PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus IMP2 MDM30 10688190,15150670 i2d,mint,intact,dip exp TRR2 MDM30 10688190 biogrid,i2d,mint,intact,dip exp MDM30 ASR1 10688190 biogrid,i2d,mint,intact,dip exp MDM30 PUF3 26493364 biogrid exp GAL80 MDM30 22479149 biogrid,dip exp CSM3 MDM30 10688190 biogrid,i2d,mint,intact,dip exp PPE1 MDM30 10688190 biogrid,i2d,mint,intact,dip exp SSA1 MDM30 19536198 intact exp MDM34 MDM30 18775025 biogrid exp KIC1 MDM30 20489023, 23023127 biogrid,mint,intact exp, pred FZO1 MDM30 24389104,21385840,21502136,16735578,19812251, 23023127 biogrid exp, pred UBX6 MDM30 10688190, 23023127 biogrid,i2d,mint,intact,dip exp, pred Uncharacterized protein YJR011C MDM30 18719252, 23023127 biogrid,intact exp, pred MDM30 HRT1 14747994, 23023127 biogrid exp, pred MDM30 CDC53 18353967,10688190,14747994, 23023127 biogrid,i2d,mint,intact,dip exp, pred SKP1 MDM30 10688190,23000173,19882662,14747994,20581845,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred MDM30 Uncharacterized protein YPR078C 10688190, 23023127 biogrid,i2d,mint,intact,dip exp, pred RAD1 MDM30 11805837, 23023127 biogrid,intact,dip exp, pred CAF4 MDM30 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38816 Q05930 - 10688190 - X 2 P46972 Q05930 - 10688190 - X 2 P52286 Q05930 - 10688190 - X 2 Q05930 Q12018 - 10688190 - X 2 Q05930 Q06813 - 10688190 - X 2 Q05930 Q06834 - 10688190 - X 2 Q05930 - 11805837 - C 17 P47049 Q05930 - 10688190 - X 2 Q04659 Q05930 - 10688190 - X 2 P38796 Q05930 - 10688190 - X 2 P06777 Q05930 affinity chromatography technology 11805837 physical association X 2 P38816 Q05930 two hybrid 10688190 direct interaction X 2 P38297 Q05930 affinity chromatography technology 19812251 physical association X 2 P38297 Q05930 affinity chromatography technology 24389104 physical association X 2 P38297 Q05930 affinity chromatography technology 16735578 physical association X 2 P38297 Q05930 affinity chromatography technology 21385840 physical association X 2 P38297 Q05930 affinity chromatography technology 21502136 physical association X 2 P52286 Q05930 pull down 23000173 direct interaction X 2 P52286 Q05930 pull down 14747994 direct interaction X 2 P52286 Q05930 two hybrid 18719252 direct interaction X 2 P52286 Q05930 affinity chromatography technology 20581845 physical association X 2 P52286 Q05930 two hybrid 10688190 direct interaction X 2 Q05930 Q12018 pull down 14747994 direct interaction X 2 Q05930 P53083 two hybrid 18775025 direct interaction X 2 Q05930 Q12018 affinity chromatography technology 18353967 physical association X 2 Q05930 Q12018 two hybrid 10688190 direct interaction X 2 Q05930 Q06813 two hybrid 10688190 direct interaction X 2 Q05930 Q06834 two hybrid 10688190 direct interaction X 2 Q08273 Q05930 pull down 14747994 direct interaction X 2 P38692 Q05930 affinity chromatography technology 20489023 physical association X 2 P47049 Q05930 two hybrid 10688190 direct interaction X 2 Q04659 Q05930 two hybrid 10688190 direct interaction X 2 P47086 Q05930 two hybrid 18719252 direct interaction X 2 P04387 Q05930 affinity chromatography technology 22479149 physical association X 2 P38796 Q05930 two hybrid 10688190 direct interaction X 2 Q05930 anti tag coimmunoprecipitation 11805837 - C 28 P06777 Q05930 anti tag coimmunoprecipitation 11805837 physical association X 2 P38816 Q05930 two hybrid 10688190 physical association X 2 P46972 Q05930 two hybrid 10688190 physical association X 2 P52286 Q05930 two hybrid 10688190 physical association X 2 P52286 Q05930 affinity chromatography technology 14747994 physical association X 2 Q05930 Q06834 two hybrid 10688190 physical association X 2 Q05930 Q12018 two hybrid 10688190 physical association X 2 Q05930 Q12018 two hybrid 10688190 physical association X 2 Q05930 Q12018 two hybrid 10688190 physical association X 2 Q05930 Q06813 two hybrid 10688190 physical association X 2 Q05930 anti tag coimmunoprecipitation 11805837 - C 19 Q05930 affinity chromatography technology 14747994 - C 4 P47049 Q05930 two hybrid 10688190 physical association X 2 Q04659 Q05930 two hybrid 10688190 physical association X 2 P04387 Q05930 pull down 22479149 physical association X 2 P38796 Q05930 two hybrid 10688190 physical association X 2 Q05930 anti tag coimmunoprecipitation 11805837 association C 17 P38816 Q05930 two hybrid 10688190 physical association X 2 P46972 Q05930 two hybrid 10688190 physical association X 2 P46972 Q05930 anti tag coimmunoprecipitation 15150670 physical association X 2 P10591 Q05930 tandem affinity purification 19536198 association X 2 P52286 Q05930 two hybrid 10688190 physical association X 2 P52286 Q05930 two hybrid 18719252 physical association X 2 Q05930 Q12018 two hybrid 10688190 physical association X 2 Q05930 Q06813 two hybrid 10688190 physical association X 2 Q05930 Q06834 two hybrid 10688190 physical association X 2 Q05930 Q12018 two hybrid 10688190 physical association X 2 Q05930 pull down 19882662 association C 51 Q05930 anti tag coimmunoprecipitation 20489023 association C 3 P47049 Q05930 two hybrid 10688190 physical association X 2 Q04659 Q05930 two hybrid 10688190 physical association X 2 P47086 Q05930 two hybrid 18719252 physical association X 2 P38796 Q05930 two hybrid 10688190 physical association X 2 P38816 Q05930 two hybrid 10688190 - X 2 P46972 Q05930 two hybrid 10688190 - X 2 P52286 Q05930 two hybrid 10688190 - X 2 Q05930 Q06813 two hybrid 10688190 - X 2 Q05930 Q06834 two hybrid 10688190 - X 2 Q05930 P19524 interaction detection method 14764870 - X 2 Q05930 Q12018 two hybrid 10688190 - X 2 Q05930 mass spectrometry studies of complexes 11805837 - C 20 P47049 Q05930 two hybrid 10688190 - X 2 Q04659 Q05930 two hybrid 10688190 - X 2 P38796 Q05930 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PPE1 MDM30 10688190,10688190 0397,0018 HT TRR2 MDM30 10688190,10688190 0397,0018 HT IMP2 MDM30 10688190,10688190 0397,0018 HT UBX6 MDM30 10688190,10688190 0397,0018 HT P47086 MDM30 18719252 0018 HT SKP1 MDM30 18719252,10688190,10688190 0018,0397,0018 HT MDM34 MDM30 18775025 0018 LC CSM3 MDM30 10688190,10688190 0397,0018 HT MDM30 Q06813 10688190,10688190 0397,0018 HT MDM30 ASR1 10688190,10688190 0397,0018 HT MDM30 CDC53 10688190,10688190 0397,0018 HT GAL80 MDM30 22479149,22479149 0096,0004 LC RAD1 MDM30 11805837,11805837 0004,0007 HT SSA1 MDM30 19536198 0676 HT FZO1 MDM30 21385840,21502136,19812251,16735578,24389104 0004,0004,0004,0004,0004 LC KIC1 MDM30 20489023,20489023 0007,0004 HT IMP2 MDM30 15150670 0007 LC SKP1 MDM30 14747994,19882662,20581845,14747994,23000173 0004,0096,0004,0096,0096 LC MDM30 HRT1 14747994 0096 LC MDM30 CDC53 18353967,14747994 0004,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12018 Q05930 CDC53 MDM30 0.623 10688190,18353967,14747994 Q05930 P04387 MDM30 GAL80 0.21 22479149 Q05930 P06777 MDM30 RAD1 0.21 11805837 Q05930 P47086 MDM30 P47086 0.332 18719252 Q05930 P52286 MDM30 SKP1 0.826 10688190,23000173,18719252,20581845,19882662,14747994 Q05930 P38692 MDM30 KIC1 0.286 20489023 Q05930 P38796 MDM30 PPE1 0.332 10688190 Q05930 P38816 MDM30 TRR2 0.332 10688190 Q05930 P46972 MDM30 IMP2 0.183 10688190 Q05930 P47049 MDM30 UBX6 0.332 10688190 Q06813 Q05930 Q06813 MDM30 0.332 10688190 Q06834 Q05930 ASR1 MDM30 0.332 10688190 Q05930 P38297 MDM30 FZO1 0.692 21385840,21502136,16735578,19812251,24389104 Q05930 P10591 MDM30 SSA1 0.126 19536198 Q05930 Q04659 MDM30 CSM3 0.332 10688190 Q05930 P53083 MDM30 MDM34 0.309 18775025