PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HTB2 HDA1 21179020 intact exp CMK1 HDA1 16319894 biogrid,i2d exp RPB9 HDA1 i2d exp TOS3 HDA1 16319894 biogrid,i2d exp HDA1 TIF6 11805826 biogrid,mint,intact,dip exp SSA2 HDA1 16429126,19536198 intact exp SSA1 HDA1 19536198 intact exp RRD1 HDA1 18719252 biogrid,intact exp HDA1 VAC14 i2d exp HTA2 HDA1 21179020 intact exp TUB3 HDA1 18022365 intact exp SIN3 HDA1 22543816 biogrid exp HDA1 RUP1 16554755 biogrid,i2d,mint,intact exp HDA1 VPS5 14690591 intact exp FPR3 HDA1 21179020 intact exp HDA1 GTR1 18022365 intact exp HDA1 HTZ1 21906795,18676811 biogrid,intact exp SSB2 HDA1 19536198 intact exp SHU1 HDA1 10688190 biogrid,i2d,mint,intact,dip exp SSB1 HDA1 19536198 biogrid,intact exp SBA1 HDA1 21777812 biogrid exp PHO84 HDA1 18022365 intact exp HDA1 PRO2 16429126 intact exp HSP26 HDA1 19536198 intact exp ARC1 HDA1 16554755 biogrid,i2d,mint,intact exp DAL80 HDA1 11283351,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred HDA1 HDA1 11805826,19573535,11287668,21179020,18719252, 23023127 biogrid,i2d,mint,intact exp, pred HDA1 HDA3 11805826,11287668,16429126,21179020,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred OCT1 HDA1 16554755, 23023127 biogrid,mint,intact exp, pred GZF3 HDA1 10688190,11283351,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred MSH2 HDA1 11805826,16429126, 23023127 biogrid,mint,intact,dip exp, pred HHF1, HHF2 HDA1 21179020, 23023127 intact exp, pred PHO85 HDA1 16319894, 23023127 biogrid,i2d exp, pred HDA1 SMT3 18719252, 23023127 biogrid,intact exp, pred HDA1 HDA2 11805826,11287668,16429126,21179020,16554755, 23023127 biogrid,i2d,mint,intact,dip exp, pred TUP1 HDA1 11172717,21651791, 23023127 biogrid,intact,dip exp, pred HDA1 ESA1 23023127 pred RIM15 HDA1 23023127 pred HDA1 HOS1 23023127 pred SIR2 HDA1 23023127 pred HDA1 HOS3 23023127 pred HDA1 GCN5 23023127 pred RPD3 HDA1 23023127 pred SPT6 HDA1 23023127 pred HOS2 HDA1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P53973 - 11805826 - C 9 P53973 - 11805826 - C 32 P53973 - 15044803 - C 3 P53973 - 11805826 - C 3 P53973 P26343 - 11283351 - X 2 P53973 Q06623 - 8663039 - X 2 P53973 - 10688190 - X 2 P53973 P42944 - 10688190 - X 2 P53973 P42944 - 11283351 - X 2 P53973 Q06623 - 11287668 - X 2 P53973 P53973 - 11287668 - X 2 P53973 Q06629 affinity chromatography technology 11287668 physical association X 2 P53973 Q06629 pull down 11287668 direct interaction X 2 P53973 P16649 pull down 11172717 direct interaction X 2 P53973 Q12306 affinity chromatography technology 15292183 physical association X 2 P53973 Q06629 affinity chromatography technology 16554755 physical association X 2 P53973 P35999 affinity chromatography technology 16554755 physical association X 2 P53973 Q06629 affinity chromatography technology 16429126 physical association X 2 P53973 Q06629 affinity chromatography technology 16429126 physical association X 2 P53973 Q06629 affinity chromatography technology 17200106 physical association X 2 P53973 Q12306 two hybrid 18719252 direct interaction X 2 P53973 Q12692 enzymatic study 18676811 direct interaction X 2 P53973 P17157 enzymatic study 16319894 direct interaction X 2 P53973 Q06629 affinity chromatography technology 11805826 physical association X 2 P53973 P16649 imaging technique 21651791 colocalization X 2 P53973 P28707 two hybrid 21777812 direct interaction X 2 P53973 Q12692 enzymatic study 21906795 direct interaction X 2 P53973 P38751 two hybrid 10688190 direct interaction X 2 P22579 P53973 pull down 22543816 direct interaction X 2 P22579 P53973 two hybrid 22543816 direct interaction X 2 P0CG63 P53973 affinity chromatography technology 23793018 physical association X 2 P53973 Q06623 affinity chromatography technology 11287668 physical association X 2 P53973 Q06623 pull down 11287668 direct interaction X 2 P53973 P46672 affinity chromatography technology 16554755 physical association X 2 P53973 Q06623 affinity chromatography technology 16554755 physical association X 2 P53973 Q12242 affinity chromatography technology 16554755 physical association X 2 P53973 Q06623 affinity chromatography technology 16429126 physical association X 2 P53973 P25847 affinity chromatography technology 16429126 physical association X 2 P53973 Q06623 affinity chromatography technology 16429126 physical association X 2 P53973 P43637 enzymatic study 16319894 direct interaction X 2 P53973 Q06623 affinity chromatography technology 17200106 physical association X 2 P53973 P40454 two hybrid 18719252 direct interaction X 2 P53973 P42944 two hybrid 18719252 direct interaction X 2 P53973 P26343 two hybrid 18719252 direct interaction X 2 P53973 P53973 two hybrid 18719252 direct interaction X 2 P53973 P11484 affinity chromatography technology 19536198 physical association X 2 P53973 P11484 affinity chromatography technology 19536198 physical association X 2 P53973 P53973 pull down 19573535 direct interaction X 2 P53973 Q12522 affinity chromatography technology 11805826 physical association X 2 P53973 Q06623 affinity chromatography technology 11805826 physical association X 2 P53973 P25847 affinity chromatography technology 11805826 physical association X 2 P53973 P42944 two hybrid 10688190 direct interaction X 2 P27466 P53973 enzymatic study 16319894 direct interaction X 2 P53973 tandem affinity purification 11805826 - C 9 P53973 tandem affinity purification 11805826 - C 32 P53973 inferred by author 11805826 physical association C 88 P53973 tandem affinity purification 11805826 physical association C 3 P53973 inferred by author 11805826 physical association C 3 P53973 P16649 coimmunoprecipitation 11172717 physical association X 2 P53973 Q06629 tandem affinity purification 11805826 physical association X 2 P53973 P38751 two hybrid 10688190 physical association X 2 P53973 inferred by author 11805826 physical association C 35 P53973 P26343 two hybrid pooling approach 11283351 physical association X 2 P53973 P42944 two hybrid pooling approach 11283351 physical association X 2 P53973 P42944 two hybrid 10688190 physical association X 2 P53973 Q12522 tandem affinity purification 11805826 physical association X 2 P53973 Q06623 tandem affinity purification 11805826 physical association X 2 P53973 P25847 tandem affinity purification 11805826 physical association X 2 P53973 tandem affinity purification 16429126 association C 19 P53973 tandem affinity purification 16429126 association C 4 P53973 tandem affinity purification 16429126 association C 4 P53973 tandem affinity purification 11805826 association C 10 P53973 anti tag coimmunoprecipitation 11287668 association C 3 P53973 anti tag coimmunoprecipitation 11287668 association C 3 P53973 anti bait coimmunoprecipitation 11287668 association C 3 P53973 P38751 two hybrid 10688190 physical association X 2 P53973 P16649 pull down 11172717 physical association X 2 P53973 Q06629 pull down 11287668 direct interaction X 2 P53973 P35999 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q06629 tandem affinity purification 16554755 physical association X 2 P53973 Q12306 two hybrid 18719252 physical association X 2 P53973 Q12692 deacetylase assay 21906795 deacetylation reaction X 2 P53973 inferred by author 16554755 association C 4 P53973 tandem affinity purification 21179020 association C 8 P53973 tandem affinity purification 21179020 association C 8 P53973 inferred by author 16429126 physical association C 5 P53973 tandem affinity purification 16429126 association C 4 P53973 tandem affinity purification 11805826 association C 33 P53973 tandem affinity purification 11805826 association C 4 P53973 tandem affinity purification 11805826 association C 4 Q92331 P53973 two hybrid array 14690591 physical association X 2 P10591 P53973 tandem affinity purification 19536198 association X 2 P53973 P42944 two hybrid 10688190 physical association X 2 P53973 P42944 two hybrid fragment pooling approach 11283351 physical association X 2 P53973 P26343 two hybrid fragment pooling approach 11283351 physical association X 2 P53973 P53973 pull down 11287668 direct interaction X 2 P53973 Q06623 pull down 11287668 direct interaction X 2 P53973 P53973 anti tag coimmunoprecipitation 11287668 physical association X 2 P53973 Q12242 tandem affinity purification 16554755 physical association X 2 P53973 Q12242 tandem affinity purification 16554755 physical association X 2 P53973 Q06623 tandem affinity purification 16554755 physical association X 2 P53973 Q06623 tandem affinity purification 16554755 physical association X 2 P53973 Q06623 tandem affinity purification 16554755 physical association X 2 P53973 Q06623 tandem affinity purification 16554755 physical association X 2 P53973 Q06623 tandem affinity purification 16554755 physical association X 2 P53973 P46672 tandem affinity purification 16554755 physical association X 2 P53973 P46672 tandem affinity purification 16554755 physical association X 2 P53973 P40454 two hybrid 18719252 physical association X 2 P53973 P42944 two hybrid 18719252 physical association X 2 P53973 P53973 two hybrid 18719252 physical association Y 1 P53973 P26343 two hybrid 18719252 physical association X 2 P53973 P10592 tandem affinity purification 19536198 association X 2 P53973 P11484 tandem affinity purification 19536198 association X 2 P53973 P15992 tandem affinity purification 19536198 association X 2 P53973 P11484 tandem affinity purification 19536198 association X 2 P53973 P40150 tandem affinity purification 19536198 association X 2 P53973 mass spectrometry studies of complexes 11805826 - C 42 P53973 mass spectrometry studies of complexes 11805826 - C 106 P53973 P38751 two hybrid 10688190 - X 2 P53973 mass spectrometry studies of complexes 11805826 - C 4 P53973 mass spectrometry studies of complexes 11805826 - C 4 P53973 P42944 two hybrid 10688190 - X 2 P53973 P42944 two hybrid 11283351 - X 2 P53973 P26343 two hybrid 11283351 - X 2 P53973 P53973 confirmational text mining - - Y 1

PPI - HINT Gene A Gene B PMID Method Quality TUP1 HDA1 11172717,11172717 0019,0096 LC PHO85 HDA1 16319894 0415 LC SIN3 HDA1 22543816,22543816 0096,0018 LC DAL80 HDA1 11283351,18719252,11283351,11283351 0018,0018,0399,0398 HT CMK1 HDA1 16319894 0415 LC SBA1 HDA1 21777812 0018 LC SHU1 HDA1 10688190,10688190 0397,0018 HT RRD1 HDA1 18719252 0018 HT GZF3 HDA1 18719252,11283351,11283351,11283351,10688190,10688190 0018,0018,0399,0398,0397,0018 HT TOS3 HDA1 16319894 0415 LC HDA1 HDA1 18719252,11287668,11287668,11287668,11287668 0018,0004,0019,0007,0096 HT,LC HDA1 HDA3 11287668,11287668,11287668,11287668,11287668 0004,0019,0006,0007,0096 LC HDA1 SMT3 18719252 0018 HT HDA1 HTZ1 18676811,21906795,21906795 0415,0415,0406 LC HDA1 VPS5 14690591 0397 LC HTB2 HDA1 21179020 0676 HT HHF1|HHF2 HDA1 21179020 0676 HT HTA2 HDA1 21179020 0676 HT SSA1 HDA1 19536198 0676 HT SSA2 HDA1 19536198,16429126 0676,0676 HT SSB1 HDA1 19536198,19536198 0004,0676 HT HSP26 HDA1 19536198 0676 HT TUP1 HDA1 11172717,11172717,21651791 0019,0096,0428 LC SIN3 HDA1 22543816,22543816 0096,0018 LC MSH2 HDA1 16429126,11805826,11805826,11805826,16429126,16429126 0676,0676,0004,0007,0004,0363 HT OCT1 HDA1 16554755,16554755,16554755 0363,0676,0004 HT FPR3 HDA1 21179020 0676 HT SSB2 HDA1 19536198 0676 HT ARC1 HDA1 16554755,16554755 0676,0004 HT HDA1 HDA1 21179020,19573535,11287668,11287668,11805826,11287668,11287668,11805826 0676,0096,0004,0019,0676,0007,0096,0007 HT,LC HDA1 PRO2 16429126 0363 HT HDA1 HDA3 21179020,16554755,16554755,11287668,16429126,16429126,11287668,11287668,11805826,11287668,11287668,11805826,17200106,11805826,16429126,16554755 0676,0363,0676,0004,0363,0004,0019,0006,0676,0007,0096,0004,0004,0007,0676,0004 HT,LC HDA1 HDA2 21179020,16554755,16554755,11287668,16429126,16429126,11287668,11805826,11287668,11287668,11805826,17200106,11805826,16429126,16554755 0676,0363,0676,0004,0363,0676,0006,0676,0007,0096,0004,0004,0007,0004,0004 HT,LC HDA1 RUP1 16554755,16554755 0676,0004 HT HDA1 SMT3 15292183 0004 LC HDA1 TIF6 11805826,11805826,11805826 0676,0007,0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53973 P15992 HDA1 HSP26 0.126 19536198 P53973 P17157 HDA1 PHO85 0.183 16319894 P53973 P11484 HDA1 SSB1 0.416 19536198 P53973 P42944 HDA1 GZF3 0.636 11283351,10688190,18719252 P53973 P10592 HDA1 SSA2 0.236 16429126,19536198 P53973 P02309 HDA1 HHF2 0.396 21179020,27665728 Q12306 P53973 SMT3 HDA1 0.332 18719252 P53973 P53973 HDA1 HDA1 0.932 11805826,19573535,18719252,21179020,11287668,27665728 P53973 P28707 HDA1 SBA1 0.183 21777812 P53973 P38751 HDA1 SHU1 0.332 10688190 P53973 P27466 HDA1 CMK1 0.183 16319894 P53973 P35999 HDA1 OCT1 0.332 16554755 P53973 P40150 HDA1 SSB2 0.126 19536198 P53973 P40454 HDA1 RRD1 0.332 18719252 Q12522 P53973 TIF6 HDA1 0.21 11805826 Q12692 P53973 HTZ1 HDA1 0.539 21906795,18676811 P53973 P16649 HDA1 TUP1 0.396 11172717,21651791 Q06623 P53973 HDA3 HDA1 0.858 11805826,16429126,16554755,21179020,11287668 Q06629 P53973 HDA2 HDA1 0.858 11805826,16429126,16554755,21179020,11287668 P53973 P02293 HDA1 HTB1 0.309 27665728 P53973 P02294 HDA1 HTB2 0.126 21179020 P53973 P04911 HDA1 HTA1 0.309 27665728 P53973 P04912 HDA1 HTA2 0.126 21179020 P53973 P10591 HDA1 SSA1 0.126 19536198 P53973 P22579 HDA1 SIN3 0.523 22543816 P53973 P25847 HDA1 MSH2 0.472 11805826,16429126 P53973 P26343 HDA1 DAL80 0.472 11283351,18719252 P53973 P38911 HDA1 FPR3 0.126 21179020 P53973 P46672 HDA1 ARC1 0.332 16554755 P54885 P53973 PRO2 HDA1 0.126 16429126 P61830 P53973 HHT2 HDA1 0.309 27665728 Q12242 P53973 RUP1 HDA1 0.236 16554755 Q92331 P53973 VPS5 HDA1 0.126 14690591