PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NAB2 HEL1 19840948 biogrid exp HEL1 THI20 11805837 dip exp HHF1, HHF2 HEL1 22570702 biogrid exp HEL1 LAA1 16429126 intact exp PGI1 HEL1 11805837 dip exp HEL1 HHT1, HHT2 22570702 biogrid exp UBC4 HEL1 22570702 biogrid exp HEL1 SSB2 23332755 biogrid exp GAL1 HEL1 11805837 dip exp RAD53 HEL1 22570702 biogrid exp HEL1 PUF3 26493364 biogrid exp HEL1 ETP1 11805837, 23023127 biogrid,mint,intact,dip exp, pred HEL1 RRS1 11283351, 23023127 i2d,mint,intact,dip exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P36113 - 11805837 - C 4 Q08746 P36113 - 11283351 - X 2 P22216 P36113 affinity chromatography technology 22570702 physical association X 2 P15731 P36113 pull down 22570702 direct interaction X 2 P15731 P36113 affinity chromatography technology 22570702 physical association X 2 P36113 P61830 affinity chromatography technology 22570702 physical association X 2 P36113 P02309 affinity chromatography technology 22570702 physical association X 2 P36113 P02309 enzymatic study 22570702 direct interaction X 2 P0CG63 P36113 affinity chromatography technology 23749301 physical association X 2 P38748 P36113 affinity chromatography technology 11805837 physical association X 2 P40150 P36113 biochemical 23332755 association X 2 P04385 P36113 anti tag coimmunoprecipitation 11805837 physical association X 2 Q08224 P36113 anti tag coimmunoprecipitation 11805837 physical association X 2 P36113 anti tag coimmunoprecipitation 11805837 - C 4 P36113 anti tag coimmunoprecipitation 11805837 - C 4 P38748 P36113 anti tag coimmunoprecipitation 11805837 physical association X 2 Q08746 P36113 two hybrid pooling approach 11283351 physical association X 2 P12709 P36113 anti tag coimmunoprecipitation 11805837 physical association X 2 P36113 tandem affinity purification 16429126 association C 18 P36113 anti tag coimmunoprecipitation 11805837 association C 4 Q08746 P36113 two hybrid fragment pooling approach 11283351 physical association X 2 P36113 mass spectrometry studies of complexes 11805837 - C 15 Q08746 P36113 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality HHF1|HHF2 HEL1 22570702,22570702 0004,0415 LC HEL1 SSB2 23332755 0401 LC HEL1 RRS1 11283351,11283351,11283351 0018,0399,0398 HT HHF1|HHF2 HEL1 22570702,22570702 0004,0415 LC GAL1 HEL1 11805837 0007 HT PGI1 HEL1 11805837 0007 HT UBC4 HEL1 22570702,22570702 0096,0004 LC RAD53 HEL1 22570702 0004 LC NAB2 HEL1 19840948 0004 LC HEL1 ETP1 11805837,11805837 0004,0007 HT HEL1 LAA1 16429126 0676 HT HEL1 SSB2 23332755 0401 LC HEL1 HHT1|HHT2 22570702 0004 LC HEL1 THI20 11805837 0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12221 P36113 PUF2 P36113 0.126 26668354 P36113 P12709 P36113 PGI1 0.126 11805837 P36113 P04385 P36113 GAL1 0.126 11805837 P36113 P02309 P36113 HHF2 0.454 22570702 P36113 P32505 P36113 NAB2 0.126 19840948 P39526 P36113 LAA1 P36113 0.126 16429126 P36113 P15731 P36113 UBC4 0.454 22570702 P61830 P36113 HHT2 P36113 0.21 22570702 P38748 P36113 ETP1 P36113 0.332 11805837 Q08746 P36113 RRS1 P36113 0.236 11283351 Q08224 P36113 THI20 P36113 0.126 11805837 P40150 P36113 SSB2 P36113 0.126 23332755 Q07807 P36113 PUF3 P36113 0.126 P36113 P22216 P36113 RAD53 0.21 22570702