PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GIS2 Putative ATP-dependent RNA helicase YLR419W 21232131 biogrid exp CDC6 Putative ATP-dependent RNA helicase YLR419W 16554755 intact exp UBC9 Putative ATP-dependent RNA helicase YLR419W 23712011 biogrid exp SSA3 Putative ATP-dependent RNA helicase YLR419W 19536198 intact exp Putative ATP-dependent RNA helicase YLR419W TYW1 i2d exp Putative ATP-dependent RNA helicase YLR419W PUF3 23409723,26493364 biogrid exp EDC3 Putative ATP-dependent RNA helicase YLR419W i2d exp HSP82 Putative ATP-dependent RNA helicase YLR419W 19536198 intact exp SSB1 Putative ATP-dependent RNA helicase YLR419W 19536198 intact exp CCT4 Putative ATP-dependent RNA helicase YLR419W 19536198 intact exp SSB2 Putative ATP-dependent RNA helicase YLR419W 23332755,19536198 biogrid,intact exp GIM4 Putative ATP-dependent RNA helicase YLR419W 19536198 intact exp Putative ATP-dependent RNA helicase YLR419W VAM6 25026036 biogrid exp PAB1 Putative ATP-dependent RNA helicase YLR419W 22836166 biogrid exp UBP10 Putative ATP-dependent RNA helicase YLR419W i2d exp SPP382 Putative ATP-dependent RNA helicase YLR419W 14690591 intact exp ULP2 Putative ATP-dependent RNA helicase YLR419W 23712011 biogrid exp HEK2 Putative ATP-dependent RNA helicase YLR419W 18805955, 23023127 biogrid exp, pred UBP3 Putative ATP-dependent RNA helicase YLR419W 21179020, 23023127 intact exp, pred SPC24 Putative ATP-dependent RNA helicase YLR419W 9520439, 23023127 biogrid,i2d exp, pred HSF1 Putative ATP-dependent RNA helicase YLR419W 16554755, 23023127 biogrid,i2d,mint,intact exp, pred BRE5 Putative ATP-dependent RNA helicase YLR419W 20508643, 23023127 biogrid,intact exp, pred DBP9 Putative ATP-dependent RNA helicase YLR419W 23023127 pred DBP7 Putative ATP-dependent RNA helicase YLR419W 23023127 pred SPB4 Putative ATP-dependent RNA helicase YLR419W 23023127 pred ROK1 Putative ATP-dependent RNA helicase YLR419W 23023127 pred DBP3 Putative ATP-dependent RNA helicase YLR419W 23023127 pred HCA4 Putative ATP-dependent RNA helicase YLR419W 23023127 pred DBP8 Putative ATP-dependent RNA helicase YLR419W 23023127 pred TIF4631 Putative ATP-dependent RNA helicase YLR419W 23023127 pred HAS1 Putative ATP-dependent RNA helicase YLR419W 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04477 Q06698 - 9520439 - X 2 P53741 Q06698 affinity chromatography technology 20508643 physical association X 2 P0CG63 Q06698 affinity chromatography technology 23749301 physical association X 2 Q04477 Q06698 two hybrid 9520439 direct interaction X 2 Q06698 P50623 affinity chromatography technology 23712011 physical association X 2 Q06698 P40150 biochemical 23332755 association X 2 P04147 Q06698 affinity chromatography technology 22836166 physical association X 2 P10961 Q06698 affinity chromatography technology 16554755 physical association X 2 P40537 Q06698 affinity chromatography technology 23712011 physical association X 2 Q06698 anti tag coimmunoprecipitation 20508643 association C 362 Q06698 tandem affinity purification 21179020 association C 23 Q06698 P11484 tandem affinity purification 19536198 association X 2 Q06698 P40150 tandem affinity purification 19536198 association X 2 Q06698 inferred by author 16554755 association C 3 P10961 Q06698 tandem affinity purification 16554755 physical association X 2 Q06698 Q06411 two hybrid array 14690591 physical association X 2 Q06698 P09435 tandem affinity purification 19536198 association X 2 Q06698 P39078 tandem affinity purification 19536198 association X 2 Q06698 P02829 tandem affinity purification 19536198 association X 2 Q06698 P40005 tandem affinity purification 19536198 association X 2 Q04477 Q06698 two hybrid 9520439 - X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q06698 Q04477 Q06698 SPC24 0.309 9520439 Q06698 P09119 Q06698 CDC6 0.126 16554755 Q06698 P04147 Q06698 PAB1 0.126 22836166 Q06698 P10961 Q06698 HSF1 0.236 16554755 Q07807 Q06698 PUF3 Q06698 0.236 26493364,23409723 Q06698 P53741 Q06698 BRE5 0.236 20508643 Q06698 P40150 Q06698 SSB2 0.236 23332755,19536198 Q06698 P38199 Q06698 HEK2 0.126 18805955 Q06698 P39078 Q06698 CCT4 0.126 19536198 Q06698 P40005 Q06698 GIM4 0.126 19536198 Q06698 P40537 Q06698 ULP2 0.126 23712011 Q06698 P50623 Q06698 UBC9 0.126 23712011 Q06698 Q01477 Q06698 UBP3 0.126 21179020 Q06698 P02829 Q06698 HSP82 0.126 19536198 Q06698 P09435 Q06698 SSA3 0.126 19536198 Q06698 P11484 Q06698 SSB1 0.126 19536198 Q06698 Q06411 Q06698 SPP382 0.126 14690591 Q07468 Q06698 VAM6 Q06698 0.126 25026036 Q06698 P53849 Q06698 GIS2 0.126 21232131