PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MAL31 CUE1 16093310 biogrid,mint,intact,dip exp RPL4A CUE1 22940862 biogrid exp SRO9 CUE1 22271760 biogrid exp CUE1 TPO1 16093310 biogrid,dip exp CUE1 BNI1 24133141 biogrid exp CUE1 UIP3 16093310 biogrid,mint,intact,dip exp CUE1 CMR1 22199229 biogrid exp CUE1 ERG25 16093310 biogrid,dip exp CUE1 COS8 16093310 biogrid,dip exp NAB2 CUE1 19840948 biogrid exp CUE1 HHT1, HHT2 22199229 biogrid exp CUE1 Protein-glutamate O-methyltransferase 16554755 intact exp SSA1 CUE1 22940862 biogrid exp SSA2 CUE1 22940862 biogrid exp CUE1 VPS73 16093310 biogrid,dip exp CAN1 CUE1 16093310 biogrid,mint,intact,dip exp CUE1 SLF1 22271760 biogrid exp TOM6 CUE1 16093310 biogrid,dip exp CUE1 GPI2 16093310 biogrid,dip exp WBP1 CUE1 16093310 biogrid,mint,intact,dip exp CUE1 SCY1 11283351 i2d,mint,intact,dip exp CUE1 UBA4 9388185 biogrid exp DED1 CUE1 22940862 biogrid exp CUE1 GIS2 21232131 biogrid exp CUE1 POM34 16093310, 23023127 biogrid,dip exp, pred CUE1 VMA10 16554755, 23023127 biogrid,i2d,mint,intact exp, pred CUE1 UBC7 18321851,19366730,17310239,9388185,23665230, 23023127 biogrid,intact exp, pred SSH1 CUE1 16093310, 23023127 biogrid,mint,intact,dip exp, pred CUE1 CUE1 22940862, 23023127 biogrid exp, pred CUE1 SSM4 16873066,23665229,16179953, 23023127 biogrid,intact exp, pred CUE1 Putative uncharacterized protein YHL042W 16093310, 23023127 biogrid,dip exp, pred CUE1 SPC1 16093310, 23023127 biogrid,dip exp, pred RPT1 CUE1 17264153, 23023127 biogrid exp, pred CUE1 UBX3 23023127 pred CUE1 CUE3 23023127 pred CUE1 UBX5 23023127 pred UBP14 CUE1 23023127 pred CUE1 UBX4 23023127 pred CUE1 RUP1 23023127 pred SHP1 CUE1 23023127 pred CUE1 DSK2 23023127 pred UBX7 CUE1 23023127 pred EDE1 CUE1 23023127 pred CUE1 UBX6 23023127 pred CUE1 UBP6 23023127 pred CUE1 HUB1 23023127 pred CUE1 CUE5 23023127 pred CUE2 CUE1 23023127 pred CUE1 UBI4 23023127 pred RAD23 CUE1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38428 - 16179953 - C 5 P53009 P38428 - 11283351 - X 2 Q12445 P38428 protein complementation assay 16093310 direct interaction X 2 P38428 P38428 affinity chromatography technology 22940862 physical association X 2 P38428 P53142 protein complementation assay 16093310 direct interaction X 2 P38428 P38729 protein complementation assay 16093310 direct interaction X 2 P40318 P38428 affinity chromatography technology 16179953 physical association X 2 P40318 P38428 affinity chromatography technology 23665229 physical association X 2 P40318 P38428 affinity chromatography technology 16873066 physical association X 2 Q02159 P38428 x-ray crystallography 23665230 association X 2 Q02159 P38428 pull down 23665230 direct interaction X 2 Q02159 P38428 affinity chromatography technology 23665230 physical association X 2 Q02159 P38428 pull down 19366730 direct interaction X 2 Q02159 P38428 pull down 19366730 direct interaction X 2 Q02159 P38428 biochemical 9388185 association X 2 Q02159 P38428 pull down 9388185 direct interaction X 2 Q02159 P38428 biochemical 9388185 colocalization X 2 Q02159 P38428 affinity chromatography technology 17310239 physical association X 2 Q02159 P38428 pull down 18321851 direct interaction X 2 Q02159 P38428 affinity chromatography technology 17310239 physical association X 2 Q02159 P38428 affinity chromatography technology 19366730 physical association X 2 Q07824 P38428 protein complementation assay 16093310 direct interaction X 2 P53045 P38428 protein complementation assay 16093310 direct interaction X 2 P33299 P38428 affinity chromatography technology 17264153 physical association X 2 Q12510 P38428 affinity chromatography technology 22199229 physical association X 2 P10664 P38428 affinity chromatography technology 22940862 physical association X 2 P10591 P38428 affinity chromatography technology 22940862 physical association X 2 P06634 P38428 affinity chromatography technology 22940862 physical association X 2 P38723 P38428 protein complementation assay 16093310 direct interaction X 2 P10592 P38428 affinity chromatography technology 22940862 physical association X 2 P38353 P38428 protein complementation assay 16093310 direct interaction X 2 P38428 P38156 protein complementation assay 16093310 direct interaction X 2 P38428 P46965 protein complementation assay 16093310 direct interaction X 2 P38428 P33448 protein complementation assay 16093310 direct interaction X 2 P38428 P61830 affinity chromatography technology 22199229 physical association X 2 P38428 P61830 affinity chromatography technology 22199229 physical association X 2 P38820 P38428 biochemical 9388185 association X 2 P38820 P38428 pull down 9388185 direct interaction X 2 P0CG63 P38428 affinity chromatography technology 23749301 physical association X 2 P0CG63 P38428 affinity chromatography technology 23793018 physical association X 2 P0CG63 P38428 affinity chromatography technology 14557538 physical association X 2 P33767 P38428 protein complementation assay 16093310 direct interaction X 2 P04817 P38428 protein complementation assay 16093310 direct interaction X 2 P39547 P38428 protein complementation assay 16093310 direct interaction X 2 P46961 P38428 protein complementation assay 16093310 direct interaction X 2 P48836 P38428 affinity chromatography technology 16554755 physical association X 2 Q12445 P38428 ubiquitin reconstruction 16093310 physical association X 2 P38428 P53142 ubiquitin reconstruction 16093310 physical association X 2 P38428 P38729 ubiquitin reconstruction 16093310 physical association X 2 Q07824 P38428 ubiquitin reconstruction 16093310 physical association X 2 P53045 P38428 ubiquitin reconstruction 16093310 physical association X 2 P38723 P38428 ubiquitin reconstruction 16093310 physical association X 2 P38353 P38428 ubiquitin reconstruction 16093310 physical association X 2 P38428 P38156 ubiquitin reconstruction 16093310 physical association X 2 P38428 P46965 ubiquitin reconstruction 16093310 physical association X 2 P38428 P33448 ubiquitin reconstruction 16093310 physical association X 2 P53009 P38428 two hybrid pooling approach 11283351 physical association X 2 P33767 P38428 ubiquitin reconstruction 16093310 physical association X 2 P04817 P38428 ubiquitin reconstruction 16093310 physical association X 2 P39547 P38428 ubiquitin reconstruction 16093310 physical association X 2 P46961 P38428 ubiquitin reconstruction 16093310 physical association X 2 P38428 inferred by author 16554755 association C 14 P38428 tandem affinity purification 16873066 association C 5 P38428 P63048 affinity chromatography technology 9388185 physical association X 2 P40318 P38428 anti tag coimmunoprecipitation 16179953 physical association X 2 Q02159 P38428 anti bait coimmunoprecipitation 9388185 physical association X 2 P38353 P38428 ubiquitin reconstruction 16093310 physical association X 2 P38428 P38156 ubiquitin reconstruction 16093310 physical association X 2 P53009 P38428 two hybrid fragment pooling approach 11283351 physical association X 2 P33767 P38428 ubiquitin reconstruction 16093310 physical association X 2 P04817 P38428 ubiquitin reconstruction 16093310 physical association X 2 P39547 P38428 ubiquitin reconstruction 16093310 physical association X 2 P48836 P38428 tandem affinity purification 16554755 physical association X 2 P10614 P38428 interaction detection method 14661025 - X 2 P53009 P38428 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CAN1 CUE1 16093310,16093310 0090,0112 HT TOM6 CUE1 16093310,16093310 0090,0112 HT WBP1 CUE1 16093310,16093310 0090,0112 HT MAL31 CUE1 16093310,16093310 0090,0112 HT SSH1 CUE1 16093310,16093310 0090,0112 HT CUE1 COS8 16093310,16093310 0090,0112 HT CUE1 P38729 16093310,16093310 0090,0112 HT CUE1 UBA4 9388185,9388185 0096,0401 LC CUE1 UIP3 16093310,16093310 0090,0112 HT CUE1 GPI2 16093310,16093310 0090,0112 HT CUE1 SPC1 16093310,16093310 0090,0112 HT CUE1 SCY1 11283351,11283351,11283351 0018,0399,0398 HT CUE1 ERG25 16093310,16093310 0090,0112 HT CUE1 VPS73 16093310,16093310 0090,0112 HT CUE1 UBC7 9388185,23665230,9388185,23665230,9388185,25646477,23665230 0096,0096,0006,0004,0401,0401,0114 LC CUE1 TPO1 16093310,16093310 0090,0112 HT CUE1 POM34 16093310,16093310 0090,0112 HT DED1 CUE1 22940862 0004 HT UBI4 CUE1 14557538 0004 LC SSA1 CUE1 22940862 0004 HT SSA2 CUE1 22940862 0004 HT RPL4A CUE1 22940862 0004 HT NAB2 CUE1 19840948 0004 LC RPT1 CUE1 17264153 0004 LC CUE1 CUE1 22940862 0004 HT CUE1 UBA4 9388185,9388185 0096,0401 LC CUE1 SSM4 16179953,16873066,16873066,23665229,16179953 0004,0004,0676,0004,0007 LC CUE1 BNI1 24133141 0096 LC CUE1 VMA10 16554755,16554755 0676,0004 HT CUE1 HHT1|HHT2 22199229 0004 HT CUE1 UBC7 9388185,19366730,23665230,18321851,9388185,23665230,9388185,17310239,19366730,25646477,23665230 0096,0096,0096,0096,0006,0004,0401,0004,0004,0401,0114 LC CUE1 Q04371 16554755 0363 HT CUE1 CMR1 22199229 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53142 P38428 VPS73 CUE1 0.183 16093310 Q12034 P38428 SLF1 CUE1 0.126 22271760 Q12445 P38428 POM34 CUE1 0.183 16093310 P38428 P25567 CUE1 SRO9 0.126 22271760 P38428 P0CG48 CUE1 UBC 0.126 23801757 P48836 P38428 VMA10 CUE1 0.236 16554755 P38820 P38428 UBA4 CUE1 0.454 9388185 P40318 P38428 SSM4 CUE1 0.507 16873066,16179953,23665229 Q02159 P38428 UBC7 CUE1 0.982 9388185,18321851,23665230,25646477,19366730,17310239 P38428 P38353 CUE1 SSH1 0.261 16093310 P38428 P04817 CUE1 CAN1 0.286 16093310 P38428 P06634 CUE1 DED1 0.126 22940862 P38428 P10591 CUE1 SSA1 0.126 22940862 P38428 P10592 CUE1 SSA2 0.126 22940862 P38428 P10664 CUE1 RPL4A 0.126 22940862 P38428 P33448 CUE1 TOM6 0.21 16093310 P38428 P33767 CUE1 WBP1 0.286 16093310 P38428 P38156 CUE1 MAL31 0.309 16093310 P38428 P38428 CUE1 CUE1 0.155 22940862 P38723 P38428 COS8 CUE1 0.21 16093310 P39547 P38428 UIP3 CUE1 0.309 16093310 P46965 P38428 SPC1 CUE1 0.21 16093310 P53009 P38428 SCY1 CUE1 0.236 11283351 P38729 P38428 P38729 CUE1 0.183 16093310 P38428 P32505 CUE1 NAB2 0.126 19840948 P46961 P38428 GPI2 CUE1 0.183 16093310 P62990 P38428 UBA52 CUE1 0.21 9388185 P41832 P38428 BNI1 CUE1 0.183 24133141 P53849 P38428 GIS2 CUE1 0.126 21232131 Q07824 P38428 TPO1 CUE1 0.183 16093310 P53045 P38428 ERG25 CUE1 0.183 16093310 Q04371 P38428 Q04371 CUE1 0.126 16554755