PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USA1 YET3 18719252 biogrid,intact exp ALG9 USA1 18719252 biogrid,intact exp PMT1 USA1 21147851 biogrid exp AAP1 USA1 16429126 intact exp PMT2 USA1 21147851 biogrid exp USA1 HTZ1 i2d exp SSB1 USA1 19536198 intact exp USA1 TVP15 18719252 biogrid,intact exp DRS2 USA1 16429126 intact exp RIM21 USA1 16554755 biogrid,i2d,mint,intact exp USA1 EMC6 18719252 biogrid,intact exp LSM1 USA1 23222640 biogrid exp TIF1, TIF2 USA1 i2d exp NRD1 USA1 22028667 biogrid exp USA1 SOV1 11805837 dip exp NAM7 USA1 18087042 biogrid exp RPB2 USA1 22028667 biogrid exp SBP1 USA1 23222640 biogrid exp PET9 USA1 16429126 intact exp SSA1 USA1 19536198 intact exp PEX6 USA1 11805837 biogrid,mint,intact,dip exp ECM29 USA1 16429126 intact exp USA1 MDN1 11805837 biogrid,mint,intact,dip exp LCB3 USA1 18719252 biogrid,intact exp CLU1 USA1 16429126 intact exp ERG25 USA1 16429126 intact exp RPL8B USA1 18719252 biogrid,intact exp USA1 MPD1 18719252 biogrid,intact exp SAC1 USA1 18719252 biogrid,intact exp PDR5 USA1 16429126 intact exp USA1 PDR15 16429126 intact exp ORM1 USA1 18719252 biogrid,intact exp PRM8 USA1 18719252 biogrid,intact exp PIS1 USA1 18719252 biogrid,intact exp HSP12 USA1 19536198 intact exp RPL8A USA1 18719252 biogrid,intact exp USA1 SCS22 18719252 biogrid,intact exp PIM1 USA1 11805837 biogrid,mint,intact,dip exp PHS1 USA1 18719252 biogrid,intact exp USA1 HRD3 16873066,19898607,20005842, 23023127 biogrid,intact exp, pred USA1 DFM1 18407841,18719252, 23023127 biogrid,intact exp, pred USA1 USA1 21074049,18719252, 23023127 biogrid,intact exp, pred SNP1 USA1 11425851, 23023127 biogrid,i2d,intact exp, pred DDR48 USA1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred USA1 HRD1 16873066,16429126,21074049,19898607,19394298,20005842, 23023127 biogrid,intact exp, pred USA1 Uncharacterized protein YLR287C 16554755, 23023127 biogrid,i2d,mint,intact exp, pred USA1 YOS9 16873066,16873065, 23023127 biogrid,intact exp, pred USA1 UBX2 16873066, 23023127 biogrid,intact exp, pred CDC48 USA1 16873066,20005842, 23023127 biogrid,intact exp, pred PRC1 USA1 16873065, 23023127 intact exp, pred DER1 USA1 23363603,16873066,24292014,19898607,18407841,20005842,18719252, 23023127 biogrid,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q03714 - 11805837 - C 4 Q00916 Q03714 - 11425851 - X 2 P47013 Q03714 two hybrid 18719252 direct interaction X 2 Q12431 Q03714 two hybrid 18719252 direct interaction X 2 P0CG63 Q03714 affinity chromatography technology 17644757 physical association X 2 P0CG63 Q03714 affinity chromatography technology 23793018 physical association X 2 P0CG63 Q03714 affinity chromatography technology 12872131 physical association X 2 P0CG63 Q03714 affinity chromatography technology 14557538 physical association X 2 P40857 Q03714 two hybrid 18719252 direct interaction X 2 Q07451 Q03714 two hybrid 18719252 direct interaction X 2 P36775 Q03714 affinity chromatography technology 11805837 physical association X 2 P32368 Q03714 two hybrid 18719252 direct interaction X 2 Q03714 Q05881 affinity chromatography technology 16554755 physical association X 2 Q03714 P25694 affinity chromatography technology 16873066 physical association X 2 Q03714 Q04228 affinity chromatography technology 16873066 physical association X 2 Q03714 Q03714 two hybrid 18719252 direct interaction X 2 Q03714 P06197 two hybrid 18719252 direct interaction X 2 Q03714 P25694 affinity chromatography technology 20005842 physical association X 2 Q03860 Q03714 two hybrid 18719252 direct interaction X 2 P53868 Q03714 two hybrid 18719252 direct interaction X 2 P33775 Q03714 affinity chromatography technology 21147851 physical association X 2 Q08109 Q03714 pull down 20005842 direct interaction X 2 Q08109 Q03714 affinity chromatography technology 16873066 physical association X 2 Q08109 Q03714 affinity chromatography technology 16873066 physical association X 2 Q08109 Q03714 affinity chromatography technology 19394298 physical association X 2 Q08109 Q03714 affinity chromatography technology 19898607 physical association X 2 Q08109 Q03714 affinity chromatography technology 21074049 physical association X 2 Q08109 Q03714 affinity chromatography technology 21074049 physical association X 2 Q08109 Q03714 affinity chromatography technology 20005842 physical association X 2 Q08109 Q03714 affinity chromatography technology 20005842 physical association X 2 Q12743 Q03714 two hybrid 18719252 direct interaction X 2 Q12743 Q03714 affinity chromatography technology 18407841 physical association X 2 P29453 Q03714 two hybrid 18719252 direct interaction X 2 Q05787 Q03714 affinity chromatography technology 16873066 physical association X 2 Q05787 Q03714 affinity chromatography technology 19898607 physical association X 2 Q05787 Q03714 affinity chromatography technology 20005842 physical association X 2 Q05787 Q03714 affinity chromatography technology 20005842 physical association X 2 P38307 Q03714 affinity chromatography technology 24292014 physical association X 2 P38307 Q03714 affinity chromatography technology 24292014 physical association X 2 P38307 Q03714 affinity chromatography technology 23363603 physical association X 2 P38307 Q03714 affinity chromatography technology 16873066 physical association X 2 P38307 Q03714 two hybrid 18719252 direct interaction X 2 P38307 Q03714 affinity chromatography technology 18407841 physical association X 2 P38307 Q03714 affinity chromatography technology 19898607 physical association X 2 P38307 Q03714 affinity chromatography technology 20005842 physical association X 2 Q6Q595 Q03714 two hybrid 18719252 direct interaction X 2 P18899 Q03714 affinity chromatography technology 16554755 physical association X 2 Q00916 Q03714 two hybrid 11425851 direct interaction X 2 Q99220 Q03714 affinity chromatography technology 16873066 physical association X 2 Q99220 Q03714 affinity chromatography technology 16873065 physical association X 2 Q12404 Q03714 two hybrid 18719252 direct interaction X 2 P48565 Q03714 affinity chromatography technology 16554755 physical association X 2 Q03714 P53174 two hybrid 18719252 direct interaction X 2 Q03714 P17076 two hybrid 18719252 direct interaction X 2 Q03714 P33760 affinity chromatography technology 11805837 physical association X 2 P53224 Q03714 two hybrid 18719252 direct interaction X 2 P31382 Q03714 affinity chromatography technology 21147851 physical association X 2 Q12019 Q03714 affinity chromatography technology 11805837 physical association X 2 Q03714 anti tag coimmunoprecipitation 11805837 - C 4 P36775 Q03714 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03714 anti tag coimmunoprecipitation 11805837 - C 5 Q04748 Q03714 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03714 P33760 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12019 Q03714 anti tag coimmunoprecipitation 11805837 physical association X 2 Q03714 tandem affinity purification 16873066 association C 5 Q03714 tandem affinity purification 16873066 association C 5 Q03714 inferred by author 16429126 physical association C 5 Q03714 tandem affinity purification 16429126 association C 38 Q03714 inferred by author 16429126 physical association C 8 Q03714 anti tag coimmunoprecipitation 11805837 association C 4 Q03714 anti tag coimmunoprecipitation 18407841 association C 11 P22943 Q03714 tandem affinity purification 19536198 association X 2 P47013 Q03714 two hybrid 18719252 physical association X 2 P11484 Q03714 tandem affinity purification 19536198 association X 2 Q12431 Q03714 two hybrid 18719252 physical association X 2 P40857 Q03714 two hybrid 18719252 physical association X 2 Q07451 Q03714 two hybrid 18719252 physical association X 2 P33302 Q03714 inferred by author 16429126 physical association X 2 P32368 Q03714 two hybrid 18719252 physical association X 2 Q03714 Q05881 tandem affinity purification 16554755 physical association X 2 Q03714 P06197 two hybrid 18719252 physical association X 2 Q03714 Q03714 two hybrid 18719252 physical association Y 1 Q03714 Q03714 anti tag coimmunoprecipitation 21074049 physical association X 2 Q03860 Q03714 two hybrid 18719252 physical association X 2 P00729 Q03714 anti tag coimmunoprecipitation 16873065 physical association X 2 P53868 Q03714 two hybrid 18719252 physical association X 2 Q03714 anti tag coimmunoprecipitation 18407841 association C 9 Q03714 tandem affinity purification 16873066 association C 10 Q03714 tandem affinity purification 16873066 association C 6 Q03714 anti tag coimmunoprecipitation 16873065 association C 9 Q03714 tandem affinity purification 16429126 association C 5 Q03714 inferred by author 16429126 physical association C 6 Q03714 tandem affinity purification 16429126 association C 29 Q03714 inferred by author 16429126 physical association C 4 Q03714 inferred by author 16554755 association C 3 Q03714 anti tag coimmunoprecipitation 21074049 association C 3 Q03714 cross-linking study 21074049 association C 3 Q03714 inferred by author 16429126 physical association C 26 Q03714 tandem affinity purification 16873066 association C 7 Q03714 tandem affinity purification 16873066 association C 7 Q03714 inferred by author 16429126 physical association C 26 Q03714 inferred by author 16429126 physical association C 17 Q03714 tandem affinity purification 16873066 association C 6 Q03714 cosedimentation through density gradient 16873066 physical association C 8 Q03714 cosedimentation through density gradient 16873066 physical association C 8 Q03714 tandem affinity purification 21074049 association C 6 Q12743 Q03714 two hybrid 18719252 physical association X 2 P29453 Q03714 two hybrid 18719252 physical association X 2 P38307 Q03714 two hybrid 18719252 physical association X 2 Q6Q595 Q03714 two hybrid 18719252 physical association X 2 P18899 Q03714 tandem affinity purification 16554755 physical association X 2 Q00916 Q03714 two hybrid 11425851 physical association X 2 Q12404 Q03714 two hybrid 18719252 physical association X 2 P48565 Q03714 tandem affinity purification 16554755 physical association X 2 Q03714 P17076 two hybrid 18719252 physical association X 2 Q03714 P53174 two hybrid 18719252 physical association X 2 P53224 Q03714 two hybrid 18719252 physical association X 2 P10591 Q03714 tandem affinity purification 19536198 association X 2 Q03714 mass spectrometry studies of complexes 11805837 - C 5 Q03714 mass spectrometry studies of complexes 11805837 - C 5

PPI - HINT Gene A Gene B PMID Method Quality PIS1 USA1 18719252 0018 HT RPL8A USA1 18719252 0018 HT CDC48 USA1 16873066,16873066,16873066 0004,0676,0029 LC RPL8B USA1 18719252 0018 HT SAC1 USA1 18719252 0018 HT DER1 USA1 18719252 0018 HT PHS1 USA1 18719252 0018 HT LCB3 USA1 18719252 0018 HT PRM8 USA1 18719252 0018 HT ORM1 USA1 18719252 0018 HT ALG9 USA1 18719252 0018 HT SNP1 USA1 11425851 0018 LC USA1 USA1 18719252 0018 HT USA1 TVP15 18719252 0018 HT USA1 YET3 18719252 0018 HT USA1 HRD1 21074049,21074049,21074049,21074049 0004,0676,0007,0030 LC USA1 MPD1 18719252 0018 HT USA1 EMC6 18719252 0018 HT USA1 DFM1 18719252 0018 HT USA1 SCS22 18719252 0018 HT PRC1 USA1 16873065 0007 LC RPB2 USA1 22028667 0004 LC UBI4 USA1 14557538 0004 LC SSA1 USA1 19536198 0676 HT SSB1 USA1 19536198 0676 HT PET9 USA1 16429126 0363 HT DDR48 USA1 16554755,16554755 0676,0004 HT HSP12 USA1 19536198 0676 HT CDC48 USA1 16873066,16873066,16873066,20005842 0004,0676,0029,0004 LC PMT2 USA1 21147851 0004 LC PDR5 USA1 16429126 0363 HT PEX6 USA1 11805837,11805837 0004,0007 HT PMT1 USA1 21147851 0004 LC PIM1 USA1 11805837,11805837 0004,0007 HT AAP1 USA1 16429126 0363 HT DER1 USA1 19898607,16873066,24292014,20005842,16873066,18407841,23363603,18407841 0004,0004,0004,0004,0676,0004,0004,0007 LC ECM29 USA1 16429126 0363 HT DRS2 USA1 16429126 0363 HT RIM21 USA1 16554755,16554755,16554755 0363,0676,0004 HT ERG25 USA1 16429126 0676 HT NRD1 USA1 22028667 0004 LC CLU1 USA1 16429126 0363 HT USA1 USA1 21074049 0007 LC USA1 PDR15 16429126 0676 HT USA1 UBX2 16873066,16873066 0004,0676 LC USA1 SOV1 11805837 0007 HT USA1 HRD3 19898607,25428985,16873066,20005842,16873066 0004,0004,0004,0004,0676 LC USA1 Q05881 16554755,16554755 0676,0004 HT USA1 HRD1 21074049,21074049,16873066,16429126,20005842,21074049,16873066,20005842,21074049,19394298,19898607 0004,0676,0004,0676,0004,0007,0676,0096,0030,0004,0004 LC,HT USA1 MDN1 11805837,11805837 0004,0007 HT USA1 DFM1 18407841,18407841 0007,0004 LC USA1 YOS9 16873066,16873066,16873065,16873065 0004,0676,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q03714 P53617 USA1 NRD1 0.126 22028667 Q03714 P08518 USA1 RPB2 0.126 22028667 Q03714 P10080 USA1 SBP1 0.126 23222640 Q03714 P06197 USA1 PIS1 0.332 18719252 Q03714 P18899 USA1 DDR48 0.236 16554755 Q03714 P25694 USA1 CDC48 0.61 16873066,20005842 Q03714 P38307 USA1 DER1 0.899 24292014,19898607,20005842,18719252,16873066,23363603,18407841 Q03860 Q03714 TVP15 USA1 0.332 18719252 Q12404 Q03714 MPD1 USA1 0.332 18719252 Q03714 P29453 USA1 RPL8B 0.332 18719252 Q03714 P47013 USA1 LCB3 0.332 18719252 Q03714 P32368 USA1 SAC1 0.332 18719252 Q03714 P53174 USA1 PRM8 0.332 18719252 Q05787 Q03714 HRD3 USA1 0.757 16873066,19898607,20005842,25428985 Q03714 Q03714 USA1 USA1 0.523 21074049,18719252 Q03714 P48565 USA1 RIM21 0.332 16554755 Q08109 Q03714 HRD1 USA1 0.943 19898607,16429126,20005842,19394298,16873066,21074049 Q03714 P36775 USA1 PIM1 0.332 11805837 Q03714 P37898 USA1 AAP1 0.126 16429126 Q03714 P30771 USA1 NAM7 0.126 18087042 Q03714 P38737 USA1 ECM29 0.126 16429126 Q03714 P39524 USA1 DRS2 0.126 16429126 Q03714 P33302 USA1 PDR5 0.126 16429126 Q03714 P33760 USA1 PEX6 0.332 11805837 Q03714 P40857 USA1 PHS1 0.332 18719252 Q03714 P47017 USA1 LSM1 0.126 23222640 Q03714 P18239 USA1 PET9 0.126 16429126 Q03714 Q00916 USA1 SNP1 0.523 11425851 Q03714 Q03690 USA1 CLU1 0.126 16429126 Q6Q595 Q03714 SCS22 USA1 0.332 18719252 Q03714 P22943 USA1 HSP12 0.126 19536198 Q03714 P00729 USA1 PRC1 0.21 16873065 Q03714 P17076 USA1 RPL8A 0.332 18719252 Q03714 P10591 USA1 SSA1 0.126 19536198 Q03714 P11484 USA1 SSB1 0.126 19536198 Q03714 P53868 USA1 ALG9 0.332 18719252 Q03714 P53224 USA1 ORM1 0.332 18719252 Q12743 Q03714 DFM1 USA1 0.583 18719252,18407841 Q04748 Q03714 SOV1 USA1 0.126 11805837 Q12431 Q03714 EMC6 USA1 0.332 18719252 Q07451 Q03714 YET3 USA1 0.332 18719252 Q05881 Q03714 Q05881 USA1 0.236 16554755 Q12019 Q03714 MDN1 USA1 0.286 11805837 Q99220 Q03714 YOS9 USA1 0.507 16873066,16873065 Q8N6L0 Q03714 CCDC155 USA1 0.332 27107014 Q04182 Q03714 PDR15 USA1 0.126 16429126 Q04228 Q03714 UBX2 USA1 0.21 16873066 Q03714 P53045 USA1 ERG25 0.126 16429126