PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DGR2 SWE1 16319894 biogrid,i2d exp HSP104 DGR2 19536198 intact exp DGR2 SSZ1 19536198 intact exp TPK1 DGR2 16319894 biogrid,i2d exp SBA1 DGR2 21777812 biogrid exp DGR2 PFD1 19536198 intact exp DGR2 NAB2 19840948 biogrid exp SSB1 DGR2 19536198 intact exp YCK1 DGR2 16319894 biogrid exp DGR2 STH1 i2d exp TPK2 DGR2 16319894 biogrid,i2d exp DGR2 PTK2 16319894 biogrid,i2d exp DGR2 HMT1 14690591 intact exp SSA2 DGR2 19536198 intact exp DGR2 YKE2 19536198 intact exp DGR2 TOS3 16319894 biogrid,i2d exp SNF1 DGR2 16319894 biogrid,i2d exp DGR2 CCT3 19536198 intact exp DGR2 SSB2 19536198 intact exp HSP82 DGR2 19536198 intact exp DGR2 PAC10 19536198 intact exp DGR2 RRP9 i2d exp DGR2 RPB7 24513203,24358479 biogrid exp DGR2 ATG1 16319894, 23023127 biogrid,i2d exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P06245 P32330 enzymatic study 16319894 direct interaction X 2 P32330 P47116 enzymatic study 16319894 direct interaction X 2 P32330 P23291 enzymatic study 16319894 direct interaction X 2 P34087 P32330 affinity chromatography technology 24358479 physical association X 2 P34087 P32330 affinity chromatography technology 24513203 physical association X 2 P06782 P32330 enzymatic study 16319894 direct interaction X 2 P32330 P32944 enzymatic study 16319894 direct interaction X 2 P32330 P43637 enzymatic study 16319894 direct interaction X 2 P32330 P28707 pull down 21777812 direct interaction X 2 P32330 P28707 two hybrid 21777812 direct interaction X 2 P53104 P32330 enzymatic study 16319894 direct interaction X 2 P06244 P32330 enzymatic study 16319894 direct interaction X 2 P48363 P32330 tandem affinity purification 19536198 association X 2 P46988 P32330 tandem affinity purification 19536198 association X 2 P32330 P31539 tandem affinity purification 19536198 association X 2 P40150 P32330 tandem affinity purification 19536198 association X 2 P38788 P32330 tandem affinity purification 19536198 association X 2 P38074 P32330 two hybrid array 14690591 physical association X 2 P52553 P32330 tandem affinity purification 19536198 association X 2 P10592 P32330 tandem affinity purification 19536198 association X 2 P39077 P32330 tandem affinity purification 19536198 association X 2 P11484 P32330 tandem affinity purification 19536198 association X 2 P02829 P32330 tandem affinity purification 19536198 association X 2

PPI - HINT Gene A Gene B PMID Method Quality TPK1 DGR2 16319894 0415 LC TPK2 DGR2 16319894 0415 LC SNF1 DGR2 16319894 0415 LC YCK1 DGR2 16319894 0415 LC SBA1 DGR2 21777812,21777812 0018,0096 LC DGR2 SWE1 16319894 0415 LC DGR2 HMT1 14690591 0397 LC DGR2 TOS3 16319894 0415 LC DGR2 PTK2 16319894 0415 LC DGR2 ATG1 16319894 0415 LC HSP82 DGR2 19536198 0676 HT SSA2 DGR2 19536198 0676 HT SSB1 DGR2 19536198 0676 HT SBA1 DGR2 21777812,21777812 0018,0096 LC HSP104 DGR2 19536198 0676 HT DGR2 NAB2 19840948 0004 LC DGR2 RPB7 24358479,24513203 0004,0004 LC DGR2 SSZ1 19536198 0676 HT DGR2 WSS1 26349035 0004 LC DGR2 CCT3 19536198 0676 HT DGR2 SSB2 19536198 0676 HT DGR2 PFD1 19536198 0676 HT DGR2 PAC10 19536198 0676 HT DGR2 YKE2 19536198 0676 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53104 P32330 ATG1 DGR2 0.183 16319894 P32330 P23291 DGR2 YCK1 0.183 16319894 P32330 P02829 DGR2 HSP82 0.126 19536198 P32330 P06244 DGR2 TPK1 0.183 16319894 P32330 P06245 DGR2 TPK2 0.183 16319894 P32330 P06782 DGR2 SNF1 0.183 16319894 P32330 P28707 DGR2 SBA1 0.332 21777812 P34087 P32330 RPB7 DGR2 0.376 24358479,24513203 P32330 P10592 DGR2 SSA2 0.126 19536198 P32330 P11484 DGR2 SSB1 0.126 19536198 P32330 P31539 DGR2 HSP104 0.126 19536198 P38074 P32330 HMT1 DGR2 0.126 14690591 P39077 P32330 CCT3 DGR2 0.126 19536198 P40150 P32330 SSB2 DGR2 0.126 19536198 P32505 P32330 NAB2 DGR2 0.126 19840948 P38788 P32330 SSZ1 DGR2 0.126 19536198 P38838 P32330 WSS1 DGR2 0.126 26349035 P43637 P32330 TOS3 DGR2 0.183 16319894 P46988 P32330 PFD1 DGR2 0.126 19536198 P47116 P32330 PTK2 DGR2 0.183 16319894 P48363 P32330 PAC10 DGR2 0.126 19536198 P52553 P32330 YKE2 DGR2 0.126 19536198