PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DBF2 NSE1 16319894 biogrid,i2d exp PUF3 NSE1 26493364 biogrid exp GIS2 NSE1 21232131 biogrid exp CRM1 NSE1 26673895 biogrid exp SSB2 NSE1 23332755 biogrid exp SSB1 NSE1 19536198 intact exp SSA2 NSE1 19536198 intact exp MMS21 NSE1 15738391 biogrid exp NSE1 SMC5 15738391,11927594,14690591, 23023127 biogrid,i2d,intact,dip exp, pred NSE3 NSE1 21364888,15752197,19141609,14690591, 23023127 biogrid,i2d,intact exp, pred NSE4 NSE1 21364888,19141609, 23023127 biogrid exp, pred NSE1 SMC6 15738391,11927594, 23023127 biogrid,intact,dip exp, pred RTT107 NSE1 21642432, 23023127 biogrid exp, pred CSE1 NSE1 23023127 pred REV7 NSE1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q07913 - 14690591 - C 6 Q05541 Q07913 - 14690591 - X 2 Q05541 Q07913 pull down 21364888 direct interaction X 2 Q05541 Q07913 two hybrid 15752197 direct interaction X 2 Q05541 Q07913 two hybrid 19141609 direct interaction X 2 Q05541 Q07913 two hybrid 19141609 direct interaction X 2 Q05541 Q07913 affinity chromatography technology 14690591 physical association X 2 Q05541 Q07913 two hybrid 14690591 direct interaction X 2 Q08204 Q07913 affinity chromatography technology 11927594 physical association X 2 Q08204 Q07913 affinity chromatography technology 15738391 physical association X 2 P40150 Q07913 biochemical 23332755 association X 2 P22204 Q07913 enzymatic study 16319894 direct interaction X 2 Q07913 Q12749 affinity chromatography technology 11927594 physical association X 2 Q07913 Q12749 affinity chromatography technology 15738391 physical association X 2 Q07913 P43124 pull down 21364888 direct interaction X 2 Q07913 P38632 affinity chromatography technology 15738391 physical association X 2 Q07913 P43124 two hybrid 19141609 direct interaction X 2 Q07913 P43124 two hybrid 19141609 direct interaction X 2 Q07913 P43124 biochemical 19141609 association X 2 Q07913 P38850 two hybrid 21642432 direct interaction X 2 Q08204 Q07913 molecular sieving 11927594 physical association X 2 Q08204 Q07913 coimmunoprecipitation 11927594 physical association X 2 Q07913 Q12749 molecular sieving 11927594 physical association X 2 Q07913 Q12749 coimmunoprecipitation 11927594 physical association X 2 Q07913 pull down 14690591 association C 8 Q07913 pull down 14690591 association C 6 Q07913 anti tag coimmunoprecipitation 11927594 association C 3 P10592 Q07913 tandem affinity purification 19536198 association X 2 Q05541 Q07913 two hybrid array 14690591 physical association X 2 Q08204 Q07913 molecular sieving 11927594 physical association X 2 Q08204 Q07913 anti tag coimmunoprecipitation 11927594 physical association X 2 Q08204 Q07913 anti tag coimmunoprecipitation 11927594 physical association X 2 Q07913 Q12749 anti tag coimmunoprecipitation 11927594 physical association X 2 Q07913 Q12749 anti tag coimmunoprecipitation 11927594 physical association X 2 Q07913 Q12749 molecular sieving 11927594 physical association X 2 Q07913 P11484 tandem affinity purification 19536198 association X 2

PPI - HINT Gene A Gene B PMID Method Quality DBF2 NSE1 16319894 0415 LC RTT107 NSE1 21642432 0018 LC SSB2 NSE1 23332755 0401 LC NSE4 NSE1 19141609,19141609 0018,0401 LC NSE3 NSE1 14690591,19141609,14690591,15752197,14690591,14690591 0004,0018,0096,0018,0018,0397 LC NSE1 SMC5 11927594,11927594,11927594,11927594 0071,0019,0004,0007 LC NSE1 SMC6 11927594,11927594,11927594,11927594 0007,0004,0071,0019 LC SSA2 NSE1 19536198 0676 HT SSB1 NSE1 19536198 0676 HT CRM1 NSE1 26673895,26673895 0096,0004 LC MMS21 NSE1 15738391 0004 LC SSB2 NSE1 23332755 0401 LC NSE4 NSE1 19141609,21364888,19141609 0018,0096,0401 LC NSE3 NSE1 21364888 0096 LC NSE1 SMC5 11927594,11927594,15738391,11927594,11927594 0071,0019,0004,0004,0007 LC NSE1 SMC6 11927594,15738391,11927594,11927594,11927594 0007,0004,0004,0071,0019 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q07913 P10592 NSE1 SSA2 0.126 19536198 Q07913 P11484 NSE1 SSB1 0.126 19536198 Q07913 Q05541 NSE1 NSE3 0.826 14690591,21364888,19141609,15752197 Q07913 P43124 NSE1 NSE4 0.74 21364888,19141609 Q08204 Q07913 SMC5 NSE1 0.354 11927594,14690591,15738391 Q07913 P30822 NSE1 CRM1 0.236 26673895 Q07913 P38632 NSE1 MMS21 0.21 15738391 Q07913 P38850 NSE1 RTT107 0.309 21642432 Q07913 P40150 NSE1 SSB2 0.126 23332755 Q12749 Q07913 SMC6 NSE1 0.21 11927594,15738391 Q07913 P53849 NSE1 GIS2 0.126 21232131 Q07913 Q07807 NSE1 PUF3 0.126 26493364 Q07913 P22204 NSE1 DBF2 0.183 16319894