PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RAD7 SAM1 11805837 dip exp RAD7 SSA1 16429126,19536198 intact exp ATP2 RAD7 11805837 dip exp RAD7 SSB2 23332755 biogrid exp HTA1 RAD7 i2d exp RAD7 MIP18 family protein YHR122W 14690591 intact exp RAD7 CCT6 19536198 intact exp ARG3 RAD7 11805837 dip exp RAD7 PUF3 26493364 biogrid exp RAD7 SSE1 19536198 intact exp RAD7 CMR1 22199229 biogrid exp RAD7 UBI4 11805837 biogrid,mint exp RAD7 GRH1 16429126 intact exp RAD7 CDC48 11805837 dip exp RAD7 SSB1 16429126,19536198 intact exp RAD7 NAB2 19840948 biogrid exp RAD7 RPL40A 11805837 intact,dip exp RAD7 SSC1 11805837 dip exp RAD7 RAD16 9268290,10601031,15226437,16675952,9792654,11805837,9001217, 23023127 biogrid,i2d,mint,intact,dip exp, pred HTA2 RAD7 16554755, 23023127 biogrid,mint,intact exp, pred RAD7 ELC1 16429126,15226437,16675952,16554755,19920177,11805837, 23023127 biogrid,i2d,mint,intact,dip exp, pred SIR3 RAD7 10835378,7958876,18719252, 23023127 biogrid,intact,dip exp, pred RAD7 CUL3 16675952, 23023127 biogrid,mint,intact exp, pred RAD7 ABF1 10601031, 23023127 biogrid exp, pred RAD7 RAD14 9852079, 23023127 biogrid,dip exp, pred RAD7 RAD23 10446201, 23023127 biogrid exp, pred RAD7 RAD4 16675952,10446201,9001217, 23023127 biogrid,i2d,mint,intact,dip exp, pred RAD7 HRT3 23023127 pred RAD7 TFB4 23023127 pred RAD7 TFB1 23023127 pred RAD7 UBI4 23023127 pred RAD7 RAD2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P06779 - 11805837 - C 3 P06779 - 11805837 - C 9 P31244 P06779 - 9268290 - X 2 P53202 P06779 affinity chromatography technology 16675952 physical association X 2 P53202 P06779 biochemical 16675952 association X 2 P06779 P06701 two hybrid 7958876 direct interaction X 2 P06779 P06701 pull down 7958876 direct interaction X 2 P06779 P06701 two hybrid 10835378 direct interaction X 2 P06779 Q03071 affinity chromatography technology 15226437 physical association X 2 P06779 P28519 pull down 9852079 direct interaction X 2 P06779 Q12306 affinity chromatography technology 23122649 physical association X 2 P06779 Q03071 affinity chromatography technology 11805837 physical association X 2 P06779 Q03071 affinity chromatography technology 16554755 physical association X 2 P06779 Q03071 affinity chromatography technology 16675952 physical association X 2 P06779 Q03071 biochemical 16675952 association X 2 P06779 Q03071 affinity chromatography technology 17200106 physical association X 2 P06779 P06701 two hybrid 18719252 direct interaction X 2 P06779 Q03071 affinity chromatography technology 19920177 physical association X 2 P06779 Q12306 affinity chromatography technology 21968059 physical association X 2 P06779 Q03071 affinity chromatography technology 11805837 physical association X 2 P06779 Q12306 affinity chromatography technology 22285753 physical association X 2 P0CG63 P06779 affinity chromatography technology 11805837 physical association X 2 P32628 P06779 affinity chromatography technology 10446201 physical association X 2 P04912 P06779 affinity chromatography technology 16554755 physical association X 2 P31244 P06779 affinity chromatography technology 9001217 physical association X 2 P31244 P06779 pull down 9001217 direct interaction X 2 P31244 P06779 two hybrid 9001217 direct interaction X 2 P31244 P06779 two hybrid 9001217 direct interaction X 2 P31244 P06779 affinity chromatography technology 15226437 physical association X 2 P31244 P06779 affinity chromatography technology 15226437 physical association X 2 P31244 P06779 biochemical 9268290 association X 2 P31244 P06779 biochemical 9792654 association X 2 P31244 P06779 biochemical 10601031 colocalization X 2 P31244 P06779 affinity chromatography technology 16675952 physical association X 2 P31244 P06779 biochemical 16675952 association X 2 P31244 P06779 biochemical 16675952 association X 2 P31244 P06779 affinity chromatography technology 11805837 physical association X 2 P40150 P06779 biochemical 23332755 association X 2 Q12510 P06779 affinity chromatography technology 22199229 physical association X 2 P06779 P14736 two hybrid 9001217 direct interaction X 2 P06779 P14736 two hybrid 9001217 direct interaction X 2 P06779 P14736 affinity chromatography technology 10446201 physical association X 2 P06779 P14164 biochemical 10601031 colocalization X 2 P06779 P14736 enzymatic study 16675952 direct interaction X 2 P06779 anti tag coimmunoprecipitation 11805837 - C 3 P06779 anti tag coimmunoprecipitation 11805837 - C 18 P06779 anti tag coimmunoprecipitation 11805837 - C 8 P06779 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P10659 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 Q03071 pull down 11805837 physical association X 2 P06779 Q03071 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P28519 affinity chromatography technology 9852079 physical association X 2 P06779 P06701 biochemical 7958876 physical association X 2 P06779 P06701 two hybrid 7958876 physical association X 2 P06779 anti tag coimmunoprecipitation 11805837 - C 9 P31244 P06779 affinity chromatography technology 9001217 physical association X 2 P31244 P06779 two hybrid 9001217 physical association X 2 P31244 P06779 molecular sieving 10601031 physical association X 2 P31244 P06779 biochemical 9268290 physical association X 2 P31244 P06779 coimmunoprecipitation 9268290 physical association X 2 P31244 P06779 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P05150 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P00830 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P25694 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P05759 anti tag coimmunoprecipitation 11805837 physical association X 2 P06779 P14736 two hybrid 9001217 physical association X 2 P06779 anti tag coimmunoprecipitation 11805837 association C 3 P06779 anti tag coimmunoprecipitation 11805837 association C 10 P53202 P06779 anti bait coimmunoprecipitation 16675952 physical association X 2 P06779 Q03071 inferred by author 16554755 association X 2 P06779 Q03071 tandem affinity purification 16554755 physical association X 2 P06779 Q03071 anti bait coimmunoprecipitation 16675952 physical association X 2 P06779 P06701 two hybrid 18719252 physical association X 2 P06779 P11484 tandem affinity purification 19536198 association X 2 P06779 tandem affinity purification 16429126 association C 5 P32589 P06779 tandem affinity purification 19536198 association X 2 P39079 P06779 tandem affinity purification 19536198 association X 2 P04912 P06779 tandem affinity purification 16554755 physical association X 2 P31244 P06779 anti bait coimmunoprecipitation 16675952 physical association X 2 P31244 P06779 anti bait coimmunoprecipitation 9268290 physical association X 2 P31244 P06779 anti bait coimmunoprecipitation 9268290 physical association X 2 P31244 P06779 chromatography technology 9268290 physical association X 2 P10591 P06779 tandem affinity purification 19536198 association X 2 P06779 P38829 two hybrid array 14690591 physical association X 2 P06779 P14736 enzymatic study 16675952 ubiquitination reaction X 2 P06779 mass spectrometry studies of complexes 11805837 - C 4 P06779 mass spectrometry studies of complexes 11805837 - C 4 P06779 mass spectrometry studies of complexes 11805837 - C 10 P31244 P06779 two hybrid - - X 2 P31244 P06779 coimmunoprecipitation 9268290 - X 2 P31244 P06779 confirmational text mining - - X 2 P06779 P14736 two hybrid - - X 2

PPI - HINT Gene A Gene B PMID Method Quality SIR3 RAD7 10835378,7958876,18719252,7958876,7958876 0018,0401,0018,0018,0096 LC,HT RAD7 ABF1 10601031 0401 LC RAD7 RAD4 9001217,16675952 0018,0415 LC RAD7 RAD16 16675952,16675952,9792654,10601031,9268290,9268290,9001217,9268290,10601031,9001217,9001217,16675952,9268290 0401,0004,0401,0401,0019,0006,0004,0401,0071,0018,0096,0006,0091 LC RAD7 P38829 14690591 0397 LC RAD7 SSB2 23332755 0401 LC RAD7 CUL3 16675952,16675952,16675952 0401,0004,0006 LC RAD7 ELC1 16675952,16675952,16675952 0401,0004,0006 LC ATP2 RAD7 11805837 0007 HT HTA2 RAD7 16554755,16554755 0676,0004 HT ARG3 RAD7 11805837 0007 HT RPS31 RAD7 11805837 0007 HT SIR3 RAD7 7958876,7958876,7958876 0401,0018,0096 LC RAD7 UBI4 11805837,11805837 0004,0007 HT RAD7 RPL40B 11805837 0007 HT RAD7 SSC1 11805837 0007 HT RAD7 SSA1 19536198,16429126 0676,0676 HT RAD7 SAM1 11805837 0007 HT RAD7 SSB1 19536198,16429126 0676,0676 HT RAD7 ABF1 10601031 0401 LC RAD7 RAD4 10446201 0004 LC RAD7 CDC48 11805837 0007 HT RAD7 RAD14 9852079,9852079 0004,0096 LC RAD7 RAD16 11805837,16675952,16675952,9792654,10601031,9268290,9268290,15226437,9001217,9268290,10601031,9001217,9001217,11805837,16675952,9268290 0004,0401,0004,0401,0401,0019,0006,0004,0004,0401,0071,0018,0096,0007,0006,0091 HT,LC RAD7 NAB2 19840948 0004 LC RAD7 SSE1 19536198 0676 HT RAD7 RAD23 10446201 0004 LC RAD7 CCT6 19536198 0676 HT RAD7 SSB2 23332755 0401 LC RAD7 CUL3 16675952,16675952,16675952 0401,0004,0006 LC RAD7 ELC1 11805837,16675952,16675952,16554755,16429126,15226437,19920177,11805837,16554755,17200106,11805837,16675952,16554755 0004,0401,0004,0676,0676,0004,0004,0096,0363,0004,0007,0006,0004 HT,LC RAD7 GRH1 16429126 0676 HT RAD7 SMT3 22285753,21968059 0004,0004 LC RAD7 CMR1 22199229 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61864 P06779 RPL40A RAD7 0.236 11805837 P25694 P06779 CDC48 RAD7 0.126 11805837 P10591 P06779 SSA1 RAD7 0.236 16429126,19536198 P11484 P06779 SSB1 RAD7 0.236 16429126,19536198 P12398 P06779 SSC1 RAD7 0.126 11805837 P06779 P04912 RAD7 HTA2 0.126 16554755 P06779 P06701 RAD7 SIR3 0.332 7958876,18719252 P06779 P00830 RAD7 ATP2 0.126 11805837 P06779 P05150 RAD7 ARG3 0.126 11805837 P10659 P06779 SAM1 RAD7 0.126 11805837 P14164 P06779 ABF1 RAD7 0.126 10601031 P32589 P06779 SSE1 RAD7 0.126 19536198 P32628 P06779 RAD23 RAD7 0.21 10446201 P38829 P06779 P38829 RAD7 0.126 14690591 P53202 P06779 CUL3 RAD7 0.21 16675952 Q04410 P06779 GRH1 RAD7 0.126 16429126 Q03071 P06779 ELC1 RAD7 0.772 19920177,16429126,16675952,15226437,16554755,11805837 P31244 P06779 RAD16 RAD7 0.884 10601031,16675952,9001217,15226437,11805837,9268290,9792654 P32505 P06779 NAB2 RAD7 0.126 19840948 P39079 P06779 CCT6 RAD7 0.126 19536198 P40150 P06779 SSB2 RAD7 0.126 23332755 P28519 P06779 RAD14 RAD7 0.309 9852079 P14736 P06779 RAD4 RAD7 0.236 16675952,9001217,10446201