PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HTB2 JHD2 i2d exp RCK1 JHD2 21460040 biogrid exp JHD2 VPS13 i2d exp SRS2 JHD2 15964827 biogrid exp NUP2 JHD2 i2d exp SIS1 JHD2 19536198 intact exp SSE1 JHD2 19536198 intact exp SSA2 JHD2 19536198 intact exp JHD2 SWA2 19536198 intact exp TEF1, TEF2 JHD2 16429126 intact exp SSB1 JHD2 19536198 intact exp JHD2 PUF3 26493364 biogrid exp HSC82 JHD2 19536198 intact exp LSM12 JHD2 i2d exp HAP3 JHD2 i2d exp IES2 JHD2 i2d exp MPP10 JHD2 16554755 intact exp SSB2 JHD2 23332755,19536198 biogrid,intact exp JHD2 ABF2 i2d exp JSN1 JHD2 11283351 i2d,mint,intact,dip exp ECM10 JHD2 19536198 intact exp NHP6A JHD2 i2d exp FUN30 JHD2 16554755 biogrid,i2d,mint,intact exp JHD2 Uncharacterized protein YGR126W i2d exp SSA1 JHD2 19536198 intact exp JHD2 SAS10 16554755 biogrid,i2d,mint,intact exp UGP1 JHD2 16554755 intact exp SET1 JHD2 17875926, 23023127 biogrid exp, pred UTP25 JHD2 16554755, 23023127 biogrid,i2d,mint,intact exp, pred JHD2 SKY1 21460040, 23023127 biogrid exp, pred JHD2 HHT1, HHT2 17875926,17310254,23091032, 23023127 biogrid exp, pred MOT2 JHD2 19346402, 23023127 biogrid exp, pred JHD2 JHD2 20538609, 23023127 biogrid exp, pred PPR1 JHD2 11283351, 23023127 i2d,mint,intact,dip exp, pred JHD2 SPP1 23023127 pred JHD2 GIS1 23023127 pred UBC4 JHD2 23023127 pred JHD2 CTI6 23023127 pred JHD2 UBI4 23023127 pred JHD1 JHD2 23023127 pred RPH1 JHD2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P47156 P47135 - 11283351 - X 2 P47156 P07272 - 11283351 - X 2 P47156 P61830 enzymatic study 23091032 direct interaction X 2 P47156 P12954 two hybrid 15964827 direct interaction X 2 P47156 P40150 biochemical 23332755 association X 2 P47156 Q12136 affinity chromatography technology 16554755 physical association X 2 P47156 P40498 affinity chromatography technology 16554755 physical association X 2 P47156 P61830 enzymatic study 17310254 direct interaction X 2 P47156 P61830 enzymatic study 17310254 direct interaction X 2 P47156 P38827 imaging technique 17875926 colocalization X 2 P47156 P61830 enzymatic study 17875926 direct interaction X 2 P47156 P61830 enzymatic study 17875926 direct interaction X 2 P47156 P34909 enzymatic study 19346402 direct interaction X 2 P47156 P31380 affinity chromatography technology 16554755 physical association X 2 P47156 P47156 pull down 20538609 direct interaction X 2 P47156 P38622 pull down 21460040 direct interaction X 2 P47156 Q03656 pull down 21460040 direct interaction X 2 P47156 P07272 two hybrid pooling approach 11283351 physical association X 2 P47156 P47135 two hybrid pooling approach 11283351 physical association X 2 P47156 P02994 tandem affinity purification 16429126 physical association X 2 P47156 P40498 tandem affinity purification 16554755 physical association X 2 P47156 Q12136 tandem affinity purification 16554755 physical association X 2 P47156 P25294 tandem affinity purification 19536198 association X 2 P47156 P11484 tandem affinity purification 19536198 association X 2 P47156 P10592 tandem affinity purification 19536198 association X 2 P47156 P40150 tandem affinity purification 19536198 association X 2 P47156 P15108 tandem affinity purification 19536198 association X 2 P10591 P47156 tandem affinity purification 19536198 association X 2 P47156 inferred by author 16554755 association C 5 P32589 P47156 tandem affinity purification 19536198 association X 2 P47156 P07272 two hybrid fragment pooling approach 11283351 physical association X 2 P47156 P47135 two hybrid fragment pooling approach 11283351 physical association X 2 P47156 P31380 tandem affinity purification 16554755 physical association X 2 P47156 Q06677 tandem affinity purification 19536198 association X 2 P47156 P39987 tandem affinity purification 19536198 association X 2 P47156 P47135 two hybrid 11283351 - X 2 P47156 P07272 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PPR1 JHD2 11283351,11283351,11283351 0018,0399,0398 HT SRS2 JHD2 15964827 0018 LC MOT2 JHD2 19346402 0415 LC SSB2 JHD2 23332755 0401 LC JSN1 JHD2 11283351,11283351,11283351 0018,0399,0398 HT JHD2 HHT1|HHT2 17875926,23091032,17310254 0415,0415,0415 LC TEF1|TEF2 JHD2 16429126 0676 HT SSA1 JHD2 19536198 0676 HT SSA2 JHD2 19536198 0676 HT SSB1 JHD2 19536198 0676 HT HSC82 JHD2 19536198 0676 HT SIS1 JHD2 19536198 0676 HT FUN30 JHD2 16554755,16554755 0676,0004 HT SSE1 JHD2 19536198 0676 HT UGP1 JHD2 16554755 0363 HT RCK1 JHD2 21460040 0096 LC SET1 JHD2 17875926 0428 LC ECM10 JHD2 19536198 0676 HT SSB2 JHD2 19536198,23332755 0676,0401 HT,LC UTP25 JHD2 16554755,16554755,16554755 0363,0676,0004 HT MPP10 JHD2 16554755 0363 HT JHD2 JHD2 20538609 0096 LC JHD2 SKY1 21460040 0096 LC JHD2 SWA2 19536198 0676 HT JHD2 SAS10 16554755,16554755,16554755 0363,0676,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P47156 P25294 JHD2 SIS1 0.126 19536198 P47156 P11484 JHD2 SSB1 0.126 19536198 P47156 P02994 JHD2 TEF2 0.126 16429126 P47156 P12954 JHD2 SRS2 0.183 15964827 P47156 P40498 JHD2 UTP25 0.236 16554755 P47156 P40150 JHD2 SSB2 0.236 23332755,19536198 P47156 P38622 JHD2 RCK1 0.183 21460040 P47156 P34909 JHD2 MOT2 0.309 19346402 P47156 P07272 JHD2 PPR1 0.236 11283351 P47156 P10591 JHD2 SSA1 0.126 19536198 P47156 P10592 JHD2 SSA2 0.126 19536198 P47156 P31380 JHD2 FUN30 0.126 16554755 P47156 P32589 JHD2 SSE1 0.126 19536198 P47156 P32861 JHD2 UGP1 0.126 16554755 P47156 P39987 JHD2 ECM10 0.126 19536198 P47156 P47083 JHD2 MPP10 0.126 16554755 P47156 P47135 JHD2 JSN1 0.21 11283351 P47156 P47156 JHD2 JHD2 0.332 20538609 P61830 P47156 HHT2 JHD2 0.309 23091032 Q12136 P47156 SAS10 JHD2 0.236 16554755 Q03656 P47156 SKY1 JHD2 0.183 21460040 P47156 P15108 JHD2 HSC82 0.126 19536198 Q06677 P47156 SWA2 JHD2 0.126 19536198 Q07807 P47156 PUF3 JHD2 0.126