PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBI4 VPS9 23649778,12628920,12787503,12573224,12654912 biogrid,mint,intact exp HSC82 VPS9 19536198 intact exp APM3 VPS9 i2d exp SNA3 VPS9 18719252 biogrid,intact exp SRB5 VPS9 i2d exp SSB2 VPS9 23332755,19536198 biogrid,intact exp SSB1 VPS9 22940862,19536198 biogrid,intact exp VPS9 PUF3 26493364 biogrid exp STE6 VPS9 23831759 biogrid exp SSE1 VPS9 19536198 intact exp RSP5 VPS9 12654912 biogrid exp NAB2 VPS9 19840948 biogrid exp NAF1 VPS9 14690591 intact exp VPS21 VPS9 22157956,10329739, 23023127 biogrid exp, pred RAM2 VPS9 11283351, 23023127 i2d,mint,intact,dip exp, pred EXO70 VPS9 16429126, 23023127 intact exp, pred YPT53 VPS9 22157956, 23023127 biogrid exp, pred SSA1 VPS9 22940862,19536198, 23023127 biogrid,intact exp, pred VPS9 VPS9 11805826,22940862, 23023127 biogrid,mint,intact exp, pred SSA2 VPS9 22940862,19536198, 23023127 biogrid,intact exp, pred EXO84 VPS9 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred SLA1 VPS9 19841731, 23023127 biogrid,mint,intact exp, pred GSP1 VPS9 23023127 pred ATG8 VPS9 23023127 pred VPS24 VPS9 23023127 pred ATG1 VPS9 23023127 pred VPS4 VPS9 23023127 pred YPT32 VPS9 23023127 pred GSP2 VPS9 23023127 pred VPS9 ARL3 23023127 pred ATG3 VPS9 23023127 pred ARF2 VPS9 23023127 pred VMA3 VPS9 23023127 pred APS1 VPS9 23023127 pred SAR1 VPS9 23023127 pred ATG12 VPS9 23023127 pred MVP1 VPS9 23023127 pred VPS9 YPT6 23023127 pred VPS9 VPS5 23023127 pred ARL1 VPS9 23023127 pred VPS9 UBX5 23023127 pred DJP1 VPS9 23023127 pred PEP5 VPS9 23023127 pred YPT7 VPS9 23023127 pred YPT11 VPS9 23023127 pred VID24 VPS9 23023127 pred SRP102 VPS9 23023127 pred DSK2 VPS9 23023127 pred VPS9 VPS30 23023127 pred YPT31 VPS9 23023127 pred PEP1 VPS9 23023127 pred YPT10 VPS9 23023127 pred SEC2 VPS9 23023127 pred VPS9 HUB1 23023127 pred UBX6 VPS9 23023127 pred RAD23 VPS9 23023127 pred VPS27 VPS9 23023127 pred SEC63 VPS9 23023127 pred SEC17 VPS9 23023127 pred SNF7 VPS9 23023127 pred GOS1 VPS9 23023127 pred VPS1 VPS9 23023127 pred ARF3 VPS9 23023127 pred VPS9 ATG13 23023127 pred VPS9 UBX3 23023127 pred UBC1 VPS9 23023127 pred PEX5 VPS9 23023127 pred YPT52 VPS9 23023127 pred VPS9 APS2 23023127 pred VPS9 SMT3 23023127 pred UBX7 VPS9 23023127 pred PEP12 VPS9 23023127 pred VPS9 UBI4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P54787 P29703 - 11283351 - X 2 P54787 - 11805826 - C 7 P83882 P54787 affinity chromatography technology 23649778 physical association X 2 P83882 P54787 affinity chromatography technology 23649778 physical association X 2 Q8CI11 P54787 affinity chromatography technology 23649778 physical association X 2 Q3V132 P54787 affinity chromatography technology 23649778 physical association X 2 Q80X85 P54787 affinity chromatography technology 23649778 physical association X 2 P09405 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWY9 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWY9 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWY9 P54787 affinity chromatography technology 23649778 physical association X 2 P99027 P54787 affinity chromatography technology 23649778 physical association X 2 E9Q634 P54787 affinity chromatography technology 23649778 physical association X 2 A2AHJ7 P54787 affinity chromatography technology 23649778 physical association X 2 P58059 P54787 affinity chromatography technology 23649778 physical association X 2 P68040 P54787 affinity chromatography technology 23649778 physical association X 2 Q9CQF0 P54787 affinity chromatography technology 23649778 physical association X 2 Q9JKB3-2 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWV7 P54787 affinity chromatography technology 23649778 physical association X 2 Q9CQM8 P54787 affinity chromatography technology 23649778 physical association X 2 P51881 P54787 affinity chromatography technology 23649778 physical association X 2 E9Q5H9 P54787 affinity chromatography technology 23649778 physical association X 2 P05213 P54787 affinity chromatography technology 23649778 physical association X 2 P62852 P54787 affinity chromatography technology 23649778 physical association X 2 P36019 P54787 two hybrid 22157956 direct interaction X 2 P61358 P54787 affinity chromatography technology 23649778 physical association X 2 Q62029 P54787 affinity chromatography technology 23649778 physical association X 2 Q3TKR5 P54787 affinity chromatography technology 23649778 physical association X 2 Q61510 P54787 affinity chromatography technology 23649778 physical association X 2 Q9Z2X1 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D0D4 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q8K2Y7 P54787 affinity chromatography technology 23649778 physical association X 2 P84104 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWY3 P54787 affinity chromatography technology 23649778 physical association X 2 P62908 P54787 affinity chromatography technology 23649778 physical association X 2 Q1HFZ0 P54787 affinity chromatography technology 23649778 physical association X 2 Q9CXW2 P54787 affinity chromatography technology 23649778 physical association X 2 P14148 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D6Z1 P54787 affinity chromatography technology 23649778 physical association X 2 Q99ME9 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D1R9 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D1R9 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D1R9 P54787 affinity chromatography technology 23649778 physical association X 2 P17182 P54787 affinity chromatography technology 23649778 physical association X 2 P17182 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q99N69 P54787 affinity chromatography technology 23649778 physical association X 2 P62992 P54787 x-ray crystallography 12787502 association X 2 P12970 P54787 affinity chromatography technology 23649778 physical association X 2 Q925I1 P54787 affinity chromatography technology 23649778 physical association X 2 P14869 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q921K2 P54787 affinity chromatography technology 23649778 physical association X 2 P52480 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q8QZY1 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWU9 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWU9 P54787 affinity chromatography technology 23649778 physical association X 2 Q8BMA6 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 P54787 affinity chromatography technology 22940862 physical association X 2 P54787 Q9EST5 affinity chromatography technology 23649778 physical association X 2 P54787 Q03265 affinity chromatography technology 23649778 physical association X 2 P54787 Q8CGC7 affinity chromatography technology 23649778 physical association X 2 P54787 Q99L45 affinity chromatography technology 23649778 physical association X 2 P54787 P17156 affinity chromatography technology 23649778 physical association X 2 P54787 Q8BU30 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 Q9D7N3 affinity chromatography technology 23649778 physical association X 2 P54787 Q7TPV4 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 Q9D8E6 affinity chromatography technology 23649778 physical association X 2 P54787 P47911 affinity chromatography technology 23649778 physical association X 2 P54787 P62849-2 affinity chromatography technology 23649778 physical association X 2 P54787 Q52KI8-2 affinity chromatography technology 23649778 physical association X 2 P54787 Q8R0X7 affinity chromatography technology 23649778 physical association X 2 P54787 P32790 two hybrid 19841731 direct interaction X 2 P67984 P54787 affinity chromatography technology 23649778 physical association X 2 P67984 P54787 affinity chromatography technology 23649778 physical association X 2 P36017 P54787 affinity chromatography technology 10329739 physical association X 2 P36017 P54787 enzymatic study 10329739 direct interaction X 2 P36017 P54787 two hybrid 10329739 direct interaction X 2 P36017 P54787 two hybrid 22157956 direct interaction X 2 Q3UPF5 P54787 affinity chromatography technology 23649778 physical association X 2 Q01853 P54787 affinity chromatography technology 23649778 physical association X 2 P35980 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D0I9 P54787 affinity chromatography technology 23649778 physical association X 2 P32067 P54787 affinity chromatography technology 23649778 physical association X 2 Q05144 P54787 affinity chromatography technology 23649778 physical association X 2 P62855 P54787 affinity chromatography technology 23649778 physical association X 2 Q14C51 P54787 affinity chromatography technology 23649778 physical association X 2 P70333 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P16381 P54787 affinity chromatography technology 23649778 physical association X 2 P10592 P54787 affinity chromatography technology 22940862 physical association X 2 P63276 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P27659 P54787 affinity chromatography technology 23649778 physical association X 2 P62264 P54787 affinity chromatography technology 23649778 physical association X 2 P12866 P54787 protein complementation assay 23831759 direct interaction X 2 P25444 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q64523 P54787 affinity chromatography technology 23649778 physical association X 2 Q6ZWN5 P54787 affinity chromatography technology 23649778 physical association X 2 Q9ERD7 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P11484 P54787 affinity chromatography technology 22940862 physical association X 2 P62918 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P0CG63 P54787 pull down 12654912 direct interaction X 2 P0CG63 P54787 two hybrid 12628920 direct interaction X 2 P0CG63 P54787 two hybrid 12573224 direct interaction X 2 P0CG63 P54787 affinity chromatography technology 23749301 physical association X 2 P0CG63 P54787 affinity chromatography technology 24821572 physical association X 2 P0CG63 P54787 pull down 12628920 direct interaction X 2 P0CG63 P54787 affinity chromatography technology 12628920 physical association X 2 P0CG63 P54787 affinity chromatography technology 23793018 physical association X 2 P0CG63 P54787 pull down 12573224 direct interaction X 2 P0CG63 P54787 affinity chromatography technology 12654912 physical association X 2 P0CG63 P54787 affinity chromatography technology 22081111 physical association X 2 P0CG63 P54787 pull down 12787503 direct interaction X 2 P0CG63 P54787 affinity chromatography technology 21427232 physical association X 2 P0CG63 P54787 affinity chromatography technology 22106047 physical association X 2 P0CG63 P54787 affinity chromatography technology 22081111 physical association X 2 Q8C3J5 P54787 affinity chromatography technology 23649778 physical association X 2 P62281 P54787 affinity chromatography technology 23649778 physical association X 2 P62960 P54787 affinity chromatography technology 23649778 physical association X 2 P61222 P54787 affinity chromatography technology 23649778 physical association X 2 P38647 P54787 affinity chromatography technology 23649778 physical association X 2 Q9DB15 P54787 affinity chromatography technology 23649778 physical association X 2 P62911 P54787 affinity chromatography technology 23649778 physical association X 2 Q91VE6 P54787 affinity chromatography technology 23649778 physical association X 2 Q570Z0 P54787 affinity chromatography technology 23649778 physical association X 2 Q8VEK3 P54787 affinity chromatography technology 23649778 physical association X 2 P14115 P54787 affinity chromatography technology 23649778 physical association X 2 P61514 P54787 affinity chromatography technology 23649778 physical association X 2 P47955 P54787 affinity chromatography technology 23649778 physical association X 2 Q6PGG6 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 Q9CPR5 P54787 affinity chromatography technology 23649778 physical association X 2 P35979 P54787 affinity chromatography technology 23649778 physical association X 2 P63017 P54787 affinity chromatography technology 23649778 physical association X 2 Q3U7T8 P54787 affinity chromatography technology 23649778 physical association X 2 P29341 P54787 affinity chromatography technology 23649778 physical association X 2 Q9D4E6 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P62830 P54787 affinity chromatography technology 23649778 physical association X 2 P20152 P54787 affinity chromatography technology 23649778 physical association X 2 P40150 P54787 biochemical 23332755 association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 O54774 affinity chromatography technology 23649778 physical association X 2 P54787 Q8BP47 affinity chromatography technology 23649778 physical association X 2 P54787 Q8BJY7 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 Q3UHZ3 affinity chromatography technology 23649778 physical association X 2 P54787 P57776 affinity chromatography technology 23649778 physical association X 2 P54787 Q9Z0N2 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 Q9CQ40 affinity chromatography technology 23649778 physical association X 2 P54787 Q8BK72 affinity chromatography technology 23649778 physical association X 2 P54787 Q6S385 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 Q9JKF1 affinity chromatography technology 23649778 physical association X 2 P54787 Q6ZWV3 affinity chromatography technology 23649778 physical association X 2 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 Q9CXW4 affinity chromatography technology 23649778 physical association X 2 P54787 P84099 affinity chromatography technology 23649778 physical association X 2 P54787 Q8CAB9 affinity chromatography technology 23649778 physical association X 2 P54787 Q9CY58-2 affinity chromatography technology 23649778 physical association X 2 P54787 Q9CWF2 affinity chromatography technology 23649778 physical association X 2 P54787 P38261 affinity chromatography technology 16429126 physical association X 2 P54787 P38261 affinity chromatography technology 11805826 physical association X 2 P62849 P54787 affinity chromatography technology 23649778 physical association X 2 Q8VEM8 P54787 affinity chromatography technology 23649778 physical association X 2 P14359 P54787 two hybrid 18719252 direct interaction X 2 P10591 P54787 affinity chromatography technology 22940862 physical association X 2 P62754 P54787 affinity chromatography technology 23649778 physical association X 2 P62754 P54787 affinity chromatography technology 23649778 physical association X 2 O70503 P54787 affinity chromatography technology 23649778 physical association X 2 Q91V55 P54787 affinity chromatography technology 23649778 physical association X 2 Q9CR57 P54787 affinity chromatography technology 23649778 physical association X 2 Q8BP67 P54787 affinity chromatography technology 23649778 physical association X 2 O35972 P54787 affinity chromatography technology 23649778 physical association X 2 Q8CIE6 P54787 affinity chromatography technology 23649778 physical association X 2 Q7TMK9-2 P54787 affinity chromatography technology 23649778 physical association X 2 Q9CQN7 P54787 affinity chromatography technology 23649778 physical association X 2 P62267 P54787 affinity chromatography technology 23649778 physical association X 2 P62717 P54787 affinity chromatography technology 23649778 physical association X 2 P39940 P54787 enzymatic study 12654912 direct interaction X 2 Q8BTS0 P54787 affinity chromatography technology 23649778 physical association X 2 P54787 P29703 two hybrid pooling approach 11283351 physical association X 2 P54787 inferred by author 11805826 physical association C 7 P54787 tandem affinity purification 11805826 physical association C 7 P54787 P38261 tandem affinity purification 11805826 physical association X 2 P54787 inferred by author 16429126 physical association C 10 P54787 tandem affinity purification 16429126 association C 11 P15108 P54787 tandem affinity purification 19536198 association X 2 P53919 P54787 two hybrid array 14690591 physical association X 2 P54787 P29703 two hybrid fragment pooling approach 11283351 physical association X 2 P54787 P54787 tandem affinity purification 11805826 physical association X 2 P54787 P32790 two hybrid pooling approach 19841731 physical association X 2 P54787 tandem affinity purification 11805826 association C 8 P10592 P54787 tandem affinity purification 19536198 association X 2 P32589 P54787 tandem affinity purification 19536198 association X 2 P11484 P54787 tandem affinity purification 19536198 association X 2 P0CG63 P54787 two hybrid 12573224 physical association X 2 P0CG63 P54787 pull down 12573224 direct interaction X 2 P40150 P54787 tandem affinity purification 19536198 association X 2 P14359 P54787 two hybrid 18719252 physical association X 2 P10591 P54787 tandem affinity purification 19536198 association X 2 P38429 P54787 interaction detection method 14764870 - X 2 P38153 P54787 interaction detection method 9412470 - X 2 P54787 P29703 two hybrid 11283351 - X 2 P54787 mass spectrometry studies of complexes 11805826 - C 8 P54787 P47124 interaction detection method 14764870 - X 2 P32485 P54787 interaction detection method 14764870 - X 2

PPI - HINT Gene A Gene B PMID Method Quality UBI4 VPS9 12628920,12573224,12628920,12573224 0018,0096,0096,0018 LC STE6 VPS9 23831759 0090 HT SNA3 VPS9 18719252 0018 HT RAM2 VPS9 11283351,11283351,11283351 0018,0399,0398 HT SLA1 VPS9 19841731,19841731 0398,0018 HT VPS21 VPS9 10329739,22157956,10329739,10329739 0018,0018,0004,0415 LC YPT53 VPS9 22157956 0018 LC RSP5 VPS9 12654912 0415 LC SSB2 VPS9 23332755 0401 LC NAF1 VPS9 14690591 0397 LC VPS9 VPS9 12787502 0114 LC UBI4 VPS9 23649778,12628920,12573224,12787503,12654912,12628920,22106047,12573224,23649778,22081111 0096,0018,0096,0096,0096,0096,0004,0018,0004,0004 LC SSA1 VPS9 22940862,19536198 0004,0676 HT SSA2 VPS9 22940862,19536198 0004,0676 HT SSB1 VPS9 22940862,19536198 0004,0676 HT HSC82 VPS9 19536198 0676 HT EXO70 VPS9 16429126 0363 HT NAB2 VPS9 19840948 0004 LC SSE1 VPS9 19536198 0676 HT VPS21 VPS9 10329739,10329739,10329739 0018,0004,0415 LC EXO84 VPS9 11805826,16429126,11805826,16429126,11805826 0004,0004,0007,0676,0676 HT RSP5 VPS9 26508657 0004 LC SSB2 VPS9 19536198,23332755 0676,0401 HT,LC VPS9 VPS9 22940862,11805826,11805826 0004,0676,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P54787 O14641 VPS9 DVL2 0.332 27107014 Q12221 P54787 PUF2 VPS9 0.126 26668354 P54787 P10592 VPS9 SSA2 0.126 19536198 P54787 P12866 VPS9 STE6 0.183 23831759 P54787 P36017 VPS9 VPS21 0.74 10329739,22157956 P54787 P39940 VPS9 RSP5 0.396 26508657,12654912 P54787 P40150 VPS9 SSB2 0.236 23332755,19536198 P54787 P0CG63 VPS9 UBI4 0.946 23649778,12573224,12628920,12654912 P54787 P29703 VPS9 RAM2 0.236 11283351 P54787 P38261 VPS9 EXO84 0.354 11805826,16429126 P54787 P32505 VPS9 NAB2 0.126 19840948 P54787 P32589 VPS9 SSE1 0.126 19536198 P54787 P36019 VPS9 YPT53 0.309 22157956 P54787 P19658 VPS9 EXO70 0.126 16429126 P54787 P15108 VPS9 HSC82 0.126 19536198 Q07807 P54787 PUF3 VPS9 0.126 26493364 P54787 P10591 VPS9 SSA1 0.126 19536198 P54787 P11484 VPS9 SSB1 0.126 19536198 P54787 P14359 VPS9 SNA3 0.332 18719252 P54787 P32790 VPS9 SLA1 0.376 19841731 P54787 P53919 VPS9 NAF1 0.126 14690591 P54787 P54787 VPS9 VPS9 0.155 11805826 P62992 P54787 RPS27A VPS9 0.309 12787502 Q15038 P54787 DAZAP2 VPS9 0.332 27107014