PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPN13 HEK2 18805955 biogrid exp RPN13 SSA2 16429126 intact exp RPN13 MLP2 24500206 biogrid exp RPN13 VMA1 16429126 intact exp RPN13 GFA1 16429126 intact exp RPN13 SSB1 16429126 intact exp RPN13 SIZ1 23712011 biogrid exp RPN13 CCT8 16429126 intact exp RPN13 SEC18 22940862 biogrid exp RPN13 HSP82 19536198 intact exp RPN13 MSK1 17707817 biogrid exp RPN13 VAM6 25026036 biogrid exp RPN13 BLM10 16429126 intact exp RPN13 SRO9 22271760 biogrid exp RPN13 NAB2 19840948 biogrid exp RPN13 FAS1 16429126 intact exp RPN13 VMA2 16429126 intact exp RPN13 CSI1 16554755 intact exp RPN13 GND1 16284124 intact exp RPN13 URA2 16429126 intact exp RPN13 HSM3 19446323,19446322 biogrid,intact exp RPN13 PUF3 23409723 biogrid exp RPN13 GIS2 21232131 biogrid exp RPN13 RPN14 19446323,11805837, 23023127 biogrid,mint,intact,dip exp, pred RPN13 ECM29 16429126,16284124, 23023127 biogrid,intact exp, pred RPN13 DSK2 20059542, 23023127 biogrid,mint,intact exp, pred RPN13 RPN11 16338358,21658604,21321079,16284124,22927375,15917626,22237024,22215586, 23023127 biogrid,i2d exp, pred RPN13 UBP6 16554755, 23023127 biogrid,i2d,mint,intact exp, pred RPN13 CDC7 19013276, 23023127 intact exp, pred RPN13 RPN5 11805826,16429126,21289098,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPN13 PRE1 15242647,11029046,21878652, 23023127 biogrid,dip exp, pred RPN13 RPN9 16429126,16554755, 23023127 biogrid,i2d,mint,intact exp, pred RPN13 RPT6 16429126,11029046, 23023127 biogrid,i2d,intact,dip exp, pred RPN13 HRT1 19882662, 23023127 intact exp, pred RPN13 RPT1 16429126,11029046,15917626, 23023127 biogrid,i2d,intact,dip exp, pred RPN13 RPT2 16429126, 23023127 biogrid,i2d,intact exp, pred RPN13 SKP1 19882662, 23023127 intact exp, pred RPN13 RPN3 16429126, 23023127 biogrid,i2d,intact exp, pred RPN13 RPN8 16429126,16554755, 23023127 biogrid,i2d,mint,intact exp, pred RPN13 RPN7 16429126, 23023127 biogrid,i2d,intact exp, pred RPN13 RPN6 11805826,16429126,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPN13 RPN2 22318722,16429126,18467557,11283351,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPN13 RPN10 16429126,17499717,11029046,16554755,24429290, 23023127 biogrid,i2d,mint,intact,dip exp, pred RPN13 RPN12 16429126, 23023127 biogrid,intact exp, pred RPN13 SEM1 15610744,16554755, 23023127 biogrid,i2d,mint,intact exp, pred RPN13 RPT4 16429126, 23023127 biogrid,i2d,intact exp, pred RPN13 NAS6 19412159,19446323, 23023127 biogrid,intact exp, pred RPN13 RPT3 16429126,24013205, 23023127 biogrid,i2d,intact,dip exp, pred RPN13 RPN1 22318722,16429126,21658604,16554755,22237024, 23023127 biogrid,i2d,mint,intact exp, pred RPN13 RPT5 16429126,16284124, 23023127 biogrid,i2d,intact exp, pred RPN13 YRB1 23023127 pred RPN13 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O13563 - 15242647 - C 32 O13563 - 15044803 - C 22 O13563 - 11805826 - C 21 O13563 - 15242647 - C 34 O13563 P32565 - 11283351 - X 2 O13563 - 11805837 - C 16 O13563 - 15610744 - C 20 O13563 - 11805837 - C 6 O13563 - 11805826 - C 18 P38886 O13563 affinity chromatography technology 11029046 physical association X 2 P38886 O13563 biochemical 24429290 association X 2 P38886 O13563 affinity chromatography technology 16554755 physical association X 2 P38886 O13563 affinity chromatography technology 16429126 physical association X 2 P38886 O13563 affinity chromatography technology 17200106 physical association X 2 P38886 O13563 affinity chromatography technology 17499717 physical association X 2 P32496 O13563 affinity chromatography technology 16429126 physical association X 2 P32496 O13563 affinity chromatography technology 17200106 physical association X 2 O13563 P32565 affinity chromatography technology 22318722 physical association X 2 O13563 P22141 affinity chromatography technology 11029046 physical association X 2 P38348 O13563 affinity chromatography technology 19446322 physical association X 2 O13563 P22141 affinity chromatography technology 15242647 physical association X 2 O13563 P40457 affinity chromatography technology 24500206 physical association X 2 O13563 P32565 affinity chromatography technology 16554755 physical association X 2 O13563 Q08723 affinity chromatography technology 16554755 physical association X 2 O13563 P38737 affinity chromatography technology 16429126 physical association X 2 O13563 P38737 affinity chromatography technology 16429126 physical association X 2 O13563 P32565 affinity chromatography technology 16429126 physical association X 2 O13563 Q08723 affinity chromatography technology 16429126 physical association X 2 O13563 P40327 affinity chromatography technology 16429126 physical association X 2 O13563 P25615 affinity chromatography technology 17200106 physical association X 2 O13563 P40327 affinity chromatography technology 17200106 physical association X 2 O13563 P38737 affinity chromatography technology 17200106 physical association X 2 O13563 P32565 affinity chromatography technology 17200106 physical association X 2 O13563 Q08723 affinity chromatography technology 17200106 physical association X 2 O13563 P32565 two hybrid 11283351 direct interaction X 2 O13563 P32565 protein complementation assay 18467557 direct interaction X 2 O13563 P53196 affinity chromatography technology 11805837 physical association X 2 O13563 P22141 affinity chromatography technology 21878652 physical association X 2 P43593 O13563 affinity chromatography technology 16554755 physical association X 2 P43593 O13563 affinity chromatography technology 17200106 physical association X 2 P33299 O13563 affinity chromatography technology 11029046 physical association X 2 P33299 O13563 affinity chromatography technology 16429126 physical association X 2 P33299 O13563 affinity chromatography technology 17200106 physical association X 2 P33299 O13563 affinity chromatography technology 15917626 physical association X 2 Q12377 O13563 affinity chromatography technology 16554755 physical association X 2 Q12377 O13563 affinity chromatography technology 16429126 physical association X 2 Q12377 O13563 affinity chromatography technology 17200106 physical association X 2 Q12377 O13563 affinity chromatography technology 11805826 physical association X 2 P50086 O13563 affinity chromatography technology 17200106 physical association X 2 P50086 O13563 affinity chromatography technology 19412159 physical association X 2 P50086 O13563 affinity chromatography technology 19446323 physical association X 2 P0CG63 O13563 affinity chromatography technology 23749301 physical association X 2 P0CG63 O13563 affinity chromatography technology 23793018 physical association X 2 P0CG63 O13563 affinity chromatography technology 21983566 physical association X 2 P0CG63 O13563 affinity chromatography technology 12872131 physical association X 2 P0CG63 O13563 affinity chromatography technology 21427232 physical association X 2 P38764 O13563 affinity chromatography technology 22318722 physical association X 2 P38764 O13563 affinity chromatography technology 16554755 physical association X 2 P38764 O13563 affinity chromatography technology 16429126 physical association X 2 P38764 O13563 affinity chromatography technology 16429126 physical association X 2 P38764 O13563 affinity chromatography technology 17200106 physical association X 2 P38764 O13563 biochemical 21658604 association X 2 P38764 O13563 pull down 22237024 direct interaction X 2 Q06103 O13563 affinity chromatography technology 16429126 physical association X 2 Q06103 O13563 affinity chromatography technology 17200106 physical association X 2 O13563 O94742 affinity chromatography technology 15610744 physical association X 2 O13563 P18759 affinity chromatography technology 22940862 physical association X 2 O13563 Q01939 affinity chromatography technology 11029046 physical association X 2 O13563 Q04195 affinity chromatography technology 23712011 physical association X 2 O13563 P43588 affinity chromatography technology 22927375 physical association X 2 O13563 P43588 affinity chromatography technology 16284124 physical association X 2 O13563 P33297 affinity chromatography technology 16284124 physical association X 2 O13563 P43588 affinity chromatography technology 16338358 physical association X 2 O13563 P43588 biochemical 22215586 association X 2 O13563 O94742 affinity chromatography technology 16554755 physical association X 2 O13563 Q04062 affinity chromatography technology 16554755 physical association X 2 O13563 Q04062 affinity chromatography technology 16429126 physical association X 2 O13563 P40016 affinity chromatography technology 16429126 physical association X 2 O13563 Q04062 affinity chromatography technology 16429126 physical association X 2 O13563 P33298 affinity chromatography technology 16429126 physical association X 2 O13563 P53549 affinity chromatography technology 16429126 physical association X 2 O13563 P33297 affinity chromatography technology 16429126 physical association X 2 O13563 Q01939 affinity chromatography technology 16429126 physical association X 2 O13563 O94742 affinity chromatography technology 17200106 physical association X 2 O13563 P33298 affinity chromatography technology 17200106 physical association X 2 O13563 Q04062 affinity chromatography technology 17200106 physical association X 2 O13563 P40016 affinity chromatography technology 17200106 physical association X 2 O13563 P43588 affinity chromatography technology 17200106 physical association X 2 O13563 Q01939 affinity chromatography technology 17200106 physical association X 2 O13563 P42933 affinity chromatography technology 17200106 physical association X 2 O13563 P33297 affinity chromatography technology 17200106 physical association X 2 O13563 P53549 affinity chromatography technology 17200106 physical association X 2 O13563 P32048 two hybrid 17707817 direct interaction X 2 O13563 P32048 two hybrid 17707817 direct interaction X 2 O13563 P43588 affinity chromatography technology 15917626 physical association X 2 O13563 P43588 affinity chromatography technology 21321079 physical association X 2 O13563 P43588 affinity chromatography technology 21658604 physical association X 2 O13563 P43588 pull down 22237024 direct interaction X 2 P48510 O13563 affinity chromatography technology 20059542 physical association X 2 P48510 O13563 pull down 20059542 direct interaction X 2 Q12250 O13563 affinity chromatography technology 16554755 physical association X 2 Q12250 O13563 affinity chromatography technology 16429126 physical association X 2 Q12250 O13563 affinity chromatography technology 17200106 physical association X 2 Q12250 O13563 affinity chromatography technology 21289098 physical association X 2 Q12250 O13563 affinity chromatography technology 11805826 physical association X 2 P32828 O13563 affinity chromatography technology 17200106 physical association X 2 O13563 molecular sieving 24013205 physical association C 12 O13563 affinity chromatography technology 24013205 physical association C 12 O13563 tandem affinity purification 11805826 - C 21 O13563 anti tag coimmunoprecipitation 11805837 - C 40 P38886 O13563 coimmunoprecipitation 11029046 physical association X 2 O13563 P32565 two hybrid pooling approach 11283351 physical association X 2 O13563 P62987 pull down 18497817 direct interaction X 2 O13563 P62987 nuclear magnetic resonance 18497817 direct interaction X 2 O13563 P53196 anti tag coimmunoprecipitation 11805837 physical association X 2 O13563 P22141 coimmunoprecipitation 11029046 physical association X 2 P33299 O13563 coimmunoprecipitation 11029046 physical association X 2 P33299 O13563 affinity chromatography technology 24013205 physical association X 2 Q12377 O13563 tandem affinity purification 11805826 physical association X 2 O13563 inferred by author 11805826 physical association C 34 O13563 electron tomography 22927375 physical association C 31 O13563 inferred by author 11805826 physical association C 36 O13563 tandem affinity purification 11805826 - C 18 O13563 anti tag coimmunoprecipitation 11805837 - C 19 O13563 P33298 affinity chromatography technology 24013205 physical association X 2 O13563 Q01939 coimmunoprecipitation 11029046 physical association X 2 Q12250 O13563 tandem affinity purification 11805826 physical association X 2 O13563 tandem affinity purification 11805826 association C 22 O13563 inferred by author 16554755 association C 52 O13563 tandem affinity purification 16429126 association C 24 O13563 pull down 19882662 association C 41 O13563 tandem affinity purification 17499717 association C 20 O13563 inferred by author 16429126 physical association C 41 O13563 anti tag coimmunoprecipitation 19446322 physical association C 12 O13563 anti tag coimmunoprecipitation 19446323 physical association C 10 O13563 tandem affinity purification 16429126 association C 25 O13563 tandem affinity purification 16429126 association C 33 O13563 affinity chromatography technology 16284124 association C 99 O13563 affinity chromatography technology 16284124 association C 35 O13563 tandem affinity purification 16429126 association C 19 O13563 tandem affinity purification 16429126 association C 17 O13563 anti tag coimmunoprecipitation 19446323 physical association C 10 O13563 anti tag coimmunoprecipitation 19446323 physical association C 10 O13563 tandem affinity purification 16429126 association C 23 P38886 O13563 tandem affinity purification 16554755 physical association X 2 P38886 O13563 tandem affinity purification 16554755 physical association X 2 P38886 O13563 tandem affinity purification 16554755 physical association X 2 P38886 O13563 tandem affinity purification 16554755 physical association X 2 O13563 P32565 two hybrid fragment pooling approach 11283351 physical association X 2 O13563 Q08723 tandem affinity purification 16554755 physical association X 2 O13563 Q08723 tandem affinity purification 16554755 physical association X 2 O13563 P32565 tandem affinity purification 16554755 physical association X 2 O13563 P32565 tandem affinity purification 16554755 physical association X 2 O13563 P32565 tandem affinity purification 16554755 physical association X 2 O13563 P32565 tandem affinity purification 16554755 physical association X 2 O13563 P32565 tandem affinity purification 16554755 physical association X 2 O13563 Q08723 tandem affinity purification 16554755 physical association X 2 O13563 P32565 dihydrofolate reductase reconstruction 18467557 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 P43593 O13563 tandem affinity purification 16554755 physical association X 2 Q12377 O13563 tandem affinity purification 16554755 physical association X 2 Q12377 O13563 tandem affinity purification 16554755 physical association X 2 Q12377 O13563 tandem affinity purification 16554755 physical association X 2 Q12377 O13563 tandem affinity purification 16554755 physical association X 2 O13563 tandem affinity purification 16429126 association C 16 O13563 anti tag coimmunoprecipitation 19446322 physical association C 19 O13563 anti tag coimmunoprecipitation 11805837 association C 16 O13563 pull down 19882662 association C 51 O13563 tandem affinity purification 19013276 association C 29 O13563 anti tag coimmunoprecipitation 19446323 association C 24 O13563 anti tag coimmunoprecipitation 11805837 association C 6 O13563 anti tag coimmunoprecipitation 19446323 association C 23 O13563 tandem affinity purification 11805826 association C 19 O13563 anti tag coimmunoprecipitation 19446323 physical association C 5 P38764 O13563 tandem affinity purification 16554755 physical association X 2 P38764 O13563 tandem affinity purification 16554755 physical association X 2 P38764 O13563 tandem affinity purification 16554755 physical association X 2 P38764 O13563 tandem affinity purification 16554755 physical association X 2 P38764 O13563 tandem affinity purification 16554755 physical association X 2 P38764 O13563 tandem affinity purification 16554755 physical association X 2 P02829 O13563 tandem affinity purification 19536198 association X 2 O13563 Q04062 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 O94742 tandem affinity purification 16554755 physical association X 2 O13563 Q04062 tandem affinity purification 16554755 physical association X 2 O13563 Q04062 tandem affinity purification 16554755 physical association X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 P48510 O13563 pull down 20059542 direct interaction X 2 Q12250 O13563 tandem affinity purification 16554755 physical association X 2 Q12250 O13563 tandem affinity purification 16554755 physical association X 2 Q12250 O13563 tandem affinity purification 16554755 physical association X 2 Q12250 O13563 tandem affinity purification 16554755 physical association X 2 O13563 mass spectrometry studies of complexes 11805826 - C 39 O13563 P32565 two hybrid 11283351 - X 2 O13563 mass spectrometry studies of complexes 11805837 - C 20 O13563 mass spectrometry studies of complexes 11805826 - C 43

PPI - HINT Gene A Gene B PMID Method Quality RPN13 PRE1 11029046,11029046 0019,0004 LC RPN13 MSK1 17707817 0018 LC RPN13 RPN2 11283351,18467557,11283351,11283351,18467557 0018,0111,0399,0398,0090 HT RPN13 RPT1 11029046,11029046 0019,0004 LC RPN13 RPN1 21658604 0401 LC RPN13 RPN10 11029046,11029046,24429290 0004,0019,0401 LC RPN13 RPN11 22215586 0401 LC RPN13 RPT6 11029046,11029046 0019,0004 LC RPN13 SEM1 17200106,15610744,16554755,16554755 0004,0004,0676,0004 HT,LC RPN13 HSP82 19536198 0676 HT RPN13 CDC7 19013276 0676 LC RPN13 FAS1 16429126 0676 HT RPN13 URA2 16429126 0676 HT RPN13 SSA2 16429126 0676 HT RPN13 SSB1 16429126 0676 HT RPN13 GFA1 16429126 0676 HT RPN13 VMA2 16429126 0676 HT RPN13 VMA1 16429126 0676 HT RPN13 SEC18 22940862 0004 HT RPN13 PRE1 15242647,21878652,11029046,11029046 0004,0004,0019,0004 LC RPN13 POL4 17200106 0004 HT RPN13 RPN12 17200106,16429126,16429126 0004,0676,0004 HT RPN13 NAB2 19840948 0004 LC RPN13 RPN2 22318722,16554755,16429126,17200106,16429126,16554755 0004,0676,0676,0004,0004,0004 LC,HT RPN13 SLX5 17200106 0004 HT RPN13 RPT5 17200106,16429126,16429126,16284124 0004,0676,0004,0004 HT,LC RPN13 RPT3 26301997,17200106,16429126,16429126,24013205 0096,0004,0676,0004,0004 LC,HT RPN13 RPT1 26301997,16429126,24013205,11029046,11029046,15917626,17200106,16429126 0096,0676,0004,0019,0004,0004,0004,0004 LC,HT RPN13 HSM3 19446323,19446322,19446322 0007,0007,0004 LC RPN13 GND1 16284124 0004 LC RPN13 ECM29 16429126,16429126,17200106,16284124 0676,0004,0004,0004 HT,LC RPN13 RPN1 21658604,22318722,16554755,16429126,16429126,17200106,22237024,16554755 0401,0004,0676,0004,0676,0004,0096,0004 LC,HT RPN13 RPN10 16554755,16429126,17499717,11029046,11029046,17499717,17200106,16429126,24429290,16554755 0676,0676,0676,0004,0019,0004,0004,0004,0401,0004 HT,LC RPN13 RPN3 17200106,16429126,16429126 0004,0676,0004 HT RPN13 RPT2 17200106,16429126,16429126 0004,0676,0004 HT RPN13 MLP2 24500206 0004 LC RPN13 SPG5 17200106 0004 HT RPN13 BLM10 16429126 0363 HT RPN13 RPN11 21321079,22215586,21658604,22927375,15917626,16338358,17200106,22237024,16284124 0004,0401,0004,0004,0004,0004,0004,0096,0004 LC,HT RPN13 UBP6 17200106,16554755,16554755 0004,0676,0004 HT RPN13 CCT8 16429126 0676 HT RPN13 DSK2 20059542,20059542 0096,0004 LC RPN13 NAS6 19446323,17200106,19412159,19446323 0007,0004,0004,0004 LC,HT RPN13 SKP1 19882662 0096 LC RPN13 INO80 26656161 0004 LC RPN13 RPN14 19446323,11805837,11805837 0007,0004,0007 LC,HT RPN13 RPT4 17200106,16429126,16429126 0004,0676,0004 HT RPN13 RPT6 17200106,11029046,16429126,16429126,11029046 0004,0019,0676,0004,0004 HT,LC RPN13 RPN9 16429126,17200106,16429126,16554755,16554755 0004,0004,0676,0676,0004 HT RPN13 SIZ1 23712011 0004 LC RPN13 CSI1 16554755 0363 HT RPN13 RPN7 17200106,16429126,16429126 0004,0676,0004 HT RPN13 HRT1 19882662 0096 LC RPN13 RPN8 16429126,17200106,16429126,16554755,16554755 0004,0004,0676,0676,0004 HT RPN13 RPN5 21289098,16554755,16429126,11805826,11805826,17200106,11805826,16429126,16554755 0004,0676,0004,0676,0004,0004,0007,0676,0004 LC,HT RPN13 RPN6 16554755,16429126,11805826,11805826,17200106,11805826,16429126,16554755 0004,0676,0676,0004,0004,0007,0004,0676 HT