PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRR1 UBR2 i2d exp PRP45 UBR2 12554883 biogrid,i2d exp SSE2 UBR2 19536198 intact exp MTW1 UBR2 23408894 biogrid exp UBR2 CMR1 22199229 biogrid exp FIN1 UBR2 23408894 biogrid exp ERB1 UBR2 11805837 biogrid,mint,intact,dip exp SPC25 UBR2 23408894 biogrid exp HSC82 UBR2 16554755 biogrid,i2d,mint,intact exp SSA2 UBR2 19536198 intact exp UBR2 DET1 16554755 biogrid,i2d,mint,intact exp RPN4 UBR2 18070918,17532487,15504724,16492666 biogrid,i2d,intact exp NDC80 UBR2 23408894 biogrid exp SSA1 UBR2 19536198 intact exp NUF2 UBR2 23408894 biogrid exp SPC24 UBR2 23408894 biogrid exp SPC105 UBR2 23408894 biogrid exp SBP1 UBR2 23222640 biogrid exp CTF19 UBR2 23408894 biogrid exp ULP1 UBR2 23712011 biogrid exp KRE28 UBR2 23408894 biogrid exp TEF1, TEF2 UBR2 11805837 dip exp DSN1 UBR2 21107429,23636741,23408894 biogrid exp STO1 UBR2 17922018 biogrid exp SSB1 UBR2 19536198 intact exp HSP60 UBR2 19536198 intact exp PUF3 UBR2 26493364 biogrid exp UBR2 NSL1 23408894 biogrid exp BZZ1 UBR2 19841731 biogrid,mint,intact exp SSZ1 UBR2 19536198 intact exp MUB1 UBR2 20566477,18070918, 23023127 biogrid,intact exp, pred RAD6 UBR2 18070918,21179020,15504724,12535539,16492666,16554755,18719252, 23023127 biogrid,i2d,mint,intact exp, pred UBI4 UBR2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q07963 - 11805837 - C 26 P06104 Q07963 - 15504724 - X 2 Q07963 Q03465 - 15504724 - X 2 Q07963 P28004 - 12554883 - X 2 P34160 Q07963 affinity chromatography technology 17922018 physical association X 2 P06104 Q07963 pull down 18070918 direct interaction X 2 P06104 Q07963 affinity chromatography technology 12535539 physical association X 2 P53148 Q07963 affinity chromatography technology 23408894 physical association X 2 Q03898 Q07963 affinity chromatography technology 23408894 physical association X 2 P06104 Q07963 affinity chromatography technology 15504724 physical association X 2 P06104 Q07963 pull down 16492666 direct interaction X 2 P06104 Q07963 pull down 18070918 direct interaction X 2 P06104 Q07963 affinity chromatography technology 16554755 physical association X 2 P06104 Q07963 two hybrid 18719252 direct interaction X 2 P0CG63 Q07963 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q07963 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q07963 affinity chromatography technology 12872131 physical association X 2 Q12143 Q07963 affinity chromatography technology 23408894 physical association X 2 Q02724 Q07963 affinity chromatography technology 23712011 physical association X 2 P40460 Q07963 affinity chromatography technology 23408894 physical association X 2 Q07963 Q04660 affinity chromatography technology 11805837 physical association X 2 Q03162 Q07963 pull down 18070918 direct interaction X 2 Q03162 Q07963 two hybrid 20566477 direct interaction X 2 P15108 Q07963 affinity chromatography technology 16554755 physical association X 2 Q04477 Q07963 affinity chromatography technology 23408894 physical association X 2 Q07963 P28004 two hybrid 12554883 direct interaction X 2 Q07963 P33895 affinity chromatography technology 23408894 physical association X 2 Q07963 P39731 affinity chromatography technology 23408894 physical association X 2 Q07963 P40014 affinity chromatography technology 23408894 physical association X 2 Q07963 Q03465 affinity chromatography technology 15504724 physical association X 2 Q07963 Q03465 enzymatic study 16492666 direct interaction X 2 Q07963 Q03465 pull down 18070918 direct interaction X 2 Q07963 Q99288 affinity chromatography technology 16554755 physical association X 2 Q07963 Q03465 pull down 17532487 direct interaction X 2 Q07963 Q03465 enzymatic study 18070918 direct interaction X 2 Q07963 P38822 two hybrid 19841731 direct interaction X 2 P40568 Q07963 affinity chromatography technology 23408894 physical association X 2 P40568 Q07963 affinity chromatography technology 21107429 physical association X 2 Q04431 Q07963 affinity chromatography technology 23408894 physical association X 2 Q12510 Q07963 affinity chromatography technology 22199229 physical association X 2 Q02732 Q07963 affinity chromatography technology 23408894 physical association X 2 Q07963 anti tag coimmunoprecipitation 11805837 - C 39 Q07963 anti tag coimmunoprecipitation 11805837 - C 39 Q07963 anti tag coimmunoprecipitation 11805837 - C 56 Q07963 anti tag coimmunoprecipitation 11805837 - C 56 Q07963 Q04660 anti tag coimmunoprecipitation 11805837 physical association X 2 Q07963 Q04660 anti tag coimmunoprecipitation 11805837 physical association X 2 Q07963 P02994 anti tag coimmunoprecipitation 11805837 physical association X 2 Q07963 tandem affinity purification 21179020 association C 10 Q07963 anti tag coimmunoprecipitation 11805837 association C 26 Q07963 ubiquitinase assay 18070918 ubiquitination reaction C 5 P10592 Q07963 tandem affinity purification 19536198 association X 2 P11484 Q07963 tandem affinity purification 19536198 association X 2 P06104 Q07963 pull down 15504724 physical association X 2 P06104 Q07963 tandem affinity purification 16554755 physical association X 2 P06104 Q07963 tandem affinity purification 16554755 physical association X 2 P06104 Q07963 pull down 18070918 physical association X 2 P06104 Q07963 two hybrid 18719252 physical association X 2 P32590 Q07963 tandem affinity purification 19536198 association X 2 P10591 Q07963 tandem affinity purification 19536198 association X 2 P38788 Q07963 tandem affinity purification 19536198 association X 2 Q03162 Q07963 anti tag coimmunoprecipitation 18070918 physical association X 2 Q07963 pull down 18070918 association C 3 Q07963 tandem affinity purification 21179020 association C 8 P19882 Q07963 tandem affinity purification 19536198 association X 2 P15108 Q07963 tandem affinity purification 16554755 physical association X 2 Q07963 Q03465 pull down 15504724 physical association X 2 Q07963 Q99288 inferred by author 16554755 association X 2 Q07963 Q99288 tandem affinity purification 16554755 physical association X 2 Q07963 Q03465 pull down 18070918 physical association X 2 Q07963 P38822 two hybrid pooling approach 19841731 physical association X 2 Q07963 mass spectrometry studies of complexes 11805837 - C 45 Q07963 mass spectrometry studies of complexes 11805837 - C 45

PPI - HINT Gene A Gene B PMID Method Quality RAD6 UBR2 18719252 0018 HT PRP45 UBR2 12554883 0018 LC BZZ1 UBR2 19841731,19841731 0398,0018 HT MUB1 UBR2 18070918,18070918,18070918,18070918,20566477 0096,0997,0004,0007,0018 LC RPN4 UBR2 18070918,15504724,16492666,18070918,18070918,15504724,15504724 0096,0004,0415,0004,0415,0096,0045 LC TEF1|TEF2 UBR2 11805837 0007 HT RAD6 UBR2 21179020,15504724,16554755,18070918,18070918,16492666,15504724,12535539,16554755 0676,0004,0676,0096,0004,0096,0096,0004,0004 HT,LC SSA1 UBR2 19536198 0676 HT SSA2 UBR2 19536198 0676 HT SSB1 UBR2 19536198 0676 HT HSC82 UBR2 16554755,16554755 0676,0004 HT HSP60 UBR2 19536198 0676 HT SSE2 UBR2 19536198 0676 HT NUF2 UBR2 23408894 0004 LC STO1 UBR2 17922018 0004 LC SSZ1 UBR2 19536198 0676 HT MTW1 UBR2 23408894 0004 LC SPC25 UBR2 23408894 0004 LC NDC80 UBR2 23408894 0004 LC DSN1 UBR2 21107429,23408894,23636741 0004,0004,0004 HT,LC SPC105 UBR2 23408894 0004 LC ULP1 UBR2 23712011 0004 LC CTF19 UBR2 23408894 0004 LC MUB1 UBR2 18070918,18070918,18070918,18070918 0096,0997,0004,0007 LC RPN4 UBR2 18070918,15504724,18070918,17532487,18070918,15504724,15504724,17532487 0096,0004,0004,0096,0415,0096,0045,0004 LC FIN1 UBR2 23408894 0004 LC KRE28 UBR2 23408894 0004 LC SPC24 UBR2 23408894 0004 LC ERB1 UBR2 11805837,11805837 0004,0007 HT UBR2 NSL1 23408894 0004 LC UBR2 CMR1 22199229 0004 HT UBR2 DET1 16554755,16554755,16554755 0363,0676,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q07963 P10080 UBR2 SBP1 0.126 23222640 Q07963 P02994 UBR2 TEF2 0.126 11805837 Q07963 P15108 UBR2 HSC82 0.236 16554755 Q07963 Q03465 UBR2 RPN4 0.837 18070918,15504724,16492666 Q07963 P06104 UBR2 RAD6 0.95 16492666,18719252,16554755,21179020,18070918,15504724 Q07963 P38788 UBR2 SSZ1 0.126 19536198 Q07963 P38822 UBR2 BZZ1 0.354 19841731 Q07963 P34160 UBR2 STO1 0.126 17922018 Q07963 P40568 UBR2 DSN1 0.376 23636741,23408894 Q07963 P19882 UBR2 HSP60 0.126 19536198 Q07963 Q02724 UBR2 ULP1 0.126 23712011 Q07963 Q07807 UBR2 PUF3 0.126 26493364 Q07963 P10591 UBR2 SSA1 0.126 19536198 Q07963 P10592 UBR2 SSA2 0.126 19536198 Q07963 P11484 UBR2 SSB1 0.126 19536198 Q07963 P32590 UBR2 SSE2 0.126 19536198 Q07963 P33895 UBR2 NUF2 0.21 23408894 Q07963 P39731 UBR2 MTW1 0.21 23408894 Q07963 P40014 UBR2 SPC25 0.21 23408894 Q07963 P40460 UBR2 TID3 0.21 23408894 Q07963 P53148 UBR2 SPC105 0.21 23408894 Q07963 Q02732 UBR2 CTF19 0.21 23408894 Q07963 Q03162 UBR2 MUB1 0.636 20566477,18070918 Q07963 Q03898 UBR2 FIN1 0.21 23408894 Q07963 Q04431 UBR2 KRE28 0.21 23408894 Q07963 Q04477 UBR2 SPC24 0.21 23408894 Q07963 Q04660 UBR2 ERB1 0.332 11805837 Q12143 Q07963 NSL1 UBR2 0.21 23408894 Q99288 Q07963 DET1 UBR2 0.332 16554755