PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SEC13 YTH1 11805826,16429126 biogrid,mint,intact,dip exp SEC17 SEC13 23904270 biogrid exp SSP120 SEC13 23904270 biogrid exp MCK1 SEC13 20489023 biogrid,mint,intact exp HOM6 SEC13 i2d exp AKR1 SEC13 23904270 biogrid exp SEC13 GIN4 21460040 biogrid exp SER2 SEC13 i2d exp YPT52 SEC13 23904270 biogrid exp UBP10 SEC13 22902402 biogrid exp DID2 SEC13 23904270 biogrid exp PEP1 SEC13 23904270 biogrid exp ERV46 SEC13 23904270 biogrid exp DID4 SEC13 23904270 biogrid exp PRM8 SEC13 23904270 biogrid exp SBP1 SEC13 23222640 biogrid exp SEC13 ESA1 23572591 biogrid exp HSP82 SEC13 26217697 biogrid exp CDC48 SEC13 23904270 biogrid exp ADH1 SEC13 18046405 biogrid exp HSP26 SEC13 11805837 dip exp NEO1 SEC13 23904270 biogrid exp ARG3 SEC13 11805837 dip exp RCR2 SEC13 23904270 biogrid exp PEP12 SEC13 23904270 biogrid exp SPB4 SEC13 21825077 biogrid exp EMP47 SEC13 23904270 biogrid exp YCK1 SEC13 23904270 biogrid exp SEA4 SEC13 21454883,25073740 biogrid,intact exp SFT1 SEC13 23904270 biogrid exp Uncharacterized protein YCR099C SEC13 11283351,10655498 i2d,mint,intact,dip exp LST4 SEC13 i2d exp SVP26 SEC13 23904270 biogrid exp SRO9 SEC13 22271760 biogrid exp IML1 SEC13 21454883,25073740 biogrid,intact exp HSP78 SEC13 19536198 intact exp RHO1 SEC13 23904270 biogrid exp SFB2 SEC13 23904270 biogrid exp MLP1 SEC13 24152732 biogrid exp ATG27 SEC13 23904270 biogrid exp PMR1 SEC13 23904270 biogrid exp SEC13 ERV41 23904270 biogrid exp YIP1 SEC13 23904270 biogrid exp SSO1 SEC13 23904270 biogrid exp MLP2 SEC13 24500206,24152732 biogrid exp COY1 SEC13 23904270 biogrid exp SEC13 ATG9 23904270 biogrid exp FKS1 SEC13 23904270 biogrid exp TVP38 SEC13 23904270 biogrid exp SNF7 SEC13 23904270 biogrid exp YIP3 SEC13 23904270 biogrid exp SFT2 SEC13 23904270 biogrid exp PIL1 SEC13 23904270 biogrid exp SSB1 SEC13 16429126 intact exp VPS17 SEC13 23904270 biogrid exp BRR2 SEC13 16429126 intact exp NPR2 SEC13 25073740 intact exp SEC22 SEC13 23904270 biogrid exp SEC13 ERP1 23904270 biogrid exp VPS1 SEC13 23904270 biogrid exp GOS1 SEC13 23904270 biogrid exp SEC13 SLF1 22271760 biogrid exp TLG1 SEC13 23904270 biogrid exp CYS4 SEC13 16429126 intact exp LST7 SEC13 i2d exp SSB2 SEC13 23332755 biogrid exp THR4 SEC13 i2d exp EFM1 SEC13 11805837 biogrid,mint,intact,dip exp STV1 SEC13 23904270 biogrid exp ERV25 SEC13 23904270,11560939, 23023127 biogrid,dip exp, ortho, pred SEC13 SEC13 11805826,8223424,23904270,18160040, 23023127 biogrid,mint,intact exp, ortho, pred MTC5 SEC13 21454883,10688190,25073740, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred SEC23 SEC13 16429126,23904270,10720463,8004676,18046405, 23023127 biogrid,intact exp, ortho, pred SEH1 SEC13 16429126,8565072,15741174,11805837,11805826,10747086,21454883,18046405, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred SEC24 SEC13 16429126,23904270,18046405, 23023127 biogrid,intact exp, ortho, pred YPT31 SEC13 23904270, 23023127 biogrid exp, ortho, pred EMP24 SEC13 23904270,11560939, 23023127 biogrid,dip exp, ortho, pred SSM4 SEC13 16606443, 23023127 biogrid,mint,intact exp, pred RPN11 SEC13 20170199, 23023127 biogrid exp, pred SEC13 RTC1 21454883,25073740, 23023127 biogrid,intact exp, pred NUP84 SEC13 16429126,8565072,18046452,15741174,11805826,10747086,12543930,19822444,18046405, 23023127 biogrid,i2d,mint,intact,dip exp, pred NUP85 SEC13 10747086,11805826,16429126,8565072,19111661,15741174,18046405, 23023127 biogrid,i2d,mint,intact,dip exp, pred TEF1, TEF2 SEC13 18046405, 23023127 biogrid exp, pred NUP157 SEC13 15741174,18046405, 23023127 biogrid exp, pred CSE4 SEC13 21070971, 23023127 biogrid exp, pred BRE5 SEC13 20508643, 23023127 biogrid,intact exp, pred VPS21 SEC13 23904270, 23023127 biogrid exp, pred NUP145 SEC13 21784248,9305650,16429126,19855394,11283351,18046452,15741174,18160040,16554755,11805826,22480613,20512149,18974315,18046405,19805193, 23023127 biogrid,i2d,mint,intact,dip exp, pred SAC3 SEC13 17922018, 23023127 biogrid exp, pred SEC16 SEC13 11805826,22675024,16429126,23904270,20696705,12235121, 23023127 biogrid,mint,intact,dip exp, pred UBP3 SEC13 20508643, 23023127 biogrid,intact exp, pred SPO20 SEC13 18719252, 23023127 biogrid,intact exp, pred BET1 SEC13 23904270,9685263, 23023127 biogrid exp, pred YPT1 SEC13 23904270, 23023127 biogrid exp, pred VTI1 SEC13 23904270, 23023127 biogrid exp, pred ERO1 SEC13 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred NAB2 SEC13 19840948, 23023127 biogrid exp, pred SAR1 SEC13 23904270, 23023127 biogrid exp, pred YPT7 SEC13 23904270, 23023127 biogrid exp, pred SEC31 SEC13 22300850,17604721,16429126,8565072,23904270,11283351,11805837,21454883,22940862,12671686,18046405,16554755,11210564,18719252,11805826,11535824,20696705,9325247, 23023127 biogrid,i2d,mint,intact,dip exp, pred SSA1 SEC13 19536198,23217712, 23023127 intact exp, pred NUP116 SEC13 12543930, 23023127 biogrid exp, pred SHR3 SEC13 10564255, 23023127 biogrid exp, pred SEC13 FAP7 11283351, 23023127 i2d,mint,intact,dip exp, pred NUP120 SEC13 11805826,16429126,8565072,15741174,18046405, 23023127 biogrid,mint,intact,dip exp, pred SEC21 SEC13 23904270, 23023127 biogrid exp, pred OST1 SEC13 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred SEC4 SEC13 23904270, 23023127 biogrid exp, pred LST8 SEC13 23023127 i2d exp, pred SSA2 SEC13 16429126, 23023127 intact exp, pred SEC1 SEC13 16554755, 23023127 biogrid,i2d,mint,intact exp, pred NUP133 SEC13 25139911,15741174,18046405,11805837, 23023127 biogrid,mint,intact,dip exp, pred SEC13 AIM45 ortho SES1 SEC13 ortho LSC2 SEC13 ortho APS1 SEC13 ortho CRM1 SEC13 ortho PRE7 SEC13 ortho SEC13 TIF6 ortho RPB5 SEC13 ortho CHC1 SEC13 ortho SEC13 AHA1 ortho ARF3 SEC13 23023127 ortho, pred BOS1 SEC13 23023127 pred RET2 SEC13 23023127 pred SED4 SEC13 23023127 pred CDC20 SEC13 23023127 pred COP1 SEC13 23023127 pred GSP1 SEC13 23023127 pred TOM22 SEC13 23023127 pred GPA1 SEC13 23023127 pred CDC5 SEC13 23023127 pred MET30 SEC13 23023127 pred SEC7 SEC13 23023127 pred SEC13 TLG2 23023127 pred CDH1 SEC13 23023127 pred ARL1 SEC13 23023127 pred SEC26 SEC13 23023127 pred ARL3 SEC13 23023127 pred SEC27 SEC13 23023127 pred YKT6 SEC13 23023127 pred SLY1 SEC13 23023127 pred GLE2 SEC13 23023127 pred YRB1 SEC13 23023127 pred RSP5 SEC13 23023127 pred SEC13 YPT6 23023127 pred ARF1 SEC13 23023127 pred ARC19 SEC13 23023127 pred ARF2 SEC13 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04491 - 11805826 - C 8 Q04491 - 15044803 - C 6 Q04491 - 11805837 - C 4 Q04491 - 11805826 - C 5 Q04491 - 8223424 - X 2 Q04491 - 11283351 - X 2 Q04491 - 11805837 - C 6 Q04491 - 11805826 - C 8 Q04491 - 11805826 - C 10 Q04491 - 11805826 - C 14 Q12055 Q04491 - 11283351 - X 2 Q04491 Q03897 - 10688190 - X 2 Q04491 P25657 - 10655498 - X 2 Q04491 P25657 - 11283351 - X 2 Q04491 P49687 - 11283351 - X 2 Q04491 P22804 pull down 9685263 direct interaction X 2 Q04491 Q02630 affinity chromatography technology 12543930 physical association X 2 Q04491 Q04491 biochemical 8223424 colocalization X 2 Q04491 P36161 affinity chromatography technology 25139911 physical association X 2 Q04491 P40457 affinity chromatography technology 24500206 physical association X 2 Q04491 P36161 affinity chromatography technology 15741174 physical association X 2 Q04491 P40064 pull down 15741174 direct interaction X 2 Q04491 Q04359 two hybrid 18719252 direct interaction X 2 Q04491 Q04491 pull down 18160040 direct interaction X 2 Q04491 P43588 affinity chromatography technology 20170199 physical association X 2 Q04491 P21965 affinity chromatography technology 20489023 physical association X 2 Q04491 P40064 affinity chromatography technology 18046405 physical association X 2 Q04491 P36161 affinity chromatography technology 18046405 physical association X 2 Q04491 P38732 affinity chromatography technology 11805837 physical association X 2 Q04491 P36161 affinity chromatography technology 11805837 physical association X 2 P40318 Q04491 unspecified method 16606443 direct interaction X 2 P40150 Q04491 biochemical 23332755 association X 2 P46674 Q04491 affinity chromatography technology 17922018 physical association X 2 P25808 Q04491 affinity chromatography technology 21825077 physical association X 2 P35729 Q04491 affinity chromatography technology 16429126 physical association X 2 P35729 Q04491 affinity chromatography technology 15741174 physical association X 2 P35729 Q04491 affinity chromatography technology 15741174 physical association X 2 P35729 Q04491 affinity chromatography technology 17200106 physical association X 2 P35729 Q04491 affinity chromatography technology 18046405 physical association X 2 P35729 Q04491 affinity chromatography technology 11805826 physical association X 2 Q01477 Q04491 affinity chromatography technology 20508643 physical association X 2 P53741 Q04491 affinity chromatography technology 20508643 physical association X 2 P48415 Q04491 pull down 12235121 direct interaction X 2 P48415 Q04491 affinity chromatography technology 22675024 physical association X 2 P48415 Q04491 affinity chromatography technology 16429126 physical association X 2 P48415 Q04491 affinity chromatography technology 16429126 physical association X 2 P48415 Q04491 affinity chromatography technology 17200106 physical association X 2 P48415 Q04491 x-ray crystallography 20696705 association X 2 P48415 Q04491 affinity chromatography technology 11805826 physical association X 2 Q04491 P38968 affinity chromatography technology 22940862 physical association X 2 Q04491 P38968 affinity chromatography technology 12671686 physical association X 2 Q04491 P49687 affinity chromatography technology 9305650 physical association X 2 Q04491 P52891 affinity chromatography technology 10747086 physical association X 2 Q04491 P46673 affinity chromatography technology 10747086 physical association X 2 Q04491 P46673 affinity chromatography technology 10747086 physical association X 2 Q04491 P53011 affinity chromatography technology 10747086 physical association X 2 Q04491 P38968 affinity chromatography technology 9325247 physical association X 2 Q04491 Q02774 affinity chromatography technology 10564255 physical association X 2 Q04491 P38968 pull down 11535824 direct interaction X 2 Q04491 P32803 pull down 11560939 direct interaction X 2 Q04491 P38968 pull down 11210564 direct interaction X 2 Q04491 P15303 pull down 8004676 direct interaction X 2 Q04491 P38968 pull down 22300850 direct interaction X 2 Q04491 P49687 x-ray crystallography 19855394 association X 2 Q04491 Q08649 affinity chromatography technology 23572591 physical association X 2 Q04491 P52891 biochemical 12543930 association X 2 Q04491 P52891 biochemical 8565072 association X 2 Q04491 P15303 biochemical 10720463 colocalization X 2 Q04491 P53874 affinity chromatography technology 22902402 physical association X 2 Q04491 P38968 affinity chromatography technology 16554755 physical association X 2 Q04491 P49687 affinity chromatography technology 16554755 physical association X 2 Q04491 P30619 affinity chromatography technology 16554755 physical association X 2 Q04491 P38968 affinity chromatography technology 16429126 physical association X 2 Q04491 P40482 affinity chromatography technology 16429126 physical association X 2 Q04491 P38968 affinity chromatography technology 16429126 physical association X 2 Q04491 P15303 affinity chromatography technology 16429126 physical association X 2 Q04491 P52891 affinity chromatography technology 16429126 physical association X 2 Q04491 P49687 affinity chromatography technology 16429126 physical association X 2 Q04491 P49687 affinity chromatography technology 16429126 physical association X 2 Q04491 P52891 affinity chromatography technology 16429126 physical association X 2 Q04491 P46673 affinity chromatography technology 16429126 physical association X 2 Q04491 P53011 affinity chromatography technology 16429126 physical association X 2 Q04491 Q03103 affinity chromatography technology 16429126 physical association X 2 Q04491 P52891 affinity chromatography technology 15741174 physical association X 2 Q04491 P46673 affinity chromatography technology 15741174 physical association X 2 Q04491 P49687 affinity chromatography technology 15741174 physical association X 2 Q04491 P53011 affinity chromatography technology 15741174 physical association X 2 Q04491 P52891 affinity chromatography technology 15741174 physical association X 2 Q04491 P46673 affinity chromatography technology 15741174 physical association X 2 Q04491 P52891 pull down 15741174 direct interaction X 2 Q04491 P52891 affinity chromatography technology 17200106 physical association X 2 Q04491 P38968 affinity chromatography technology 17200106 physical association X 2 Q04491 P49687 affinity chromatography technology 17200106 physical association X 2 Q04491 P53011 affinity chromatography technology 17200106 physical association X 2 Q04491 P46673 affinity chromatography technology 17200106 physical association X 2 Q04491 P15303 affinity chromatography technology 17200106 physical association X 2 Q04491 P38968 two hybrid 11283351 direct interaction X 2 Q04491 P38968 x-ray crystallography 17604721 association X 2 Q04491 P52891 affinity chromatography technology 18046452 physical association X 2 Q04491 P49687 pull down 18046452 direct interaction X 2 Q04491 P38968 two hybrid 18719252 direct interaction X 2 Q04491 P46673 biochemical 19111661 association X 2 Q04491 P49687 pull down 18974315 direct interaction X 2 Q04491 P52891 affinity chromatography technology 19822444 physical association X 2 Q04491 P49687 biochemical 18160040 association X 2 Q04491 P49687 affinity chromatography technology 20512149 physical association X 2 Q04491 P36012 affinity chromatography technology 21070971 physical association X 2 Q04491 P38968 pull down 20696705 direct interaction X 2 Q04491 P38968 x-ray crystallography 20696705 association X 2 Q04491 Q12263 pull down 21460040 direct interaction X 2 Q04491 P53011 affinity chromatography technology 21454883 physical association X 2 Q04491 P47170 affinity chromatography technology 21454883 physical association X 2 Q04491 Q03897 affinity chromatography technology 21454883 physical association X 2 Q04491 P38968 affinity chromatography technology 21454883 physical association X 2 Q04491 Q03103 affinity chromatography technology 11805826 physical association X 2 Q04491 P46673 affinity chromatography technology 18046405 physical association X 2 Q04491 P52891 affinity chromatography technology 18046405 physical association X 2 Q04491 P49687 affinity chromatography technology 18046405 physical association X 2 Q04491 P53011 affinity chromatography technology 18046405 physical association X 2 Q04491 P38968 affinity chromatography technology 18046405 physical association X 2 Q04491 P15303 affinity chromatography technology 18046405 physical association X 2 Q04491 P40482 affinity chromatography technology 18046405 physical association X 2 Q04491 P02994 affinity chromatography technology 18046405 physical association X 2 Q04491 P00330 affinity chromatography technology 18046405 physical association X 2 Q04491 P49687 affinity chromatography technology 11805826 physical association X 2 Q04491 P52891 affinity chromatography technology 11805826 physical association X 2 Q04491 P46673 affinity chromatography technology 11805826 physical association X 2 Q04491 P38968 affinity chromatography technology 11805826 physical association X 2 Q04491 P38968 affinity chromatography technology 11805826 physical association X 2 Q04491 P53011 affinity chromatography technology 11805826 physical association X 2 Q04491 Q06102 affinity chromatography technology 11805826 physical association X 2 Q04491 P53011 affinity chromatography technology 11805837 physical association X 2 Q04491 P38968 affinity chromatography technology 11805837 physical association X 2 Q04491 Q03897 two hybrid 10688190 direct interaction X 2 Q04491 P49687 pull down 22480613 direct interaction X 2 P0CG63 Q04491 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q04491 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q04491 affinity chromatography technology 22213798 physical association X 2 P54837 Q04491 pull down 11560939 direct interaction X 2 Q08281 Q04491 affinity chromatography technology 21454883 physical association X 2 P41543 Q04491 affinity chromatography technology 11805826 physical association X 2 P38164 Q04491 affinity chromatography technology 21454883 physical association X 2 Q04491 tandem affinity purification 11805826 - C 8 Q04491 anti tag coimmunoprecipitation 11805837 - C 4 Q04491 inferred by author 11805826 physical association C 5 Q04491 tandem affinity purification 11805826 physical association C 5 Q04491 anti tag coimmunoprecipitation 11805837 - C 7 Q04491 pull down 19576787 physical association C 5 Q04491 pull down 20512149 physical association C 5 Q04491 electron microscopy 20512149 physical association C 5 Q04491 molecular sieving 19576787 physical association C 5 Q04491 inferred by author 11805826 physical association C 16 Q04491 tandem affinity purification 19503077 physical association C 7 Q04491 transmission electron microscopy 19503077 physical association C 7 Q04491 tandem affinity purification 19503077 physical association C 7 Q04491 light scattering 19503077 physical association C 7 Q04491 anti tag coimmunoprecipitation 11805837 - C 6 Q04491 P15992 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04491 P36161 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04491 P38732 anti tag coimmunoprecipitation 11805837 physical association X 2 P35729 Q04491 affinity chromatography technology 8565072 physical association X 2 P35729 Q04491 tandem affinity purification 11805826 physical association X 2 P35729 Q04491 pull down 19576787 physical association X 2 Q04491 tandem affinity purification 11805826 - C 8 Q04491 tandem affinity purification 11805826 - C 10 Q04491 tandem affinity purification 11805826 - C 14 Q04491 anti tag coimmunoprecipitation 11805837 - C 23 Q04491 inferred by author 11805826 physical association C 36 Q04491 molecular sieving 19805193 physical association C 3 Q04491 x-ray crystallography 19805193 physical association C 3 Q04491 light scattering 19805193 physical association C 3 Q04491 cosedimentation in solution 19805193 physical association C 3 Q04491 inferred by author 11805826 physical association C 9 Q12055 Q04491 two hybrid pooling approach 11283351 physical association X 2 P48415 Q04491 tandem affinity purification 11805826 physical association X 2 Q04491 P05150 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04491 P49687 pull down 20512149 direct interaction X 2 Q04491 P49687 tandem affinity purification 11805826 direct interaction X 2 Q04491 P49687 cosedimentation in solution 19805193 direct interaction X 2 Q04491 P49687 molecular sieving 19805193 direct interaction X 2 Q04491 P49687 pull down 19805193 direct interaction X 2 Q04491 P49687 two hybrid pooling approach 11283351 direct interaction X 2 Q04491 P49687 molecular sieving 19576787 direct interaction X 2 Q04491 P38968 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04491 P38968 two hybrid 9325247 physical association X 2 Q04491 P38968 affinity chromatography technology 9325247 physical association X 2 Q04491 P38968 biochemical 8223424 physical association X 2 Q04491 P38968 two hybrid pooling approach 11283351 physical association X 2 Q04491 P38968 tandem affinity purification 11805826 physical association X 2 Q04491 P38968 tandem affinity purification 11805826 physical association X 2 Q04491 P38968 affinity chromatography technology 8565072 physical association X 2 Q04491 P32803 affinity chromatography technology 11560939 physical association X 2 Q04491 P53011 anti tag coimmunoprecipitation 11805837 physical association X 2 Q04491 P53011 tandem affinity purification 11805826 physical association X 2 Q04491 P53011 affinity chromatography technology 8565072 physical association X 2 Q04491 P53011 affinity chromatography technology 10747086 physical association X 2 Q04491 Q03103 tandem affinity purification 11805826 physical association X 2 Q04491 P52891 affinity chromatography technology 10747086 physical association X 2 Q04491 P52891 affinity chromatography technology 8565072 physical association X 2 Q04491 P52891 tandem affinity purification 11805826 physical association X 2 Q04491 P46673 tandem affinity purification 11805826 physical association X 2 Q04491 P46673 tandem affinity purification 19503077 physical association X 2 Q04491 P46673 affinity chromatography technology 8565072 physical association X 2 Q04491 Q06102 tandem affinity purification 11805826 physical association X 2 Q04491 Q03897 two hybrid 10688190 physical association X 2 Q04491 P25657 two hybrid pooling approach 11283351 physical association X 2 Q04491 P25657 two hybrid 10655498 physical association X 2 P54837 Q04491 affinity chromatography technology 11560939 physical association X 2 P41543 Q04491 tandem affinity purification 11805826 physical association X 2 Q04491 anti tag coimmunoprecipitation 20508643 association C 383 Q04491 anti tag coimmunoprecipitation 20508643 association C 362 Q04491 tandem affinity purification 16429126 association C 46 Q04491 tandem affinity purification 16429126 association C 10 Q04491 pull down 23217712 association C 317 Q04491 anti tag coimmunoprecipitation 11805837 association C 4 Q04491 inferred by author 16429126 physical association C 16 Q04491 tandem affinity purification 16429126 association C 11 Q04491 tandem affinity purification 11805826 association C 15 Q04491 tandem affinity purification 16429126 association C 14 Q04491 inferred by author 16554755 association C 3 Q04491 tandem affinity purification 11805826 association C 9 Q04491 tandem affinity purification 11805826 association C 9 Q04491 affinity chromatography technology 25073740 association C 5 Q04491 affinity chromatography technology 25073740 association C 5 Q04491 tandem affinity purification 16429126 association C 21 Q04491 tandem affinity purification 16429126 association C 44 Q04491 affinity chromatography technology 25073740 association C 9 Q04491 tandem affinity purification 16429126 association C 13 Q04491 affinity chromatography technology 25073740 association C 36 Q04491 tandem affinity purification 16429126 association C 7 Q04491 Q04491 molecular sieving 18160040 physical association Y 1 Q04491 Q04359 two hybrid 18719252 physical association X 2 Q04491 P33416 tandem affinity purification 19536198 association X 2 P40318 Q04491 protein array 16606443 direct interaction X 2 Q04491 inferred by author 16429126 physical association C 13 Q04491 anti tag coimmunoprecipitation 11805837 association C 6 Q04491 affinity chromatography technology 25073740 association C 7 Q04491 tandem affinity purification 18046452 association C 8 Q04491 tandem affinity purification 11805826 association C 11 Q04491 tandem affinity purification 16429126 association C 8 Q04491 affinity chromatography technology 25073740 association C 24 Q04491 affinity chromatography technology 25073740 association C 27 Q04491 anti tag coimmunoprecipitation 20489023 association C 8 Q04491 affinity chromatography technology 25073740 association C 5 Q04491 affinity chromatography technology 25073740 association C 10 Q04491 tandem affinity purification 11805826 association C 6 Q04491 tandem affinity purification 16429126 association C 28 Q04491 affinity chromatography technology 25073740 association C 24 Q04491 tandem affinity purification 11805826 association C 9 Q04491 tandem affinity purification 16429126 association C 28 Q04491 tandem affinity purification 16429126 association C 14 Q04491 affinity chromatography technology 25073740 association C 8 Q04491 affinity chromatography technology 25073740 association C 8 Q04491 cross-linking study 25073740 physical association C 8 Q04491 cosedimentation through density gradient 25073740 physical association C 8 Q04491 affinity chromatography technology 25073740 association C 8 Q12055 Q04491 two hybrid fragment pooling approach 11283351 physical association X 2 Q04491 Q03897 two hybrid 10688190 physical association X 2 Q04491 P25657 two hybrid fragment pooling approach 11283351 physical association X 2 Q04491 P38968 two hybrid fragment pooling approach 11283351 physical association X 2 Q04491 P49687 two hybrid fragment pooling approach 11283351 physical association X 2 Q04491 P30619 tandem affinity purification 16554755 physical association X 2 Q04491 P38968 tandem affinity purification 16554755 physical association X 2 Q04491 P49687 tandem affinity purification 16554755 physical association X 2 Q04491 P49687 tandem affinity purification 16554755 physical association X 2 Q04491 P38968 tandem affinity purification 16554755 physical association X 2 Q04491 P38968 tandem affinity purification 16554755 physical association X 2 Q04491 P38968 tandem affinity purification 16554755 physical association X 2 Q04491 P49687 tandem affinity purification 16554755 physical association X 2 Q04491 P49687 molecular sieving 18160040 physical association X 2 Q04491 P49687 molecular sieving 18160040 physical association X 2 Q04491 P49687 molecular sieving 18160040 physical association X 2 Q04491 P49687 molecular sieving 18160040 physical association X 2 Q04491 P38968 two hybrid 18719252 physical association X 2 Q04491 P49687 two hybrid 21784248 physical association X 2 Q04491 P38968 two hybrid 9325247 physical association X 2 Q04491 P38968 pull down 9325247 physical association X 2 P10591 Q04491 tandem affinity purification 19536198 association X 2 Q04491 confirmational text mining - - C 6 Q04491 confirmational text mining - - C 11 Q04491 mass spectrometry studies of complexes 11805837 - C 5 Q04491 mass spectrometry studies of complexes 11805837 - C 5 Q04491 mass spectrometry studies of complexes 11805826 - C 53 Q04491 P31116 interaction detection method 9409822 - X 2 Q04491 Q06631 interaction detection method 9472076 - X 2 Q04491 P42941 interaction detection method 9409822 - X 2 P16120 Q04491 interaction detection method 9409822 - X 2 Q04491 mass spectrometry studies of complexes 11805837 - C 8 Q04491 mass spectrometry studies of complexes 11805826 - C 12 Q04491 mass spectrometry studies of complexes 11805826 - C 6 Q04491 mass spectrometry studies of complexes 11805826 - C 18 Q04491 mass spectrometry studies of complexes 11805826 - C 18 Q12055 Q04491 two hybrid 11283351 - X 2 Q04491 P34239 interaction detection method 9409822 - X 2 Q04491 P25657 two hybrid 11283351 - X 2 Q04491 P38968 two hybrid 11283351 - X 2 Q04491 P49687 two hybrid 11283351 - X 2 Q04491 P25657 two hybrid 10655498 - X 2 Q04491 P38968 two hybrid 7724544,7760818,8223424,9325247 - X 2 Q04491 P38968 affinity chromatography technology 8223424 - X 2 Q04491 Q03897 two hybrid 10688190 - X 2 Q04491 P53237 interaction detection method 9409822 - X 2 P41318 Q04491 interaction detection method 9409822 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SEC23 SEC13 10720463 0401 LC P25657 SEC13 11283351,11283351,10655498,11283351 0018,0399,0018,0398 HT,LC NUP120 SEC13 25745173 0114 LC SEC31 SEC13 8223424,9325247,17604721,24062940,11283351,7724544,11283351,8223424,20696705,18719252,9325247,11283351,9325247,8223424,7760818,20696705 0018,0004,0114,0114,0398,0018,0399,0004,0114,0018,0096,0018,0018,0401,0018,0096 LC,HT SSB2 SEC13 23332755 0401 LC SSM4 SEC13 16606443 0089 HT NUP85 SEC13 19111661 0401 LC IML1 SEC13 25073740,25073740,25073740 0004,0029,0030 LC SEC16 SEC13 20696705 0114 LC NUP145 SEC13 19576787,18160040,19855394,19805193,19805193,27194810,11283351,19805193,11283351,21784248,18160040,25745173,11283351 0071,0071,0114,0071,0028,0397,0398,0096,0399,0018,0401,0114,0018 LC,HT NUP84 SEC13 19855394,8565072,12543930,8565072 0114,0401,0401,0004 LC MTC5 SEC13 10688190,10688190 0397,0018 HT SPO20 SEC13 18719252 0018 HT SEC13 SEC13 18160040,8223424,18160040 0096,0401,0071 LC SEC13 FAP7 11283351,11283351,11283351 0018,0399,0398 HT ADH1 SEC13 18046405 0004 LC YPT1 SEC13 23904270 0004 LC HSP82 SEC13 26217697 0004 LC TEF1|TEF2 SEC13 18046405 0004 LC ARG3 SEC13 11805837 0007 HT RHO1 SEC13 23904270 0004 LC SEC4 SEC13 23904270 0004 LC UBI4 SEC13 22213798 0004 LC SSA1 SEC13 19536198,23217712 0676,0096 HT,LC SSA2 SEC13 16429126 0676 HT SSB1 SEC13 16429126 0676 HT PMR1 SEC13 23904270 0004 LC SEC23 SEC13 23904270,10720463,16429126,8004676,17200106,16429126,18046405 0004,0401,0676,0096,0004,0004,0004 LC,HT HSP26 SEC13 11805837 0007 HT SAR1 SEC13 23904270 0004 LC VPS1 SEC13 23904270 0004 LC MCK1 SEC13 20489023,20489023 0007,0004 HT SEC22 SEC13 23904270 0004 LC BET1 SEC13 23904270,9685263 0004,0096 LC YCK1 SEC13 23904270 0004 LC CDC48 SEC13 23904270 0004 LC SPB4 SEC13 21825077 0004 LC SEC1 SEC13 16554755,16554755,16554755 0363,0676,0004 HT SEC21 SEC13 23904270 0004 LC PEP1 SEC13 23904270 0004 LC NAB2 SEC13 19840948 0004 LC CYS4 SEC13 16429126 0363 HT BRR2 SEC13 16429126 0676 HT EMP24 SEC13 11560939,11560939,23904270 0096,0004,0004 LC PEP12 SEC13 23904270 0004 LC SSO1 SEC13 23904270 0004 LC VPS17 SEC13 23904270 0004 LC YPT7 SEC13 23904270 0004 LC HSP78 SEC13 19536198 0676 HT SAS3 SEC13 23904270 0004 LC COY1 SEC13 23904270 0004 LC NUP120 SEC13 16429126,15741174,11805826,19576787,8565072,11805826,17200106,11805826,16429126,18046405 0676,0004,0004,0096,0004,0676,0004,0007,0004,0004 HT,LC CSE4 SEC13 21070971 0004 LC VPS21 SEC13 23904270 0004 LC YPT52 SEC13 23904270 0004 LC DID4 SEC13 23904270 0004 LC NUP133 SEC13 25139911,11805837,15741174,11805837,18046405 0004,0004,0004,0007,0004 LC,HT TVP38 SEC13 23904270 0004 LC STV1 SEC13 23904270 0004 LC SEA4 SEC13 25073740,21454883 0004,0004 LC SFT2 SEC13 23904270 0004 LC YPT31 SEC13 23904270 0004 LC FKS1 SEC13 23904270 0004 LC EFM1 SEC13 11805837,11805837 0004,0007 HT GOS1 SEC13 23904270 0004 LC SVP26 SEC13 23904270 0004 LC SEC31 SEC13 21454883,8223424,9325247,8565072,17200106,18046405,22940862,11210564,11805837,16554755,22300850,16429126,8223424,11805826,12671686,11805837,20696705,9325247,16554755,23904270,16429126,9325247,8223424,11805826,11535824,16554755,20696705,11805826 0004,0018,0004,0004,0004,0004,0004,0096,0004,0363,0096,0676,0004,0004,0004,0007,0114,0096,0004,0004,0004,0018,0401,0676,0096,0676,0096,0007 LC,HT AKR1 SEC13 23904270 0004 LC ERV46 SEC13 23904270 0004 LC NPR2 SEC13 25073740 0004 LC SNF7 SEC13 23904270 0004 LC SSP120 SEC13 23904270 0004 LC NUP157 SEC13 15741174,18046405 0096,0004 LC SSB2 SEC13 23332755 0401 LC MLP2 SEC13 24500206,24152732 0004,0004 LC SEC24 SEC13 16429126,16429126,23904270,18046405 0676,0004,0004,0004 HT,LC NEO1 SEC13 23904270 0004 LC OST1 SEC13 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT EMP47 SEC13 23904270 0004 LC RPN11 SEC13 20170199 0004 LC SFT1 SEC13 23904270 0004 LC NUP85 SEC13 19111661,19503077,10747086,15741174,16429126,11805826,8565072,11805826,17200106,11805826,16429126,18046405 0401,0676,0004,0004,0676,0004,0004,0676,0004,0007,0004,0004 LC,HT SAC3 SEC13 17922018 0004 LC ATG27 SEC13 23904270 0004 LC ENT3 SEC13 25512335 0096 LC IML1 SEC13 25073740,25073740,21454883,25073740 0004,0029,0004,0030 LC SEC16 SEC13 16429126,23904270,16429126,11805826,22675024,11805826,17200106,11805826,12235121 0004,0004,0676,0004,0004,0676,0004,0007,0096 HT,LC NUP145 SEC13 20512149,18160040,17200106,18046405,19805193,20512149,19805193,22480613,9305650,18046452,19805193,16554755,15741174,16429126,11805826,18160040,16554755,16429126,18974315,11805826,11805826 0096,0071,0004,0004,0071,0004,0028,0096,0004,0096,0096,0676,0004,0676,0004,0401,0004,0004,0096,0676,0007 LC,HT NUP84 SEC13 18046452,16429126,10747086,15741174,8565072,11805826,12543930,8565072,11805826,15741174,18046452,19822444,17200106,11805826,16429126,18046405 0676,0004,0004,0004,0401,0004,0401,0004,0676,0096,0004,0004,0004,0007,0676,0004 LC,HT SEH1 SEC13 11805837,10747086,21454883,15741174,16429126,11805826,11805837,8565072,11805826,17200106,11805826,16429126,18046405 0004,0004,0004,0004,0676,0004,0007,0004,0676,0004,0007,0004,0004 HT,LC YIP1 SEC13 23904270 0004 LC PRM8 SEC13 23904270 0004 LC PIL1 SEC13 23904270 0004 LC YIP3 SEC13 23904270 0004 LC BRE5 SEC13 20508643,20508643 0007,0004 LC UBP10 SEC13 22902402 0004 LC SFB2 SEC13 23904270 0004 LC ERV25 SEC13 11560939,11560939,23904270 0096,0004,0004 LC DID2 SEC13 23904270 0004 LC UBP3 SEC13 20508643,20508643 0007,0004 LC MLP1 SEC13 24152732 0004 LC NUP116 SEC13 12543930 0004 LC SHR3 SEC13 10564255 0004 LC ERO1 SEC13 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT TLG1 SEC13 23904270 0004 LC RCR2 SEC13 23904270 0004 LC MTC5 SEC13 25073740,21454883 0004,0004 LC VTI1 SEC13 23904270 0004 LC SEC13 SEC13 23904270,18160040,8223424,11805826,18160040,11805826 0004,0096,0401,0676,0071,0007 LC,HT SEC13 ERV41 23904270 0004 LC SEC13 ERP1 23904270 0004 LC SEC13 YTH1 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT SEC13 RTC1 25073740,21454883 0004,0004 LC SEC13 ESA1 23572591 0004 LC SEC13 ATG9 23904270 0004 LC SEC13 GIN4 21460040 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12142 Q04491 ATG9 SEC13 0.126 23904270 Q12055 Q04491 FAP7 SEC13 0.236 11283351 Q05359 Q04491 ERP1 SEC13 0.126 23904270 Q04491 P00330 SEC13 ADH1 0.126 18046405 Q04491 P39727 SEC13 ERV46 0.126 23904270 Q04491 P25694 SEC13 CDC48 0.126 23904270 Q04491 P11484 SEC13 SSB1 0.126 16429126 Q04491 P05150 SEC13 ARG3 0.126 11805837 Q04491 P01123 SEC13 YPT1 0.126 23904270 Q04491 P02994 SEC13 TEF2 0.126 18046405 Q04491 P10592 SEC13 SSA2 0.126 16429126 Q04491 P06780 SEC13 RHO1 0.126 23904270 Q04491 P07560 SEC13 SEC4 0.126 23904270 Q04491 P23291 SEC13 YCK1 0.126 23904270 Q04491 P22804 SEC13 BET1 0.126 23904270 Q04491 P13586 SEC13 PMR1 0.126 23904270 Q04491 P20606 SEC13 SAR1 0.126 23904270 Q04491 P22214 SEC13 SEC22 0.126 23904270 Q04491 P21576 SEC13 VPS1 0.126 23904270 Q04491 P21965 SEC13 MCK1 0.332 20489023 Q04491 P36018 SEC13 YPT52 0.126 23904270 Q04491 P32854 SEC13 PEP12 0.126 23904270 Q04491 P32074 SEC13 SEC21 0.126 23904270 Q04491 P32319 SEC13 PEP1 0.126 23904270 Q04491 P32803 SEC13 EMP24 0.126 23904270,11560939 Q04491 P32602 SEC13 SEC17 0.126 23904270 Q04491 P39010 SEC13 AKR1 0.126 23904270 Q04491 P32939 SEC13 YPT7 0.126 23904270 Q04491 P32867 SEC13 SSO1 0.126 23904270 Q04491 P32913 SEC13 VPS17 0.126 23904270 Q04491 P36017 SEC13 VPS21 0.126 23904270 Q04491 P33416 SEC13 HSP78 0.126 19536198 Q04491 P34237 SEC13 COY1 0.126 23904270 Q04491 P36161 SEC13 NUP133 0.21 11805837 Q04491 P36108 SEC13 DID4 0.126 23904270 Q04491 P38166 SEC13 SFT2 0.126 23904270 Q04491 P37296 SEC13 STV1 0.126 23904270 Q04491 P36164 SEC13 TVP38 0.126 23904270 Q04491 P38732 SEC13 EFM1 0.21 11805837 Q04491 P38555 SEC13 YPT31 0.126 23904270 Q04491 P38631 SEC13 FKS1 0.126 23904270 Q04491 P38869 SEC13 SVP26 0.126 23904270 Q04491 P38736 SEC13 GOS1 0.126 23904270 Q04651 Q04491 ERV41 SEC13 0.126 23904270 Q04491 P40527 SEC13 NEO1 0.126 23904270 Q04491 P54837 SEC13 ERV25 0.126 23904270,11560939 Q04491 P39929 SEC13 SNF7 0.126 23904270 Q04491 P39931 SEC13 SSP120 0.126 23904270 Q04491 P43555 SEC13 EMP47 0.126 23904270 Q04491 P43682 SEC13 SFT1 0.126 23904270 Q04491 P46989 SEC13 ATG27 0.126 23904270 Q04491 P48415 SEC13 SEC16 0.78 11805826,22675024,16429126,20696705,23904270,12235121 Q04491 P53953 SEC13 SFB2 0.126 23904270 Q04491 P53039 SEC13 YIP1 0.126 23904270 Q04491 P53633 SEC13 YIP3 0.126 23904270 Q04491 P53252 SEC13 PIL1 0.126 23904270 Q04491 P53174 SEC13 PRM8 0.126 23904270 Q04491 P69771 SEC13 DID2 0.126 23904270 Q04491 Q03103 SEC13 ERO1 0.416 11805826,16429126 Q04491 Q03446 SEC13 RCR2 0.126 23904270 Q04491 Q03322 SEC13 TLG1 0.126 23904270 Q04491 Q04338 SEC13 VTI1 0.126 23904270 Q04491 Q03897 SEC13 MTC5 0.539 10688190,25073740,21454883 Q04491 P15992 SEC13 HSP26 0.126 11805837 Q12221 Q04491 PUF2 SEC13 0.126 26668354 Q12263 Q04491 GIN4 SEC13 0.183 21460040 Q04491 P25567 SEC13 SRO9 0.126 22271760 Q04491 P25657 SEC13 P25657 0.21 11283351,10655498 Q04491 P0CG48 SEC13 UBC 0.126 23801757 Q04491 P10080 SEC13 SBP1 0.126 23222640 Q04491 P02829 SEC13 HSP82 0.126 26217697 Q04491 P10591 SEC13 SSA1 0.236 19536198,23217712 Q08281 Q04491 RTC1 SEC13 0.309 25073740,21454883 Q04491 P15303 SEC13 SEC23 0.49 10720463,16429126,18046405,23904270 Q04491 Q01477 SEC13 UBP3 0.236 20508643 Q04491 P40482 SEC13 SEC24 0.416 16429126,18046405,23904270 Q04491 P53741 SEC13 BRE5 0.236 20508643 Q04491 P38164 SEC13 SEA4 0.309 25073740,21454883 Q04491 P40064 SEC13 NUP157 0.396 18046405,15741174 Q04491 P35729 SEC13 NUP120 0.554 11805826,8565072,19576787,16429126 Q04491 P52891 SEC13 NUP84 0.826 11805826,10747086,18046452,16429126,8565072,19822444,15741174 Q04491 P53011 SEC13 SEH1 0.671 11805826,10747086,16429126,21454883,11805837,8565072,18046405 Q04491 P46673 SEC13 NUP85 0.648 11805826,8565072,19503077,16429126,19111661 Q04491 P47170 SEC13 IML1 0.472 25073740,21454883 Q04491 Q04491 SEC13 SEC13 0.692 11805826,8223424,23904270,18160040 Q04491 P49687 SEC13 NUP145 0.994 18974315,19855394,27194810,21784248,22480613,16554755,19805193,18160040,20512149,11805826,19576787,16429126,11283351 Q04491 P38968 SEC13 SEC31 0.983 17604721,8223424,16554755,11805837,9325247,22300850,8565072,20696705,18046405,18719252,21454883,11805826,16429126,23904270,11283351 Q04491 P25808 SEC13 SPB4 0.126 21825077 Q04491 P30619 SEC13 SEC1 0.332 16554755 Q04491 P32505 SEC13 NAB2 0.126 19840948 Q04491 P32582 SEC13 CYS4 0.126 16429126 Q04491 P32639 SEC13 BRR2 0.126 16429126 Q04491 P39923 SEC13 NPR2 0.126 25073740 Q04491 P40150 SEC13 SSB2 0.126 23332755 Q04491 P36012 SEC13 CSE4 0.126 21070971 Q04491 P40318 SEC13 SSM4 0.332 16606443 Q04491 P43588 SEC13 RPN11 0.126 20170199 Q04491 P40457 SEC13 MLP2 0.126 24152732 Q04491 P46674 SEC13 SAC3 0.126 17922018 Q04491 P47160 SEC13 ENT3 0.183 25512335 Q04491 P41543 SEC13 OST1 0.286 11805826,16429126 Q04491 Q02455 SEC13 MLP1 0.126 24152732 Q06102 Q04491 YTH1 SEC13 0.286 11805826,16429126 Q04491 Q02630 SEC13 NUP116 0.126 12543930 Q04491 P53874 SEC13 UBP10 0.126 22902402 Q08649 Q04491 ESA1 SEC13 0.126 23572591 Q04491 Q04359 SEC13 SPO20 0.332 18719252