PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RGA1 ENT2 16537494 dip exp GZF3 ENT2 22875988 biogrid exp SSB1 ENT2 19536198 intact exp RPT6 ENT2 22875988 biogrid exp GIM5 ENT2 19536198 intact exp KAR2 ENT2 22875988 biogrid exp Uncharacterized protein YGR130C ENT2 22875988 biogrid exp MYO1 ENT2 22875988 biogrid exp YKE2 ENT2 22875988 biogrid exp CAF4 ENT2 11805837 biogrid,mint,intact,dip exp BNR1 ENT2 22875988 biogrid exp TSR4 ENT2 14690591 intact exp PRP43 ENT2 i2d exp ENT2 ADY3 22875988 biogrid exp UBI4 ENT2 11988742 biogrid exp GAL80 ENT2 18719252 biogrid,intact exp SMY1 ENT2 22875988 biogrid exp SSA1 ENT2 19536198,23217712 intact exp Uncharacterized protein YEL043W ENT2 22875988 biogrid exp ENT2 RGA2 16537494,19531587 biogrid,dip exp BEM3 ENT2 16537494,19531587 biogrid,dip exp MET30 ENT2 14690591 intact exp CDC3 ENT2 22875988 biogrid exp BIK1 ENT2 22875988 biogrid exp SSA2 ENT2 16429126 intact exp STE50 ENT2 22875988 biogrid exp HEK2 ENT2 18805955 biogrid exp ENT2 PUF3 23409723 biogrid exp TYE7 ENT2 22875988 biogrid exp ENT2 HDA2 22875988 biogrid exp STB2 ENT2 22875988 biogrid exp SPC72 ENT2 22875988 biogrid exp NAB2 ENT2 18719252 biogrid,intact exp AKL1 ENT2 16319894, 23023127 biogrid,i2d exp, pred CHC1 ENT2 14704157,15992543, 23023127 biogrid exp, pred SRO77 ENT2 10688190,11489916, 23023127 biogrid,i2d,mint,intact,dip exp, pred SLA1 ENT2 19841731, 23023127 biogrid,mint,intact exp, pred YSC84 ENT2 19841731, 23023127 biogrid,mint,intact exp, pred CDC24 ENT2 10688190,11489916, 23023127 biogrid,i2d,mint,intact,dip exp, pred LSB3 ENT2 19841731, 23023127 biogrid,mint,intact exp, pred BBC1 ENT2 19841731, 23023127 biogrid,mint,intact exp, pred ENT2 MDY2 18719252, 23023127 biogrid,intact exp, pred ENT2 ENT1 23023127 i2d exp, pred ARK1 ENT2 16319894, 23023127 biogrid,i2d exp, pred RSP5 ENT2 17551511, 23023127 biogrid exp, pred SYP1 ENT2 18467557, 23023127 biogrid,i2d,mint,intact exp, pred HUA1 ENT2 18719252, 23023127 biogrid,intact exp, pred PRK1 ENT2 18719252, 23023127 biogrid,intact exp, pred YAP1802 ENT2 22875988, 23023127 biogrid exp, pred STE20 ENT2 21118957, 23023127 biogrid exp, pred HSE1 ENT2 23023127 pred SLA2 ENT2 23023127 pred UBI4 ENT2 23023127 pred ENT3 ENT2 23023127 pred ARC15 ENT2 23023127 pred ABP1 ENT2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q05785 - 11805837 - C 10 P11433 Q05785 - 11489916 - X 2 Q05785 - 11489916 - X 2 P33122 Q05785 two hybrid 22875988 direct interaction X 2 P38080 Q05785 enzymatic study 16319894 direct interaction X 2 Q12285 Q05785 two hybrid 18719252 direct interaction X 2 P32618 Q05785 two hybrid 22875988 direct interaction X 2 P11433 Q05785 two hybrid 11489916 direct interaction X 2 P04387 Q05785 two hybrid 18719252 direct interaction X 2 P40450 Q05785 two hybrid 22875988 direct interaction X 2 Q06407 Q05785 two hybrid 19531587 direct interaction X 2 Q01939 Q05785 two hybrid 22875988 direct interaction X 2 P39723 Q05785 two hybrid 22875988 direct interaction X 2 P46679 Q05785 two hybrid 22875988 direct interaction X 2 P53278 Q05785 two hybrid 22875988 direct interaction X 2 P11709 Q05785 two hybrid 22875988 direct interaction X 2 P52553 Q05785 two hybrid 22875988 direct interaction X 2 Q05785 P32364 two hybrid 22875988 direct interaction X 2 P32457 Q05785 two hybrid 22875988 direct interaction X 2 Q05785 P32505 two hybrid 18719252 direct interaction X 2 Q05785 P40325 two hybrid 18719252 direct interaction X 2 Q05785 P36130 affinity chromatography technology 11805837 physical association X 2 P47068 Q05785 two hybrid 19841731 direct interaction X 2 P53309 Q05785 two hybrid 22875988 direct interaction X 2 P16474 Q05785 two hybrid 22875988 direct interaction X 2 P22137 Q05785 affinity chromatography technology 14704157 physical association X 2 P22137 Q05785 imaging technique 15992543 colocalization X 2 P53974 Q05785 enzymatic study 16319894 direct interaction X 2 P0CG63 Q05785 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q05785 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q05785 pull down 11988742 direct interaction X 2 P0CG63 Q05785 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q05785 affinity chromatography technology 21427232 physical association X 2 P0CG63 Q05785 affinity chromatography technology 22106047 physical association X 2 Q06629 Q05785 two hybrid 22875988 direct interaction X 2 P40494 Q05785 two hybrid 18719252 direct interaction X 2 P32793 Q05785 two hybrid 19841731 direct interaction X 2 P25623 Q05785 protein complementation assay 18467557 direct interaction X 2 P38163 Q05785 two hybrid 11489916 direct interaction X 2 P32873 Q05785 two hybrid 19531587 direct interaction X 2 P08964 Q05785 two hybrid 22875988 direct interaction X 2 P42944 Q05785 two hybrid 22875988 direct interaction X 2 P25344 Q05785 two hybrid 22875988 direct interaction X 2 Q07732 Q05785 two hybrid 22875988 direct interaction X 2 Q03497 Q05785 protein complementation assay 21118957 direct interaction X 2 Q05785 P43603 two hybrid 19841731 direct interaction X 2 Q05785 P32790 two hybrid 19841731 direct interaction X 2 P39940 Q05785 enzymatic study 17551511 direct interaction X 2 Q05785 anti tag coimmunoprecipitation 11805837 - C 28 P11433 Q05785 two hybrid 11489916 physical association X 2 P11433 Q05785 two hybrid 10688190 physical association X 2 Q06407 Q05785 two hybrid 16537494 direct interaction X 2 Q06407 Q05785 pull down 16537494 direct interaction X 2 Q05785 P39083 pull down 16537494 direct interaction X 2 Q05785 P39083 two hybrid 16537494 direct interaction X 2 Q05785 P36130 anti tag coimmunoprecipitation 11805837 physical association X 2 Q05785 anti tag coimmunoprecipitation 11805837 - C 11 P32873 Q05785 two hybrid 16537494 physical association X 2 Q05785 two hybrid 10688190 physical association X 2 Q05785 two hybrid 11489916 physical association X 2 Q05785 anti tag coimmunoprecipitation 11805837 association C 10 Q05785 pull down 23217712 association C 317 Q12285 Q05785 two hybrid 18719252 physical association X 2 P11484 Q05785 tandem affinity purification 19536198 association X 2 Q04493 Q05785 tandem affinity purification 19536198 association X 2 P25040 Q05785 two hybrid array 14690591 physical association X 2 P11433 Q05785 two hybrid 10688190 physical association X 2 P04387 Q05785 two hybrid 18719252 physical association X 2 P0CG48 Q05785 pull down 11988742 physical association X 2 Q05785 P40325 two hybrid 18719252 physical association X 2 Q05785 P32505 two hybrid 18719252 physical association X 2 P47068 Q05785 two hybrid pooling approach 19841731 physical association X 2 P10592 Q05785 tandem affinity purification 16429126 physical association X 2 P39014 Q05785 two hybrid array 14690591 physical association X 2 P40494 Q05785 two hybrid 18719252 physical association X 2 P32793 Q05785 two hybrid array 19841731 physical association X 2 P25623 Q05785 dihydrofolate reductase reconstruction 18467557 physical association X 2 P38163 Q05785 two hybrid 10688190 physical association X 2 P10591 Q05785 tandem affinity purification 19536198 association X 2 Q05785 P43603 two hybrid array 19841731 physical association X 2 Q05785 P32790 two hybrid pooling approach 19841731 physical association X 2 P11433 Q05785 two hybrid 11489916 - X 2 P11433 Q05785 two hybrid 11489916 - X 2 Q12518 Q05785 interaction detection method 10449404 - X 2 Q05785 mass spectrometry studies of complexes 11805837 - C 12 P38163 Q05785 two hybrid 11489916 - X 2 P38163 Q05785 two hybrid 11489916 - X 2

PPI - HINT Gene A Gene B PMID Method Quality GAL80 ENT2 18719252 0018 HT MYO1 ENT2 22875988 0018 HT CDC24 ENT2 11489916,10688190 0018,0018 HT BIK1 ENT2 22875988 0018 HT KAR2 ENT2 22875988 0018 HT TSR4 ENT2 14690591 0397 LC STE50 ENT2 22875988 0018 HT SYP1 ENT2 18467557,18467557 0111,0090 HT SMY1 ENT2 22875988 0018 HT CDC3 ENT2 22875988 0018 HT NAB2 ENT2 18719252 0018 HT P32618 ENT2 22875988 0018 HT SLA1 ENT2 19841731,19841731 0398,0018 HT YSC84 ENT2 19841731,19841731 0397,0018 HT BEM3 ENT2 16537494,19531587 0018,0018 LC TYE7 ENT2 22875988 0018 HT AKL1 ENT2 16319894 0415 LC SRO77 ENT2 11489916,10688190 0018,0018 HT MET30 ENT2 14690591 0397 LC RGA1 ENT2 16537494,16537494 0096,0018 LC SPC72 ENT2 22875988 0018 HT RSP5 ENT2 17551511 0415 LC HUA1 ENT2 18719252 0018 HT BNR1 ENT2 22875988 0018 HT PRK1 ENT2 18719252 0018 HT GZF3 ENT2 22875988 0018 HT LSB3 ENT2 19841731,19841731 0397,0018 HT STB2 ENT2 22875988 0018 HT BBC1 ENT2 19841731,19841731 0398,0018 HT YKE2 ENT2 22875988 0018 HT P53278 ENT2 22875988 0018 HT YAP1802 ENT2 22875988 0018 HT ARK1 ENT2 16319894 0415 LC RPT6 ENT2 22875988 0018 HT STE20 ENT2 21118957 0090 HT ENT2 RGA2 16537494,16537494,19531587 0096,0018,0018 LC ENT2 HDA2 22875988 0018 HT ENT2 ADY3 22875988 0018 HT ENT2 MDY2 18719252 0018 HT UBI4 ENT2 22106047,11988742,11988742 0004,0004,0096 LC SSA1 ENT2 19536198,23217712 0676,0096 HT,LC SSA2 ENT2 16429126 0676 HT SSB1 ENT2 19536198 0676 HT CHC1 ENT2 15992543,14704157 0428,0004 LC CAF4 ENT2 11805837,11805837 0004,0007 HT RGA1 ENT2 16537494,16537494 0096,0018 LC GIM5 ENT2 19536198 0676 HT ENT2 RGA2 16537494,16537494 0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q05785 Q04493 ENT2 GIM5 0.126 19536198 Q05785 P0CG48 ENT2 UBC 0.21 11988742 Q05785 P32873 ENT2 BEM3 0.309 19531587 Q05785 P25040 ENT2 TSR4 0.126 14690591 Q05785 P11433 ENT2 CDC24 0.183 10688190,11489916 Q05785 P32790 ENT2 SLA1 0.376 19841731 Q05785 P39014 ENT2 MET30 0.126 14690591 Q06407 Q05785 RGA2 ENT2 0.309 19531587 Q05785 P0CG63 ENT2 UBI4 0.309 11988742 Q05785 P10592 ENT2 SSA2 0.126 16429126 Q05785 P11484 ENT2 SSB1 0.126 19536198 Q05785 P04387 ENT2 GAL80 0.332 18719252 Q05785 P10591 ENT2 SSA1 0.236 19536198,23217712 Q12285 Q05785 MDY2 ENT2 0.332 18719252 Q05785 P25623 ENT2 SYP1 0.286 18467557 Q05785 P32793 ENT2 YSC84 0.286 19841731 Q05785 P38080 ENT2 AKL1 0.183 16319894 Q05785 P38163 ENT2 SRO77 0.332 10688190,11489916 Q05785 P38199 ENT2 HEK2 0.126 18805955 Q05785 P32505 ENT2 NAB2 0.332 18719252 Q05785 P40325 ENT2 HUA1 0.332 18719252 Q05785 P36130 ENT2 CAF4 0.236 11805837 Q05785 P43603 ENT2 LSB3 0.286 19841731 Q05785 P40494 ENT2 PRK1 0.332 18719252 Q05785 P47068 ENT2 BBC1 0.286 19841731 Q06629 Q05785 HDA2 ENT2 0.183 22875988 Q05785 Q03497 ENT2 STE20 0.183 21118957 Q07807 Q05785 PUF3 ENT2 0.126 23409723 Q05785 P53974 ENT2 ARK1 0.183 16319894 Q05785 P22137 ENT2 CHC1 0.309 15992543,14704157