PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RAD5 UBC7 14690591 intact exp RAD5 LHS1 19536198 intact exp RAD5 CCT2 19536198 intact exp RAD5 ORC1 20595233 biogrid exp SSA2 RAD5 19536198 intact exp RAD5 LSM12 16554755 biogrid,i2d,mint,intact exp RAD5 RRP1 16554755 biogrid,i2d,mint,intact exp RAD5 DEF1 24465179 biogrid,dip exp RAD5 HMT1 23706744,14690591 biogrid,intact exp RAD5 SSB2 23332755 biogrid exp SSB1 RAD5 19536198 intact exp HSP82 RAD5 19536198 intact exp UBI4 RAD5 19706603 biogrid exp SSA1 RAD5 19536198 intact exp NAB2 RAD5 19840948 biogrid exp RAD5 ALT2 16554755 intact exp RAD5 UBC9 12226657 biogrid exp RAD5 PCH2 18719252 biogrid,intact exp RAD5 PUF3 26493364 biogrid exp RAD18 RAD5 10880451,18342608,16224103, 23023127 biogrid,dip exp, pred RAD5 UBC13 10880451,19706603,19851286,12496280,24674630,16224103, 23023127 biogrid,dip exp, pred POL30 RAD5 19706603,19851286,12226657,16224103, 23023127 biogrid exp, pred YDJ1 RAD5 19536198, 23023127 intact exp, pred RAD5 PAC10 19536198, 23023127 intact exp, pred SRS2 RAD5 15931174, 23023127 biogrid,i2d exp, pred REV1 RAD5 23142547,24674630,18757916, 23023127 biogrid exp, pred RAD5 SOH1 8849885, 23023127 biogrid exp, pred RAD5 RAD5 10880451,12496280,18342608, 23023127 biogrid,dip exp, pred RAD52 RAD5 23023127 pred MEI5 RAD5 23023127 pred HTB1 RAD5 23023127 pred NSR1 RAD5 23023127 pred RAD5 POL31 23023127 pred RAD6 RAD5 23023127 pred RAS2 RAD5 23023127 pred REV3 RAD5 23023127 pred POL3 RAD5 23023127 pred RAD5 POL32 23023127 pred RAD5 REV7 23023127 pred RAD3 RAD5 23023127 pred RAD5 Y' element ATP-dependent helicase YEL077C 23023127 pred RAD5 PES4 23023127 pred RAD5 SGS1 23023127 pred RAD5 UBI4 23023127 pred RAD5 RDH54 23023127 pred RAD5 RAD54 23023127 pred RAD5 MMS2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P12954 P32849 - 15931174 - X 2 P12954 P32849 two hybrid 15931174 direct interaction X 2 P40150 P32849 biochemical 23332755 association X 2 P38633 P32849 two hybrid 8849885 direct interaction X 2 P32849 P12689 two hybrid 23142547 direct interaction X 2 P32849 P12689 two hybrid 23142547 direct interaction X 2 P32849 P12689 biochemical 23142547 association X 2 P32849 P12689 two hybrid 24674630 direct interaction X 2 P32849 P38126 two hybrid 18719252 direct interaction X 2 P32849 P12689 pull down 18757916 direct interaction X 2 P35732 P32849 affinity chromatography technology 24465179 physical association X 2 P10862 P32849 affinity chromatography technology 10880451 physical association X 2 P10862 P32849 two hybrid 10880451 direct interaction X 2 P10862 P32849 two hybrid 10880451 direct interaction X 2 P10862 P32849 two hybrid 16224103 direct interaction X 2 P10862 P32849 two hybrid 18342608 direct interaction X 2 P0CG63 P32849 affinity chromatography technology 23793018 physical association X 2 P0CG63 P32849 affinity chromatography technology 12872131 physical association X 2 P0CG63 P32849 enzymatic study 19706603 direct interaction X 2 P38828 P32849 affinity chromatography technology 16554755 physical association X 2 P54784 P32849 affinity chromatography technology 20595233 physical association X 2 P15873 P32849 two hybrid 16224103 direct interaction X 2 P15873 P32849 two hybrid 16224103 direct interaction X 2 P15873 P32849 two hybrid 12226657 direct interaction X 2 P15873 P32849 affinity chromatography technology 19706603 physical association X 2 P15873 P32849 enzymatic study 19851286 direct interaction X 2 P15873 P32849 enzymatic study 19706603 direct interaction X 2 P52490 P32849 pull down 19706603 direct interaction X 2 P52490 P32849 pull down 19851286 direct interaction X 2 P52490 P32849 affinity chromatography technology 10880451 physical association X 2 P52490 P32849 two hybrid 12496280 direct interaction X 2 P52490 P32849 two hybrid 10880451 direct interaction X 2 P52490 P32849 two hybrid 10880451 direct interaction X 2 P52490 P32849 two hybrid 16224103 direct interaction X 2 P52490 P32849 two hybrid 24674630 direct interaction X 2 P32849 P32849 affinity chromatography technology 10880451 physical association X 2 P32849 P32849 two hybrid 12496280 direct interaction X 2 P32849 P32849 two hybrid 10880451 direct interaction X 2 P32849 P50623 affinity chromatography technology 12226657 physical association X 2 P32849 P50623 two hybrid 12226657 direct interaction X 2 P32849 P32849 two hybrid 18342608 direct interaction X 2 P32849 Q12306 affinity chromatography technology 22285753 physical association X 2 P32849 Q12306 affinity chromatography technology 22285753 physical association X 2 P35178 P32849 affinity chromatography technology 16554755 physical association X 2 P35732 P32849 tandem affinity purification 24465179 physical association X 2 P10862 P32849 two hybrid 10880451 physical association X 2 P10862 P32849 coimmunoprecipitation 10880451 physical association X 2 P52490 P32849 two hybrid 10880451 physical association X 2 P52490 P32849 coimmunoprecipitation 10880451 physical association X 2 P32849 P32849 coimmunoprecipitation 10880451 physical association Y 1 P32849 P32849 two hybrid 10880451 physical association Y 1 P32849 inferred by author 16554755 association C 3 P10592 P32849 tandem affinity purification 19536198 association X 2 Q02159 P32849 two hybrid array 14690591 physical association X 2 P39076 P32849 tandem affinity purification 19536198 association X 2 P10591 P32849 tandem affinity purification 19536198 association X 2 P32849 P38126 two hybrid 18719252 physical association X 2 P38074 P32849 two hybrid array 14690591 physical association X 2 P38074 P32849 dihydrofolate reductase reconstruction 23706744 physical association X 2 P48363 P32849 tandem affinity purification 19536198 association X 2 P11484 P32849 tandem affinity purification 19536198 association X 2 P02829 P32849 tandem affinity purification 19536198 association X 2 P38828 P32849 tandem affinity purification 16554755 physical association X 2 P36016 P32849 tandem affinity purification 19536198 association X 2 P32849 P25491 tandem affinity purification 19536198 association X 2 P35178 P32849 tandem affinity purification 16554755 physical association X 2 P53840 P32849 interaction detection method 14764870 - X 2 Q04659 P32849 interaction detection method 14764870 - X 2 Q01454 P32849 interaction detection method 14764870 - X 2 P38877 P32849 interaction detection method 14764870 - X 2 P49956 P32849 interaction detection method 14764870 - X 2 P12753 P32849 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBI4 RAD5 19706603 0415 LC RAD18 RAD5 10880451,10880451,10880451,16224103,18342608 0004,0018,0019,0018,0018 LC REV1 RAD5 24674630,23142547,27001510,23142547,27001510,27001510 0018,0401,0096,0018,0114,0018 LC SRS2 RAD5 15931174 0018 LC POL30 RAD5 19706603,19706603,16224103,12226657,19851286 0415,0004,0018,0018,0415 LC RAD5 RAD5 10880451,12496280,10880451,10880451,18342608 0018,0018,0019,0004,0018 LC RAD5 HMT1 23706744,23706744,14690591 0111,0090,0397 LC RAD5 PCH2 18719252 0018 HT RAD5 SOH1 8849885 0018 LC RAD5 SSB2 23332755 0401 LC RAD5 UBC9 12226657,12226657 0004,0018 LC RAD5 UBC13 24674630,10880451,10880451,10880451,12496280,16224103 0018,0004,0019,0018,0018,0018 LC RAD5 UBC7 14690591 0397 LC HSP82 RAD5 19536198 0676 HT SSA1 RAD5 19536198 0676 HT SSA2 RAD5 19536198 0676 HT RAD18 RAD5 10880451,10880451,10880451 0004,0018,0019 LC SSB1 RAD5 19536198 0676 HT REV1 RAD5 23142547,27001510,23142547,27001510,18757916,27001510 0401,0096,0018,0114,0096,0018 LC POL30 RAD5 19706603,19706603 0415,0004 LC YDJ1 RAD5 19536198 0676 HT NAB2 RAD5 19840948 0004 LC RAD5 RAD5 10880451,10880451,10880451 0018,0019,0004 LC RAD5 RRP1 16554755,16554755 0676,0004 HT RAD5 DEF1 24465179,24465179 0004,0676 LC RAD5 LHS1 19536198 0676 HT RAD5 LSM12 16554755,16554755 0676,0004 HT RAD5 CCT2 19536198 0676 HT RAD5 SSB2 23332755 0401 LC RAD5 PAC10 19536198 0676 HT RAD5 UBC9 12226657,12226657 0004,0018 LC RAD5 UBC13 19706603,10880451,10880451,10880451,19851286 0096,0004,0019,0018,0096 LC RAD5 ALT2 16554755 0363 HT RAD5 ORC1 20595233 0004 LC RAD5 SMT3 22285753 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P32849 P15873 RAD5 POL30 0.843 19851286,16224103,19706603,12226657 P32849 P25491 RAD5 YDJ1 0.126 19536198 P32849 P11484 RAD5 SSB1 0.126 19536198 P32849 P10862 RAD5 RAD18 0.554 16224103,18342608,10880451 P50623 P32849 UBC9 RAD5 0.454 12226657 P52490 P32849 UBC13 RAD5 0.772 10880451,24674630,16224103,19706603,19851286 P32849 P12689 RAD5 REV1 0.941 27001510,18757916,23142547,24674630 P38126 P32849 PCH2 RAD5 0.332 18719252 P38633 P32849 SOH1 RAD5 0.309 8849885 P32849 P32505 RAD5 NAB2 0.126 19840948 P38828 P32849 LSM12 RAD5 0.126 16554755 P32849 P02829 RAD5 HSP82 0.126 19536198 P32849 P0CG63 RAD5 UBI4 0.309 19706603 P32849 P10591 RAD5 SSA1 0.126 19536198 P32849 P10592 RAD5 SSA2 0.126 19536198 P32849 P32849 RAD5 RAD5 0.332 10880451,18342608 P35732 P32849 DEF1 RAD5 0.21 24465179 P38074 P32849 HMT1 RAD5 0.376 23706744,14690591 P39076 P32849 CCT2 RAD5 0.126 19536198 Q02159 P32849 UBC7 RAD5 0.126 14690591 P40150 P32849 SSB2 RAD5 0.126 23332755 P35178 P32849 RRP1 RAD5 0.126 16554755 P36016 P32849 LHS1 RAD5 0.126 19536198 P48363 P32849 PAC10 RAD5 0.126 19536198 Q07807 P32849 PUF3 RAD5 0.126 26493364 P52892 P32849 ALT2 RAD5 0.126 16554755 P54784 P32849 ORC1 RAD5 0.126 20595233