PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PRP45 DAS1 12554883 biogrid,i2d exp SSA1 DAS1 19536198 intact exp SSB1 DAS1 19536198 intact exp SSB2 DAS1 23332755 biogrid exp GAL80 DAS1 22479149 biogrid,dip exp DAS1 CDC14 21127052 biogrid exp DAS1 MIG2 21323640 biogrid exp DAS1 LAG2 19763088 biogrid,mint,intact exp DAS1 SKP1 11283612,23000173,10582239,14747994,20581845,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred DAS1 HRT1 14747994, 23023127 biogrid exp, pred LIN1 DAS1 12402242, 23023127 mint,intact exp, pred DAS1 CDC53 11283612,10582239,14747994,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC4 DAS1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P47005 P38852 - 12402242 - X 2 P47005 P28004 - 12554883 - X 2 P52286 P47005 - 11283612 - X 2 P47005 - 11805837 - C 3 P47005 Q12018 - 11283612 - X 2 Q08273 P47005 pull down 14747994 direct interaction X 2 P47005 P28004 two hybrid 12554883 direct interaction X 2 P52286 P47005 pull down 23000173 direct interaction X 2 P52286 P47005 pull down 14747994 direct interaction X 2 P52286 P47005 affinity chromatography technology 10582239 physical association X 2 P52286 P47005 affinity chromatography technology 20581845 physical association X 2 P52286 P47005 affinity chromatography technology 11805837 physical association X 2 Q00684 P47005 affinity chromatography technology 21127052 physical association X 2 P0CG63 P47005 affinity chromatography technology 23749301 physical association X 2 P0CG63 P47005 affinity chromatography technology 17644757 physical association X 2 P04387 P47005 affinity chromatography technology 22479149 physical association X 2 P47005 Q12018 pull down 14747994 direct interaction X 2 P47005 Q12018 affinity chromatography technology 10582239 physical association X 2 P47005 Q12018 affinity chromatography technology 11283612 physical association X 2 P47005 Q92325 two hybrid 19763088 direct interaction X 2 P47005 P53035 protein complementation assay 21323640 direct interaction X 2 P47005 Q12018 affinity chromatography technology 11805837 physical association X 2 P40150 P47005 biochemical 23332755 association X 2 P47005 affinity chromatography technology 14747994 - C 4 P52286 P47005 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 P47005 affinity chromatography technology 14747994 physical association X 2 P47005 anti tag coimmunoprecipitation 11805837 - C 3 P04387 P47005 pull down 22479149 physical association X 2 P47005 Q12018 anti tag coimmunoprecipitation 11805837 physical association X 2 P47005 Q12018 coimmunoprecipitation 11283612 physical association X 2 P47005 anti tag coimmunoprecipitation 11283612 association C 12 P47005 P38852 two hybrid 12402242 physical association X 2 P47005 anti tag coimmunoprecipitation 11805837 association C 3 P47005 anti tag coimmunoprecipitation 11283612 association C 5 P47005 P11484 tandem affinity purification 19536198 association X 2 P47005 Q92325 two hybrid 19763088 physical association X 2 P10591 P47005 tandem affinity purification 19536198 association X 2 P47005 mass spectrometry studies of complexes 11805837 - C 4 P47005 mass spectrometry studies of complexes 11805837 - C 4

PPI - HINT Gene A Gene B PMID Method Quality PRP45 DAS1 12554883 0018 LC LIN1 DAS1 12402242 0018 LC SSB2 DAS1 23332755 0401 LC DAS1 SKP1 11283612,11283612 0019,0007 LC DAS1 MIG2 21323640 0090 LC DAS1 CDC53 11283612,11283612,11283612 0004,0007,0019 LC DAS1 LAG2 19763088 0018 LC GAL80 DAS1 22479149,22479149 0096,0004 LC SSA1 DAS1 19536198 0676 HT SSB1 DAS1 19536198 0676 HT SSB2 DAS1 23332755 0401 LC DAS1 SKP1 11805837,11283612,14747994,11283612,23000173,20581845,10582239,14747994,11805837 0004,0019,0004,0007,0096,0004,0004,0096,0007 HT,LC DAS1 CDC14 21127052 0004 LC DAS1 HRT1 14747994 0096 LC DAS1 CDC53 11805837,11283612,11283612,11283612,10582239,14747994,11805837 0004,0004,0007,0019,0004,0096,0007 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P47005 P04387 DAS1 GAL80 0.21 22479149 P52286 P47005 SKP1 DAS1 0.702 11283612,10582239,23000173,20581845,11805837,14747994 Q92325 P47005 LAG2 DAS1 0.523 19763088 Q12018 P47005 CDC53 DAS1 0.671 14747994,11283612,10582239,11805837 P47005 P28004 DAS1 PRP45 0.309 12554883 P47005 P40150 DAS1 SSB2 0.126 23332755 P47005 P10591 DAS1 SSA1 0.126 19536198 P47005 P11484 DAS1 SSB1 0.126 19536198 Q00684 P47005 CDC14 DAS1 0.126 21127052 P53035 P47005 MIG2 DAS1 0.309 21323640