PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ENT3 CSL4 16554755 intact exp ENT3 RRP45 16554755 biogrid,i2d,mint,intact exp ENT3 HRT1 14690591 intact exp ENT3 Maf-like protein YOR111W 10688190,11283351 biogrid,i2d,mint,intact,dip exp SSB2 ENT3 19536198 intact exp CRM1 ENT3 26673895 biogrid exp MEK1 ENT3 16319894 biogrid,i2d exp CHS3 ENT3 17344475 biogrid exp CHC1 ENT3 17344475,12967568 biogrid exp SYN8 ENT3 20658963 biogrid exp HRR25 ENT3 16319894, 23023127 biogrid,i2d exp, pred PEP1 ENT3 18467557, 23023127 biogrid,i2d,mint,intact exp, pred PEP12 ENT3 17344475,20658963, 23023127 biogrid exp, pred ENT3 VTI1 14630930,20658963,21746902, 23023127 biogrid,dip exp, pred GGA2 ENT3 12483220,17344475,22940862,20704189, 23023127 biogrid exp, pred CLC1 ENT3 12483220,17344475, 23023127 biogrid exp, pred VPS27 ENT3 15107463, 23023127 biogrid exp, pred ENT3 APL4 12483220,18467557, 23023127 biogrid,i2d,mint,intact exp, pred ENT3 ENT5 15107463, 23023127 biogrid exp, pred ENT3 VPS5 14690591, 23023127 intact exp, pred ENT3 GGA1 23023127 pred SLA2 ENT3 23023127 pred HSE1 ENT3 23023127 pred ENT3 YIP1 23023127 pred ENT3 ENT2 23023127 pred PEP3 ENT3 23023127 pred ENT3 ENT1 23023127 pred ENT3 IST1 23023127 pred SNF7 ENT3 23023127 pred ENT3 VAM3 23023127 pred ENT3 CHS5 23023127 pred VPS55 ENT3 23023127 pred ENT3 DID2 23023127 pred ENT3 YAP1802 23023127 pred ENT3 VPS68 23023127 pred ENT3 TLG2 23023127 pred ENT3 VPS4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P47160 P38817 - 12483220 - X 2 P47160 Q99210 - 10688190 - X 2 P47160 Q99210 - 11283351 - X 2 P22137 P47160 affinity chromatography technology 12967568 physical association X 2 P22137 P47160 affinity chromatography technology 17344475 physical association X 2 Q05636 P47160 affinity chromatography technology 16554755 physical association X 2 P0CG63 P47160 affinity chromatography technology 23749301 physical association X 2 P0CG63 P47160 affinity chromatography technology 23793018 physical association X 2 P0CG63 P47160 affinity chromatography technology 21427232 physical association X 2 P0CG63 P47160 affinity chromatography technology 22106047 physical association X 2 Q04338 P47160 pull down 14630930 direct interaction X 2 Q04338 P47160 two hybrid 14630930 direct interaction X 2 Q04338 P47160 two hybrid 20658963 direct interaction X 2 Q04338 P47160 x-ray crystallography 21746902 association X 2 Q04338 P47160 two hybrid 21746902 direct interaction X 2 Q04338 P47160 pull down 21746902 direct interaction X 2 P47160 P38817 affinity chromatography technology 22940862 physical association X 2 P47160 P38817 two hybrid 12483220 direct interaction X 2 P47160 Q12028 two hybrid 12483220 direct interaction X 2 P47160 P38817 pull down 12483220 direct interaction X 2 P47160 Q12028 pull down 12483220 direct interaction X 2 P47160 P38817 affinity chromatography technology 12483220 physical association X 2 P47160 Q03769 affinity chromatography technology 15107463 physical association X 2 P47160 P29295 enzymatic study 16319894 direct interaction X 2 P47160 Q99210 two hybrid 11283351 direct interaction X 2 P47160 P38817 affinity chromatography technology 17344475 physical association X 2 P47160 P32319 protein complementation assay 18467557 direct interaction X 2 P47160 Q12028 protein complementation assay 18467557 direct interaction X 2 P47160 P31377 two hybrid 20658963 direct interaction X 2 P47160 P38817 pull down 20704189 direct interaction X 2 P47160 Q99210 two hybrid 10688190 direct interaction X 2 P32854 P47160 affinity chromatography technology 17344475 physical association X 2 P32854 P47160 two hybrid 20658963 direct interaction X 2 P24719 P47160 enzymatic study 16319894 direct interaction X 2 P29465 P47160 affinity chromatography technology 17344475 physical association X 2 P17891 P47160 affinity chromatography technology 12483220 physical association X 2 P17891 P47160 affinity chromatography technology 17344475 physical association X 2 P40343 P47160 affinity chromatography technology 15107463 physical association X 2 Q04338 P47160 pull down 21746902 direct interaction X 2 Q04338 P47160 molecular sieving 21746902 direct interaction X 2 Q04338 P47160 two hybrid 21746902 direct interaction X 2 Q04338 P47160 x-ray crystallography 21746902 direct interaction X 2 Q04338 P47160 isothermal titration calorimetry 21746902 direct interaction X 2 Q04338 P47160 two hybrid 21746902 direct interaction X 2 Q04338 P47160 pull down 18033301 direct interaction X 2 P47160 Q99210 two hybrid pooling approach 11283351 physical association X 2 P47160 Q99210 two hybrid 10688190 physical association X 2 P47160 inferred by author 16554755 association C 18 Q05636 P47160 tandem affinity purification 16554755 physical association X 2 P47160 Q99210 two hybrid 10688190 physical association X 2 P47160 Q99210 two hybrid fragment pooling approach 11283351 physical association X 2 P47160 P32319 dihydrofolate reductase reconstruction 18467557 physical association X 2 P47160 Q12028 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q92331 P47160 two hybrid array 14690591 physical association X 2 Q08273 P47160 two hybrid array 14690591 physical association X 2 P40150 P47160 tandem affinity purification 19536198 association X 2 P47160 Q99210 two hybrid 10688190 - X 2 P47160 Q99210 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality MEK1 ENT3 16319894 0415 LC HRR25 ENT3 16319894 0415 LC SYN8 ENT3 20658963 0018 LC PEP1 ENT3 18467557,18467557 0111,0090 HT PEP12 ENT3 20658963 0018 LC GGA2 ENT3 12483220,12483220,12483220 0096,0018,0004 LC ENT3 ENT3 21746902 0114 LC ENT3 VTI1 21746902,21746902,20658963,21746902,21746902,14630930,21746902,14630930 0071,0114,0018,0065,0096,0018,0018,0096 LC ENT3 HRT1 14690591 0397 LC ENT3 APL4 18467557,18467557,12483220,12483220 0111,0090,0018,0096 HT,LC ENT3 VPS5 14690591 0397 LC ENT3 Q99210 11283351,11283351,10688190,11283351,10688190 0018,0399,0397,0398,0018 HT MET6 ENT3 25512335 0096 LC GPH1 ENT3 25512335 0096 LC UBI4 ENT3 22106047 0004 LC ERR2 ENT3 25512335 0096 LC PYC1 ENT3 25512335 0096 LC IDI1 ENT3 25512335 0096 LC TRM1 ENT3 25512335 0096 LC CLC1 ENT3 17344475,12483220 0004,0004 LC CHC1 ENT3 12967568,17344475 0004,0004 LC NAP1 ENT3 25512335 0096 LC P25617 ENT3 25512335 0096 LC GSY2 ENT3 25512335 0096 LC CHS3 ENT3 17344475 0004 LC CRM1 ENT3 26673895,26673895 0096,0004 LC MLS1 ENT3 25512335 0096 LC GLN1 ENT3 25512335 0096 LC EFB1 ENT3 25512335 0096 LC SPT16 ENT3 25512335 0096 LC HBS1 ENT3 25512335 0096 LC PEP12 ENT3 17344475 0004 LC LHP1 ENT3 25512335 0096 LC TOD6 ENT3 25512335 0096 LC THI80 ENT3 25512335 0096 LC ABZ1 ENT3 25512335 0096 LC ADE17 ENT3 25512335 0096 LC PCS60 ENT3 25512335 0096 LC MAL32 ENT3 25512335 0096 LC GND1 ENT3 25512335 0096 LC TDA3 ENT3 25512335,25512335 0096,0004 LC GGA2 ENT3 12483220,22940862,12483220,20704189,17344475,12483220 0096,0004,0018,0096,0004,0004 LC,HT TOM71 ENT3 25512335 0096 LC FAD1 ENT3 25512335 0096 LC STM1 ENT3 25512335 0096 LC NPT1 ENT3 25512335 0096 LC AIM10 ENT3 25512335 0096 LC GPP2 ENT3 25512335 0096 LC SSB2 ENT3 19536198 0676 HT VPS27 ENT3 15107463 0004 LC UTP25 ENT3 25512335 0096 LC MAM33 ENT3 25512335 0096 LC P40892 ENT3 25512335 0096 LC OYE3 ENT3 25512335 0096 LC ELP2 ENT3 25512335 0096 LC AIP1 ENT3 25512335 0096 LC P47137 ENT3 25512335 0096 LC ENT3 UBP15 25512335 0096 LC ENT3 IMA1 25512335 0096 LC ENT3 P53066 25512335 0096 LC ENT3 MAL12 25512335 0096 LC ENT3 CSL4 16554755 0363 HT ENT3 NPL3 25512335 0096 LC ENT3 FOX2 25512335 0096 LC ENT3 SKI8 25512335 0096 LC ENT3 ENT5 15107463 0004 LC ENT3 ARA2 25512335 0096 LC ENT3 VTI1 21746902,21746902,21746902,21746902,14630930,18033301,21746902,14630930 0071,0114,0065,0096,0018,0096,0018,0096 LC ENT3 EMI2 25512335 0096 LC ENT3 SEC13 25512335 0096 LC ENT3 RRP45 16554755,16554755 0676,0004 HT ENT3 BNA5 25512335 0096 LC ENT3 NOB1 25512335 0096 LC ENT3 FMP40 25512335 0096 LC ENT3 LAP2 25512335 0096 LC ENT3 APL4 12483220,25512335,12483220 0018,0096,0096 LC ENT3 RIB2 25512335 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P47160 P24719 ENT3 MEK1 0.183 16319894 Q99210 P47160 Q99210 ENT3 0.569 11283351,10688190 Q05636 P47160 RRP45 ENT3 0.236 16554755 Q12028 P47160 APL4 ENT3 0.722 12483220,18467557,25512335 P47160 P30822 ENT3 CRM1 0.236 26673895 P47160 P38758 ENT3 TDA3 0.286 25512335 P47160 P38817 ENT3 GGA2 0.74 20704189,12483220 Q04338 P47160 VTI1 ENT3 0.891 20658963,14630930,21746902 P47160 P31377 ENT3 SYN8 0.309 20658963 P47160 P29295 ENT3 HRR25 0.183 16319894 P47160 P32319 ENT3 PEP1 0.286 18467557 P47160 P32854 ENT3 PEP12 0.309 20658963 P47160 P40150 ENT3 SSB2 0.126 19536198 P47160 P05694 ENT3 MET6 0.183 25512335 P47160 P06738 ENT3 GPH1 0.183 25512335 P47160 P0CX10 ENT3 ERR1 0.183 25512335 P47160 P0CX11 ENT3 ERR2 0.183 25512335 P47160 P11154 ENT3 PYC1 0.183 25512335 P47160 P15496 ENT3 IDI1 0.183 25512335 P47160 P15565 ENT3 TRM1 0.183 25512335 P47160 P17891 ENT3 CLC1 0.21 12483220 P47160 P22137 ENT3 CHC1 0.21 12967568 P47160 P25293 ENT3 NAP1 0.183 25512335 P47160 P25617 ENT3 P25617 0.183 25512335 P47160 P27472 ENT3 GSY2 0.183 25512335 P47160 P30952 ENT3 MLS1 0.183 25512335 P47160 P32288 ENT3 GLN1 0.183 25512335 P47160 P32471 ENT3 EFB1 0.183 25512335 P47160 P32558 ENT3 SPT16 0.183 25512335 P47160 P32769 ENT3 HBS1 0.183 25512335 P47160 P33399 ENT3 LHP1 0.183 25512335 P47160 P34220 ENT3 P34220 0.183 25512335 P47160 P35202 ENT3 THI80 0.183 25512335 P47160 P37254 ENT3 ABZ1 0.183 25512335 P47160 P38009 ENT3 ADE17 0.183 25512335 P47160 P38137 ENT3 PCS60 0.183 25512335 P47160 P38158 ENT3 MAL32 0.183 25512335 P47160 P38720 ENT3 GND1 0.183 25512335 P47160 P38825 ENT3 TOM71 0.183 25512335 P47160 P38913 ENT3 FAD1 0.183 25512335 P47160 P39015 ENT3 STM1 0.183 25512335 P47160 P39683 ENT3 NPT1 0.183 25512335 P47160 P39965 ENT3 AIM10 0.183 25512335 P47160 P40106 ENT3 HOR2 0.183 25512335 P47160 P40343 ENT3 VPS27 0.21 15107463 P47160 P40498 ENT3 UTP25 0.183 25512335 P47160 P40513 ENT3 MAM33 0.183 25512335 P47160 P40892 ENT3 P40892 0.183 25512335 P47160 P41816 ENT3 OYE3 0.183 25512335 P47160 P42935 ENT3 ELP2 0.183 25512335 P47160 P46680 ENT3 AIP1 0.183 25512335 P47160 P47137 ENT3 P47137 0.183 25512335 P50101 P47160 UBP15 ENT3 0.183 25512335 P53051 P47160 IMA1 ENT3 0.183 25512335 P53066 P47160 P53066 ENT3 0.183 25512335 P53341 P47160 MAL12 ENT3 0.183 25512335 Q01560 P47160 NPL3 ENT3 0.183 25512335 Q02207 P47160 FOX2 ENT3 0.183 25512335 Q02793 P47160 SKI8 ENT3 0.183 25512335 Q04212 P47160 ARA2 ENT3 0.183 25512335 Q04409 P47160 EMI2 ENT3 0.183 25512335 Q04491 P47160 SEC13 ENT3 0.183 25512335 Q05979 P47160 BNA5 ENT3 0.183 25512335 Q08273 P47160 HRT1 ENT3 0.126 14690591 Q08444 P47160 NOB1 ENT3 0.183 25512335 Q08968 P47160 FMP40 ENT3 0.183 25512335 Q10740 P47160 LAP2 ENT3 0.183 25512335 Q12362 P47160 RIB2 ENT3 0.183 25512335 Q92331 P47160 VPS5 ENT3 0.126 14690591 Q03769 P47160 ENT5 ENT3 0.21 15107463 P53859 P47160 CSL4 ENT3 0.126 16554755