PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HHF1, HHF2 SIP5 22199229 biogrid exp SIP5 EGD1 16554755 biogrid,i2d,mint,intact exp SIP5 SSK2 21460040 biogrid exp SIP5 VID22 11283351 i2d,mint,intact,dip exp SSE2 SIP5 19536198 intact exp HTB2 SIP5 22199229 biogrid exp HTB1 SIP5 22199229 biogrid exp SIP5 TOS3 21460040 biogrid exp HMT1 SIP5 14690591 intact exp SIP5 HMO1 16554755 biogrid,i2d,mint,intact exp MEK1 SIP5 21460040 biogrid exp CDC34 SIP5 i2d exp TPK1 SIP5 16319894 biogrid,i2d exp CRM1 SIP5 26673895 biogrid exp YCK2 SIP5 16319894 biogrid,i2d exp CMK1 SIP5 16319894 biogrid,i2d exp DBP2 SIP5 i2d exp SIP5 PKP2 16319894 biogrid,i2d exp RSP5 SIP5 17551511 biogrid exp LSM12 SIP5 i2d exp SPT16 SIP5 i2d exp TPK2 SIP5 16319894,21460040 biogrid,i2d exp NAP1 SIP5 18086883 biogrid exp SSA1 SIP5 19536198 intact exp KKQ8 SIP5 21460040 biogrid exp SIP5 VHS1 16319894 biogrid,i2d exp GLC7 SIP5 10628972 biogrid exp SSB1 SIP5 19536198 intact exp SIP5 NAF1 14690591 intact exp SIP5 SVF1 i2d exp SAT4 SIP5 21460040 biogrid exp SWE1 SIP5 i2d exp UBC8 SIP5 i2d exp RPF2 SIP5 i2d exp SSA2 SIP5 19536198 intact exp NAB2 SIP5 19840948 biogrid exp SIP5 UBC13 18467557,16554755 biogrid,i2d,mint,intact exp SBP1 SIP5 i2d exp SIP5 CDC55 i2d exp SIP5 TFG2 18467557 mint,intact exp IRE1 SIP5 16319894 biogrid,i2d exp SIP5 PRR2 16319894 biogrid,i2d exp SIP5 VAM6 25026036 biogrid exp YCK1 SIP5 16319894 biogrid exp HSP78 SIP5 19536198 intact exp KCC4 SIP5 21460040 biogrid exp SIP5 PTK2 16319894,21460040 biogrid,i2d exp SIP5 SKY1 21460040 biogrid exp SIP5 ESA1 19303850 biogrid exp SSE1 SIP5 19536198 intact exp EGD2 SIP5 16554755 biogrid,i2d,mint,intact exp SIP5 ATG1 16319894, 23023127 biogrid,i2d exp, pred FUS1 SIP5 11743162,19841731, 23023127 biogrid,mint,intact exp, pred SNF1 SIP5 10628972, 23023127 biogrid exp, pred SIP5 MMS2 22615397,18467557,16554755, 23023127 biogrid,i2d,mint,intact exp, pred MSN2 SIP5 23023127 pred SIP2 SIP5 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P40210 Q05934 - 11283351 - X 2 P0CG63 P40210 affinity chromatography technology 23749301 physical association X 2 P0CG63 P40210 affinity chromatography technology 23793018 physical association X 2 P0CG63 P40210 affinity chromatography technology 12872131 physical association X 2 P40210 P32598 affinity chromatography technology 10628972 physical association X 2 P40210 P32598 two hybrid 10628972 direct interaction X 2 P40210 P25293 affinity chromatography technology 18086883 physical association X 2 P40210 P53104 enzymatic study 16319894 direct interaction X 2 P40210 Q12310 enzymatic study 16319894 direct interaction X 2 P40210 P47116 enzymatic study 16319894 direct interaction X 2 P40210 P06244 enzymatic study 16319894 direct interaction X 2 P40210 P06245 enzymatic study 16319894 direct interaction X 2 P40210 Q03785 enzymatic study 16319894 direct interaction X 2 P40210 P53170 enzymatic study 16319894 direct interaction X 2 P40210 Q08649 enzymatic study 19303850 direct interaction X 2 P40210 P36004 pull down 21460040 direct interaction X 2 P40210 P24719 pull down 21460040 direct interaction X 2 P40210 P47116 pull down 21460040 direct interaction X 2 P40210 P06245 pull down 21460040 direct interaction X 2 P52490 P40210 affinity chromatography technology 16554755 physical association X 2 P52490 P40210 protein complementation assay 18467557 direct interaction X 2 P27466 P40210 enzymatic study 16319894 direct interaction X 2 P32361 P40210 enzymatic study 16319894 direct interaction X 2 P23292 P40210 enzymatic study 16319894 direct interaction X 2 P40210 P06782 affinity chromatography technology 10628972 physical association X 2 P40210 P06782 two hybrid 10628972 direct interaction X 2 P40210 P53152 affinity chromatography technology 16554755 physical association X 2 P40210 Q03973 affinity chromatography technology 16554755 physical association X 2 P40210 P38879 affinity chromatography technology 16554755 physical association X 2 P40210 Q02642 affinity chromatography technology 16554755 physical association X 2 P40210 P23291 enzymatic study 16319894 direct interaction X 2 P40210 P39940 enzymatic study 17551511 direct interaction X 2 P40210 P53152 protein complementation assay 18467557 direct interaction X 2 P40210 P11710 two hybrid 19841731 direct interaction X 2 P40210 P25389 pull down 21460040 direct interaction X 2 P40210 P25333 pull down 21460040 direct interaction X 2 P40210 Q03656 pull down 21460040 direct interaction X 2 P40210 P43637 pull down 21460040 direct interaction X 2 P40210 P02309 affinity chromatography technology 22199229 physical association X 2 P40210 P02309 affinity chromatography technology 22199229 physical association X 2 P40210 P02293 affinity chromatography technology 22199229 physical association X 2 P40210 P02294 affinity chromatography technology 22199229 physical association X 2 P40210 P53152 protein complementation assay 22615397 direct interaction X 2 P53599 P40210 pull down 21460040 direct interaction X 2 P40210 Q05934 two hybrid pooling approach 11283351 physical association X 2 P40210 P38074 two hybrid array 14690591 physical association X 2 P40210 P53919 two hybrid array 14690591 physical association X 2 P40210 P41896 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40210 P33416 tandem affinity purification 19536198 association X 2 P52490 P40210 tandem affinity purification 16554755 physical association X 2 P52490 P40210 dihydrofolate reductase reconstruction 18467557 physical association X 2 P52490 P40210 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40210 inferred by author 16554755 association C 3 P32589 P40210 tandem affinity purification 19536198 association X 2 P40210 Q05934 two hybrid fragment pooling approach 11283351 physical association X 2 P40210 Q02642 tandem affinity purification 16554755 physical association X 2 P40210 P38879 tandem affinity purification 16554755 physical association X 2 P40210 Q03973 tandem affinity purification 16554755 physical association X 2 P40210 P53152 tandem affinity purification 16554755 physical association X 2 P40210 P53152 tandem affinity purification 16554755 physical association X 2 P40210 P53152 tandem affinity purification 16554755 physical association X 2 P40210 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40210 P53152 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40210 P11484 tandem affinity purification 19536198 association X 2 P40210 P10592 tandem affinity purification 19536198 association X 2 P40210 P32590 tandem affinity purification 19536198 association X 2 P40210 P11710 inferred by author 19841731 direct interaction X 2 P40210 P11710 two hybrid pooling approach 19841731 physical association X 2 P10591 P40210 tandem affinity purification 19536198 association X 2 P40210 Q05934 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality TPK1 SIP5 16319894 0415 LC TPK2 SIP5 16319894 0415 LC SNF1 SIP5 10628972,10628972 0004,0018 LC FUS1 SIP5 19841731,19841731,19841731 0398,0363,0018 HT YCK1 SIP5 16319894 0415 LC YCK2 SIP5 16319894 0415 LC CMK1 SIP5 16319894 0415 LC IRE1 SIP5 16319894 0415 LC GLC7 SIP5 10628972,10628972 0004,0018 LC HMT1 SIP5 14690591 0397 LC RSP5 SIP5 17551511 0415 LC SIP5 TFG2 18467557 0111 HT SIP5 PTK2 16319894 0415 LC SIP5 UBC13 18467557,18467557 0111,0090 HT SIP5 ATG1 16319894 0415 LC SIP5 MMS2 18467557,18467557,22615397 0111,0090,0090 HT,LC SIP5 PKP2 16319894 0415 LC SIP5 NAF1 14690591 0397 LC SIP5 VHS1 16319894 0415 LC SIP5 VID22 11283351,11283351,11283351 0018,0399,0398 HT SIP5 ESA1 19303850 0415 LC SIP5 PRR2 16319894 0415 LC HTB1 SIP5 22199229 0004 HT HTB2 SIP5 22199229 0004 HT HHF1|HHF2 SIP5 22199229 0004 HT TPK2 SIP5 21460040 0096 LC SNF1 SIP5 10628972,10628972 0004,0018 LC SSA1 SIP5 19536198 0676 HT SSA2 SIP5 19536198 0676 HT SSB1 SIP5 19536198 0676 HT FUS1 SIP5 19841731,19841731,19841731 0398,0363,0018 LC MEK1 SIP5 21460040 0096 LC NAP1 SIP5 18086883 0004 LC SAT4 SIP5 21460040 0096 LC KCC4 SIP5 21460040 0096 LC CRM1 SIP5 26673895,26673895 0096,0004 LC NAB2 SIP5 19840948 0004 LC SSE1 SIP5 19536198 0676 HT SSE2 SIP5 19536198 0676 HT GLC7 SIP5 10628972,10628972 0004,0018 LC HSP78 SIP5 19536198 0676 HT KKQ8 SIP5 21460040 0096 LC EGD2 SIP5 16554755,16554755 0676,0004 HT SIP5 TOS3 21460040 0096 LC SIP5 PTK2 21460040 0096 LC SIP5 UBC13 16554755,16554755 0676,0004 HT SIP5 MMS2 16554755,16554755,16554755 0363,0676,0004 HT SIP5 SSK2 21460040 0096 LC SIP5 EGD1 16554755,16554755 0676,0004 HT SIP5 SKY1 21460040 0096 LC SIP5 HMO1 16554755,16554755 0676,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53104 P40210 ATG1 SIP5 0.183 16319894 P53170 P40210 PKP2 SIP5 0.183 16319894 P53599 P40210 SSK2 SIP5 0.183 21460040 P40210 P23292 SIP5 YCK2 0.183 16319894 P40210 P24719 SIP5 MEK1 0.183 21460040 Q12310 P40210 PRR2 SIP5 0.183 16319894 P40210 P25293 SIP5 NAP1 0.21 18086883 P40210 P25333 SIP5 SAT4 0.183 21460040 P40210 P25389 SIP5 KCC4 0.183 21460040 P40210 P10591 SIP5 SSA1 0.126 19536198 P40210 P10592 SIP5 SSA2 0.126 19536198 P40210 P06244 SIP5 TPK1 0.183 16319894 P40210 P06782 SIP5 SNF1 0.309 10628972 P40210 P06245 SIP5 TPK2 0.332 21460040,16319894 P40210 P30822 SIP5 CRM1 0.236 26673895 P47116 P40210 PTK2 SIP5 0.332 21460040,16319894 P53152 P40210 MMS2 SIP5 0.49 16554755,18467557 P52490 P40210 UBC13 SIP5 0.332 16554755,18467557 P40210 P32361 SIP5 IRE1 0.183 16319894 P40210 P32505 SIP5 NAB2 0.126 19840948 P40210 P38879 SIP5 EGD2 0.236 16554755 P40210 P32590 SIP5 SSE2 0.126 19536198 P40210 P27466 SIP5 CMK1 0.183 16319894 P40210 P33416 SIP5 HSP78 0.126 19536198 P40210 P36004 SIP5 KKQ8 0.183 21460040 P40210 P11484 SIP5 SSB1 0.126 19536198 P40210 P11710 SIP5 FUS1 0.472 19841731 P40210 P32589 SIP5 SSE1 0.126 19536198 P40210 P38074 SIP5 HMT1 0.126 14690591 P41896 P40210 TFG2 SIP5 0.126 18467557 P53919 P40210 NAF1 SIP5 0.126 14690591 Q03973 P40210 HMO1 SIP5 0.236 16554755 Q05934 P40210 VID22 SIP5 0.21 11283351 P43637 P40210 TOS3 SIP5 0.183 21460040 Q02642 P40210 EGD1 SIP5 0.126 16554755 Q03656 P40210 SKY1 SIP5 0.183 21460040 Q03785 P40210 VHS1 SIP5 0.183 16319894 Q07468 P40210 VAM6 SIP5 0.126 25026036 Q08649 P40210 ESA1 SIP5 0.183 19303850