PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MET4 END3 11087867,22875988 biogrid,i2d,mint,intact,dip exp MET4 RPN12 17157252 biogrid exp CDC48 MET4 24613342 biogrid exp RPS31 MET4 i2d exp MET4 HEK2 18805955 biogrid exp RPL40A MET4 10975521 i2d,dip exp RPL40B MET4 i2d exp MET4 NAB2 19840948 biogrid exp SSB1 MET4 19536198 intact exp MET4 ZUO1 11087867 biogrid exp MET4 YAP5 i2d exp MET4 COY1 22875988 biogrid exp MET4 HDA2 22875988 biogrid exp MET4 NOP53 22875988 biogrid exp MET4 BUD27 22875988 biogrid exp MET4 CAB3 14690591 intact exp CDC34 MET4 21453497 biogrid exp MET4 ECM10 19536198 intact exp MET4 RVS167 16554755 biogrid,i2d,mint,intact exp MET4 SPT10 25228766 biogrid exp MET4 RPN10 17157252 biogrid exp SSA1 MET4 19536198 intact exp MET4 SKP1 17157252 biogrid exp UBI4 MET4 20694217,21041680 biogrid,i2d exp MET4 SSE1 19536198 intact exp SSA2 MET4 16429126,19536198 intact exp SEC2 MET4 11087867,22875988 biogrid,i2d,mint,intact,dip exp ZIP1 MET4 22875988 biogrid exp MET4 MET28 11087867,9171357,9799240,23661758,8665859,17157252, 23023127 biogrid,i2d,mint,intact,dip exp, pred GLN3 MET4 16554755, 23023127 biogrid,i2d,mint,intact exp, pred MET4 MET32 9799240,21172660, 23023127 biogrid,i2d,intact,dip exp, pred MET4 MET31 9799240,17157252, 23023127 biogrid,i2d,intact,dip exp, pred MET4 MET4 11087867,23661758, 23023127 biogrid,i2d,mint,intact,dip exp, pred CBF1 MET4 18308733,9171357,8665859,17157252, 23023127 biogrid,i2d,intact,dip exp, pred MET4 NDL1 11087867,22875988, 23023127 biogrid,i2d,mint,intact,dip exp, pred MET4 MET30 10975521,21172660,15660125,11805837,24389104,8524217,23000173,15883825,10637232,14690591,17157252, 23023127 biogrid,i2d,intact,dip exp, pred BAS1 MET4 23023127 pred MET4 LYS20 23023127 pred YAP1 MET4 23023127 pred MET4 PIP2 23023127 pred UGA3 MET4 23023127 pred MET4 STR2 23023127 pred MET16 MET4 23023127 pred MET4 MET5 23023127 pred MET4 AGX1 23023127 pred URE2 MET4 23023127 pred MET4 MET10 23023127 pred MET4 RPN4 23023127 pred MET4 SER3 23023127 pred GCN4 MET4 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P14682 P32389 enzymatic study 21453497 direct interaction X 2 P39013 P32389 two hybrid 22875988 direct interaction X 2 P39013 P32389 two hybrid 11087867 direct interaction X 2 P0CG63 P32389 pull down 23000173 direct interaction X 2 P0CG63 P32389 affinity chromatography technology 23749301 physical association X 2 P0CG63 P32389 biochemical 23583075 association X 2 P0CG63 P32389 affinity chromatography technology 17644757 physical association X 2 P0CG63 P32389 affinity chromatography technology 23793018 physical association X 2 P0CG63 P32389 affinity chromatography technology 17904100 physical association X 2 P0CG63 P32389 pull down 21041680 direct interaction X 2 P0CG63 P32389 affinity chromatography technology 21983566 physical association X 2 P0CG63 P32389 affinity chromatography technology 12872131 physical association X 2 P0CG63 P32389 affinity chromatography technology 17157252 physical association X 2 P0CG63 P32389 affinity chromatography technology 20694217 physical association X 2 P0CG63 P32389 affinity chromatography technology 21427232 physical association X 2 P0CG63 P32389 affinity chromatography technology 14557538 physical association X 2 P39014 P32389 affinity chromatography technology 23000173 physical association X 2 P39014 P32389 affinity chromatography technology 10637232 physical association X 2 P39014 P32389 affinity chromatography technology 10975521 physical association X 2 P39014 P32389 two hybrid 10637232 direct interaction X 2 P39014 P32389 two hybrid 8524217 direct interaction X 2 P39014 P32389 affinity chromatography technology 15660125 physical association X 2 P39014 P32389 affinity chromatography technology 15883825 physical association X 2 P39014 P32389 affinity chromatography technology 24389104 physical association X 2 P39014 P32389 affinity chromatography technology 17157252 physical association X 2 P39014 P32389 affinity chromatography technology 17157252 physical association X 2 P39014 P32389 affinity chromatography technology 21172660 physical association X 2 P39014 P32389 affinity chromatography technology 11805837 physical association X 2 P32496 P32389 pull down 17157252 direct interaction X 2 P32496 P32389 affinity chromatography technology 17157252 physical association X 2 P32389 P31111 two hybrid 22875988 direct interaction X 2 P32389 P43573 two hybrid 22875988 direct interaction X 2 P32389 P17065 two hybrid 22875988 direct interaction X 2 P32389 P17065 two hybrid 11087867 direct interaction X 2 P32389 P17065 two hybrid 11087867 direct interaction X 2 P32389 P32527 two hybrid 11087867 direct interaction X 2 P32389 Q12306 affinity chromatography technology 23935535 physical association X 2 P32389 P39743 affinity chromatography technology 16554755 physical association X 2 P32389 P18494 affinity chromatography technology 16554755 physical association X 2 P32389 Q12306 affinity chromatography technology 15326169 physical association X 2 P35208 P32389 affinity chromatography technology 25228766 physical association X 2 Q03081 P32389 two hybrid 9799240 direct interaction X 2 Q03081 P32389 pull down 9799240 direct interaction X 2 Q03081 P32389 affinity chromatography technology 17157252 physical association X 2 Q03081 P32389 affinity chromatography technology 17157252 physical association X 2 Q12080 P32389 two hybrid 22875988 direct interaction X 2 P34237 P32389 two hybrid 22875988 direct interaction X 2 Q12041 P32389 two hybrid 9799240 direct interaction X 2 Q12041 P32389 pull down 9799240 direct interaction X 2 Q12041 P32389 affinity chromatography technology 21172660 physical association X 2 P17106 P32389 two hybrid 8665859 direct interaction X 2 P17106 P32389 pull down 9171357 direct interaction X 2 P17106 P32389 affinity chromatography technology 18308733 physical association X 2 P17106 P32389 affinity chromatography technology 17157252 physical association X 2 P17106 P32389 affinity chromatography technology 17157252 physical association X 2 P38886 P32389 pull down 17157252 direct interaction X 2 P38886 P32389 affinity chromatography technology 17157252 physical association X 2 Q06629 P32389 two hybrid 22875988 direct interaction X 2 P32389 Q06568 two hybrid 22875988 direct interaction X 2 P32389 P40573 two hybrid 9799240 direct interaction X 2 P32389 P40573 pull down 9171357 direct interaction X 2 P32389 Q06568 two hybrid 11087867 direct interaction X 2 P32389 P32389 two hybrid 11087867 direct interaction X 2 P32389 P40573 two hybrid 8665859 direct interaction X 2 P32389 P40573 fluorescent resonance energy transfer 23661758 direct interaction X 2 P32389 P32389 fluorescent resonance energy transfer 23661758 direct interaction X 2 P32389 P40573 fluorescent resonance energy transfer 23661758 direct interaction X 2 P32389 P25694 imaging technique 24613342 colocalization X 2 P32389 P40573 affinity chromatography technology 17157252 physical association X 2 P32389 P40573 affinity chromatography technology 17157252 physical association X 2 P52286 P32389 affinity chromatography technology 17157252 physical association X 2 P32389 anti tag coimmunoprecipitation 11805837 association C 8 P32389 inferred by author 16554755 association C 3 P32589 P32389 tandem affinity purification 19536198 association X 2 P39013 P32389 two hybrid 11087867 physical association X 2 P39014 P32389 anti tag coimmunoprecipitation 10637232 physical association X 2 P39014 P32389 two hybrid 10637232 physical association X 2 P39014 P32389 two hybrid array 14690591 physical association X 2 P39014 P32389 anti tag coimmunoprecipitation 15883825 physical association X 2 P39014 P32389 pull down 15883825 physical association X 2 P39014 P32389 two hybrid 8524217 physical association X 2 P32389 P17065 two hybrid 11087867 physical association X 2 P32389 P17065 two hybrid 11087867 physical association X 2 P32389 P18494 tandem affinity purification 16554755 physical association X 2 P32389 P39743 tandem affinity purification 16554755 physical association X 2 Q03081 P32389 two hybrid 9799240 physical association X 2 P10591 P32389 tandem affinity purification 19536198 association X 2 P36076 P32389 two hybrid array 14690591 physical association X 2 Q12041 P32389 two hybrid 9799240 physical association X 2 P32389 anti tag coimmunoprecipitation 11805837 association C 5 P10592 P32389 tandem affinity purification 16429126 physical association X 2 P10592 P32389 tandem affinity purification 19536198 association X 2 P17106 P32389 two hybrid 8665859 physical association X 2 P11484 P32389 tandem affinity purification 19536198 association X 2 P32389 Q06568 two hybrid 11087867 physical association X 2 P32389 P40573 two hybrid 11087867 physical association X 2 P32389 P32389 two hybrid 11087867 physical association X 2 P32389 P39987 tandem affinity purification 19536198 association X 2 P32389 P40573 two hybrid 8665859 physical association X 2 P32389 P40573 two hybrid 9799240 physical association X 2 P32389 confirmational text mining - - C 3 P32389 confirmational text mining - - C 3 P39013 P32389 two hybrid 11087867 - X 2 P39014 P32389 interaction detection method - - X 2 P39014 P32389 two hybrid 8524217 - X 2 P32389 P17065 two hybrid 11087867 - X 2 P32389 mass spectrometry studies of complexes 11805837 - C 11 P32389 confirmational text mining - - C 3 P17106 P32389 two hybrid 8665859 - X 2 P32389 P40573 two hybrid 8665859 - X 2 P32389 P32389 two hybrid 11087867 - X 2 P32389 Q06568 two hybrid 11087867 - X 2 P32389 P40573 two hybrid 11087867 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC34 MET4 21453497 0415 LC SEC2 MET4 11087867,22875988,11087867 0397,0018,0018 HT CBF1 MET4 8665859 0018 LC ZIP1 MET4 22875988 0018 HT MET4 MET4 11087867,23661758,11087867 0397,0055,0018 HT,LC MET4 ZUO1 11087867 0018 HT MET4 COY1 22875988 0018 HT MET4 CAB3 14690591 0397 LC MET4 END3 11087867,22875988,11087867 0397,0018,0018 HT MET4 MET30 8524217,10637232,10637232,14690591,10637232 0018,0007,0004,0397,0018 LC MET4 MET28 9799240,8665859,23661758,11087867,11087867,9799240 0018,0018,0055,0397,0018,0404 LC,HT MET4 BUD27 22875988 0018 HT MET4 MET31 9799240,9799240,9799240 0096,0018,0404 LC MET4 NDL1 11087867,22875988,11087867 0397,0018,0018 HT MET4 HDA2 22875988 0018 HT MET4 MET32 9799240,9799240,9799240 0018,0096,0404 LC MET4 NOP53 22875988 0018 HT UBI4 MET4 21453497,17157252,20694217,21041680,14557538,21041680 0096,0004,0004,0004,0004,0096 LC SSA1 MET4 19536198 0676 HT SSA2 MET4 19536198,16429126 0676,0676 HT SSB1 MET4 19536198 0676 HT CBF1 MET4 10975521,18308733,9171357,17157252 0004,0004,0096,0004 LC GLN3 MET4 16554755,16554755,16554755 0363,0676,0004 HT CDC48 MET4 24613342 0428 LC MET4 RPN12 17157252,17157252 0096,0004 LC MET4 NAB2 19840948 0004 LC MET4 SSE1 19536198 0676 HT MET4 SPT10 25228766 0004 HT MET4 RPN10 17157252,17157252 0096,0004 LC MET4 MET30 15660125,23000173,21172660,10637232,15883825,24389104,11805837,10637232,17157252,10975521,15883825,11805837,10637232,15883825 0004,0004,0004,0007,0007,0004,0004,0004,0004,0004,0004,0007,0018,0096 LC,HT MET4 RVS167 16554755,16554755 0676,0004 HT MET4 ECM10 19536198 0676 HT MET4 MET28 17157252,9171357 0004,0096 LC MET4 SKP1 17157252 0004 LC MET4 MET31 9799240,9799240,9799240,17157252 0096,0018,0404,0004 LC MET4 MET32 9799240,21172660,9799240,9799240 0018,0004,0096,0404 LC MET4 SMT3 15326169 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12080 P32389 NOP53 MET4 0.183 22875988 P32389 P11484 MET4 SSB1 0.126 19536198 Q12041 P32389 MET32 MET4 0.74 9799240,21172660 Q03081 P32389 MET31 MET4 0.794 9799240,17157252 P32389 P17106 MET4 CBF1 0.757 18308733,10975521,17157252,9171357,8665859 P32389 P0CG63 MET4 UBI4 0.454 20694217,21041680 P40573 P32389 MET28 MET4 0.939 11087867,9171357,23661758,8665859,9799240,17157252 P39014 P32389 MET30 MET4 0.967 14690591,15883825,10637232,11805837,24389104,15660125,8524217,10975521,21172660,23000173 P61864 P32389 RPL40A MET4 0.096 10975521,15208638 P32389 P31111 MET4 ZIP1 0.183 22875988 P38199 P32389 HEK2 MET4 0.126 18805955 P32389 P10591 MET4 SSA1 0.126 19536198 P32389 P10592 MET4 SSA2 0.236 16429126,19536198 P32389 P17065 MET4 SEC2 0.332 11087867 P32389 P18494 MET4 GLN3 0.236 16554755 P32389 P25694 MET4 CDC48 0.126 24613342 P32389 P32389 MET4 MET4 0.332 11087867,23661758 P32496 P32389 RPN12 MET4 0.21 17157252 P36076 P32389 CAB3 MET4 0.126 14690591 P38886 P32389 RPN10 MET4 0.21 17157252 P39013 P32389 END3 MET4 0.21 11087867 P39743 P32389 RVS167 MET4 0.126 16554755 P39987 P32389 ECM10 MET4 0.126 19536198 P52286 P32389 SKP1 MET4 0.21 17157252 Q06568 P32389 NDL1 MET4 0.183 11087867 P32505 P32389 NAB2 MET4 0.126 19840948 P32589 P32389 SSE1 MET4 0.126 19536198 P32389 P14682 MET4 CDC34 0.309 21453497 Q06629 P32389 HDA2 MET4 0.183 22875988