PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DOA1 NAB6 i2d exp UBI4 DOA1 15096053,16427015,16705165,16428438,18508771,21070969 biogrid,i2d exp STE11 DOA1 i2d exp RPS31 DOA1 i2d exp SPT23 DOA1 16427015 biogrid exp RPL40B DOA1 i2d exp SSB1 DOA1 16429126 intact exp HSP104 DOA1 19536198 intact exp TUP1 DOA1 16554755 biogrid,i2d,mint,intact exp SSA2 DOA1 16429126 intact exp DOA1 SSB2 23332755 biogrid exp DOA1 GIS2 21232131 biogrid exp HSC82 DOA1 19536198 intact exp DOA1 VMS1 21148305 biogrid exp DOA1 HSE1 19841731,11743162,24607902,18508771 biogrid,i2d,mint,intact,dip exp HSP78 DOA1 19536198 intact exp DOA1 VPS27 18508771 biogrid exp DOA1 UBX4 14755638 biogrid exp RPA190 DOA1 11805826,16429126 biogrid,mint,intact,dip exp DOA1 BFA1 16554755 intact exp RPL40A DOA1 i2d exp MSK1 DOA1 17707817 biogrid exp RPO31 DOA1 11805826,16429126 biogrid,mint,intact,dip exp, ortho DOA1 DOA1 11805826, 23023127 mint,intact exp, ortho, pred SHP1 DOA1 11805826,16427015,16429126,21211725, 23023127 biogrid,mint,intact,dip exp, ortho, pred CDC48 DOA1 16429126,21148305,21211725,8890162,16428438,16554755,21282470,11805826,14755638,16427015,20508643,19805280, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred DOA1 UFD1 16427015, 23023127 biogrid exp, pred DPB2 DOA1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred DOA1 UBX6 14755638, 23023127 biogrid exp, pred RPA135 DOA1 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred DOA1 OTU1 16427015, 23023127 biogrid exp, pred DOA1 UBX2 21211725, 23023127 biogrid exp, pred DOA1 RPN11 20170199, 23023127 biogrid exp, pred DOA1 UBX7 14755638, 23023127 biogrid exp, pred DOA1 UBP3 20508643, 23023127 biogrid,mint,intact exp, pred NPL4 DOA1 16427015, 23023127 biogrid exp, pred PUT2 DOA1 ortho CSE1 DOA1 ortho POL30 DOA1 ortho DOA1 FRA1 ortho PKC1 DOA1 ortho ERG20 DOA1 ortho TUF1 DOA1 ortho DOA1 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P36037 P38753 - 11743162 - X 2 P36037 - 11805826 - C 6 P36037 P25694 - 8890162 - X 2 P47049 P36037 two hybrid 14755638 direct interaction X 2 P38349 P36037 two hybrid 14755638 direct interaction X 2 P40343 P36037 affinity chromatography technology 18508771 physical association X 2 P36037 P38753 two hybrid 11743162 direct interaction X 2 P36037 P38753 pull down 24607902 direct interaction X 2 P36037 P38753 pull down 24607902 direct interaction X 2 P36037 P38753 x-ray crystallography 24607902 association X 2 P36037 P43558 two hybrid 16427015 direct interaction X 2 P36037 P24482 affinity chromatography technology 16554755 physical association X 2 P36037 P43558 pull down 16427015 direct interaction X 2 P36037 P43558 affinity chromatography technology 16427015 physical association X 2 P36037 P32048 two hybrid 17707817 direct interaction X 2 P36037 P38753 affinity chromatography technology 18508771 physical association X 2 P36037 P38753 two hybrid 19841731 direct interaction X 2 P36037 Q04228 affinity chromatography technology 21211725 physical association X 2 P36037 P10964 affinity chromatography technology 11805826 physical association X 2 P04051 P36037 affinity chromatography technology 11805826 physical association X 2 Q01477 P36037 affinity chromatography technology 20508643 physical association X 2 Q04311 P36037 affinity chromatography technology 21148305 physical association X 2 P0CG63 P36037 affinity chromatography technology 23749301 physical association X 2 P0CG63 P36037 affinity chromatography technology 17644757 physical association X 2 P0CG63 P36037 affinity chromatography technology 23793018 physical association X 2 P0CG63 P36037 pull down 16428438 direct interaction X 2 P0CG63 P36037 x-ray crystallography 21070969 association X 2 P0CG63 P36037 pull down 21070969 direct interaction X 2 P0CG63 P36037 two hybrid 16705165 direct interaction X 2 P0CG63 P36037 pull down 16705165 direct interaction X 2 P0CG63 P36037 pull down 16427015 direct interaction X 2 P0CG63 P36037 pull down 18508771 direct interaction X 2 P0CG63 P36037 affinity chromatography technology 12872131 physical association X 2 P0CG63 P36037 affinity chromatography technology 15096053 physical association X 2 P0CG63 P36037 pull down 15096053 direct interaction X 2 P0CG63 P36037 affinity chromatography technology 21427232 physical association X 2 P54730 P36037 two hybrid 14755638 direct interaction X 2 P34223 P36037 biochemical 16427015 association X 2 P34223 P36037 affinity chromatography technology 16427015 physical association X 2 P34223 P36037 affinity chromatography technology 21211725 physical association X 2 P34223 P36037 affinity chromatography technology 11805826 physical association X 2 P22138 P36037 affinity chromatography technology 11805826 physical association X 2 P40150 P36037 biochemical 23332755 association X 2 P36037 P25694 affinity chromatography technology 8890162 physical association X 2 P36037 P25694 two hybrid 14755638 direct interaction X 2 P36037 P25694 two hybrid 14755638 direct interaction X 2 P36037 P25694 affinity chromatography technology 8890162 physical association X 2 P36037 P25694 two hybrid 8890162 direct interaction X 2 P36037 P25694 affinity chromatography technology 16428438 physical association X 2 P36037 P16649 affinity chromatography technology 16554755 physical association X 2 P36037 P25694 affinity chromatography technology 16554755 physical association X 2 P36037 P25694 pull down 16428438 direct interaction X 2 P36037 P25694 biochemical 16427015 association X 2 P36037 P53044 biochemical 16427015 association X 2 P36037 P25694 affinity chromatography technology 16427015 physical association X 2 P36037 P53044 affinity chromatography technology 16427015 physical association X 2 P36037 P25694 pull down 16427015 direct interaction X 2 P36037 P35210 affinity chromatography technology 16427015 physical association X 2 P36037 P43588 affinity chromatography technology 20170199 physical association X 2 P36037 P25694 affinity chromatography technology 20508643 physical association X 2 P36037 P25694 affinity chromatography technology 20508643 physical association X 2 P36037 P25694 affinity chromatography technology 21211725 physical association X 2 P36037 P25694 two hybrid 21282470 direct interaction X 2 P36037 P25694 affinity chromatography technology 21282470 physical association X 2 P36037 P25694 affinity chromatography technology 21282470 physical association X 2 P36037 P25694 unspecified method 21282470 direct interaction X 2 P36037 P25694 affinity chromatography technology 11805826 physical association X 2 P36037 P25694 affinity chromatography technology 21148305 physical association X 2 P33755 P36037 biochemical 16427015 association X 2 P33755 P36037 affinity chromatography technology 16427015 physical association X 2 P36037 inferred by author 11805826 physical association C 14 P36037 isothermal titration calorimetry 19805280 direct interaction X 2 P36037 isothermal titration calorimetry 19805280 direct interaction X 2 P36037 P38753 two hybrid 11743162 physical association X 2 P36037 P10964 tandem affinity purification 11805826 physical association X 2 P36037 tandem affinity purification 11805826 - C 6 P04051 P36037 tandem affinity purification 11805826 physical association X 2 P34223 P36037 tandem affinity purification 11805826 physical association X 2 P22138 P36037 tandem affinity purification 11805826 physical association X 2 P36037 P25694 isothermal titration calorimetry 19805280 direct interaction X 2 P36037 P25694 coimmunoprecipitation 8890162 direct interaction X 2 P36037 P25694 two hybrid 8890162 direct interaction X 2 P36037 P25694 anti tag coimmunoprecipitation 19805280 direct interaction X 2 P36037 P25694 tandem affinity purification 11805826 direct interaction X 2 P36037 tandem affinity purification 11805826 association C 7 P36037 tandem affinity purification 11805826 association C 7 P36037 inferred by author 16554755 association C 22 P36037 P38753 two hybrid array 11743162 physical association X 2 P36037 P24482 tandem affinity purification 16554755 physical association X 2 P36037 P38753 pull down 18508771 physical association X 2 P36037 P33416 tandem affinity purification 19536198 association X 2 P36037 P38753 two hybrid pooling approach 19841731 physical association X 2 P36037 anti bait coimmunoprecipitation 20508643 association C 3 P36037 tandem affinity purification 16429126 association C 8 Q01477 P36037 pull down 20508643 direct interaction X 2 Q01477 P36037 anti bait coimmunoprecipitation 20508643 physical association X 2 Q01477 P36037 anti tag coimmunoprecipitation 20508643 physical association X 2 P15108 P36037 tandem affinity purification 19536198 association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P16649 tandem affinity purification 16554755 physical association X 2 P36037 P25694 tandem affinity purification 16554755 physical association X 2 P36037 P31539 tandem affinity purification 19536198 association X 2 P36037 P25694 pull down 20508643 direct interaction X 2 P36037 P25694 anti bait coimmunoprecipitation 20508643 physical association X 2 P36037 mass spectrometry studies of complexes 11805826 - C 19 P36037 mass spectrometry studies of complexes 11805826 - C 19 P25343 P36037 interaction detection method 14764870 - X 2 Q06697 P36037 interaction detection method 14764870 - X 2 P36037 P39743 interaction detection method 14764870 - X 2 P36037 P38753 two hybrid 11743162 - X 2 P36037 P32641 interaction detection method 14764870 - X 2 P36037 P25694 two hybrid 8890162 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBI4 DOA1 21070969,16705165,16705165,21070969,21070969 0096,0096,0018,0004,0114 LC CDC48 DOA1 19805280,8890162,19805280,16427015,14755638,8890162,16427015,21282470,21282470,8890162,16427015 0007,0018,0065,0401,0018,0004,0004,0004,0018,0019,0096 LC MSK1 DOA1 17707817 0018 LC NPL4 DOA1 16427015,16427015 0401,0004 LC SAS3 DOA1 16427015,16427015 0401,0004 LC DOA1 DOA1 19805280,21070969 0114,0114 LC DOA1 UBX7 14755638 0018 LC DOA1 HSE1 19841731,11743162,11743162,24607902,19841731,24607902 0018,0397,0018,0114,0398,0096 HT,LC DOA1 SSB2 23332755 0401 LC DOA1 OTU1 16427015,16427015,16427015 0004,0018,0096 LC DOA1 UBX6 14755638 0018 LC DOA1 UFD1 16427015,16427015 0401,0004 LC DOA1 UBX4 14755638 0018 LC RPO31 DOA1 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT RPS31 DOA1 26349035 0004 LC ADR1 DOA1 26349035 0004 LC RPC40 DOA1 26349035 0004 LC UBI4 DOA1 21070969,16428438,15096053,16705165,16705165,26349035,21070969,18508771,26349035,16427015,15096053,21070969 0096,0096,0096,0096,0018,0004,0004,0096,0096,0096,0004,0114 LC SSA2 DOA1 16429126 0676 HT RPA190 DOA1 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT SSB1 DOA1 16429126 0676 HT HSC82 DOA1 19536198 0676 HT TUP1 DOA1 16554755,16554755 0676,0004 HT HCA4 DOA1 26349035 0004 LC SAR1 DOA1 26349035 0004 LC RPA135 DOA1 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT DPB2 DOA1 16554755,16554755 0676,0004 HT CDC48 DOA1 21211725,19805280,8890162,16428438,19805280,16427015,20508643,8890162,16554755,16427015,16429126,21148305,11805826,21282470,20508643,21282470,16554755,20508643,26349035,8890162,11805826,16427015,27044889,11805826,16428438,26349035 0004,0007,0018,0096,0065,0401,0004,0004,0676,0004,0676,0004,0004,0004,0006,0018,0004,0096,0096,0019,0676,0096,0004,0007,0004,0004 LC,HT UBC8 DOA1 26349035 0004 LC HSP104 DOA1 19536198 0676 HT NAB2 DOA1 26349035 0004 LC GSP1 DOA1 26349035 0004 LC GSP2 DOA1 26349035 0004 LC HSP78 DOA1 19536198 0676 HT SOF1 DOA1 26349035 0004 LC NPL4 DOA1 16427015,26349035,16427015 0401,0004,0004 LC SAS3 DOA1 16427015,21211725,16427015,16429126,11805826,11805826,26349035,11805826 0401,0004,0004,0676,0676,0004,0004,0007 LC,HT SPT23 DOA1 16427015 0004 LC DOA1 DOA1 11805826,11805826 0676,0007 HT DOA1 FZO1 27044889 0004 LC DOA1 HSE1 18508771,24607902,18508771,24607902 0096,0114,0004,0096 LC DOA1 WSS1 26349035,26349035 0096,0004 LC DOA1 ALD5 26349035 0004 LC DOA1 SSB2 23332755 0401 LC DOA1 HUA1 26349035 0004 LC DOA1 VPS27 18508771 0004 LC DOA1 OTU1 16427015,16427015,16427015 0004,0018,0096 LC DOA1 RPN11 20170199 0004 LC DOA1 BFA1 16554755 0363 HT DOA1 RPL38 26349035 0004 LC DOA1 UFD1 16427015,16427015,26349035,27044889 0401,0004,0004,0004 LC DOA1 ARI1 26349035 0004 LC DOA1 DCP2 26349035 0004 LC DOA1 UBP3 20508643,20508643,20508643,20508643 0004,0007,0096,0006 LC DOA1 OSH6 26349035 0004 LC DOA1 DIG1 26349035 0004 LC DOA1 FIN1 26349035 0004 LC DOA1 RPN9 26349035 0004 LC DOA1 UBX2 21211725,26349035 0004,0004 LC DOA1 VMS1 21148305 0004 LC DOA1 ADH6 26349035 0004 LC DOA1 LCB4 26349035 0004 LC DOA1 SMT3 26349035 0096 LC DOA1 PAA1 26349035 0004 LC DOA1 CEX1 26349035 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12306 P36037 SMT3 DOA1 0.183 26349035 P36037 P16649 DOA1 TUP1 0.236 16554755 P53044 P36037 UFD1 DOA1 0.309 26349035,27044889 Q04228 P36037 UBX2 DOA1 0.309 26349035,21211725 P36037 P0CG63 DOA1 UBI4 0.946 26349035,21070969,16705165,16428438,18508771,15096053 P36037 P25694 DOA1 CDC48 0.998 26349035,16427015,16554755,21282470,14755638,8890162,27044889,16428438,21211725,11805826,16429126,21148305,20508643,19805280 P36037 P32048 DOA1 MSK1 0.309 17707817 P40150 P36037 SSB2 DOA1 0.126 23332755 P40343 P36037 VPS27 DOA1 0.21 18508771 P43588 P36037 RPN11 DOA1 0.126 20170199 P36037 P07248 DOA1 ADR1 0.126 26349035 P36037 P05759 DOA1 RPS31 0.126 26349035 P36037 P04051 DOA1 RPO31 0.286 11805826,16429126 P36037 P07703 DOA1 RPC40 0.126 26349035 P36037 P15108 DOA1 HSC82 0.126 19536198 P38297 P36037 FZO1 DOA1 0.21 27044889 P36037 P10592 DOA1 SSA2 0.126 16429126 P36037 P11484 DOA1 SSB1 0.126 16429126 P36037 P10964 DOA1 RPA190 0.286 11805826,16429126 P36037 P24482 DOA1 DPB2 0.126 16554755 P36037 P20448 DOA1 HCA4 0.126 26349035 P36037 P20606 DOA1 SAR1 0.126 26349035 P36037 P32505 DOA1 NAB2 0.126 26349035 P36037 P31539 DOA1 HSP104 0.126 19536198 P36037 P28263 DOA1 UBC8 0.126 26349035 P36037 P36037 DOA1 DOA1 0.155 11805826 P36037 P33416 DOA1 HSP78 0.126 19536198 P36037 P32835 DOA1 GSP1 0.126 26349035 P36037 P32836 DOA1 GSP2 0.126 26349035 P36037 P34223 DOA1 SHP1 0.472 11805826,26349035,16429126,21211725 P36037 P33750 DOA1 SOF1 0.126 26349035 P36037 P33755 DOA1 NPL4 0.126 26349035 P47049 P36037 UBX6 DOA1 0.309 14755638 P38349 P36037 UBX7 DOA1 0.309 14755638 P38753 P36037 HSE1 DOA1 0.88 18508771,19841731,24607902,11743162 P40325 P36037 HUA1 DOA1 0.126 26349035 P38838 P36037 WSS1 DOA1 0.376 26349035 P40047 P36037 ALD5 DOA1 0.126 26349035 Q03063 P36037 DIG1 DOA1 0.126 26349035 P53550 P36037 DCP2 DOA1 0.126 26349035 P49167 P36037 RPL38 DOA1 0.126 26349035 P53111 P36037 ARI1 DOA1 0.126 26349035 Q02201 P36037 OSH6 DOA1 0.126 26349035 P54730 P36037 UBX4 DOA1 0.309 14755638 Q01853 P36037 VCP DOA1 0.309 19805280 Q04894 P36037 ADH6 DOA1 0.126 26349035 Q03898 P36037 FIN1 DOA1 0.126 26349035 Q04062 P36037 RPN9 DOA1 0.126 26349035 Q12453 P36037 CEX1 DOA1 0.126 26349035 Q12246 P36037 LCB4 DOA1 0.126 26349035 Q12447 P36037 PAA1 DOA1 0.126 26349035 P47113 P36037 BFA1 DOA1 0.126 16554755 P43558 P36037 OTU1 DOA1 0.309 16427015 Q01477 P36037 UBP3 DOA1 0.523 20508643 P53849 P36037 GIS2 DOA1 0.126 21232131 P36037 P22138 DOA1 RPA135 0.332 11805826,16429126 Q04311 P36037 VMS1 DOA1 0.21 21148305