PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MRS6 LST8 19684114 biogrid exp MIR1 LST8 11805837 dip exp MDH2 LST8 20457600 biogrid exp MPM1 LST8 11805837 dip exp EFT1, EFT2 LST8 16429126 intact exp LST8 PUF3 26493364 biogrid exp DSN1 LST8 21107429 biogrid exp PCK1 LST8 20457600 biogrid exp LST8 VAM6 25026036 biogrid exp PHO8 LST8 17507646 biogrid exp SSB2 LST8 23332755 biogrid exp IME2 LST8 20489023 biogrid,mint,intact exp SRB4 LST8 11283351 i2d,mint,intact,dip exp LST8 RTC1 25073740 intact exp SPB4 LST8 21825077 biogrid exp LST8 STU2 21179020 intact exp LST8 LGE1 21179020 intact exp HTA2 LST8 21179020 intact exp NNK1 LST8 20489023 biogrid,mint,intact exp SEC61 LST8 17507646 biogrid exp SPT5 LST8 21179020 intact exp ENO2 LST8 11805826,16429126 biogrid,mint,intact,dip exp SSA1 LST8 19536198 intact exp LST8 OSW7 11805837 biogrid,mint,intact,dip exp FBP1 LST8 20457600,20617129 biogrid exp TEF1, TEF2 LST8 16429126 intact exp LST8 FMP48 20489023 biogrid,mint,intact exp ICL1 LST8 20457600 biogrid exp YPK2 LST8 22207764 biogrid exp FPR2 LST8 21179020 intact exp SET3 LST8 21179020 intact exp PGK1 LST8 11805826,16429126 biogrid,mint,intact,dip exp LST8 SAP4 20489023 biogrid,mint,intact exp SEA4 LST8 25073740 intact exp FPR1 LST8 12408816 biogrid,intact exp SAP185 LST8 20489023 biogrid,mint,intact exp LST8 BRE1 21179020 intact exp NAB2 LST8 19840948 biogrid exp PEP1 LST8 17507646 biogrid exp LST8 YKU80 11805837 biogrid,mint,intact,dip exp GPM1 LST8 11805837 dip exp HSP60 LST8 11805837 dip exp CPR1 LST8 21179020 intact exp LST8 CCT7 11805837 dip exp, ortho VMA2 LST8 16429126 intact exp, ortho KOG1 LST8 24514902,12408816,14736892, 23023127 biogrid,intact,dip exp, ortho, pred LST8 LST8 14736892, 23023127 intact exp, ortho, pred TOR2 LST8 20489023,14736892,12408816,18552287,16002396,12631735,12719473, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred LST8 AVO2 12408816,14736892, 23023127 biogrid,intact,dip exp, pred TSC11 LST8 12408816,14736892,16002396, 23023127 biogrid,intact,dip exp, pred LST8 BIT61 14736892, 23023127 biogrid,intact,dip exp, pred SFP1 LST8 19328065,19684114, 23023127 biogrid exp, pred KSP1 LST8 20489023, 23023127 biogrid,mint,intact exp, pred LST8 TCO89 14736892, 23023127 biogrid,intact,dip exp, pred LST8 AVO1 12408816,14736892,16002396, 23023127 biogrid,intact,dip exp, pred RTG3 LST8 20489023, 23023127 biogrid,mint,intact exp, pred NPR1 LST8 20489023, 23023127 biogrid,mint,intact exp, pred TOR1 LST8 20489023,12408816,14736892,18552287,12631735,12719473,18513215, 23023127 biogrid,i2d,mint,intact,dip exp, pred LST8 SEC13 23023127 i2d exp, pred CRM1 LST8 ortho LST8 ERG13 ortho LST8 GIM5 ortho STI1 LST8 ortho LST8 EAF3 ortho CCT6 LST8 ortho RHB1 LST8 ortho LST8 RPL10 ortho FAD1 LST8 ortho RPF1 LST8 ortho HMT1 LST8 ortho LST8 ATG4 ortho SEC23 LST8 ortho LST8 MEX67 ortho CCT2 LST8 ortho RHO1 LST8 23023127 pred ARC40 LST8 23023127 pred LST8 SGT1 23023127 pred YPT10 LST8 23023127 pred SEC4 LST8 23023127 pred YPT52 LST8 23023127 pred YPT53 LST8 23023127 pred ASC1 LST8 23023127 pred SEC31 LST8 23023127 pred LST8 ARL3 23023127 pred ARF1 LST8 23023127 pred YPT31 LST8 23023127 pred LST8 ROT1 23023127 pred MYO2 LST8 23023127 pred LST8 YPT6 23023127 pred RAS2 LST8 23023127 pred VPS15 LST8 23023127 pred SAR1 LST8 23023127 pred ARL1 LST8 23023127 pred GPA1 LST8 23023127 pred YPT7 LST8 23023127 pred ARF2 LST8 23023127 pred LST8 YPT32 23023127 pred VPS21 LST8 23023127 pred ARP2 LST8 23023127 pred ARF3 LST8 23023127 pred CDC42 LST8 23023127 pred GEM1 LST8 23023127 pred SPS1 LST8 23023127 pred YPT1 LST8 23023127 pred LST8 SEC27 23023127 pred ARC19 LST8 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P41318 - 11805826 - C 3 P41318 - 11805837 - C 23 P35169 P41318 - 12631735 - X 2 P35169 P41318 - 14736892 - X 2 P43611 P41318 - 11805837 - X 2 P32600 P41318 - 12631735 - X 2 P41318 P32569 - 11283351 - X 2 P41318 Q08236 affinity chromatography technology 12408816 physical association X 2 P41318 P40061 affinity chromatography technology 12408816 physical association X 2 P41318 Q08921 affinity chromatography technology 14736892 physical association X 2 P41318 P40061 affinity chromatography technology 14736892 physical association X 2 P41318 Q08236 affinity chromatography technology 14736892 physical association X 2 P41318 P40061 affinity chromatography technology 16002396 physical association X 2 P41318 Q08236 affinity chromatography technology 16002396 physical association X 2 P41318 P32319 biochemical 17507646 colocalization X 2 P41318 P32864 affinity chromatography technology 19684114 physical association X 2 P41318 P22211 affinity chromatography technology 20489023 physical association X 2 P41318 P40856 affinity chromatography technology 20489023 physical association X 2 P41318 P36003 affinity chromatography technology 20489023 physical association X 2 P41318 P09201 affinity chromatography technology 20457600 physical association X 2 P41318 P28240 affinity chromatography technology 20457600 physical association X 2 P41318 P40568 affinity chromatography technology 21107429 physical association X 2 P41318 P00925 affinity chromatography technology 11805826 physical association X 2 P41318 P00560 affinity chromatography technology 11805826 physical association X 2 P41318 P09201 affinity chromatography technology 20617129 physical association X 2 P41318 P09201 biochemical 20617129 colocalization X 2 P41318 P18961 affinity chromatography technology 22207764 physical association X 2 P38873 P41318 affinity chromatography technology 12408816 physical association X 2 P38873 P41318 affinity chromatography technology 14736892 physical association X 2 P38873 P41318 affinity chromatography technology 14736892 physical association X 2 P38873 P41318 affinity chromatography technology 24514902 physical association X 2 P35169 P41318 affinity chromatography technology 12719473 physical association X 2 P35169 P41318 affinity chromatography technology 12631735 physical association X 2 P35169 P41318 affinity chromatography technology 12408816 physical association X 2 P35169 P41318 affinity chromatography technology 12408816 physical association X 2 P35169 P41318 affinity chromatography technology 14736892 physical association X 2 P35169 P41318 affinity chromatography technology 14736892 physical association X 2 P35169 P41318 biochemical 18513215 association X 2 P35169 P41318 affinity chromatography technology 18552287 physical association X 2 P35169 P41318 affinity chromatography technology 20489023 physical association X 2 P11491 P41318 biochemical 17507646 colocalization X 2 P43611 P41318 affinity chromatography technology 11805837 physical association X 2 P20081 P41318 affinity chromatography technology 12408816 physical association X 2 P32600 P41318 affinity chromatography technology 12719473 physical association X 2 P32600 P41318 affinity chromatography technology 12631735 physical association X 2 P32600 P41318 affinity chromatography technology 12631735 physical association X 2 P32600 P41318 affinity chromatography technology 12408816 physical association X 2 P32600 P41318 affinity chromatography technology 14736892 physical association X 2 P32600 P41318 affinity chromatography technology 14736892 physical association X 2 P32600 P41318 affinity chromatography technology 16002396 physical association X 2 P32600 P41318 biochemical 12631735 association X 2 P32600 P41318 affinity chromatography technology 12408816 physical association X 2 P32600 P41318 affinity chromatography technology 18552287 physical association X 2 P32600 P41318 affinity chromatography technology 20489023 physical association X 2 P53233 P41318 affinity chromatography technology 20489023 physical association X 2 P38165 P41318 affinity chromatography technology 20489023 physical association X 2 P41318 Q04749 affinity chromatography technology 12408816 physical association X 2 P41318 P47041 affinity chromatography technology 14736892 physical association X 2 P41318 Q04749 affinity chromatography technology 14736892 physical association X 2 P41318 P40150 biochemical 23332755 association X 2 P41318 P32915 biochemical 17507646 colocalization X 2 P41318 P32432 affinity chromatography technology 19328065 physical association X 2 P41318 P32432 affinity chromatography technology 19684114 physical association X 2 P41318 P32581 affinity chromatography technology 20489023 physical association X 2 P41318 P38691 affinity chromatography technology 20489023 physical association X 2 P41318 P53036 affinity chromatography technology 20489023 physical association X 2 P41318 P22133 affinity chromatography technology 20457600 physical association X 2 P10963 P41318 affinity chromatography technology 20457600 physical association X 2 P25808 P41318 affinity chromatography technology 21825077 physical association X 2 Q04437 P41318 affinity chromatography technology 11805837 physical association X 2 P41318 tandem affinity purification 11805826 - C 3 P41318 anti tag coimmunoprecipitation 11805837 - C 7 P41318 anti tag coimmunoprecipitation 11805837 - C 37 P41318 anti tag coimmunoprecipitation 11805837 - C 76 P41318 P42943 anti tag coimmunoprecipitation 11805837 physical association X 2 P41318 P00950 anti tag coimmunoprecipitation 11805837 physical association X 2 P41318 P19882 anti tag coimmunoprecipitation 11805837 physical association X 2 P41318 P23641 anti tag coimmunoprecipitation 11805837 physical association X 2 P41318 P00925 tandem affinity purification 11805826 physical association X 2 P41318 P00560 tandem affinity purification 11805826 physical association X 2 P41318 Q08236 coimmunoprecipitation 14736892 physical association X 2 P41318 P40061 coimmunoprecipitation 14736892 physical association X 2 P41318 Q08921 coimmunoprecipitation 14736892 physical association X 2 P38873 P41318 coimmunoprecipitation 14736892 physical association X 2 P38873 P41318 coimmunoprecipitation 14736892 physical association X 2 P35169 P41318 coimmunoprecipitation 14736892 physical association X 2 P35169 P41318 coimmunoprecipitation 12719473 physical association X 2 P35169 P41318 coimmunoprecipitation 14736892 physical association X 2 P43611 P41318 anti tag coimmunoprecipitation 11805837 physical association X 2 P32600 P41318 coimmunoprecipitation 14736892 physical association X 2 P32600 P41318 coimmunoprecipitation 12719473 physical association X 2 P32600 P41318 coimmunoprecipitation 14736892 physical association X 2 P40364 P41318 anti tag coimmunoprecipitation 11805837 physical association X 2 P41318 P32569 two hybrid pooling approach 11283351 physical association X 2 P41318 Q04749 coimmunoprecipitation 14736892 physical association X 2 P41318 P47041 coimmunoprecipitation 14736892 physical association X 2 Q04437 P41318 anti tag coimmunoprecipitation 11805837 physical association X 2 P41318 anti tag coimmunoprecipitation 20489023 association C 8 P41318 anti tag coimmunoprecipitation 20489023 association C 8 P41318 tandem affinity purification 11805826 association C 3 P41318 tandem affinity purification 21179020 association C 36 P41318 anti tag coimmunoprecipitation 12408816 association C 5 P41318 tandem affinity purification 21179020 association C 28 P41318 anti tag coimmunoprecipitation 20489023 association C 15 P41318 tandem affinity purification 21179020 association C 47 P41318 anti tag coimmunoprecipitation 20489023 association C 5 P41318 anti tag coimmunoprecipitation 20489023 association C 12 P41318 anti tag coimmunoprecipitation 20489023 association C 7 P41318 tandem affinity purification 21179020 association C 28 P41318 tandem affinity purification 21179020 association C 80 P41318 tandem affinity purification 21179020 association C 121 P41318 tandem affinity purification 21179020 association C 74 P41318 affinity chromatography technology 25073740 association C 36 P41318 anti tag coimmunoprecipitation 20489023 association C 10 P41318 Q08236 anti tag coimmunoprecipitation 12408816 physical association X 2 P41318 P40061 anti tag coimmunoprecipitation 12408816 physical association X 2 P38873 P41318 anti tag coimmunoprecipitation 12408816 physical association X 2 P10591 P41318 tandem affinity purification 19536198 association X 2 P35169 P41318 anti tag coimmunoprecipitation 12408816 physical association X 2 P41318 anti tag coimmunoprecipitation 12408816 association C 3 P41318 tandem affinity purification 16429126 association C 6 P41318 anti tag coimmunoprecipitation 20489023 association C 4 P41318 anti tag coimmunoprecipitation 14736892 association C 4 P41318 affinity chromatography technology 25073740 association C 27 P41318 tandem affinity purification 21179020 association C 53 P41318 affinity chromatography technology 25073740 association C 32 P41318 anti tag coimmunoprecipitation 20489023 association C 13 P41318 anti tag coimmunoprecipitation 12408816 association C 5 P41318 anti tag coimmunoprecipitation 14736892 association C 10 P41318 anti tag coimmunoprecipitation 14736892 association C 10 P41318 anti tag coimmunoprecipitation 20489023 association C 10 P41318 anti tag coimmunoprecipitation 14736892 association C 6 P41318 anti tag coimmunoprecipitation 11805837 association C 49 P41318 tandem affinity purification 21179020 association C 42 P41318 anti tag coimmunoprecipitation 20489023 association C 15 P41318 anti tag coimmunoprecipitation 14736892 association C 5 P43611 P41318 anti tag coimmunoprecipitation 11805837 physical association X 2 P32600 P41318 anti tag coimmunoprecipitation 12408816 physical association X 2 P32600 P41318 anti tag coimmunoprecipitation 12408816 physical association X 2 P32600 P41318 anti tag coimmunoprecipitation 12408816 physical association X 2 P41318 P32569 two hybrid fragment pooling approach 11283351 physical association X 2 P41318 Q04749 anti tag coimmunoprecipitation 12408816 physical association X 2 P41318 mass spectrometry studies of complexes 11805837 - C 3 P41318 mass spectrometry studies of complexes 11805837 - C 3 P35169 P41318 copurification 14736892 - X 2 P41318 mass spectrometry studies of complexes 11805837 - C 38 P41318 Q04491 interaction detection method 9409822 - X 2 P41318 P32569 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality FBP1 LST8 20617129,20617129 0004,0401 LC PHO8 LST8 17507646 0401 LC PEP1 LST8 17507646 0401 LC SRB4 LST8 11283351,11283351,11283351 0018,0399,0398 HT TOR2 LST8 12631735,12631735,14736892,14736892,14736892,12719473,12719473 0004,0401,0004,0007,0019,0019,0004 LC SEC61 LST8 17507646 0401 LC TOR1 LST8 14736892,14736892,12719473,14736892,14736892,18513215,12719473 0004,0007,0019,0019,0025,0401,0004 LC KOG1 LST8 14736892,14736892,14736892 0004,0007,0019 LC TSC11 LST8 14736892,14736892,14736892 0004,0007,0019 LC SSB2 LST8 23332755 0401 LC LST8 BIT61 14736892,14736892,14736892 0007,0019,0004 LC LST8 AVO2 14736892,14736892,14736892 0007,0019,0004 LC LST8 AVO1 14736892,14736892,14736892 0004,0007,0019 LC LST8 TCO89 14736892,14736892,14736892 0007,0019,0004 LC PGK1 LST8 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT ENO2 LST8 11805826,16429126,11805826,11805826 0004,0676,0007,0676 HT GPM1 LST8 11805837 0007 HT TEF1|TEF2 LST8 16429126 0676 HT HTA2 LST8 21179020 0676 HT FBP1 LST8 20617129,20617129,20457600 0004,0401,0004 LC SSA1 LST8 19536198 0676 HT PCK1 LST8 20457600 0004 LC PHO8 LST8 17507646 0401 LC CPR1 LST8 21179020 0676 HT VMA2 LST8 16429126 0676 HT YPK2 LST8 22207764 0004 LC HSP60 LST8 11805837 0007 HT FPR1 LST8 12408816,12408816 0007,0004 LC MDH2 LST8 20457600 0004 LC NPR1 LST8 20489023,20489023 0007,0004 HT MIR1 LST8 11805837 0007 HT SPB4 LST8 21825077 0004 LC SPT5 LST8 21179020 0676 HT ICL1 LST8 20457600 0004 LC PEP1 LST8 17507646 0401 LC EFT1|EFT2 LST8 16429126 0676 HT SFP1 LST8 19684114,19328065 0004,0004 LC FPR2 LST8 21179020 0676 HT NAB2 LST8 19840948 0004 LC IME2 LST8 20489023,20489023 0007,0004 HT TOR2 LST8 12631735,12631735,14736892,20489023,14736892,20489023,14736892,12719473,18552287,12408816,16002396,12408816,12719473 0004,0401,0004,0004,0007,0007,0019,0019,0004,0004,0004,0007,0004 LC,HT MRS6 LST8 19684114 0004 LC SEC61 LST8 17507646 0401 LC TOR1 LST8 12631735,14736892,20489023,14736892,12719473,20489023,14736892,14736892,18552287,12408816,18513215,12408816,12719473 0004,0004,0004,0007,0019,0007,0019,0025,0004,0004,0401,0007,0004 LC,HT NNK1 LST8 20489023,20489023 0007,0004 HT SET3 LST8 21179020 0676 HT SEA4 LST8 25073740 0004 LC RTG3 LST8 20489023,20489023 0007,0004 HT KSP1 LST8 20489023,20489023 0007,0004 HT KOG1 LST8 12408816,14736892,14736892,14736892,24514902,12408816 0004,0004,0007,0019,0004,0007 LC TSC11 LST8 26028537,12408816,14736892,14736892,14736892,16002396,12408816 0004,0004,0004,0007,0019,0004,0007 LC SSB2 LST8 23332755 0401 LC MPM1 LST8 11805837 0007 HT DSN1 LST8 21107429 0004 HT SAP185 LST8 20489023,20489023 0007,0004 HT LST8 LST8 14736892 0007 LC LST8 CCT7 11805837 0007 HT LST8 OSW7 11805837,11805837 0004,0007 HT LST8 STU2 21179020 0676 HT LST8 BIT61 14736892,14736892,14736892 0007,0019,0004 LC LST8 SAP4 20489023,20489023 0007,0004 HT LST8 FMP48 20489023,20489023 0007,0004 HT LST8 LGE1 21179020 0676 HT LST8 YKU80 11805837,11805837 0004,0007 HT LST8 AVO2 14736892,12408816,12408816,14736892,14736892 0007,0007,0004,0019,0004 LC LST8 BRE1 21179020 0676 HT LST8 AVO1 12408816,14736892,14736892,14736892,16002396,12408816 0004,0004,0007,0019,0004,0007 LC LST8 RTC1 25073740 0004 LC LST8 TCO89 14736892,14736892,14736892 0007,0019,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04437 P41318 YKU80 LST8 0.21 11805837 P41318 P23641 LST8 MIR1 0.126 11805837 P41318 P10591 LST8 SSA1 0.126 19536198 P41318 P00950 LST8 GPM1 0.126 11805837 P41318 P10963 LST8 PCK1 0.21 20457600 P41318 P04912 LST8 HTA2 0.126 21179020 P41318 P20081 LST8 FPR1 0.376 12408816 P41318 P32600 LST8 TOR2 0.876 14736892,18552287,20489023,12719473,12408816,12631735 P41318 P35169 LST8 TOR1 0.832 14736892,18552287,18513215,20489023,12719473,12408816 P41318 P09201 LST8 FBP1 0.454 20457600,20617129 P41318 P25808 LST8 SPB4 0.126 21825077 P41318 P38164 LST8 SEA4 0.126 25073740 P41318 P28240 LST8 ICL1 0.21 20457600 P41318 P32432 LST8 SFP1 0.376 19684114,19328065 P41318 P32472 LST8 FPR2 0.126 21179020 P41318 P32505 LST8 NAB2 0.126 19840948 P41318 P38873 LST8 KOG1 0.583 12408816,14736892,24514902 P41318 P27692 LST8 SPT5 0.126 21179020 P41318 P40061 LST8 TSC11 0.49 12408816,14736892,26028537 P41318 P40150 LST8 SSB2 0.126 23332755 P41318 P36124 LST8 SET3 0.126 21179020 P43611 P41318 P43611 LST8 0.236 11805837 P41318 P40856 LST8 SAP185 0.286 20489023 P41318 P40568 LST8 DSN1 0.126 21107429 P46675 P41318 STU2 LST8 0.126 21179020 P47041 P41318 BIT61 LST8 0.236 14736892 P41318 P00560 LST8 PGK1 0.354 11805826,16429126 P41318 P00925 LST8 ENO2 0.354 11805826,16429126 P41318 P32319 LST8 PEP1 0.126 17507646 P41318 P02994 LST8 TEF2 0.126 16429126 P41318 P32915 LST8 SEC61 0.126 17507646 P41318 P11491 LST8 PHO8 0.126 17507646 P41318 P16140 LST8 VMA2 0.126 16429126 P41318 P32569 LST8 SRB4 0.21 11283351 P41318 P32324 LST8 EFT2 0.126 16429126 P41318 P32864 LST8 MRS6 0.21 19684114 P41318 P32581 LST8 IME2 0.332 20489023 P41318 P36003 LST8 NNK1 0.332 20489023 P41318 P38165 LST8 RTG3 0.332 20489023 P41318 P38691 LST8 KSP1 0.332 20489023 P41318 P41318 LST8 LST8 0.236 14736892 P41318 P40364 LST8 MPM1 0.126 11805837 Q08921 P41318 TCO89 LST8 0.354 14736892 P53233 P41318 FMP48 LST8 0.332 20489023 Q04749 P41318 AVO2 LST8 0.376 12408816,14736892 Q08236 P41318 AVO1 LST8 0.376 12408816,14736892 P41318 P18961 LST8 YPK2 0.21 22207764 P41318 P14832 LST8 CPR1 0.126 21179020 P42943 P41318 CCT7 LST8 0.126 11805837 P41318 P19882 LST8 HSP60 0.126 11805837 Q02796 P41318 LGE1 LST8 0.126 21179020 Q07457 P41318 BRE1 LST8 0.126 21179020 Q07468 P41318 VAM6 LST8 0.126 25026036 Q07807 P41318 PUF3 LST8 0.126 26493364 Q08281 P41318 RTC1 LST8 0.126 25073740 P41318 P22133 LST8 MDH2 0.21 20457600 P53036 P41318 SAP4 LST8 0.286 20489023 P41318 P22211 LST8 NPR1 0.286 20489023