PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CDC27 SSL1 16429126 biogrid,intact exp SSB1 SSL1 19536198 intact exp SSC1 SSL1 19536198 intact exp FPR1 SSL1 11805826,16429126 biogrid,mint,intact,dip exp HSP78 SSL1 19536198 intact exp SSL1 PHM7 i2d exp GIS2 SSL1 21277287 biogrid exp YPP1 SSL1 14690591 intact exp UBC4 SSL1 21816351 biogrid exp SSE1 SSL1 19536198 intact exp SPT10 SSL1 25228766 biogrid exp IMD3 SSL1 16429126 biogrid,intact exp SPT16 SSL1 i2d exp CRM1 SSL1 26673895 biogrid exp IFA38 SSL1 i2d exp SUP35 SSL1 i2d exp CDC34 SSL1 i2d exp SSA1 SSL1 19536198 intact exp TFB3 SSL1 22308316,19818408,22411836,16554755, 23023127 biogrid,i2d,mint,intact exp, ortho, pred SSL1 TFB4 19818408,16429126,21876155,8657139,14500720,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred KIN28 SSL1 20489023,16554755, 23023127 biogrid,i2d,mint,intact exp, ortho, pred RAD3 SSL1 8631896,8621533,8171014,7768886,7961739,8557668,11007479, 23023127 biogrid,intact,dip exp, ortho, pred TFA1 SSL1 22411836, 23023127 biogrid exp, pred SSL1 KAP95 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred PRP43 SSL1 16227579, 23023127 biogrid exp, pred RPO21 SSL1 17376774, 23023127 biogrid exp, pred RAD2 SSL1 8855246, 23023127 biogrid exp, pred TFA2 SSL1 22411836, 23023127 biogrid exp, pred SSL1 SSL1 11805826,8171014, 23023127 biogrid,mint,intact,dip exp, pred GAL11 SSL1 17919657, 23023127 biogrid exp, pred TFB1 SSL1 8621533,11805826,8171014,16429126,15837426,14500720,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred HTB1 SSL1 21179020, 23023127 intact exp, pred TFG2 SSL1 9032243, 23023127 biogrid exp, pred CCL1 SSL1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred TFB2 SSL1 23023127 ortho, pred SSL2 SSL1 23023127 ortho, pred RFA1 SSL1 23023127 pred IRC5 SSL1 23023127 pred TAF6 SSL1 23023127 pred MAC1 SSL1 23023127 pred TAF5 SSL1 23023127 pred SUA7 SSL1 23023127 pred TAF11 SSL1 23023127 pred RAD27 SSL1 23023127 pred RPB5 SSL1 23023127 pred POL3 SSL1 23023127 pred RAP1 SSL1 23023127 pred SIR2 SSL1 23023127 pred RAD10 SSL1 23023127 pred RAD57 SSL1 23023127 pred SPT5 SSL1 23023127 pred RAD54 SSL1 23023127 pred RPB7 SSL1 23023127 pred SSL1 TAF9 23023127 pred MCM1 SSL1 23023127 pred TOA1 SSL1 23023127 pred SSL1 TAF3 23023127 pred SSC1 SSL1 23023127 pred TOA2 SSL1 23023127 pred POL2 SSL1 23023127 pred RAD1 SSL1 23023127 pred TAF13 SSL1 23023127 pred RAD51 SSL1 23023127 pred SSU72 SSL1 23023127 pred SSL1 TAF7 23023127 pred POL31 SSL1 23023127 pred YKU80 SSL1 23023127 pred SPT15 SSL1 23023127 pred TAF12 SSL1 23023127 pred RAD52 SSL1 23023127 pred SSL1 TAF10 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04673 - 15837426 - C 5 Q04673 - 11805826 - C 3 Q04673 - 11805826 - C 5 Q04673 - 15044803 - C 11 Q04673 - 11805826 - C 4 Q04673 - 14500720 - C 5 Q04673 - 12590263 - C 46 P20081 Q04673 affinity chromatography technology 11805826 physical association X 2 P0CG63 Q04673 affinity chromatography technology 23793018 physical association X 2 P35208 Q04673 affinity chromatography technology 25228766 physical association X 2 Q04673 Q04673 pull down 8171014 direct interaction X 2 Q04673 P50095 affinity chromatography technology 16429126 physical association X 2 Q04673 Q8W4M7 two hybrid 16623910 direct interaction X 2 Q04673 P04050 enzymatic study 17376774 direct interaction X 2 Q04673 Q06142 affinity chromatography technology 11805826 physical association X 2 Q04673 P36100 biochemical 22411836 association X 2 Q12004 Q04673 affinity chromatography technology 14500720 physical association X 2 Q12004 Q04673 affinity chromatography technology 21876155 physical association X 2 Q12004 Q04673 biochemical 8657139 association X 2 Q12004 Q04673 affinity chromatography technology 16554755 physical association X 2 Q12004 Q04673 affinity chromatography technology 16429126 physical association X 2 Q12004 Q04673 affinity chromatography technology 17200106 physical association X 2 Q12004 Q04673 affinity chromatography technology 19818408 physical association X 2 P37366 Q04673 affinity chromatography technology 16554755 physical association X 2 Q03290 Q04673 affinity chromatography technology 16554755 physical association X 2 Q03290 Q04673 affinity chromatography technology 17200106 physical association X 2 Q03290 Q04673 affinity chromatography technology 19818408 physical association X 2 Q03290 Q04673 affinity chromatography technology 22308316 physical association X 2 Q03290 Q04673 x-ray crystallography 22308316 association X 2 Q03290 Q04673 biochemical 22411836 association X 2 P06242 Q04673 affinity chromatography technology 16554755 physical association X 2 P06242 Q04673 affinity chromatography technology 20489023 physical association X 2 P15731 Q04673 pull down 21816351 direct interaction X 2 P06839 Q04673 pull down 8171014 direct interaction X 2 P06839 Q04673 pull down 8171014 direct interaction X 2 P06839 Q04673 biochemical 11007479 association X 2 P06839 Q04673 biochemical 8557668 association X 2 P06839 Q04673 biochemical 7961739 association X 2 P06839 Q04673 biochemical 7768886 association X 2 P06839 Q04673 biochemical 8631896 association X 2 P06839 Q04673 biochemical 8621533 association X 2 Q04673 P41896 affinity chromatography technology 9032243 physical association X 2 Q04673 P32776 pull down 8171014 direct interaction X 2 Q04673 P32776 affinity chromatography technology 15837426 physical association X 2 Q04673 P32776 biochemical 14500720 association X 2 Q04673 P32776 affinity chromatography technology 16554755 physical association X 2 Q04673 P38042 affinity chromatography technology 16429126 physical association X 2 Q04673 P32776 affinity chromatography technology 16429126 physical association X 2 Q04673 P32776 affinity chromatography technology 16429126 physical association X 2 Q04673 P32776 affinity chromatography technology 17200106 physical association X 2 Q04673 P19659 protein complementation assay 17919657 direct interaction X 2 Q04673 P53849 affinity chromatography technology 21277287 physical association X 2 Q04673 P32776 affinity chromatography technology 11805826 physical association X 2 Q04673 P32776 affinity chromatography technology 11805826 physical association X 2 Q04673 Q12306 affinity chromatography technology 22285753 physical association X 2 Q04673 P36145 biochemical 22411836 association X 2 P07276 Q04673 biochemical 8855246 association X 2 P53131 Q04673 affinity chromatography technology 16227579 physical association X 2 Q04673 pull down 21876155 - C 22 Q04673 tandem affinity purification 11805826 - C 3 Q04673 tandem affinity purification 11805826 - C 5 Q04673 tandem affinity purification 11805826 - C 4 Q04673 pull down 21876155 - C 20 P20081 Q04673 tandem affinity purification 11805826 physical association X 2 Q04673 Q06142 tandem affinity purification 11805826 physical association X 2 Q04673 Q04673 two hybrid 8171014 physical association Y 1 Q12004 Q04673 pull down 21876155 physical association X 2 Q12004 Q04673 pull down 21876155 physical association X 2 Q04673 inferred by author 11805826 physical association C 29 Q04673 inferred by author 11805826 physical association C 14 P06839 Q04673 coimmunoprecipitation 8171014 physical association X 2 P06839 Q04673 two hybrid 8171014 physical association X 2 P06839 Q04673 two hybrid 8269516 physical association X 2 Q04673 P32776 two hybrid 8171014 physical association X 2 Q04673 P32776 tandem affinity purification 11805826 physical association X 2 Q04673 P32776 tandem affinity purification 11805826 physical association X 2 Q04673 molecular sieving 8621533 physical association C 3 Q04673 inferred by author 16554755 association C 8 Q04673 tandem affinity purification 21179020 association C 193 Q04673 tandem affinity purification 11805826 association C 6 Q04673 tandem affinity purification 16429126 association C 9 Q04673 tandem affinity purification 16429126 association C 19 Q04673 tandem affinity purification 20489023 association C 4 P46951 Q04673 two hybrid array 14690591 physical association X 2 Q12004 Q04673 tandem affinity purification 16554755 physical association X 2 Q12004 Q04673 tandem affinity purification 16554755 physical association X 2 Q12004 Q04673 tandem affinity purification 16554755 physical association X 2 Q12004 Q04673 tandem affinity purification 16554755 physical association X 2 P37366 Q04673 tandem affinity purification 16554755 physical association X 2 P37366 Q04673 tandem affinity purification 16554755 physical association X 2 P37366 Q04673 tandem affinity purification 16554755 physical association X 2 P37366 Q04673 tandem affinity purification 16554755 physical association X 2 P37366 Q04673 tandem affinity purification 16554755 physical association X 2 Q03290 Q04673 tandem affinity purification 16554755 physical association X 2 Q03290 Q04673 tandem affinity purification 16554755 physical association X 2 Q03290 Q04673 tandem affinity purification 16554755 physical association X 2 P06242 Q04673 tandem affinity purification 16554755 physical association X 2 Q04673 tandem affinity purification 11805826 association C 5 Q04673 tandem affinity purification 16429126 association C 7 Q04673 tandem affinity purification 11805826 association C 4 Q04673 tandem affinity purification 11805826 association C 4 Q04673 inferred by author 16429126 physical association C 9 Q04673 tandem affinity purification 16429126 association C 20 Q04673 tandem affinity purification 16429126 association C 4 Q04673 tandem affinity purification 16429126 association C 4 Q04673 pull down 8621533 association C 4 P32589 Q04673 tandem affinity purification 19536198 association X 2 P11484 Q04673 tandem affinity purification 19536198 association X 2 Q04673 P32776 tandem affinity purification 16554755 physical association X 2 Q04673 P32776 tandem affinity purification 16554755 physical association X 2 Q04673 P0CS90 tandem affinity purification 19536198 association X 2 Q04673 P33416 tandem affinity purification 19536198 association X 2 P10591 Q04673 tandem affinity purification 19536198 association X 2 Q04673 confirmational text mining - - C 9 Q04673 mass spectrometry studies of complexes 11805826 - C 18 Q04673 mass spectrometry studies of complexes 11805826 - C 18 Q04673 confirmational text mining - - C 9 Q04673 mass spectrometry studies of complexes 11805826 - C 32

PPI - HINT Gene A Gene B PMID Method Quality RPO21 SSL1 17376774 0415 LC RAD3 SSL1 8631896,8171014,8621533,8621533,8171014,7768886,11007479,8557668,7961739,8171014,8269516 0401,0019,0071,0401,0096,0401,0401,0401,0401,0018,0018 LC RAD2 SSL1 8855246 0401 LC GAL11 SSL1 17919657 0090 LC TFB1 SSL1 14500720,8171014,8171014 0401,0096,0018 LC TFA1 SSL1 22411836 0401 LC TFA2 SSL1 22411836 0401 LC YPP1 SSL1 14690591 0397 LC TFB3 SSL1 22411836,22308316,22308316 0401,0114,0004 LC SSL1 SSL1 8171014,8171014 0096,0018 LC SSL1 TFB4 8657139 0401 LC HTB1 SSL1 21179020 0676 HT KIN28 SSL1 20489023,20489023,16554755,20489023,16554755 0007,0676,0676,0004,0004 HT RAD3 SSL1 8631896,8171014,8621533,8621533,8171014,7768886,11007479,8557668,7961739,8171014 0401,0019,0071,0401,0096,0401,0401,0401,0401,0018 LC RAD2 SSL1 8855246 0401 LC SSC1 SSL1 19536198 0676 HT SSA1 SSL1 19536198 0676 HT SSB1 SSL1 19536198 0676 HT UBC4 SSL1 21816351 0096 LC FPR1 SSL1 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT CRM1 SSL1 26673895,26673895 0096,0004 LC SSE1 SSL1 19536198 0676 HT TFB1 SSL1 14500720,16554755,16429126,15837426,11805826,11805826,8171014,17200106,11805826,8621533,16429126,8171014,16554755 0401,0676,0676,0004,0004,0676,0096,0004,0007,0096,0004,0018,0004 LC,HT HSP78 SSL1 19536198 0676 HT SPT10 SSL1 25228766 0004 HT TFA1 SSL1 22411836 0401 LC TFA2 SSL1 22411836 0401 LC CCL1 SSL1 16554755,16554755,16554755 0363,0676,0004 HT CDC27 SSL1 16429126,16429126,16429126 0676,0004,0363 HT TFG2 SSL1 9032243 0004 LC IMD3 SSL1 16429126,16429126 0676,0004 HT PRP43 SSL1 16227579,16227579 0676,0004 LC GIS2 SSL1 21277287 0004 LC TFB3 SSL1 16554755,19818408,22411836,22308316,22308316,17200106,16554755 0676,0004,0401,0114,0004,0004,0004 HT,LC SSL1 SSL1 11805826,11805826,8171014,8171014 0676,0007,0096,0018 HT,LC SSL1 KAP95 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT SSL1 TFB4 14500720,21876155,16554755,19818408,16429126,21876155,17200106,8657139,16429126,16554755 0004,0096,0676,0004,0004,0004,0004,0401,0676,0004 LC,HT SSL1 SMT3 22285753 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04673 P15731 SSL1 UBC4 0.309 21816351 Q04673 P20081 SSL1 FPR1 0.332 11805826,16429126 Q04673 P11484 SSL1 SSB1 0.126 19536198 Q04673 P04050 SSL1 RPO21 0.309 17376774 Q04673 Q04673 SSL1 SSL1 0.155 8171014,11805826 Q04673 P37366 SSL1 CCL1 0.416 16554755 Q04673 P33416 SSL1 HSP78 0.126 19536198 Q04673 P46951 SSL1 YPP1 0.126 14690591 Q04673 Q03290 SSL1 TFB3 0.74 22411836,19818408,22308316,16554755 Q8W4M7 Q04673 UVH6 SSL1 0.309 16623910 Q06142 Q04673 KAP95 SSL1 0.286 11805826,16429126 Q04673 P0CS90 SSL1 SSC1 0.126 19536198 Q04673 P10591 SSL1 SSA1 0.126 19536198 Q04673 P02293 SSL1 HTB1 0.126 21179020 Q04673 P06242 SSL1 KIN28 0.416 16554755,20489023 Q04673 P07276 SSL1 RAD2 0.21 8855246 Q04673 P50095 SSL1 IMD3 0.236 16429126 Q12004 Q04673 TFB4 SSL1 0.748 21876155,16429126,19818408,14500720,16554755 Q04673 P30822 SSL1 CRM1 0.236 26673895 Q04673 P53131 SSL1 PRP43 0.236 16227579 Q04673 P32776 SSL1 TFB1 0.78 11805826,16429126,8171014,8621533,14500720,16554755 Q04673 P38042 SSL1 CDC27 0.332 16429126 Q04673 P06839 SSL1 RAD3 0.597 8631896,8171014,8621533,8269516,7768886 Q04673 P36145 SSL1 TFA2 0.21 22411836 Q04673 P35208 SSL1 SPT10 0.126 25228766 Q04673 P36100 SSL1 TFA1 0.21 22411836 Q04673 P32589 SSL1 SSE1 0.126 19536198 Q04673 P19659 SSL1 GAL11 0.183 17919657 Q04673 P53849 SSL1 GIS2 0.126 21277287