PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CAF4 CCT3 11805837 biogrid,mint,intact,dip exp SRP54 CAF4 11805837 biogrid,mint,intact,dip exp CAF4 LYS12 11805837 dip exp CAF4 RVS167 i2d exp CAF4 ETP1 22875988 biogrid exp HSP26 CAF4 11805837 dip exp HSP60 CAF4 19536198 intact exp SSA1 CAF4 19536198 intact exp ATP1 CAF4 11805837 dip exp SSA3 CAF4 11805837 dip exp CCR4 CAF4 11113136 biogrid,i2d,dip exp CAF4 ECM27 16554755 intact exp TDH2 CAF4 11805837 dip exp CAF4 VHR2 i2d exp CAF4 CCT6 11805837 biogrid,mint,intact,dip exp CAF4 CCT7 11805837 dip exp CAF4 ENT2 11805837 biogrid,mint,intact,dip exp CAF4 PUF3 26493364 biogrid exp CAF4 OSH7 11805837 biogrid,mint,intact,dip exp CAF4 SPC72 22875988 biogrid exp LEU2 CAF4 11805837 dip exp TCP1 CAF4 11805837 biogrid,mint,intact,dip exp CAF4 CCT2 11805837 biogrid,mint,intact,dip exp CAF4 PZF1 16554755 intact exp PRE8 CAF4 i2d exp ARE1 CAF4 22875988 biogrid exp CAF4 ATP3 11805837 biogrid,intact,dip exp CAF4 CCT4 11805837 dip exp RNA1 CAF4 22875988 biogrid exp CDC39 CAF4 11113136 biogrid,i2d,dip exp CAF4 HSP42 19536198,11805837 intact,dip exp CAF4 SSZ1 19536198 intact exp SSA2 CAF4 19536198 intact exp MDJ1 CAF4 11805837 dip exp CAF4 UBC7 14690591 intact exp CAF4 MPM1 11805837 dip exp CAF4 SPR3 22875988 biogrid exp ERG6 CAF4 16554755 intact exp CAF4 CCT5 11805837 biogrid,mint,intact,dip exp MIR1 CAF4 11805837 dip exp CAF4 ACT1 11805837 dip exp CAF4 SGM1 22875988 biogrid exp SSB1 CAF4 19536198 intact exp CAF4 CCT8 11805837 dip exp ATP2 CAF4 11805837 dip exp MYO2 CAF4 i2d exp VMA2 CAF4 11805837 dip exp GAL1 CAF4 11805837 dip exp CAF4 Uncharacterized protein YBL029W 11805837, 23023127 biogrid,mint,intact,dip exp, pred CAF4 DNM1 23810512,16009724, 23023127 biogrid exp, pred MTF1 CAF4 16554755, 23023127 biogrid,i2d,mint,intact exp, pred DBF2 CAF4 11113136, 23023127 biogrid,i2d,dip exp, pred CAF4 FIS1 16009724,17998537,18445678, 23023127 biogrid,dip exp, pred CAF4 SSN2 11113136, 23023127 biogrid,i2d,dip exp, pred CAF4 CAF4 16009724, 23023127 biogrid exp, pred CAF4 MDV1 23300936,16009724, 23023127 biogrid exp, pred CAF4 SSN3 11113136, 23023127 biogrid,i2d,dip exp, pred CAF4 MDM30 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P39077 P36130 affinity chromatography technology 11805837 physical association X 2 P25628 P36130 two hybrid 22875988 direct interaction X 2 Q12306 P36130 affinity chromatography technology 15292183 physical association X 2 P25655 P36130 two hybrid 11113136 direct interaction X 2 P39079 P36130 affinity chromatography technology 11805837 physical association X 2 P14908 P36130 affinity chromatography technology 16554755 physical association X 2 P38755 P36130 affinity chromatography technology 11805837 physical association X 2 P36130 P36130 affinity chromatography technology 16009724 physical association X 2 P20424 P36130 affinity chromatography technology 11805837 physical association X 2 Q05785 P36130 affinity chromatography technology 11805837 physical association X 2 P54861 P36130 two hybrid 16009724 direct interaction X 2 P54861 P36130 imaging technique 16009724 colocalization X 2 P38931 P36130 affinity chromatography technology 11113136 physical association X 2 P38931 P36130 two hybrid 11113136 direct interaction X 2 P47166 P36130 two hybrid 22875988 direct interaction X 2 P38748 P36130 two hybrid 22875988 direct interaction X 2 P47025 P36130 imaging technique 23300936 colocalization X 2 P47025 P36130 two hybrid 16009724 direct interaction X 2 P47025 P36130 two hybrid 16009724 direct interaction X 2 P47025 P36130 affinity chromatography technology 16009724 physical association X 2 P31384 P36130 two hybrid 11113136 direct interaction X 2 P38201 P36130 affinity chromatography technology 11805837 physical association X 2 P38077 P36130 affinity chromatography technology 11805837 physical association X 2 P11745 P36130 two hybrid 22875988 direct interaction X 2 P40515 P36130 affinity chromatography technology 16009724 physical association X 2 P40515 P36130 affinity chromatography technology 16009724 physical association X 2 P40515 P36130 two hybrid 16009724 direct interaction X 2 P40515 P36130 two hybrid 16009724 direct interaction X 2 P40515 P36130 imaging technique 16009724 colocalization X 2 P40515 P36130 x-ray crystallography 17998537 association X 2 P40515 P36130 two hybrid 17998537 direct interaction X 2 P40515 P36130 affinity chromatography technology 17998537 physical association X 2 P40515 P36130 imaging technique 18445678 colocalization X 2 P39723 P36130 two hybrid 22875988 direct interaction X 2 P39076 P36130 affinity chromatography technology 11805837 physical association X 2 P22204 P36130 two hybrid 11113136 direct interaction X 2 P41901 P36130 two hybrid 22875988 direct interaction X 2 P36130 P39073 two hybrid 11113136 direct interaction X 2 P36130 P40413 affinity chromatography technology 11805837 physical association X 2 P36130 P12612 affinity chromatography technology 11805837 physical association X 2 P36130 anti tag coimmunoprecipitation 11805837 - C 28 P00358 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P39077 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P04385 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P23641 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P25655 P36130 two hybrid 11113136 physical association X 2 P25655 P36130 coimmunoprecipitation 11113136 physical association X 2 P40495 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P35191 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P39079 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P38755 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12329 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P36130 P60010 anti tag coimmunoprecipitation 11805837 physical association X 2 P36130 P07251 anti tag coimmunoprecipitation 11805837 physical association X 2 P20424 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 Q05785 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P38931 P36130 coimmunoprecipitation 11113136 physical association X 2 P38931 P36130 two hybrid 11113136 physical association X 2 P36130 anti tag coimmunoprecipitation 11805837 - C 11 P16140 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P09435 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P40364 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P39078 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P31384 P36130 two hybrid 11113136 physical association X 2 P04173 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P38201 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P38077 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P40515 P36130 molecular sieving 17998537 direct interaction X 2 P40515 P36130 x-ray crystallography 17998537 direct interaction X 2 P40515 P36130 anti tag coimmunoprecipitation 17998537 direct interaction X 2 P40515 P36130 two hybrid 17998537 direct interaction X 2 P39076 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P42943 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P22204 P36130 coimmunoprecipitation 11113136 physical association X 2 P22204 P36130 two hybrid 11113136 physical association X 2 P36130 P47079 anti tag coimmunoprecipitation 11805837 physical association X 2 P36130 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 P36130 P39073 two hybrid 11113136 physical association X 2 P36130 P40413 anti tag coimmunoprecipitation 11805837 physical association X 2 P36130 P12612 anti tag coimmunoprecipitation 11805837 physical association X 2 P00830 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P36130 anti tag coimmunoprecipitation 11805837 association C 10 P19882 P36130 tandem affinity purification 19536198 association X 2 P14908 P36130 tandem affinity purification 16554755 physical association X 2 Q12329 P36130 tandem affinity purification 19536198 association X 2 P10591 P36130 tandem affinity purification 19536198 association X 2 P36130 inferred by author 16554755 association C 5 P10592 P36130 tandem affinity purification 19536198 association X 2 P11484 P36130 tandem affinity purification 19536198 association X 2 Q02159 P36130 two hybrid array 14690591 physical association X 2 P38077 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 P38788 P36130 tandem affinity purification 19536198 association X 2 P36130 confirmational text mining - - C 13 P36130 mass spectrometry studies of complexes 11805837 - C 12 P36130 mass spectrometry studies of complexes 11805837 - C 12

PPI - HINT Gene A Gene B PMID Method Quality RNA1 CAF4 22875988 0018 HT DBF2 CAF4 11113136,11113136 0018,0019 LC ARE1 CAF4 22875988 0018 HT CDC39 CAF4 11113136,11113136 0018,0019 LC CCR4 CAF4 11113136 0018 LC CAF4 CAF4 17998537 0114 LC CAF4 ETP1 22875988 0018 HT CAF4 SSN2 11113136,11113136,11113136 0018,0004,0019 LC CAF4 SSN3 11113136 0018 LC CAF4 SPC72 22875988 0018 HT CAF4 FIS1 16009724,16009724,17998537,16009724,17998537,17998537,17998537,17998537 0428,0004,0114,0018,0004,0018,0007,0071 LC CAF4 SPR3 22875988 0018 HT CAF4 MDV1 16009724,16009724 0018,0004 LC CAF4 SGM1 22875988 0018 HT CAF4 DNM1 16009724,16009724 0428,0018 LC CAF4 UBC7 14690591 0397 LC TDH2 CAF4 11805837 0007 HT ATP2 CAF4 11805837 0007 HT LEU2 CAF4 11805837 0007 HT GAL1 CAF4 11805837 0007 HT ATP1 CAF4 11805837 0007 HT SSA3 CAF4 11805837 0007 HT SSA1 CAF4 19536198 0676 HT SSA2 CAF4 19536198 0676 HT SSB1 CAF4 19536198 0676 HT TCP1 CAF4 11805837,11805837 0004,0007 HT MTF1 CAF4 16554755,16554755,16554755 0363,0676,0004 HT HSP26 CAF4 11805837 0007 HT VMA2 CAF4 11805837 0007 HT HSP60 CAF4 19536198 0676 HT SRP54 CAF4 11805837,11805837 0004,0007 HT MIR1 CAF4 11805837 0007 HT ERG6 CAF4 16554755 0363 HT MDJ1 CAF4 11805837 0007 HT CAF4 CAF4 21149566,16009724,21149566 0096,0004,0004 LC CAF4 ATP3 11805837,11805837 0004,0007 HT CAF4 P38201 11805837,11805837 0004,0007 HT CAF4 OSH7 11805837,11805837 0004,0007 HT CAF4 SSZ1 19536198 0676 HT CAF4 SSN2 11113136,11113136,11113136 0018,0004,0019 LC CAF4 CCT2 11805837,11805837 0004,0007 HT CAF4 CCT3 11805837,11805837 0004,0007 HT CAF4 CCT4 11805837 0007 HT CAF4 CCT6 11805837,11805837 0004,0007 HT CAF4 PZF1 16554755 0363 HT CAF4 MPM1 11805837 0007 HT CAF4 CCT5 11805837,11805837 0004,0007 HT CAF4 LYS12 11805837 0007 HT CAF4 FIS1 16009724,16009724,21149566,17998537,16009724,17998537,17998537,17998537,18445678,17998537 0428,0004,0004,0114,0018,0004,0018,0007,0428,0071 LC CAF4 CCT7 11805837 0007 HT CAF4 MDV1 16009724,23300936,16009724 0018,0428,0004 LC CAF4 CCT8 11805837 0007 HT CAF4 ECM27 16554755 0363 HT CAF4 DNM1 23810512,16009724,21149566,16009724 0004,0428,0004,0018 LC CAF4 ACT1 11805837 0007 HT CAF4 ENT2 11805837,11805837 0004,0007 HT CAF4 SMT3 15292183 0004 LC CAF4 HSP42 19536198,11805837 0676,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P60010 P36130 ACT1 CAF4 0.126 11805837 P36130 P23641 CAF4 MIR1 0.126 11805837 Q12329 P36130 HSP42 CAF4 0.21 11805837,19536198 P36130 P16140 CAF4 VMA2 0.126 11805837 P36130 P10591 CAF4 SSA1 0.126 19536198 P36130 P10592 CAF4 SSA2 0.126 19536198 P36130 P11484 CAF4 SSB1 0.126 19536198 P36130 P09435 CAF4 SSA3 0.126 11805837 P36130 P00358 CAF4 TDH2 0.126 11805837 P36130 P04173 CAF4 LEU2 0.126 11805837 P36130 P07251 CAF4 ATP1 0.126 11805837 P36130 P36130 CAF4 CAF4 0.49 21149566 P36130 P22204 CAF4 DBF2 0.065 11113136 P38931 P36130 SSN2 CAF4 0.065 11113136 P40515 P36130 FIS1 CAF4 0.902 17998537,18445678,21149566 P38077 P36130 ATP3 CAF4 0.126 11805837 P38201 P36130 P38201 CAF4 0.236 11805837 P38755 P36130 OSH7 CAF4 0.236 11805837 P39073 P36130 SSN3 CAF4 0.309 11113136 P39077 P36130 CCT3 CAF4 0.236 11805837 P39079 P36130 CCT6 CAF4 0.236 11805837 P36130 P35191 CAF4 MDJ1 0.126 11805837 P36130 P31384 CAF4 CCR4 0.033 11113136 P36130 P15992 CAF4 HSP26 0.126 11805837 P36130 P25655 CAF4 CDC39 0.309 11113136 P36130 P14908 CAF4 MTF1 0.332 16554755 P36130 P00830 CAF4 ATP2 0.126 11805837 P36130 P12612 CAF4 TCP1 0.236 11805837 P36130 P04385 CAF4 GAL1 0.126 11805837 P36130 P20424 CAF4 SRP54 0.21 11805837 P36130 P25087 CAF4 ERG6 0.126 16554755 P39076 P36130 CCT2 CAF4 0.21 11805837 P38788 P36130 SSZ1 CAF4 0.126 19536198 P39078 P36130 CCT4 CAF4 0.126 11805837 P47025 P36130 MDV1 CAF4 0.126 23300936 P40495 P36130 LYS12 CAF4 0.126 11805837 P39933 P36130 PZF1 CAF4 0.126 16554755 P40413 P36130 CCT5 CAF4 0.236 11805837 P40364 P36130 MPM1 CAF4 0.126 11805837 Q02159 P36130 UBC7 CAF4 0.126 14690591 P47079 P36130 CCT8 CAF4 0.126 11805837 P47144 P36130 ECM27 CAF4 0.126 16554755 P54861 P36130 DNM1 CAF4 0.376 23810512,21149566 Q05785 P36130 ENT2 CAF4 0.236 11805837 P42943 P36130 CCT7 CAF4 0.126 11805837 P36130 P19882 CAF4 HSP60 0.126 19536198