PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PSA1 HRT3 11805837 dip exp NAB2 HRT3 19840948 biogrid exp IDH1 HRT3 11805837 biogrid,mint,intact,dip exp DLD3 HRT3 26297823 biogrid,intact exp RPL12A HRT3 16554755 i2d,mint,intact exp CDC48 HRT3 11805837 dip exp GIS2 HRT3 21232131 biogrid exp RPL40A HRT3 11805837 intact,dip exp SIS1 HRT3 19536198 intact exp RPL12B HRT3 16554755 biogrid,i2d exp SIT4 HRT3 16554755 biogrid,i2d,mint,intact exp MPM1 HRT3 11805837 dip exp APJ1 HRT3 19536198 intact exp SSZ1 HRT3 19536198 intact exp GRS1 HRT3 26297823 biogrid,intact exp SSE1 HRT3 19536198 intact exp CHA1 HRT3 11805837 dip exp SAP155 HRT3 16554755 intact exp PPZ2 HRT3 16554755 intact exp LEU2 HRT3 11805837 dip exp PAC10 HRT3 19536198 intact exp MIP18 family protein YHR122W HRT3 14690591 intact exp UBI4 HRT3 11805837 biogrid,mint exp SDS24 HRT3 16554755 intact exp CCT8 HRT3 19536198,11805837 intact,dip exp GUF1 HRT3 11805837 biogrid,mint,intact,dip exp RPB2 HRT3 11805837 dip exp CRM1 HRT3 26673895 biogrid exp HSP26 HRT3 11805837 dip exp HSP60 HRT3 11805837 dip exp ADH2 HRT3 11805837 biogrid,mint,intact,dip exp HRT3 HRT3 14747994 biogrid exp HSP82 HRT3 19536198,11805837 intact,dip exp SSB1 HRT3 19536198 intact exp SSA1 HRT3 19536198 intact exp SSB2 HRT3 23332755 biogrid exp GIM3 HRT3 19536198 intact exp SKP1 HRT3 17141224,11805837,11283612,10688190,10582239,23000173,14747994,20581845, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPN11 HRT3 20170199, 23023127 biogrid exp, pred HRT1 HRT3 19882662,14747994, 23023127 biogrid,intact exp, pred CDC53 HRT3 10582239,19882662,14747994,11805837, 23023127 biogrid,mint,intact,dip exp, pred RAD7 HRT3 23023127 pred UBC1 HRT3 23023127 pred UBI4 HRT3 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12347 - 11805837 - C 7 P52286 Q12347 - 10688190 - X 2 P52286 Q12347 - 11283612 - X 2 Q08273 Q12347 pull down 14747994 direct interaction X 2 Q12347 Q12018 pull down 14747994 direct interaction X 2 Q12347 Q12018 affinity chromatography technology 10582239 physical association X 2 Q12347 Q12018 affinity chromatography technology 10582239 physical association X 2 Q12347 P28834 affinity chromatography technology 11805837 physical association X 2 Q12347 Q12018 affinity chromatography technology 11805837 physical association X 2 P20604 Q12347 affinity chromatography technology 16554755 physical association X 2 P0CG63 Q12347 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q12347 affinity chromatography technology 11805837 physical association X 2 P0CX53 Q12347 affinity chromatography technology 16554755 physical association X 2 Q12347 Q12347 enzymatic study 14747994 direct interaction X 2 Q12347 P43588 affinity chromatography technology 20170199 physical association X 2 Q12347 P46943 affinity chromatography technology 11805837 physical association X 2 P00331 Q12347 affinity chromatography technology 11805837 physical association X 2 P40150 Q12347 biochemical 23332755 association X 2 P52286 Q12347 pull down 23000173 direct interaction X 2 P52286 Q12347 pull down 14747994 direct interaction X 2 P52286 Q12347 affinity chromatography technology 10582239 physical association X 2 P52286 Q12347 affinity chromatography technology 11283612 physical association X 2 P52286 Q12347 affinity chromatography technology 20581845 physical association X 2 P52286 Q12347 affinity chromatography technology 11805837 physical association X 2 P52286 Q12347 two hybrid 10688190 direct interaction X 2 Q12347 anti tag coimmunoprecipitation 11805837 - C 7 P19882 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P25379 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P08518 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P40364 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P02829 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 P47079 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 P25694 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 Q12018 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 P28834 anti tag coimmunoprecipitation 11805837 physical association X 2 P04173 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 anti tag coimmunoprecipitation 11805837 - C 17 Q12347 affinity chromatography technology 14747994 - C 4 Q12347 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 P46943 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12347 P05759 anti tag coimmunoprecipitation 11805837 physical association X 2 P41940 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P00331 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 Q12347 two hybrid 10688190 physical association X 2 P52286 Q12347 coimmunoprecipitation 11283612 physical association X 2 P52286 Q12347 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 Q12347 affinity chromatography technology 14747994 physical association X 2 Q12347 pull down 19882662 association C 41 Q12347 anti tag coimmunoprecipitation 11805837 association C 7 Q12347 pull down 19882662 association C 35 P32589 Q12347 tandem affinity purification 19536198 association X 2 P53900 Q12347 tandem affinity purification 19536198 association X 2 P48363 Q12347 tandem affinity purification 19536198 association X 2 P11484 Q12347 tandem affinity purification 19536198 association X 2 P02829 Q12347 tandem affinity purification 19536198 association X 2 Q12347 P47079 tandem affinity purification 19536198 association X 2 P20604 Q12347 tandem affinity purification 16554755 physical association X 2 P10591 Q12347 tandem affinity purification 19536198 association X 2 Q12347 inferred by author 16554755 association C 5 P0CX53 Q12347 tandem affinity purification 16554755 physical association X 2 P0CX53 Q12347 tandem affinity purification 16554755 physical association X 2 P0CX53 Q12347 tandem affinity purification 16554755 physical association X 2 P0CX53 Q12347 tandem affinity purification 16554755 physical association X 2 Q12347 P38829 two hybrid array 14690591 physical association X 2 Q12347 P25294 tandem affinity purification 19536198 association X 2 P53940 Q12347 tandem affinity purification 19536198 association X 2 P38788 Q12347 tandem affinity purification 19536198 association X 2 P52286 Q12347 two hybrid 10688190 physical association X 2 P52286 Q12347 anti tag coimmunoprecipitation 17141224 physical association X 2 Q12347 mass spectrometry studies of complexes 11805837 - C 8 Q12347 mass spectrometry studies of complexes 11805837 - C 8 P52286 Q12347 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality GRS1 HRT3 26297823,26297823,26297823 0007,0018,0004 LC P38829 HRT3 14690591 0397 LC DLD3 HRT3 26297823,26297823,26297823 0007,0018,0004 LC SSB2 HRT3 23332755 0401 LC SKP1 HRT3 11283612,11283612,10688190,10688190 0019,0004,0397,0018 LC,HT HRT3 HRT3 14747994 0415 LC ADH2 HRT3 11805837,11805837 0004,0007 HT HSP82 HRT3 19536198,11805837 0676,0007 HT LEU2 HRT3 11805837 0007 HT RPS31 HRT3 11805837 0007 HT RPB2 HRT3 11805837 0007 HT UBI4 HRT3 11805837,11805837 0004,0007 HT RPL40B HRT3 11805837 0007 HT RPL12A HRT3 16554755,16554755 0676,0004 HT RPL12B HRT3 16554755,16554755 0676,0004 HT SSA1 HRT3 19536198 0676 HT SSB1 HRT3 19536198 0676 HT HSP26 HRT3 11805837 0007 HT HSP60 HRT3 11805837 0007 HT SIT4 HRT3 16554755,16554755,16554755 0363,0676,0004 HT SIS1 HRT3 19536198 0676 HT CHA1 HRT3 11805837 0007 HT CDC48 HRT3 11805837 0007 HT IDH1 HRT3 11805837,11805837 0004,0007 HT CRM1 HRT3 26673895,26673895 0096,0004 LC NAB2 HRT3 19840948 0004 LC SSE1 HRT3 19536198 0676 HT PPZ2 HRT3 16554755 0363 HT GRS1 HRT3 26297823,26297823,26297823 0007,0018,0004 LC SDS24 HRT3 16554755 0363 HT SSZ1 HRT3 19536198 0676 HT DLD3 HRT3 26297823,26297823,26297823 0007,0018,0004 LC SSB2 HRT3 23332755 0401 LC MPM1 HRT3 11805837 0007 HT PSA1 HRT3 11805837 0007 HT RPN11 HRT3 20170199 0004 LC SAP155 HRT3 16554755 0363 HT GUF1 HRT3 11805837,11805837 0004,0007 HT CCT8 HRT3 19536198,11805837 0676,0007 HT PAC10 HRT3 19536198 0676 HT SKP1 HRT3 11805837,11283612,11283612,14747994,23000173,20581845,10582239,14747994,17141224,11805837 0004,0019,0004,0004,0096,0004,0004,0096,0007,0007 HT,LC GIM3 HRT3 19536198 0676 HT APJ1 HRT3 19536198 0676 HT HRT1 HRT3 19882662,14747994 0096,0096 LC CDC53 HRT3 11805837,19882662,14747994,11805837,10582239 0004,0096,0096,0007,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12347 P61864 HRT3 RPL40A 0.236 11805837 Q12347 P17079 HRT3 RPL12A 0.236 16554755 Q12347 P00331 HRT3 ADH2 0.236 11805837 Q12347 P11484 HRT3 SSB1 0.126 19536198 Q12347 P15992 HRT3 HSP26 0.126 11805837 Q12347 P25294 HRT3 SIS1 0.126 19536198 Q12347 P25379 HRT3 CHA1 0.126 11805837 Q12347 P25694 HRT3 CDC48 0.126 11805837 Q12347 P32589 HRT3 SSE1 0.126 19536198 Q12347 P33329 HRT3 PPZ2 0.126 16554755 Q12347 P38088 HRT3 GRS1 0.569 26297823 Q12347 P38314 HRT3 SDS24 0.126 16554755 Q12347 P38788 HRT3 SSZ1 0.126 19536198 Q12347 P38829 HRT3 P38829 0.126 14690591 Q12347 P39976 HRT3 DLD3 0.569 26297823 Q12347 P40364 HRT3 MPM1 0.126 11805837 Q12347 P41940 HRT3 PSA1 0.126 11805837 Q12347 P43612 HRT3 SAP155 0.126 16554755 Q12347 P46943 HRT3 GUF1 0.21 11805837 Q12347 P47079 HRT3 CCT8 0.21 11805837,19536198 Q12347 P53900 HRT3 GIM3 0.126 19536198 Q12347 Q12347 HRT3 HRT3 0.332 14747994 Q12347 P08518 HRT3 RPB2 0.126 11805837 Q12347 P0CX53 HRT3 RPL12A 0.126 16554755 Q12347 P0CX54 HRT3 RPL12B 0.126 16554755 Q12347 P10591 HRT3 SSA1 0.126 19536198 Q12347 P02829 HRT3 HSP82 0.21 11805837,19536198 Q12347 P04173 HRT3 LEU2 0.126 11805837 Q12347 Q12018 HRT3 CDC53 0.722 14747994,10582239,11805837,19882662 Q12347 P30822 HRT3 CRM1 0.236 26673895 Q12347 P52286 HRT3 SKP1 0.843 10688190,11283612,10582239,20581845,17141224,11805837,14747994,23000173 Q12347 P32505 HRT3 NAB2 0.126 19840948 Q12347 P40150 HRT3 SSB2 0.126 23332755 Q12347 P28834 HRT3 IDH1 0.236 11805837 Q12347 P43588 HRT3 RPN11 0.126 20170199 Q12347 P48363 HRT3 PAC10 0.126 19536198 Q12347 P19882 HRT3 HSP60 0.126 11805837 Q12347 P20604 HRT3 SIT4 0.332 16554755 Q12347 P53849 HRT3 GIS2 0.126 21232131 Q12347 P53940 HRT3 APJ1 0.126 19536198 Q12347 Q08273 HRT3 HRT1 0.236 19882662