PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSB1 UBX2 22940862,19536198 biogrid,intact exp SSA1 UBX2 22940862,19536198 biogrid,intact exp RSP5 UBX2 23793018 biogrid exp CUZ1 UBX2 24121501 biogrid exp PAB1 UBX2 22940862 biogrid exp FMP48 UBX2 21460040 biogrid exp UFD2 UBX2 21211725 biogrid exp FPR3 UBX2 16873066 intact exp DED1 UBX2 22940862 biogrid exp RPL4A UBX2 22940862 biogrid exp TDH3 UBX2 22940862 biogrid exp YDJ1 UBX2 19536198 intact exp UBX2 VAM6 25026036 biogrid exp RPL40A UBX2 16007098 dip exp SNA3 UBX2 18467557 biogrid,i2d,mint,intact exp UBX2 DGA1 22454508 biogrid exp CDC14 UBX2 21127052 biogrid exp ESC1 UBX2 24152732 biogrid exp RPS17B UBX2 22940862 biogrid exp HMG2 UBX2 16179952 biogrid,intact exp SPT23 UBX2 23793018 biogrid exp HSP82 UBX2 19536198 intact exp UBX2 VMS1 21148305 biogrid exp UBI4 UBX2 16007098,15258615 biogrid exp TPK3 UBX2 16319894 biogrid,i2d exp PRC1 UBX2 16179952 i2d,intact exp UFD1 UBX2 16179952,16873066,22615397,18467557,21211725,23793018, 23023127 biogrid,i2d,mint,intact exp, pred JSN1 UBX2 11283351, 23023127 i2d,mint,intact,dip exp, pred SSM4 UBX2 16179952,16873066,23665229,16179953, 23023127 biogrid,intact exp, pred UBX2 UBX2 22940862,22615397,18467557, 23023127 biogrid,i2d,mint,intact exp, pred UBX2 DFM1 16179952,18407841, 23023127 biogrid,intact exp, pred DOA1 UBX2 21211725, 23023127 biogrid exp, pred UBX2 HRD3 16873066,20005842, 23023127 biogrid,intact exp, pred NPL4 UBX2 25215493,16179952,16429126,21211725,16919153, 23023127 biogrid,intact exp, pred UBX2 ACF2 18467557, 23023127 biogrid,i2d,mint,intact exp, pred UBC7 UBX2 16873066, 23023127 intact exp, pred USA1 UBX2 16873066, 23023127 biogrid,intact exp, pred DER1 UBX2 16179952,16873066,18407841, 23023127 biogrid,intact exp, pred UBX2 YOS9 16873066,16873065, 23023127 biogrid,intact exp, pred UBX2 HRD1 23891562,25215493,16179952,16873066,21074049,16179953,19394298, 23023127 biogrid,intact exp, pred CDC48 UBX2 22454508,25215493,16873066,16429126,21148305,21211725,16919153,16179953,21896481,19359248,15258615,16179952,22940862,23793018,15200949, 23023127 biogrid,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04228 - 16179952 - C 4 Q04228 - 16179952 - C 3 Q04228 - 16179952 - C 4 Q04228 - 15200949 - C 6 P47135 Q04228 - 11283351 - X 2 Q04228 - 16179953 - C 4 Q04228 - 16179952 - C 4 Q04228 - 16179952 - C 4 Q04228 - 16179952 - C 4 P00729 Q04228 - 16179952 - X 2 Q04228 Q04228 affinity chromatography technology 22940862 physical association X 2 Q04228 Q04228 protein complementation assay 18467557 direct interaction X 2 Q04228 Q04228 protein complementation assay 22615397 direct interaction X 2 P04147 Q04228 affinity chromatography technology 22940862 physical association X 2 Q08109 Q04228 affinity chromatography technology 16179953 physical association X 2 Q08109 Q04228 affinity chromatography technology 23891562 physical association X 2 Q08109 Q04228 affinity chromatography technology 16873066 physical association X 2 Q08109 Q04228 affinity chromatography technology 16179952 physical association X 2 Q08109 Q04228 affinity chromatography technology 19394298 physical association X 2 Q08109 Q04228 affinity chromatography technology 21074049 physical association X 2 Q05787 Q04228 affinity chromatography technology 20005842 physical association X 2 Q04311 Q04228 affinity chromatography technology 21148305 physical association X 2 P12684 Q04228 affinity chromatography technology 16179952 physical association X 2 P38307 Q04228 affinity chromatography technology 16179952 physical association X 2 P38307 Q04228 affinity chromatography technology 18407841 physical association X 2 P11484 Q04228 affinity chromatography technology 22940862 physical association X 2 P0CG63 Q04228 affinity chromatography technology 23749301 physical association X 2 P0CG63 Q04228 biochemical 23583075 association X 2 P0CG63 Q04228 affinity chromatography technology 17644757 physical association X 2 P0CG63 Q04228 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q04228 two hybrid 15258615 direct interaction X 2 P0CG63 Q04228 pull down 15258615 direct interaction X 2 P0CG63 Q04228 pull down 16007098 direct interaction X 2 P0CG63 Q04228 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q04228 affinity chromatography technology 21427232 physical association X 2 P0CG63 Q04228 affinity chromatography technology 14557538 physical association X 2 Q08650 Q04228 affinity chromatography technology 22454508 physical association X 2 P40318 Q04228 affinity chromatography technology 16179953 physical association X 2 P40318 Q04228 affinity chromatography technology 16179953 physical association X 2 P40318 Q04228 affinity chromatography technology 23665229 physical association X 2 P40318 Q04228 affinity chromatography technology 16873066 physical association X 2 P40318 Q04228 affinity chromatography technology 16179952 physical association X 2 P00359 Q04228 affinity chromatography technology 22940862 physical association X 2 P14127 Q04228 affinity chromatography technology 22940862 physical association X 2 Q03714 Q04228 affinity chromatography technology 16873066 physical association X 2 P10664 Q04228 affinity chromatography technology 22940862 physical association X 2 P10591 Q04228 affinity chromatography technology 22940862 physical association X 2 P06634 Q04228 affinity chromatography technology 22940862 physical association X 2 P05986 Q04228 enzymatic study 16319894 direct interaction X 2 P36037 Q04228 affinity chromatography technology 21211725 physical association X 2 P39940 Q04228 affinity chromatography technology 23793018 physical association X 2 P33755 Q04228 affinity chromatography technology 16179952 physical association X 2 P33755 Q04228 affinity chromatography technology 16919153 physical association X 2 P33755 Q04228 affinity chromatography technology 21211725 physical association X 2 P33755 Q04228 affinity chromatography technology 21211725 physical association X 2 Q04228 P25694 affinity chromatography technology 22940862 physical association X 2 Q04228 P25694 affinity chromatography technology 15200949 physical association X 2 Q04228 P25694 two hybrid 15258615 direct interaction X 2 Q04228 P25694 affinity chromatography technology 16179953 physical association X 2 Q04228 P25694 affinity chromatography technology 23793018 physical association X 2 Q04228 P53044 affinity chromatography technology 23793018 physical association X 2 Q04228 P25694 two hybrid 15258615 direct interaction X 2 Q04228 P25694 affinity chromatography technology 15258615 physical association X 2 Q04228 P53044 affinity chromatography technology 16179952 physical association X 2 Q04228 P25694 affinity chromatography technology 16179952 physical association X 2 Q04228 P53044 affinity chromatography technology 16179952 physical association X 2 Q04228 P25694 affinity chromatography technology 16179952 physical association X 2 Q04228 P25694 affinity chromatography technology 16919153 physical association X 2 Q04228 P25694 affinity chromatography technology 16919153 physical association X 2 Q04228 P53044 protein complementation assay 18467557 direct interaction X 2 Q00684 Q04228 affinity chromatography technology 21127052 physical association X 2 Q04228 P25694 affinity chromatography technology 21211725 physical association X 2 Q04228 P25694 affinity chromatography technology 21211725 physical association X 2 Q04228 P53044 affinity chromatography technology 21211725 physical association X 2 Q04228 P25694 affinity chromatography technology 19359248 physical association X 2 Q04228 P25694 affinity chromatography technology 21148305 physical association X 2 Q04228 P25694 affinity chromatography technology 21896481 physical association X 2 Q04228 P25694 affinity chromatography technology 22454508 physical association X 2 Q04228 P53044 protein complementation assay 22615397 direct interaction X 2 Q12743 Q04228 affinity chromatography technology 18407841 physical association X 2 P53233 Q04228 pull down 21460040 direct interaction X 2 Q99220 Q04228 affinity chromatography technology 16873065 physical association X 2 Q99220 Q04228 affinity chromatography technology 16873065 physical association X 2 Q12168 Q04228 protein complementation assay 18467557 direct interaction X 2 P35210 Q04228 affinity chromatography technology 23793018 physical association X 2 P53899 Q04228 affinity chromatography technology 24121501 physical association X 2 P54860 Q04228 affinity chromatography technology 21211725 physical association X 2 P14359 Q04228 protein complementation assay 18467557 direct interaction X 2 Q04228 P05759 pull down 16007098 direct interaction X 2 P47135 Q04228 two hybrid pooling approach 11283351 physical association X 2 Q04228 anti tag coimmunoprecipitation 16179952 association C 4 Q04228 anti bait coimmunoprecipitation 16179952 association C 4 Q04228 anti bait coimmunoprecipitation 16179952 association C 4 Q04228 anti tag coimmunoprecipitation 16179952 association C 3 Q04228 molecular sieving 25215493 physical association C 3 Q04228 molecular sieving 25215493 physical association C 3 Q04228 anti tag coimmunoprecipitation 16179952 association C 4 Q04228 tandem affinity purification 16873066 association C 5 Q04228 anti tag coimmunoprecipitation 18407841 association C 11 Q04228 Q04228 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q08109 Q04228 pull down 25215493 direct interaction X 2 P11484 Q04228 tandem affinity purification 19536198 association X 2 P40318 Q04228 anti tag coimmunoprecipitation 16179953 physical association X 2 P10591 Q04228 tandem affinity purification 19536198 association X 2 P47135 Q04228 two hybrid fragment pooling approach 11283351 physical association X 2 Q04228 anti tag coimmunoprecipitation 18407841 association C 9 Q04228 tandem affinity purification 16873066 association C 10 Q04228 pull down 16179953 association C 4 Q04228 anti tag coimmunoprecipitation 16179952 association C 4 Q04228 tandem affinity purification 16429126 association C 3 Q04228 anti tag coimmunoprecipitation 16919153 association C 3 Q04228 anti tag coimmunoprecipitation 16179952 association C 4 Q04228 anti tag coimmunoprecipitation 16179952 association C 3 Q04228 anti tag coimmunoprecipitation 16873065 association C 9 Q04228 anti tag coimmunoprecipitation 16179952 association C 4 Q04228 molecular sieving 25215493 physical association C 4 Q04228 molecular sieving 25215493 physical association C 4 Q04228 tandem affinity purification 16873066 association C 7 Q04228 tandem affinity purification 16873066 association C 7 Q04228 anti tag coimmunoprecipitation 16179952 association C 4 Q04228 pull down 25215493 association C 5 Q04228 tandem affinity purification 16873066 association C 6 Q04228 cosedimentation through density gradient 16873066 physical association C 8 Q04228 tandem affinity purification 21074049 association C 6 Q04228 P25694 two hybrid 15258615 physical association X 2 Q04228 P25694 anti tag coimmunoprecipitation 15258615 physical association X 2 Q04228 P25694 two hybrid 15258615 physical association X 2 Q04228 P25694 anti tag coimmunoprecipitation 16919153 physical association X 2 Q04228 P53044 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q04228 P53044 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q04228 P25694 molecular sieving 25215493 direct interaction X 2 Q04228 P25694 molecular sieving 25215493 direct interaction X 2 P25491 Q04228 tandem affinity purification 19536198 association X 2 Q99220 Q04228 anti tag coimmunoprecipitation 16873065 physical association X 2 P02829 Q04228 tandem affinity purification 19536198 association X 2 Q12168 Q04228 dihydrofolate reductase reconstruction 18467557 physical association X 2 P14359 Q04228 dihydrofolate reductase reconstruction 18467557 physical association X 2 P14359 Q04228 dihydrofolate reductase reconstruction 18467557 physical association X 2 Q04659 Q04228 interaction detection method 14764870 - X 2 P47135 Q04228 two hybrid 11283351 - X 2 P10614 Q04228 interaction detection method 14661025 - X 2

PPI - HINT Gene A Gene B PMID Method Quality PRC1 UBX2 16179952,16179952 0019,0007 LC TPK3 UBX2 16319894 0415 LC UBI4 UBX2 15258615,15258615 0096,0018 LC SNA3 UBX2 18467557,18467557 0111,0090 HT CDC48 UBX2 16873066,25215493,15258615,15258615,16873066,15258615 0676,0071,0004,0018,0029,0007 LC NPL4 UBX2 25215493 0071 LC JSN1 UBX2 11283351,11283351,11283351 0018,0399,0398 HT UFD1 UBX2 18467557,22615397,18467557 0111,0090,0090 HT,LC UBX2 UBX2 18467557,18467557,22615397 0111,0090,0090 HT,LC UBX2 ACF2 18467557,18467557 0111,0090 HT TDH3 UBX2 22940862 0004 HT PRC1 UBX2 16179952,16179952 0019,0007 LC HSP82 UBX2 19536198 0676 HT PAB1 UBX2 22940862 0004 HT DED1 UBX2 22940862 0004 HT UBI4 UBX2 16007098,15258615,14557538,15258615 0096,0096,0004,0018 LC SSA1 UBX2 22940862,19536198 0004,0676 HT RPL4A UBX2 22940862 0004 HT SSB1 UBX2 22940862,19536198 0004,0676 HT HMG2 UBX2 16179952,16179952 0004,0007 LC RPS17B UBX2 22940862 0004 HT YDJ1 UBX2 19536198 0676 HT CDC48 UBX2 21211725,16873066,21896481,16919153,22454508,22940862,23793018,16179952,16179953,19359248,16429126,16179953,16179952,21148305,15258615,15258615,16873066,16179952,15200949,16919153,15258615 0004,0676,0004,0007,0004,0004,0004,0004,0004,0004,0676,0096,0006,0004,0004,0018,0029,0007,0004,0004,0007 LC,HT NPL4 UBX2 21211725,16429126,16179952,16919153,16179952,16919153 0004,0676,0007,0004,0004,0007 LC,HT SPT23 UBX2 23793018 0004 LC DOA1 UBX2 21211725,26349035 0004,0004 LC DER1 UBX2 16873066,18407841,16179952,18407841,16179952 0676,0007,0007,0004,0004 LC FPR3 UBX2 16873066 0676 LC RSP5 UBX2 23793018 0004 LC SSM4 UBX2 16873066,16179952,16179952,16873066,16179953,23665229,16179953,16179953 0004,0004,0007,0676,0096,0004,0007,0004 LC UFD1 UBX2 21211725,16873066,16179952,23793018,16179952,16179952 0004,0676,0004,0004,0007,0006 LC FMP48 UBX2 21460040 0096 LC CUZ1 UBX2 24121501 0004 LC UFD2 UBX2 21211725 0004 LC CDC14 UBX2 21127052 0004 LC UBC7 UBX2 16873066 0676 LC ESC1 UBX2 24152732 0004 LC USA1 UBX2 16873066,16873066 0004,0676 LC UBX2 UBX2 22940862 0004 HT UBX2 VMS1 21148305 0004 LC UBX2 HRD3 16873066,20005842,25428985 0676,0004,0004 LC UBX2 HRD1 21074049,21074049,16873066,16179952,16873066,16179952,23891562,25215493,16179953,16179953,19394298 0004,0676,0004,0004,0676,0007,0004,0096,0096,0004,0004 LC UBX2 DGA1 22454508 0004 LC UBX2 DFM1 18407841,16179952,18407841 0007,0007,0004 LC UBX2 YOS9 16873066,16873065,16873065 0676,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04228 P53233 UBX2 FMP48 0.183 21460040 Q04228 P10591 UBX2 SSA1 0.126 19536198 Q04228 P11484 UBX2 SSB1 0.126 19536198 Q04228 P02829 UBX2 HSP82 0.126 19536198 Q04228 P05986 UBX2 TPK3 0.183 16319894 Q12743 Q04228 DFM1 UBX2 0.376 18407841 Q04228 P33755 UBX2 NPL4 0.569 16429126,25215493,21211725 Q04228 P40318 UBX2 SSM4 0.692 16873066,16179953,23665229 Q12168 Q04228 ACF2 UBX2 0.286 18467557 Q04228 P36037 UBX2 DOA1 0.309 26349035,21211725 Q04228 P38307 UBX2 DER1 0.507 16873066,18407841 Q04228 Q04228 UBX2 UBX2 0.472 22615397,18467557 Q08109 Q04228 HRD1 UBX2 0.895 16179953,23891562,25215493,19394298,16873066,21074049 Q04228 P25694 UBX2 CDC48 0.983 22454508,23793018,25215493,21148305,16873066,19359248,21211725,16179953,16429126,21896481,15258615 Q04228 Q00684 UBX2 CDC14 0.126 21127052 Q04228 Q03661 UBX2 ESC1 0.126 24152732 Q07468 Q04228 VAM6 UBX2 0.126 25026036 Q04228 P53899 UBX2 P53899 0.21 24121501 Q04228 P54860 UBX2 UFD2 0.21 21211725 Q04228 P35210 UBX2 SPT23 0.21 23793018 Q04228 P0CG63 UBX2 UBI4 0.671 16007098,15258615 Q04228 P25491 UBX2 YDJ1 0.126 19536198 Q04228 P14359 UBX2 SNA3 0.376 18467557 Q04228 Q02159 UBX2 UBC7 0.21 16873066 Q04228 P39940 UBX2 RSP5 0.21 23793018 Q04228 P38911 UBX2 FPR3 0.21 16873066 Q99220 Q04228 YOS9 UBX2 0.507 16873065,16873066 Q04228 P47135 UBX2 JSN1 0.21 11283351 Q08650 Q04228 DGA1 UBX2 0.21 22454508 Q04228 Q03714 UBX2 USA1 0.21 16873066 Q05787 Q04228 HRD3 UBX2 0.61 16873066,25428985,20005842 Q04311 Q04228 VMS1 UBX2 0.21 21148305 Q04228 P53044 UBX2 UFD1 0.569 16873066,23793018,18467557,21211725