PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SSB1 PEP5 16429126 intact exp SSA2 PEP5 16429126 intact exp PEP5 CMR1 25817432 biogrid exp PEP5 SSB2 23332755,19536198 biogrid,intact exp PEP5 GLC7 21179020 intact exp PEP5 PAC10 19536198 intact exp PEP5 HHT1, HHT2 22570702 biogrid exp PEP5 AAP1 16429126 intact exp PEP5 PUF3 26493364 biogrid exp PEP5 UBC4 22570702 biogrid exp HHF1, HHF2 PEP5 22570702 biogrid exp PEP5 VPS34 23904270 biogrid exp PEP5 PRS3 16429126 intact exp PEP5 APL5 19741093, 23023127 biogrid exp, pred PEP5 PEP3 11805826,16429126,9362071,20604902,21325627,10978279,10944212, 23023127 biogrid,i2d,mint,intact,dip exp, pred PEP5 VTI1 15889152, 23023127 biogrid exp, pred PEP5 VPS8 11805826,20173035,16429126,23840658,20604902,21325627,15047864, 23023127 biogrid,mint,intact,dip exp, pred PEP5 VPS3 23840658,20604902,21325627,17488625,19828734, 23023127 biogrid exp, pred PEP5 VPS16 16429126,9362071,20604902,21325627,10944212, 23023127 biogrid,i2d,intact,dip exp, pred PEP5 VAM6 11062257,16429126,22940862,15889152,20604902,21325627,11283351,25026036,10944212, 23023127 biogrid,i2d,mint,intact,dip exp, pred PEP5 YPT11 21325627, 23023127 biogrid exp, pred PEP5 YPT52 21325627, 23023127 biogrid exp, pred PEP5 MON1 14662743, 23023127 biogrid,dip exp, pred PEP5 VAM3 24471450,15889152,23051737, 23023127 biogrid,dip exp, pred PEP5 VAM7 23438067,17347148,15889152,18467557,23955338, 23023127 biogrid,i2d,mint,intact exp, pred PEP5 VPS33 18385512,16429126,15889152,9362071,22940862,11694574,16601699,21325627,20604902,10944212, 23023127 biogrid,i2d,mint,intact,dip exp, pred PEP5 YPT7 21325627,10944212, 23023127 biogrid,intact exp, pred PEP5 PEP7 11422941,10978279, 23023127 biogrid,intact exp, pred PEP5 VPS41 16429126,19193765,17488625,11805826,21325627,20604902,10944212,21079247, 23023127 biogrid,mint,intact,dip exp, pred PEP5 VPS30 23904270, 23023127 biogrid exp, pred PEP5 YDJ1 19536198, 23023127 intact exp, pred PEP5 VPS21 21325627, 23023127 biogrid exp, pred PEP5 PEP5 22754631,10978279, 23023127 biogrid,intact exp, pred PEP5 YPT6 23023127 pred PEP5 ATG5 23023127 pred PEP5 VPS45 23023127 pred PEP5 SSO2 23023127 pred PEP5 VPS5 23023127 pred PEP5 SNX3 23023127 pred PEP5 SYS1 23023127 pred PEP5 YPT10 23023127 pred PEP5 ARL1 23023127 pred PEP5 ATG20 23023127 pred PEP5 VPS9 23023127 pred PEP5 UGO1 23023127 pred PEP5 APL4 23023127 pred PEP5 APM4 23023127 pred PEP5 EXO70 23023127 pred PEP5 SNF7 23023127 pred PEP5 VPS4 23023127 pred PEP5 ATG3 23023127 pred PEP5 APS1 23023127 pred PEP5 NYV1 23023127 pred PEP5 ATG8 23023127 pred PEP5 ATG4 23023127 pred PEP5 VPS20 23023127 pred PEP5 SEC15 23023127 pred PEP5 VPS35 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P12868 - 15889152 - C 11 P12868 - 15044803 - C 7 P12868 - 15889152 - C 6 P12868 - 11805826 - C 7 P27801 P12868 - 9362071 - X 2 Q07468 P12868 - 11283351 - X 2 P20795 P12868 - 9362071 - X 2 P12868 - 11805826 - C 8 P12868 - 11805826 - C 5 Q03308 P12868 affinity chromatography technology 10944212 physical association X 2 Q03308 P12868 affinity chromatography technology 10944212 physical association X 2 Q03308 P12868 affinity chromatography technology 9362071 physical association X 2 Q03308 P12868 affinity chromatography technology 16429126 physical association X 2 Q03308 P12868 affinity chromatography technology 16429126 physical association X 2 Q03308 P12868 affinity chromatography technology 17200106 physical association X 2 Q03308 P12868 pull down 21325627 direct interaction X 2 Q03308 P12868 two hybrid 21325627 direct interaction X 2 Q03308 P12868 two hybrid 21325627 direct interaction X 2 Q03308 P12868 affinity chromatography technology 20604902 physical association X 2 P27801 P12868 affinity chromatography technology 10944212 physical association X 2 P27801 P12868 affinity chromatography technology 10944212 physical association X 2 P27801 P12868 affinity chromatography technology 9362071 physical association X 2 P27801 P12868 two hybrid 10978279 direct interaction X 2 P27801 P12868 affinity chromatography technology 16429126 physical association X 2 P27801 P12868 affinity chromatography technology 16429126 physical association X 2 P27801 P12868 affinity chromatography technology 17200106 physical association X 2 P27801 P12868 pull down 21325627 direct interaction X 2 P27801 P12868 two hybrid 21325627 direct interaction X 2 P27801 P12868 two hybrid 21325627 direct interaction X 2 P27801 P12868 two hybrid 20604902 direct interaction X 2 P27801 P12868 two hybrid 20604902 direct interaction X 2 P27801 P12868 affinity chromatography technology 20604902 physical association X 2 P27801 P12868 affinity chromatography technology 11805826 physical association X 2 Q12241 P12868 affinity chromatography technology 23051737 physical association X 2 Q12241 P12868 affinity chromatography technology 24471450 physical association X 2 Q12241 P12868 affinity chromatography technology 15889152 physical association X 2 P15731 P12868 pull down 22570702 direct interaction X 2 P15731 P12868 affinity chromatography technology 22570702 physical association X 2 P32939 P12868 affinity chromatography technology 10944212 physical association X 2 P32939 P12868 two hybrid 21325627 direct interaction X 2 Q04338 P12868 affinity chromatography technology 15889152 physical association X 2 P38959 P12868 affinity chromatography technology 10944212 physical association X 2 P38959 P12868 affinity chromatography technology 10944212 physical association X 2 P38959 P12868 affinity chromatography technology 21079247 physical association X 2 P38959 P12868 affinity chromatography technology 16429126 physical association X 2 P38959 P12868 affinity chromatography technology 17200106 physical association X 2 P38959 P12868 affinity chromatography technology 17488625 physical association X 2 P38959 P12868 affinity chromatography technology 19193765 physical association X 2 P38959 P12868 pull down 21325627 direct interaction X 2 P38959 P12868 two hybrid 21325627 direct interaction X 2 P38959 P12868 two hybrid 21325627 direct interaction X 2 P38959 P12868 affinity chromatography technology 20604902 physical association X 2 P38959 P12868 affinity chromatography technology 11805826 physical association X 2 P53129 P12868 two hybrid 14662743 direct interaction X 2 P61830 P12868 affinity chromatography technology 22570702 physical association X 2 Q07468 P12868 affinity chromatography technology 22940862 physical association X 2 Q07468 P12868 affinity chromatography technology 10944212 physical association X 2 Q07468 P12868 affinity chromatography technology 10944212 physical association X 2 Q07468 P12868 affinity chromatography technology 11062257 physical association X 2 Q07468 P12868 two hybrid 11062257 direct interaction X 2 Q07468 P12868 affinity chromatography technology 16429126 physical association X 2 Q07468 P12868 biochemical 15889152 association X 2 Q07468 P12868 affinity chromatography technology 17200106 physical association X 2 Q07468 P12868 two hybrid 21325627 direct interaction X 2 Q07468 P12868 two hybrid 21325627 direct interaction X 2 Q07468 P12868 affinity chromatography technology 20604902 physical association X 2 Q07468 P12868 affinity chromatography technology 20604902 physical association X 2 Q07468 P12868 two hybrid 20604902 direct interaction X 2 P20795 P12868 affinity chromatography technology 22940862 physical association X 2 P20795 P12868 affinity chromatography technology 10944212 physical association X 2 P20795 P12868 affinity chromatography technology 10944212 physical association X 2 P20795 P12868 affinity chromatography technology 9362071 physical association X 2 P20795 P12868 affinity chromatography technology 16429126 physical association X 2 P20795 P12868 affinity chromatography technology 16429126 physical association X 2 P20795 P12868 biochemical 15889152 association X 2 P20795 P12868 affinity chromatography technology 16601699 physical association X 2 P20795 P12868 affinity chromatography technology 17200106 physical association X 2 P20795 P12868 pull down 18385512 direct interaction X 2 P20795 P12868 pull down 21325627 direct interaction X 2 P20795 P12868 two hybrid 21325627 direct interaction X 2 P20795 P12868 two hybrid 21325627 direct interaction X 2 P20795 P12868 affinity chromatography technology 20604902 physical association X 2 P36017 P12868 two hybrid 21325627 direct interaction X 2 P32609 P12868 affinity chromatography technology 11422941 physical association X 2 P32609 P12868 two hybrid 10978279 direct interaction X 2 Q08951 P12868 pull down 19741093 direct interaction X 2 P12868 P12868 affinity chromatography technology 22754631 physical association X 2 P12868 P12868 two hybrid 10978279 direct interaction X 2 P48559 P12868 two hybrid 21325627 direct interaction X 2 P32912 P12868 affinity chromatography technology 15889152 physical association X 2 P32912 P12868 pull down 17347148 direct interaction X 2 P32912 P12868 protein complementation assay 18467557 direct interaction X 2 P36018 P12868 two hybrid 21325627 direct interaction X 2 P23643 P12868 affinity chromatography technology 17488625 physical association X 2 P23643 P12868 affinity chromatography technology 19828734 physical association X 2 P23643 P12868 two hybrid 21325627 direct interaction X 2 P23643 P12868 two hybrid 21325627 direct interaction X 2 P23643 P12868 affinity chromatography technology 20604902 physical association X 2 P23643 P12868 affinity chromatography technology 20604902 physical association X 2 P23643 P12868 two hybrid 20604902 direct interaction X 2 P23643 P12868 two hybrid 20604902 direct interaction X 2 P40150 P12868 biochemical 23332755 association X 2 P39702 P12868 affinity chromatography technology 15047864 physical association X 2 P39702 P12868 affinity chromatography technology 16429126 physical association X 2 P39702 P12868 affinity chromatography technology 17200106 physical association X 2 P39702 P12868 affinity chromatography technology 20173035 physical association X 2 P39702 P12868 two hybrid 21325627 direct interaction X 2 P39702 P12868 two hybrid 21325627 direct interaction X 2 P39702 P12868 affinity chromatography technology 20604902 physical association X 2 P39702 P12868 affinity chromatography technology 20604902 physical association X 2 P39702 P12868 two hybrid 20604902 direct interaction X 2 P39702 P12868 affinity chromatography technology 11805826 physical association X 2 P02309 P12868 affinity chromatography technology 22570702 physical association X 2 P02309 P12868 enzymatic study 22570702 direct interaction X 2 P12868 tandem affinity purification 11805826 - C 7 P12868 tandem affinity purification 11805826 - C 5 Q03308 P12868 cross-linking study 9362071 direct interaction X 2 P27801 P12868 cross-linking study 9362071 direct interaction X 2 P27801 P12868 tandem affinity purification 11805826 direct interaction X 2 Q12241 P12868 pull down 23051737 physical association X 2 P38959 P12868 tandem affinity purification 11805826 physical association X 2 Q07468 P12868 two hybrid pooling approach 11283351 physical association X 2 P20795 P12868 cross-linking study 9362071 direct interaction X 2 P20795 P12868 affinity chromatography technology 11694574 direct interaction X 2 P12868 inferred by author 11805826 physical association C 10 P12868 tandem affinity purification 11805826 - C 8 P12868 pull down 23051737 - C 4 P12868 two hybrid 14662743 physical association X 2 P39702 P12868 tandem affinity purification 11805826 physical association X 2 P12868 inferred by author 16429126 physical association C 9 P12868 tandem affinity purification 16429126 association C 7 P12868 anti bait coimmunoprecipitation 10944212 association C 6 P12868 anti bait coimmunoprecipitation 10944212 association C 6 P12868 anti bait coimmunoprecipitation 10944212 association C 6 P12868 anti bait coimmunoprecipitation 10944212 association C 6 P12868 anti bait coimmunoprecipitation 10944212 association C 6 P12868 cosedimentation through density gradient 10944212 physical association C 6 P12868 anti bait coimmunoprecipitation 10944212 association C 6 P12868 pull down 10944212 association C 6 P12868 tandem affinity purification 21179020 association C 57 P12868 tandem affinity purification 16429126 association C 7 P12868 tandem affinity purification 16429126 association C 11 P27801 P12868 two hybrid 10978279 physical association X 2 Q07468 P12868 two hybrid fragment pooling approach 11283351 physical association X 2 P20795 P12868 affinity chromatography technology 16601699 physical association X 2 P32609 P12868 two hybrid 10978279 physical association X 2 P12868 tandem affinity purification 11805826 association C 6 P12868 tandem affinity purification 11805826 association C 8 P12868 tandem affinity purification 11805826 association C 9 P12868 tandem affinity purification 16429126 association C 8 P12868 tandem affinity purification 16429126 association C 10 P12868 tandem affinity purification 16429126 association C 23 P12868 tandem affinity purification 16429126 association C 7 P48363 P12868 tandem affinity purification 19536198 association X 2 P12868 P12868 two hybrid 10978279 physical association X 2 P25491 P12868 tandem affinity purification 19536198 association X 2 P32912 P12868 dihydrofolate reductase reconstruction 18467557 physical association X 2 P40150 P12868 tandem affinity purification 19536198 association X 2 P12868 confirmational text mining - - C 4 Q03308 P12868 coimmunoprecipitation - - X 2 P27801 P12868 coimmunoprecipitation 9362071 - X 2 Q07468 P12868 two hybrid 11283351 - X 2 P20795 P12868 coimmunoprecipitation 9362071 - X 2 P12868 mass spectrometry studies of complexes 11805826 - C 13

PPI - HINT Gene A Gene B PMID Method Quality HHF1|HHF2 PEP5 22570702,22570702 0004,0415 LC PEP5 PEP5 10978279 0018 LC PEP5 VPS33 21325627,9362071,9362071,9362071,15889152,21325627 0018,0019,0004,0030,0401,0096 LC PEP5 VPS3 20604902,21325627,20604902 0004,0018,0018 LC PEP5 PEP3 25324549,20604902,25324549,21325627,9362071,10944212,25324549,9362071,9362071,10978279,20604902,10944212,10944212,21325627 0401,0004,0004,0018,0019,0004,0096,0004,0030,0018,0018,0029,0006,0096 LC PEP5 PEP7 10978279 0018 LC PEP5 VAM7 18467557,18467557 0111,0090 HT PEP5 YPT7 21325627 0018 LC PEP5 VPS21 21325627 0018 LC PEP5 YPT52 21325627 0018 LC PEP5 VPS41 21325627,21325627 0018,0096 LC PEP5 VPS8 20604902,21325627,20604902 0004,0018,0018 LC PEP5 YCK3 25411340 0415 LC PEP5 SSB2 23332755 0401 LC PEP5 YPT11 21325627 0018 LC PEP5 MON1 14662743 0018 LC PEP5 VPS16 21325627,9362071,9362071,21325627 0018,0004,0030,0096 LC PEP5 VAM6 20604902,11283351,11283351,11283351,11062257,21325627,15889152,20604902,11062257 0004,0018,0399,0398,0018,0018,0401,0018,0004 LC,HT HHF1|HHF2 PEP5 22570702,22570702 0004,0415 LC SSA2 PEP5 16429126 0676 HT SSB1 PEP5 16429126 0676 HT PEP5 PEP5 22754631 0004 LC PEP5 UBC4 22570702,22570702 0096,0004 LC PEP5 VPS33 20604902,16429126,22940862,21325627,16429126,9362071,11694574,18385512,10944212,9362071,9362071,16601699,15889152,17200106,10944212,21325627 0004,0004,0004,0018,0676,0019,0004,0096,0004,0004,0030,0004,0401,0004,0006,0096 LC,HT PEP5 VPS34 23904270 0004 LC PEP5 VPS3 20604902,19828734,17488625,20604902,23840658 0004,0004,0004,0018,0004 LC PEP5 YDJ1 19536198 0676 HT PEP5 PEP3 25324549,11805826,20604902,16429126,25324549,21325627,16429126,11805826,9362071,10944212,11805826,25324549,9362071,9362071,17200106,20604902,10944212,10944212,21325627 0401,0007,0004,0004,0004,0018,0676,0004,0019,0004,0676,0096,0004,0030,0004,0018,0029,0006,0096 LC,HT PEP5 GLC7 21179020 0676 HT PEP5 PEP7 11422941 0004 LC PEP5 VAM7 23955338,17347148,23438067,15889152 0096,0096,0004,0004 LC PEP5 YPT7 10944212,10944212 0004,0096 LC PEP5 AAP1 16429126 0363 HT PEP5 PRS3 16429126 0676 HT PEP5 VPS41 20604902,16429126,25324549,21325627,16429126,11805826,17488625,10944212,11805826,21079247,17200106,19193765,11805826,10944212,21325627 0004,0004,0004,0018,0676,0676,0004,0004,0004,0004,0004,0004,0007,0006,0096 LC,HT PEP5 VPS8 17200106,20604902,16429126,11805826,11805826,15047864,20173035,20604902,11805826,16429126,23840658 0004,0004,0676,0004,0676,0004,0004,0018,0007,0004,0004 HT,LC PEP5 SSB2 19536198,23332755 0676,0401 HT,LC PEP5 PAC10 19536198 0676 HT PEP5 HHT1|HHT2 22570702 0004 LC PEP5 VPS30 23904270 0004 LC PEP5 VPS16 20604902,21325627,10944212,16429126,10944212,9362071,9362071,17200106,16429126,21325627 0004,0018,0006,0676,0004,0004,0030,0004,0004,0096 LC,HT PEP5 VTI1 15889152 0004 LC PEP5 VAM6 20604902,16429126,22940862,16429126,10944212,11062257,17200106,15889152,20604902,10944212,11062257 0004,0004,0004,0676,0004,0018,0004,0401,0018,0006,0004 LC,HT PEP5 APL5 19741093 0096 LC PEP5 VAM3 23051737,15889152,23051737,24471450 0096,0004,0004,0004 LC PEP5 CMR1 25817432 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P15731 P12868 UBC4 PEP5 0.454 22570702 P22543 P12868 VPS34 PEP5 0.126 23904270 P53129 P12868 MON1 PEP5 0.332 14662743 P25491 P12868 YDJ1 PEP5 0.126 19536198 P12868 P10592 PEP5 SSA2 0.126 16429126 P12868 P11484 PEP5 SSB1 0.126 16429126 P12868 P12868 PEP5 PEP5 0.236 22754631 P36017 P12868 VPS21 PEP5 0.183 21325627 P36018 P12868 YPT52 PEP5 0.183 21325627 P38959 P12868 VPS41 PEP5 0.88 11805826,21079247,16429126,21325627,19193765,17488625,20604902,25324549 P48363 P12868 PAC10 PEP5 0.126 19536198 P48559 P12868 YPT11 PEP5 0.183 21325627 P61830 P12868 HHT2 PEP5 0.21 22570702 Q03308 P12868 VPS16 PEP5 0.863 9362071,16429126,21325627,20604902,10944212 P20795 P12868 VPS33 PEP5 0.928 16601699,9362071,16429126,21325627,11694574,18385512,20604902,10944212 P12868 P02309 PEP5 HHF2 0.454 22570702 P27801 P12868 PEP3 PEP5 0.978 11805826,9362071,16429126,21325627,20604902,10944212,25324549 Q12241 P12868 VAM3 PEP5 0.376 23051737,24471450 P23643 P12868 VPS3 PEP5 0.902 20604902,19828734,21325627,17488625,23840658 P32912 P12868 VAM7 PEP5 0.671 17347148,23438067,18467557,23955338 P37898 P12868 AAP1 PEP5 0.126 16429126 P38689 P12868 PRS3 PEP5 0.126 16429126 P32598 P12868 GLC7 PEP5 0.126 21179020 P32939 P12868 YPT7 PEP5 0.354 21325627,10944212 P39702 P12868 VPS8 PEP5 0.876 11805826,15047864,20173035,16429126,21325627,23840658,20604902 P39962 P12868 YCK3 PEP5 0.309 25411340 P40150 P12868 SSB2 PEP5 0.236 23332755,19536198 Q12510 P12868 Q12510 PEP5 0.126 25817432 Q02948 P12868 VPS30 PEP5 0.126 23904270 Q07468 P12868 VAM6 PEP5 0.867 11062257,16429126,21325627,11283351,25026036,20604902 Q08951 P12868 APL5 PEP5 0.309 19741093