PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus AIP1 Putative uncharacterized oxidoreductase YGL039W i2d exp SIS1 AIP1 19536198 intact exp SSB2 AIP1 23332755 biogrid exp SSA2 AIP1 19536198 intact exp AIM46 AIP1 11805837 dip exp CCT2 AIP1 19536198 intact exp AIP1 PUF3 23409723 biogrid exp EDS1 AIP1 i2d exp RPN11 AIP1 20170199 biogrid exp NAB2 AIP1 19840948 biogrid exp TRZ1 AIP1 i2d exp BNI1 AIP1 24133141 biogrid exp SSB1 AIP1 19536198 intact exp AIP1 APC9 10688190 biogrid,i2d,mint,intact,dip exp SSM4 AIP1 16606443 biogrid,mint,intact exp RVS167 AIP1 i2d exp SBA1 AIP1 i2d exp AIP1 Cell wall protein YJL171C i2d exp FES1 AIP1 11283351 i2d,mint,intact,dip exp SSA1 AIP1 19536198 intact exp ECM10 AIP1 19536198 intact exp SSE1 AIP1 19536198 biogrid,intact exp, ortho AIP1 COF1 16421248,10366597,11805837, 23023127 biogrid,mint,intact,dip exp, ortho, pred AIP1 ACT1 16421248,10366597,7719850,17483419,16611742,18719252, 23023127 biogrid,i2d,intact,dip exp, pred RSP5 AIP1 16606443, 23023127 biogrid,mint,intact exp, pred PRP40 AIP1 16606443, 23023127 biogrid,mint,intact exp, pred SRV2 AIP1 11489916,10688190, 23023127 biogrid,i2d,mint,intact,dip exp, pred AIP1 KEL3 11283351, 23023127 i2d,mint,intact,dip exp, pred SSE2 AIP1 19536198, 23023127 intact exp, pred SKI2 AIP1 ortho PPE1 AIP1 ortho HOG1 AIP1 ortho Uncharacterized protein YBR053C AIP1 ortho AIP1 MEX67 ortho QRI1 AIP1 ortho PSA1 AIP1 ortho PGI1 AIP1 ortho AIP1 DIS3 ortho CDC21 AIP1 ortho TRX3 AIP1 ortho PRX1 AIP1 ortho CYS3 AIP1 ortho CDC28 AIP1 ortho INO1 AIP1 ortho AAT2 AIP1 ortho AIP1 UBP15 ortho HSP10 AIP1 ortho AIP1 RLI1 ortho CKB2 AIP1 ortho MVD1 AIP1 ortho TAL1 AIP1 ortho AIP1 RVB2 ortho DUG1 AIP1 ortho UBC1 AIP1 ortho AIP1 RVB1 ortho CAP1 AIP1 23023127 ortho, pred BIM1 AIP1 23023127 ortho, pred PFY1 AIP1 23023127 pred AIP1 ARC18 23023127 pred KIP1 AIP1 23023127 pred CAP2 AIP1 23023127 pred AIP1 TWF1 23023127 pred TPM1 AIP1 23023127 pred RHO2 AIP1 23023127 pred MYO3 AIP1 23023127 pred AIP1 ARP7 23023127 pred SLA1 AIP1 23023127 pred AIP1 CRN1 23023127 pred AIP1 ARC35 23023127 pred AIP1 ARP9 23023127 pred TPM2 AIP1 23023127 pred RVS161 AIP1 23023127 pred ARC19 AIP1 23023127 pred AIP1 LAS17 23023127 pred AIP1 MYO5 23023127 pred END3 AIP1 23023127 pred SAC6 AIP1 23023127 pred KIP2 AIP1 23023127 pred ARP2 AIP1 23023127 pred ARC15 AIP1 23023127 pred RHO1 AIP1 23023127 pred AIP1 KIP3 23023127 pred ARC40 AIP1 23023127 pred AIP1 ARP3 23023127 pred CIN8 AIP1 23023127 pred AIP1 ASE1 23023127 pred MHP1 AIP1 23023127 pred CDC5 AIP1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P46680 P38260 - 11283351 - X 2 P17555 P46680 - 11489916 - X 2 Q12107 P46680 - 10688190 - X 2 P46680 - 11805837 - C 9 P46680 Q08979 - 11283351 - X 2 P46680 P60010 two hybrid 10366597 direct interaction X 2 P46680 P60010 two hybrid 10366597 direct interaction X 2 P46680 P60010 pull down 16611742 direct interaction X 2 P46680 P60010 two hybrid 16421248 direct interaction X 2 P46680 P60010 two hybrid 17483419 direct interaction X 2 P46680 P60010 two hybrid 18719252 direct interaction X 2 P46680 P43588 affinity chromatography technology 20170199 physical association X 2 P17555 P46680 two hybrid 11489916 direct interaction X 2 Q12107 P46680 two hybrid 10688190 direct interaction X 2 P32589 P46680 affinity chromatography technology 19536198 physical association X 2 P32589 P46680 affinity chromatography technology 19536198 physical association X 2 P46680 Q03048 two hybrid 10366597 direct interaction X 2 P46680 Q03048 two hybrid 10366597 direct interaction X 2 P46680 Q03048 two hybrid 16421248 direct interaction X 2 P46680 Q03048 affinity chromatography technology 11805837 physical association X 2 P46680 P33203 unspecified method 16606443 direct interaction X 2 P0CG63 P46680 affinity chromatography technology 23749301 physical association X 2 P40318 P46680 unspecified method 16606443 direct interaction X 2 P40150 P46680 biochemical 23332755 association X 2 P39940 P46680 unspecified method 16606443 direct interaction X 2 P46680 anti tag coimmunoprecipitation 11805837 - C 10 P46680 anti tag coimmunoprecipitation 11805837 - C 15 P46680 P38260 two hybrid pooling approach 11283351 physical association X 2 P46680 P60010 two hybrid 7719850 physical association X 2 P46680 P60010 two hybrid 7719850 physical association X 2 P46680 P60010 two hybrid 10366597 physical association X 2 P17555 P46680 two hybrid 11489916 physical association X 2 P17555 P46680 two hybrid 10688190 physical association X 2 P38885 P46680 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12107 P46680 two hybrid 10688190 physical association X 2 P46680 Q08979 two hybrid pooling approach 11283351 physical association X 2 P46680 Q03048 two hybrid 10366597 physical association X 2 P46680 Q03048 anti tag coimmunoprecipitation 11805837 physical association X 2 P10592 P46680 tandem affinity purification 19536198 association X 2 P46680 P38260 two hybrid fragment pooling approach 11283351 physical association X 2 P46680 P60010 two hybrid 18719252 physical association X 2 P46680 P25294 tandem affinity purification 19536198 association X 2 P17555 P46680 two hybrid 10688190 physical association X 2 P32590 P46680 tandem affinity purification 19536198 association X 2 P39076 P46680 tandem affinity purification 19536198 association X 2 Q12107 P46680 two hybrid 10688190 physical association X 2 P46680 anti tag coimmunoprecipitation 11805837 association C 9 P32589 P46680 tandem affinity purification 19536198 association X 2 P32589 P46680 tandem affinity purification 19536198 association X 2 P46680 Q03048 two hybrid 10366597 physical association X 2 P46680 Q08979 two hybrid fragment pooling approach 11283351 physical association X 2 P46680 P33203 protein array 16606443 direct interaction X 2 P46680 P39987 tandem affinity purification 19536198 association X 2 P11484 P46680 tandem affinity purification 19536198 association X 2 P40318 P46680 protein array 16606443 direct interaction X 2 P10591 P46680 tandem affinity purification 19536198 association X 2 P39940 P46680 protein array 16606443 direct interaction X 2 P46680 confirmational text mining - - C 25 P46680 P38260 two hybrid 11283351 - X 2 P46680 P60010 two hybrid - - X 2 P17555 P46680 two hybrid 11489916 - X 2 P17555 P46680 two hybrid 11489916 - X 2 Q12107 P46680 two hybrid 10688190 - X 2 P46680 mass spectrometry studies of complexes 11805837 - C 11 P46680 Q08979 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SRV2 AIP1 11489916,10688190 0018,0018 HT PRP40 AIP1 16606443 0089 HT FES1 AIP1 11283351,11283351,11283351 0018,0399,0398 HT RSP5 AIP1 16606443 0089 HT SSB2 AIP1 23332755 0401 LC SSM4 AIP1 16606443 0089 HT AIP1 AIP1 12807914 0114 LC AIP1 ACT1 18719252,10366597,17483419,7719850,16421248 0018,0018,0018,0018,0018 HT,LC AIP1 COF1 10366597,16421248 0018,0018 LC AIP1 KEL3 11283351,11283351,11283351 0018,0399,0398 HT AIP1 APC9 10688190,10688190 0397,0018 HT SSA1 AIP1 19536198 0676 HT SSA2 AIP1 19536198 0676 HT SSB1 AIP1 19536198 0676 HT SIS1 AIP1 19536198 0676 HT NAB2 AIP1 19840948 0004 LC SSE1 AIP1 19536198,19536198 0004,0676 HT SSE2 AIP1 19536198 0676 HT AIM46 AIP1 11805837 0007 HT CCT2 AIP1 19536198 0676 HT ECM10 AIP1 19536198 0676 HT SSB2 AIP1 23332755 0401 LC BNI1 AIP1 24133141 0096 LC RPN11 AIP1 20170199 0004 LC AIP1 ENT3 25512335 0096 LC AIP1 ACT1 16611742 0096 LC AIP1 COF1 11805837,11805837 0004,0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P60010 P46680 ACT1 AIP1 0.539 16611742,10366597,18719252,7719850 P60709 P46680 ACTB AIP1 0.332 27107014 P46680 P25294 AIP1 SIS1 0.126 19536198 Q9Y281 P46680 CFL2 AIP1 0.332 27107014 P46680 P11484 AIP1 SSB1 0.126 19536198 P46680 P17555 AIP1 SRV2 0.376 10688190,11489916 P46680 P32589 AIP1 SSE1 0.416 19536198 P46680 P32505 AIP1 NAB2 0.126 19840948 P46680 P33203 AIP1 PRP40 0.332 16606443 P46680 P39940 AIP1 RSP5 0.332 16606443 P46680 P40123 AIP1 CAP2 0.332 27107014 P46680 P40150 AIP1 SSB2 0.126 23332755 P46680 P40318 AIP1 SSM4 0.332 16606443 P46680 P43588 AIP1 RPN11 0.126 20170199 P46680 P10591 AIP1 SSA1 0.126 19536198 P46680 P10592 AIP1 SSA2 0.126 19536198 P46680 P32590 AIP1 SSE2 0.126 19536198 P46680 P38260 AIP1 FES1 0.21 11283351 P46680 P38885 AIP1 AIM46 0.126 11805837 P46680 P39076 AIP1 CCT2 0.126 19536198 P46680 P39987 AIP1 ECM10 0.126 19536198 P63261 P46680 ACTG1 AIP1 0.332 27107014 Q08979 P46680 KEL3 AIP1 0.21 11283351 Q12107 P46680 APC9 AIP1 0.332 10688190 P47160 P46680 ENT3 AIP1 0.183 25512335 P46680 P41832 AIP1 BNI1 0.183 24133141 Q03048 P46680 COF1 AIP1 0.21 11805837,10366597 Q07807 P46680 PUF3 AIP1 0.126 23409723