PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NAB2 APC9 19840948 biogrid exp CMK1 APC9 16319894 biogrid,i2d exp CDC28 APC9 10871279,23751495 biogrid exp PUF3 APC9 26493364 biogrid exp NSE3 APC9 14690591 intact exp CFT1 APC9 14690591 intact exp SSA1 APC9 19536198 intact exp PHO85 APC9 16319894 biogrid,i2d exp SSB1 APC9 19536198 intact exp GPI14 APC9 14690591 intact exp AIM26 APC9 16554755 intact exp AIP1 APC9 10688190 biogrid,i2d,mint,intact,dip exp RIX7 APC9 14690591 i2d,intact exp HSC82 APC9 19536198 intact exp MRPL4 APC9 14690591 intact exp SDO1 APC9 14690591 intact exp PPH22 APC9 23751495 biogrid exp PPH21 APC9 23751495 biogrid exp APC9 SWM1 12477395,15060174,12609981,12574115, 23023127 biogrid,intact exp, pred SML1 APC9 16554755, 23023127 biogrid,i2d,mint,intact exp, pred APC1 APC9 16429126,9469814, 23023127 i2d,intact exp, pred CDC27 APC9 17634282,12609981,9469814, 23023127 biogrid,intact exp, pred PRE8 APC9 11283351, 23023127 i2d,mint,intact,dip exp, pred CDC23 APC9 9469814, 23023127 biogrid,i2d,intact,dip exp, pred DOC1 APC9 10318877,17634282, 23023127 biogrid,i2d exp, pred APC4 APC9 12477395,15060174,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC26 APC9 9469814, 23023127 i2d,intact exp, pred APC9 APC2 15060174,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC9 APC11 9469814, 23023127 biogrid,i2d,intact,dip exp, pred TDA7 APC9 11283351, 23023127 i2d,mint,intact,dip exp, pred CDC5 APC9 19013276,10871279, 23023127 biogrid,intact exp, pred MND2 APC9 12477395,12609981, 23023127 biogrid,intact exp, pred APC5 APC9 16429126,9469814, 23023127 biogrid,i2d,intact,dip exp, pred CDC16 APC9 10318877,16429126,12402045,21186364,9469814,16364911,15649358,15060174,16275330,17406682,12574115,12887895,15797379, 23023127 biogrid,i2d,intact,dip exp, pred PDS1 APC9 23023127 pred CDC20 APC9 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12107 - 15797379 - C 13 Q12107 - 15649358 - C 13 Q12107 - 9469814 - C 12 Q12107 P16522 - 9469814 - X 2 Q12107 P09798 - 9469814 - X 2 Q12107 P14724 - 9469814 - X 2 Q12107 P46680 - 10688190 - X 2 Q12107 Q12157 - 9469814 - X 2 Q12107 P53068 - 9469814 - X 2 Q12107 Q07844 - 14690591 - X 2 Q12107 Q12440 - 9469814 - X 2 Q12107 Q08683 - 9469814 - X 2 Q12107 - 9469814 - X 2 Q12107 - 15044803 - C 11 Q12107 - 11283351 - X 2 Q12107 Q04601 - 9469814 - X 2 Q12107 P23639 - 11283351 - X 2 Q12107 P09798 affinity chromatography technology 12574115 physical association X 2 Q12107 P09798 affinity chromatography technology 10318877 physical association X 2 Q12107 P38042 affinity chromatography technology 12609981 physical association X 2 Q12107 P53068 affinity chromatography technology 10318877 physical association X 2 Q12107 P40577 affinity chromatography technology 12609981 physical association X 2 Q12107 P09798 affinity chromatography technology 12887895 physical association X 2 Q12107 P09798 affinity chromatography technology 12402045 physical association X 2 Q12107 P09798 affinity chromatography technology 15649358 physical association X 2 Q12107 P09798 affinity chromatography technology 15060174 physical association X 2 Q12107 Q12440 affinity chromatography technology 15060174 physical association X 2 Q12107 P09798 affinity chromatography technology 9469814 physical association X 2 Q12107 P16522 affinity chromatography technology 9469814 physical association X 2 Q12107 P40577 affinity chromatography technology 12477395 physical association X 2 Q12107 Q12440 affinity chromatography technology 9469814 physical association X 2 Q12107 Q08683 affinity chromatography technology 9469814 physical association X 2 Q12107 Q12157 affinity chromatography technology 9469814 physical association X 2 Q12107 P00546 enzymatic study 10871279 direct interaction X 2 Q12107 P32562 enzymatic study 10871279 direct interaction X 2 Q12107 P23594 enzymatic study 23751495 direct interaction X 2 Q12107 P00546 enzymatic study 23751495 direct interaction X 2 Q12107 P09798 affinity chromatography technology 16429126 physical association X 2 Q12107 Q08683 affinity chromatography technology 16429126 physical association X 2 Q12107 P09798 affinity chromatography technology 16275330 physical association X 2 Q12107 P16522 affinity chromatography technology 17200106 physical association X 2 Q12107 P09798 affinity chromatography technology 17200106 physical association X 2 Q12107 Q08683 affinity chromatography technology 17200106 physical association X 2 Q12107 P38042 two hybrid 17634282 direct interaction X 2 Q12107 P53068 two hybrid 17634282 direct interaction X 2 Q12107 P32562 affinity chromatography technology 19013276 physical association X 2 Q12107 P09798 affinity chromatography technology 17406682 physical association X 2 Q12107 P09798 affinity chromatography technology 15797379 physical association X 2 Q12107 P09798 affinity chromatography technology 21186364 physical association X 2 Q12107 P09798 affinity chromatography technology 16364911 physical association X 2 Q12107 P46680 two hybrid 10688190 direct interaction X 2 Q12107 Q12379 affinity chromatography technology 12609981 physical association X 2 Q12107 Q12379 affinity chromatography technology 12574115 physical association X 2 Q12107 Q12379 affinity chromatography technology 15060174 physical association X 2 Q12107 Q04601 affinity chromatography technology 15060174 physical association X 2 Q12107 Q04601 affinity chromatography technology 12477395 physical association X 2 Q12107 Q12379 affinity chromatography technology 12477395 physical association X 2 Q12107 Q04601 affinity chromatography technology 9469814 physical association X 2 Q12107 P23595 enzymatic study 23751495 direct interaction X 2 Q12107 Q04601 affinity chromatography technology 16554755 physical association X 2 Q12107 Q04964 affinity chromatography technology 16554755 physical association X 2 Q12107 P27466 enzymatic study 16319894 direct interaction X 2 Q12107 Q04601 affinity chromatography technology 17200106 physical association X 2 Q12107 P17157 enzymatic study 16319894 direct interaction X 2 Q12107 Q04601 affinity chromatography technology 21186364 physical association X 2 Q12107 pull down 21107322 - C 13 Q12107 tandem affinity purification 21107322 - C 12 Q12107 tandem affinity purification 21107322 - C 13 Q12107 P53882 two hybrid pooling approach 11283351 physical association X 2 Q12107 P09798 coimmunoprecipitation 9469814 physical association X 2 Q12107 P09798 tandem affinity purification 21186364 physical association X 2 Q12107 P09798 coimmunoprecipitation 10318877 physical association X 2 Q12107 P09798 tandem affinity purification 21107322 physical association X 2 Q12107 P09798 tandem affinity purification 21107322 physical association X 2 Q12107 P09798 pull down 21107322 physical association X 2 Q12107 P09798 pull down 21107322 physical association X 2 Q12107 Q12440 coimmunoprecipitation 9469814 physical association X 2 Q12107 P16522 coimmunoprecipitation 9469814 physical association X 2 Q12107 P46680 two hybrid 10688190 physical association X 2 Q12107 Q08683 coimmunoprecipitation 9469814 physical association X 2 Q12107 Q12157 coimmunoprecipitation 9469814 physical association X 2 Q12107 tandem affinity purification 21186364 physical association C 11 Q12107 electron tomography 21186364 physical association C 11 Q12107 pull down 21107322 - C 14 Q12107 P23639 two hybrid pooling approach 11283351 physical association X 2 Q12107 Q04601 coimmunoprecipitation 9469814 physical association X 2 Q12107 anti tag coimmunoprecipitation 9469814 association C 9 Q12107 anti tag coimmunoprecipitation 9469814 association C 9 Q12107 anti tag coimmunoprecipitation 9469814 association C 9 Q12107 anti tag coimmunoprecipitation 9469814 association C 9 Q12107 anti tag coimmunoprecipitation 9469814 association C 9 Q12107 tandem affinity purification 16429126 association C 22 Q12107 affinity chromatography technology 12609981 association C 11 Q12107 affinity chromatography technology 12609981 association C 11 Q12107 tandem affinity purification 12477395 association C 13 Q12107 tandem affinity purification 12477395 association C 13 Q12107 tandem affinity purification 12477395 association C 13 Q12107 affinity chromatography technology 12609981 association C 13 Q12107 anti tag coimmunoprecipitation 9469814 association C 10 Q12107 anti tag coimmunoprecipitation 9469814 association C 10 Q12107 anti tag coimmunoprecipitation 9469814 association C 10 Q12107 anti tag coimmunoprecipitation 9469814 association C 12 Q12107 anti tag coimmunoprecipitation 9469814 association C 12 Q12107 anti tag coimmunoprecipitation 9469814 association C 12 Q12107 anti tag coimmunoprecipitation 9469814 association C 12 Q12107 anti tag coimmunoprecipitation 9469814 association C 12 Q12107 P46680 two hybrid 10688190 physical association X 2 Q12107 P53882 two hybrid fragment pooling approach 11283351 physical association X 2 Q12107 P47088 two hybrid array 14690591 physical association X 2 Q12107 Q07844 two hybrid array 14690591 physical association X 2 Q12107 Q07953 two hybrid array 14690591 physical association X 2 Q12107 P10591 tandem affinity purification 19536198 association X 2 Q12107 tandem affinity purification 19013276 association C 41 Q12107 inferred by author 16554755 association C 17 Q12107 tandem affinity purification 16429126 association C 19 Q12107 inferred by author 16429126 physical association C 9 Q12107 anti tag coimmunoprecipitation 9469814 association C 8 Q12107 anti tag coimmunoprecipitation 9469814 association C 8 Q12107 P23639 two hybrid fragment pooling approach 11283351 physical association X 2 Q12107 Q06632 two hybrid array 14690591 physical association X 2 Q12107 P36517 two hybrid array 14690591 physical association X 2 Q12107 Q05541 two hybrid array 14690591 physical association X 2 Q12107 Q04964 tandem affinity purification 16554755 physical association X 2 Q12107 Q04601 tandem affinity purification 16554755 physical association X 2 Q12107 P11484 tandem affinity purification 19536198 association X 2 Q12107 P15108 tandem affinity purification 19536198 association X 2 Q12107 P16522 coimmunoprecipitation 9469814 - X 2 Q12107 P09798 coimmunoprecipitation 9469814 - X 2 Q12107 Q12440 coimmunoprecipitation 9469814 - X 2 Q12107 P46680 two hybrid 10688190 - X 2 Q12107 P53886 coimmunoprecipitation 9469814 - X 2 Q12107 Q08683 coimmunoprecipitation 9469814 - X 2 Q12107 P53882 two hybrid 11283351 - X 2 Q12107 P48562 interaction detection method 12686605 - X 2 Q12107 Q12157 coimmunoprecipitation 9469814 - X 2 Q12107 P14724 coimmunoprecipitation 9469814 - X 2 Q12107 P53068 coimmunoprecipitation 9469814 - X 2 Q12107 confirmational text mining - - C 11 Q12107 P23639 two hybrid 11283351 - X 2 Q12107 Q04601 coimmunoprecipitation 9469814 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 APC9 23751495,10871279 0415,0415 LC CDC16 APC9 9469814,9469814,10318877,10318877,9469814 0004,0019,0019,0004,0007 LC CDC26 APC9 9469814,9469814 0019,0007 LC CDC23 APC9 9469814,9469814,9469814 0004,0019,0007 LC PHO85 APC9 16319894 0415 LC PPH21 APC9 23751495 0415 LC PPH22 APC9 23751495 0415 LC PRE8 APC9 11283351,11283351,11283351 0018,0399,0398 HT CMK1 APC9 16319894 0415 LC CDC5 APC9 10871279 0415 LC MRPL4 APC9 14690591 0397 LC CDC27 APC9 17634282 0018 HT PDS1 APC9 16364911 0415 LC AIP1 APC9 10688190,10688190 0397,0018 HT GPI14 APC9 14690591 0397 LC DOC1 APC9 17634282,9469814 0018,0019 HT,LC NRM1 APC9 21562221 0415 LC TDA7 APC9 11283351,11283351,11283351 0018,0399,0398 HT APC1 APC9 9469814,9469814 0019,0007 LC YHP1 APC9 21562221 0415 LC APC4 APC9 9469814,9469814,9469814 0004,0019,0007 LC NSE3 APC9 14690591 0397 LC CFT1 APC9 14690591 0397 LC RIX7 APC9 14690591,14690591 0018,0397 LC SDO1 APC9 14690591 0397 LC APC5 APC9 9469814,9469814,9469814 0004,0019,0007 LC APC9 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC9 APC2 9469814,9469814,9469814 0019,0004,0007 LC CDC16 APC9 17406682,15649358,21107322,12574115,17200106,9469814,12887895,12402045,9469814,10318877,15797379,21107322,16429126,10318877,21186364,15060174,16429126,21186364,16275330,16364911,9469814 0004,0004,0096,0004,0004,0004,0004,0004,0019,0019,0004,0676,0676,0004,0676,0004,0004,0004,0004,0004,0007 LC,HT SSA1 APC9 19536198 0676 HT SSB1 APC9 19536198 0676 HT CDC26 APC9 9469814,9469814 0019,0007 LC HSC82 APC9 19536198 0676 HT CDC23 APC9 9469814,9469814,17200106,9469814 0004,0019,0004,0007 LC,HT NAB2 APC9 19840948 0004 LC CDC5 APC9 19013276,19013276 0004,0676 LC AIM26 APC9 16554755 0363 HT CDC27 APC9 12609981,9469814 0004,0007 LC MND2 APC9 12477395,12609981,12477395 0004,0004,0676 LC DOC1 APC9 10318877 0004 LC CDH1 APC9 21107322 0004 LC APC1 APC9 9469814,9469814,16429126 0019,0007,0363 LC,HT APC4 APC9 12477395,16554755,9469814,15060174,12477395,21186364,9469814,17200106,9469814,16554755 0676,0676,0004,0004,0004,0004,0019,0004,0007,0004 LC,HT SML1 APC9 16554755,16554755 0676,0004 HT APC5 APC9 9469814,16429126,17200106,9469814,16429126,9469814 0004,0676,0004,0019,0004,0007 LC,HT APC9 APC11 9469814,9469814,9469814 0019,0007,0004 LC APC9 SWM1 12477395,12609981,12477395,15060174,12574115 0676,0004,0004,0004,0004 LC APC9 APC2 9469814,9469814,9469814,15060174 0019,0004,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12107 P23594 APC9 PPH21 0.309 23751495 Q12107 P23595 APC9 PPH22 0.309 23751495 Q12107 Q04601 APC9 APC4 0.569 12477395,16554755,9469814,21186364 Q12107 P10591 APC9 SSA1 0.126 19536198 Q12107 P11484 APC9 SSB1 0.126 19536198 Q12107 P15108 APC9 HSC82 0.126 19536198 Q12107 P16522 APC9 CDC23 0.261 9469814 Q12107 P23639 APC9 PRE8 0.21 11283351 Q12107 P47088 APC9 GPI14 0.126 14690591 Q12107 Q05541 APC9 NSE3 0.126 14690591 Q12107 Q07953 APC9 SDO1 0.126 14690591 Q12107 Q08683 APC9 APC5 0.354 9469814,16429126 Q12157 Q12107 APC11 APC9 0.261 9469814 Q12440 Q12107 APC2 APC9 0.261 9469814 Q12107 P00546 APC9 CDC28 0.309 23751495 Q12107 P09798 APC9 CDC16 0.808 16275330,17406682,16429126,9469814,15797379,21186364,16364911,10318877 Q12379 Q12107 SWM1 APC9 0.236 12477395 Q12107 Q04964 APC9 SML1 0.236 16554755 Q12107 P53068 APC9 DOC1 0.354 10318877,17634282 Q12107 P40577 APC9 MND2 0.236 12477395 Q12107 P53886 APC9 APC1 0.236 9469814,16429126 Q12107 P38042 APC9 CDC27 0.286 9469814,17634282 Q12107 P32505 APC9 NAB2 0.126 19840948 Q12107 P32562 APC9 CDC5 0.286 19013276 Q12107 P36517 APC9 MRPL4 0.126 14690591 Q12107 P27466 APC9 CMK1 0.183 16319894 Q12107 P32858 APC9 AIM26 0.126 16554755 Q12107 P46680 APC9 AIP1 0.332 10688190 Q12107 P14724 APC9 CDC26 0.126 9469814 Q12107 P17157 APC9 PHO85 0.183 16319894 Q12107 Q06632 APC9 CFT1 0.126 14690591 Q12107 P53882 APC9 TDA7 0.236 11283351 Q12107 Q07844 APC9 RIX7 0.126 14690591