0.523 16554755,24209620 P47050 P0CS90 RTT101 SSC1 0.126 19536198 P47050 P10591 RTT101 SSA1 0.126 19536198 P47050 P05375 RTT101 OPI3 0.183 10688190 P47050 P02309 RTT101 HHF2 0.523 16554755,24209620 P47050 P04912 RTT101 HTA2 0.236 16554755 P47050 P32558 RTT101 SPT16 0.454 20634314 P47050 P38850 RTT101 RTT107 0.731 20139071,20670896,17978089,26439300 Q08273 P47050 HRT1 RTT101 0.681 12676951,18719252,11805837,19882662 P47050 P30822 RTT101 CRM1 0.126 26673895 Q92325 P47050 LAG2 RTT101 0.309 19942853 P47050 P32505 RTT101 NAB2 0.126 19840948 P47050 P38822 RTT101 BZZ1 0.236 11283351 P47050 P39015 RTT101 STM1 0.332 16554755 P47050 P34225 RTT101 YEL1 0.236 16554755 P47050 P40150 RTT101 SSB2 0.126 23332755 P47050 P43568 RTT101 CAK1 0.126 16554755 P47050 P02299 RTT101 HIS3:CG33866 0.21 24209620 P47050 P06104 RTT101 RAD6 0.21 18704118 P47050 P09435 RTT101 SSA3 0.126 19536198 P47050 P11484 RTT101 SSB1 0.126 19536198 P47050 P11710 RTT101 FUS1 0.332 19841731 P47050 P14682 RTT101 CDC34 0.636 16554755,18704118 P47050 P15731 RTT101 UBC4 0.21 18704118 P47050 P15992 RTT101 HSP26 0.332 16554755,19536198 P47050 P19882 RTT101 HSP60 0.126 19536198 P47050 P30657 RTT101 PRE4 0.126 11595789 P47050 P39987 RTT101 ECM10 0.126 19536198 P47050 P46988 RTT101 PFD1 0.126 19536198 P47135 P47050 JSN1 RTT101 0.21 11283351 Q03919 P47050 RUB1 RTT101 0.033 14519104 Q06164 P47050 MMS22 RTT101 0.843 20139071,20174551,26849847,11805837,18704118 Q06340 P47050 ESC2 RTT101 0.376 20139071 Q08964 P47050 Q08964 RTT101 0.236 16554755 P50278 P47050 SOL1 RTT101 0.126 16429126 P50874 P47050 ORC5 RTT101 0.21 20139071 Q01454 P47050 CTF4 RTT101 0.21 20139071 P47050 P43545 RTT101 SNZ3 0.21 11283351 Q06211 P47050 MMS1 RTT101 0.794 24209620,18704118,20139071,25534857 Q03406 P47050 SLD5 RTT101 0.126 26849847 Q08226 P47050 CRT10 RTT101 0.597 18704118,25534857