PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SIC1 VPS36 i2d exp SNF7 VPS36 23063125 intact exp SIS1 VPS36 19536198 intact exp SSA2 VPS36 19536198 intact exp UBI4 VPS36 19380877 biogrid exp SSB1 VPS36 19536198 intact exp ADH7 VPS36 16554755 intact exp DID4 VPS36 23063125 intact exp VPS36 VPS36 22940862 biogrid exp, ortho VPS36 SNF8 15086794,15469844,23063125,11283351,16371348,16554755,10688190,15329733, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred HSP82 VPS36 19536198,15766533, 23023127 biogrid,i2d,intact exp, pred STP22 VPS36 17145965, 23023127 biogrid exp, pred VPS36 SRN2 15086794, 23023127 biogrid exp, pred VPS25 VPS36 15086794,15469844,23063125,11283351,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred VPS20 VPS36 15086794,11283351,16371348,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred SST2 VPS36 11940600, 23023127 biogrid,i2d,dip exp, pred VPS28 VPS36 15086794,17215868,16615894,16615893, 23023127 biogrid,mint,intact exp, pred VPS36 MEX67 ortho CMP2 VPS36 ortho VPS35 VPS36 ortho ATG7 VPS36 ortho VPS36 YTM1 ortho CNS1 VPS36 ortho SWD1 VPS36 ortho UFD2 VPS36 ortho GCD14 VPS36 ortho VPS27 VPS36 23023127 pred GGA1 VPS36 23023127 pred UBX6 VPS36 23023127 pred PEP8 VPS36 23023127 pred PRB1 VPS36 23023127 pred VPS36 VPS5 23023127 pred ATG8 VPS36 23023127 pred DOA4 VPS36 23023127 pred SEC63 VPS36 23023127 pred VPS4 VPS36 23023127 pred IST1 VPS36 23023127 pred MIG1 VPS36 23023127 pred RPN7 VPS36 23023127 pred TUL1 VPS36 23023127 pred UBI4 VPS36 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06696 Q12483 - 11283351 - X 2 Q06696 Q12483 - 15086794 - X 2 Q06696 P11972 - 11940600 - X 2 Q06696 Q12483 - 10688190 - X 2 Q06696 Q12483 - 15329733,15469844 - X 2 Q06696 Q12483 - 15329733 - X 2 Q06696 P47142 - 11283351 - X 2 Q06696 P47142 - 15086794 - X 2 Q06696 P47142 - 15329733 - X 2 Q06696 P47142 - 15329733 - X 2 Q06696 Q04272 - 11283351 - X 2 Q06696 Q04272 - 15086794 - X 2 Q06696 P02829 - 15766533 - X 2 Q06696 P47142 - 15329733,15469844 - X 2 Q06696 P47142 - 15329733,15469844 - X 2 Q06696 P11972 two hybrid 11940600 direct interaction X 2 Q06696 Q12483 two hybrid 15086794 direct interaction X 2 Q06696 Q12483 two hybrid 15086794 direct interaction X 2 Q06696 Q99176 two hybrid 15086794 direct interaction X 2 Q06696 Q12483 x-ray crystallography 15469844 association X 2 Q06696 Q12483 affinity chromatography technology 16554755 physical association X 2 Q06696 Q12483 affinity chromatography technology 17200106 physical association X 2 Q06696 Q12483 two hybrid 11283351 direct interaction X 2 Q06696 Q12483 two hybrid 16371348 direct interaction X 2 Q06696 Q12483 two hybrid 16371348 direct interaction X 2 Q06696 Q12483 x-ray crystallography 15329733 association X 2 Q06696 Q12483 two hybrid 10688190 direct interaction X 2 P0CG63 Q06696 pull down 19380877 direct interaction X 2 P0CG63 Q06696 affinity chromatography technology 22493318 physical association X 2 Q06696 Q06696 affinity chromatography technology 22940862 physical association X 2 Q06696 Q04272 two hybrid 15086794 direct interaction X 2 Q06696 Q04272 two hybrid 15086794 direct interaction X 2 Q06696 P47142 two hybrid 15086794 direct interaction X 2 Q06696 Q02767 two hybrid 15086794 direct interaction X 2 Q06696 Q02767 two hybrid 15086794 direct interaction X 2 Q06696 P47142 x-ray crystallography 15469844 association X 2 Q06696 P02829 two hybrid 15766533 direct interaction X 2 Q06696 P0CG48 pull down 15029239 direct interaction X 2 Q06696 Q02767 x-ray crystallography 17215868 association X 2 Q06696 Q02767 pull down 16615893 direct interaction X 2 Q06696 Q02767 biochemical 16615893 association X 2 Q06696 Q02767 affinity chromatography technology 16615894 physical association X 2 Q06696 P47142 two hybrid 11283351 direct interaction X 2 Q06696 Q04272 two hybrid 11283351 direct interaction X 2 Q06696 P25604 affinity chromatography technology 17145965 physical association X 2 Q06696 P47142 two hybrid 18719252 direct interaction X 2 Q06696 Q04272 two hybrid 18719252 direct interaction X 2 Q06696 Q04272 two hybrid 16371348 direct interaction X 2 Q06696 A0A024R1X3 two hybrid 16371348 direct interaction X 2 Q06696 Q04272 two hybrid 16371348 direct interaction X 2 Q06696 A0A024R1X3 two hybrid 16371348 direct interaction X 2 Q06696 Q96H20 two hybrid 16371348 direct interaction X 2 Q06696 P11972 two hybrid 11940600 physical association X 2 Q06696 Q12483 fluorescent resonance energy transfer 22579254 direct interaction X 2 Q06696 Q12483 pull down 22579254 direct interaction X 2 Q06696 Q12483 pull down 20305637 direct interaction X 2 Q06696 Q12483 fluorescent resonance energy transfer 22579254 direct interaction X 2 Q06696 Q12483 two hybrid pooling approach 11283351 direct interaction X 2 Q06696 Q12483 two hybrid 10688190 direct interaction X 2 Q06696 x ray scattering 22579254 physical association C 3 Q06696 molecular sieving 22579254 physical association C 3 Q06696 pull down 22579254 physical association C 3 Q06696 molecular sieving 20305637 physical association C 5 Q06696 pull down 20305637 physical association C 5 Q06696 x ray scattering 22579254 physical association C 7 Q06696 Q04272 two hybrid pooling approach 11283351 physical association X 2 Q06696 P47142 pull down 22579254 physical association X 2 Q06696 P47142 two hybrid pooling approach 11283351 physical association X 2 Q06696 B7UI22 methyltransferase assay 22158122 direct interaction X 2 Q06696 Q12483 two hybrid 10688190 physical association X 2 Q06696 Q12483 two hybrid fragment pooling approach 11283351 physical association X 2 Q06696 Q12483 tandem affinity purification 16554755 physical association X 2 Q06696 Q12483 tandem affinity purification 16554755 physical association X 2 Q06696 P25294 tandem affinity purification 19536198 association X 2 Q06696 P10592 tandem affinity purification 19536198 association X 2 Q06696 P62984 pull down 19927120 direct interaction X 2 Q06696 P62984 pull down 19927120 direct interaction X 2 Q06696 x-ray crystallography 15329733 physical association C 3 Q06696 x-ray crystallography 15469844 physical association C 3 Q06696 pull down 23063125 association C 3 Q06696 electron microscopy 23063125 physical association C 5 Q06696 electron microscopy 23063125 physical association C 4 Q06696 inferred by author 16554755 association C 6 Q06696 electron microscopy 23063125 physical association C 7 Q06696 Q04272 two hybrid fragment pooling approach 11283351 physical association X 2 Q06696 P47142 two hybrid fragment pooling approach 11283351 physical association X 2 Q06696 P02829 two hybrid array 15766533 physical association X 2 Q06696 Q02767 fluorescence technology 17215868 direct interaction X 2 Q06696 Q02767 fluorescence technology 17215868 direct interaction X 2 Q06696 Q02767 x-ray crystallography 17215868 direct interaction X 2 Q06696 Q02767 fluorescence technology 17215868 direct interaction X 2 Q06696 Q02767 fluorescence technology 17215868 direct interaction X 2 Q06696 Q02767 fluorescence technology 17215868 direct interaction X 2 Q06696 Q04272 two hybrid 18719252 physical association X 2 Q06696 P47142 two hybrid 18719252 physical association X 2 Q06696 P11484 tandem affinity purification 19536198 association X 2 Q06696 P02829 tandem affinity purification 19536198 association X 2 Q06696 Q12483 two hybrid 10688190 - X 2 Q06696 Q12483 two hybrid 11283351 - X 2 Q06696 P11972 two hybrid 11940600 - X 2 Q06696 P47142 two hybrid 11283351 - X 2 Q06696 Q04272 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality HSP82 VPS36 15766533,15766533 0397,0018 LC SST2 VPS36 11940600 0018 LC DID4 VPS36 23063125 0040 LC SNF7 VPS36 23063125 0040 LC VPS25 VPS36 15086794,18719252,15469844,11283351,11283351,11283351,15329733 0018,0018,0114,0018,0399,0398,0114 LC,HT VPS28 VPS36 15086794,16615893,16615893,17215868,17215868 0018,0401,0096,0051,0114 LC VPS20 VPS36 15086794,18719252,16371348,11283351,11283351,11283351 0018,0018,0018,0018,0399,0398 LC,HT VPS36 VPS36 16615893 0114 LC VPS36 SNF8 15086794,16371348,15469844,11283351,11283351,11283351,22579254,22579254,15329733,10688190,10688190 0018,0018,0114,0018,0399,0398,0055,0096,0114,0397,0018 LC,HT VPS36 SRN2 15086794 0018 LC HSP82 VPS36 19536198 0676 HT UBI4 VPS36 19380877,19380877,22493318 0096,0004,0004 LC SSA2 VPS36 19536198 0676 HT SSB1 VPS36 19536198 0676 HT SIS1 VPS36 19536198 0676 HT ADH7 VPS36 16554755 0363 HT STP22 VPS36 17145965 0004 LC VPS25 VPS36 23063125,22579254 0096,0096 LC VPS28 VPS36 16615893,16615893,16615894 0401,0096,0004 LC VPS36 VPS36 22940862 0004 HT VPS36 SNF8 16554755,23063125,22579254,22579254,20305637,17200106,16554755 0676,0096,0055,0096,0096,0004,0004 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q06696 P25377 VPS36 ADH7 0.126 16554755 Q06696 P11972 VPS36 SST2 0.309 11940600 Q12483 Q06696 SNF8 VPS36 0.946 10688190,15329733,16554755,11283351,16371348,23063125,15469844 Q96H20 Q06696 SNF8 VPS36 0.309 16371348 Q9BRG1 Q06696 VPS25 VPS36 0.523 16371348 Q06696 P36108 VPS36 DID4 0.21 23063125 Q06696 P39929 VPS36 SNF7 0.21 23063125 Q06696 P47142 VPS36 VPS25 0.74 23063125,18719252,15469844,11283351 Q06696 P62991 VPS36 UBA52 0.523 19927120 Q06696 P02829 VPS36 HSP82 0.376 15766533,19536198 Q06696 P0CG48 VPS36 UBC 0.309 15029239 Q06696 P0CG63 VPS36 UBI4 0.309 19380877 Q06696 P10592 VPS36 SSA2 0.126 19536198 Q06696 P11484 VPS36 SSB1 0.126 19536198 Q06696 P25294 VPS36 SIS1 0.126 19536198 Q06696 Q02767 VPS36 VPS28 0.843 17215868,16615893 Q06696 Q04272 VPS36 VPS20 0.74 11283351,16371348,18719252