PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSB1 F-box protein YLR224W 19536198 intact exp F-box protein YLR224W F-box protein YLR224W 14747994 biogrid exp F-box protein YLR224W CDC53 14747994 biogrid exp ENO2 F-box protein YLR224W 26297823 biogrid,intact exp NAB2 F-box protein YLR224W 19840948 biogrid exp SRO9 F-box protein YLR224W 22271760 biogrid exp F-box protein YLR224W SGT1 11283351, 23023127 i2d,mint,intact,dip exp, pred F-box protein YLR224W HRT1 19882662,14747994, 23023127 biogrid,intact exp, pred SKP1 F-box protein YLR224W 17141224,10688190,14747994, 23023127 biogrid,i2d,mint,intact,dip exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P52286 Q05947 - 10688190 - X 2 Q08446 Q05947 - 11283351 - X 2 Q08273 Q05947 pull down 14747994 direct interaction X 2 P0CG63 Q05947 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q05947 biochemical 23583075 association X 2 P52286 Q05947 pull down 14747994 direct interaction X 2 P52286 Q05947 two hybrid 10688190 direct interaction X 2 Q05947 Q12018 pull down 14747994 direct interaction X 2 Q05947 Q05947 enzymatic study 14747994 direct interaction X 2 P52286 Q05947 affinity chromatography technology 14747994 physical association X 2 P52286 Q05947 two hybrid 10688190 physical association X 2 Q05947 affinity chromatography technology 14747994 - C 4 Q08446 Q05947 two hybrid pooling approach 11283351 physical association X 2 Q05947 pull down 19882662 association C 41 P52286 Q05947 two hybrid 10688190 physical association X 2 P52286 Q05947 anti tag coimmunoprecipitation 17141224 physical association X 2 Q08446 Q05947 two hybrid fragment pooling approach 11283351 physical association X 2 Q05947 P11484 tandem affinity purification 19536198 association X 2 P52286 Q05947 two hybrid 10688190 - X 2 Q08446 Q05947 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality ENO2 Q05947 26297823,26297823,26297823 0007,0018,0004 LC SKP1 Q05947 10688190,10688190 0397,0018 HT Q05947 Q05947 14747994 0415 LC Q05947 SGT1 11283351,11283351,11283351 0018,0399,0398 HT ENO2 Q05947 26297823,26297823,26297823 0007,0018,0004 LC SSB1 Q05947 19536198 0676 HT NAB2 Q05947 19840948 0004 LC SKP1 Q05947 14747994,14747994,17141224 0096,0004,0007 LC Q05947 HRT1 19882662,14747994 0096,0096 LC Q05947 CDC53 14747994 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12018 Q05947 CDC53 Q05947 0.309 14747994 Q12221 Q05947 PUF2 Q05947 0.126 26668354 Q05947 P49760 Q05947 CLK2 0.332 27107014 Q05947 Q05947 Q05947 Q05947 0.332 14747994 Q05947 P11484 Q05947 SSB1 0.126 19536198 Q05947 P00925 Q05947 ENO2 0.569 26297823 Q05947 P52286 Q05947 SKP1 0.472 17141224,10688190,14747994 Q05947 P25567 Q05947 SRO9 0.126 22271760 Q05947 P32505 Q05947 NAB2 0.126 19840948 Q08273 Q05947 HRT1 Q05947 0.236 19882662 Q08446 Q05947 SGT1 Q05947 0.21 11283351