PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PPH22 APC1 23751495 biogrid exp APC1 URN1 21386897 biogrid exp AIM4 APC1 21386897 biogrid exp CDC28 APC1 23751495 biogrid exp APC1 DDP1 17634282 biogrid exp SSB1 APC1 19536198 intact exp APC1 PUF3 23409723,26493364 biogrid exp HSP12 APC1 19536198 intact exp APC1 SYC1 17634282 biogrid exp SSA2 APC1 19536198 intact exp YEF3 APC1 16429126 intact exp APC1 HSP31 19536198 intact exp PPH21 APC1 23751495 biogrid exp RPA14 APC1 17634282 biogrid exp ZTA1 APC1 17634282 biogrid exp APC1 SML1 16554755 biogrid,i2d,mint,intact exp SSE1 APC1 19536198 intact exp SPO12 APC1 17634282 biogrid exp APC1 SFG1 17634282 biogrid exp UGX2 APC1 17634282 biogrid exp FHN1 APC1 17634282 biogrid exp AAT2 APC1 i2d exp SSZ1 APC1 19536198 intact exp SSB2 APC1 19536198 intact exp CDC26 APC1 16554755,9469814,8895471, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC27 APC1 16429126,17459880,16481473,12609981,16554755,9469814,8895471, 23023127 biogrid,i2d,mint,intact,dip exp, pred CDC23 APC1 16429126,16481473,9469814,8895471, 23023127 biogrid,i2d,intact,dip exp, pred MRE11 APC1 17634282, 23023127 biogrid exp, pred CDC5 APC1 19013276, 23023127 biogrid,intact exp, pred APC1 APC9 16429126,9469814, 23023127 i2d,intact exp, pred MAD3 APC1 17634282, 23023127 biogrid exp, pred CDH1 APC1 16481473, 23023127 biogrid exp, pred APC1 BSP1 16554755, 23023127 biogrid,i2d,mint,intact exp, pred APC1 APC2 11805826,16429126,15060174,16481473,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC1 APC5 16429126,16481473,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC1 APC11 16481473,9469814, 23023127 biogrid,i2d,intact,dip exp, pred APC1 TAF9 17634282, 23023127 biogrid exp, pred DOC1 APC1 10318877,15060174,16481473,17634282,21186364,16554755,9469814, 23023127 biogrid,i2d,mint,intact,dip exp, pred APC1 APC1 21186364,8895471, 23023127 biogrid,dip exp, pred DSN1 APC1 21107429, 23023127 biogrid exp, pred YCK1 APC1 11805837, 23023127 biogrid,intact,dip exp, pred MCM3 APC1 17634282, 23023127 biogrid exp, pred MND2 APC1 12477395,12609981,12574115, 23023127 biogrid,intact exp, pred APC1 APC4 12477395,16429126,15060174,16481473,21186364,9469814, 23023127 biogrid,i2d,intact,dip exp, pred IPL1 APC1 17634282, 23023127 biogrid exp, pred APC1 SWM1 12477395,15060174,12609981,12574115,9469814, 23023127 biogrid,intact exp, pred CDC16 APC1 10318877,16429126,12402045,21186364,9469814,16364911,8895471,15060174,16275330,17406682,12887895,15797379,16481473,15649358,12574115,23751495, 23023127 biogrid,i2d,intact,dip exp, pred CBF2 APC1 23023127 pred SPC98 APC1 23023127 pred APC1 HRD1 23023127 pred APC1 NSL1 23023127 pred DOA4 APC1 23023127 pred RAD18 APC1 23023127 pred RSP5 APC1 23023127 pred MET30 APC1 23023127 pred APC1 RPN5 23023127 pred CEP3 APC1 23023127 pred APC1 ESP1 23023127 pred PDS1 APC1 23023127 pred UBC9 APC1 23023127 pred MIF2 APC1 23023127 pred CDC20 APC1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12157 P53886 affinity chromatography technology 9469814 physical association X 2 Q12157 P53886 affinity chromatography technology 16481473 physical association X 2 Q12157 P53886 affinity chromatography technology 16481473 physical association X 2 P53886 P09798 affinity chromatography technology 12574115 physical association X 2 P53886 P09798 affinity chromatography technology 10318877 physical association X 2 P53886 P53886 affinity chromatography technology 8895471 physical association X 2 P53886 P09798 affinity chromatography technology 8895471 physical association X 2 P53886 P09798 affinity chromatography technology 8895471 physical association X 2 P53886 P16522 affinity chromatography technology 8895471 physical association X 2 P53886 P16522 affinity chromatography technology 8895471 physical association X 2 P53886 P09798 affinity chromatography technology 12887895 physical association X 2 P53886 P09798 affinity chromatography technology 12402045 physical association X 2 P53886 P09798 affinity chromatography technology 15649358 physical association X 2 P53886 P09798 affinity chromatography technology 15060174 physical association X 2 P53886 P09798 affinity chromatography technology 9469814 physical association X 2 P53886 P16522 affinity chromatography technology 16481473 physical association X 2 P53886 P09798 affinity chromatography technology 16481473 physical association X 2 P53886 P16522 affinity chromatography technology 16481473 physical association X 2 P53886 P09798 affinity chromatography technology 23751495 physical association X 2 P53886 P16522 affinity chromatography technology 16429126 physical association X 2 P53886 P09798 affinity chromatography technology 16429126 physical association X 2 P53886 P09798 affinity chromatography technology 16275330 physical association X 2 P53886 P09798 affinity chromatography technology 16481473 physical association X 2 P53886 P16522 affinity chromatography technology 16481473 physical association X 2 P53886 P16522 affinity chromatography technology 17200106 physical association X 2 P53886 P09798 affinity chromatography technology 17200106 physical association X 2 P53886 P32772 two hybrid 17634282 direct interaction X 2 P53886 P24279 two hybrid 17634282 direct interaction X 2 P53886 P17123 two hybrid 17634282 direct interaction X 2 P53886 P32829 two hybrid 17634282 direct interaction X 2 P53886 Q08553 two hybrid 17634282 direct interaction X 2 P53886 P38991 two hybrid 17634282 direct interaction X 2 P53886 P32562 affinity chromatography technology 19013276 physical association X 2 P53886 P09798 affinity chromatography technology 17406682 physical association X 2 P53886 P09798 affinity chromatography technology 15797379 physical association X 2 P53886 P09798 affinity chromatography technology 21186364 physical association X 2 P53886 P53886 affinity chromatography technology 21186364 physical association X 2 P53886 P38305 affinity chromatography technology 21386897 physical association X 2 P53886 P09798 affinity chromatography technology 16364911 physical association X 2 Q06525 P53886 affinity chromatography technology 21386897 physical association X 2 Q12379 P53886 affinity chromatography technology 12609981 physical association X 2 Q12379 P53886 affinity chromatography technology 12574115 physical association X 2 Q12379 P53886 affinity chromatography technology 15060174 physical association X 2 Q12379 P53886 affinity chromatography technology 12477395 physical association X 2 Q12379 P53886 biochemical 15060174 colocalization X 2 Q08683 P53886 affinity chromatography technology 9469814 physical association X 2 Q08683 P53886 affinity chromatography technology 16481473 physical association X 2 Q08683 P53886 affinity chromatography technology 16429126 physical association X 2 Q08683 P53886 affinity chromatography technology 17200106 physical association X 2 Q12507 P53886 two hybrid 17634282 direct interaction X 2 Q04601 P53886 affinity chromatography technology 15060174 physical association X 2 Q04601 P53886 affinity chromatography technology 12477395 physical association X 2 Q04601 P53886 affinity chromatography technology 9469814 physical association X 2 Q04601 P53886 affinity chromatography technology 16481473 physical association X 2 Q04601 P53886 affinity chromatography technology 17200106 physical association X 2 Q04601 P53886 affinity chromatography technology 21186364 physical association X 2 P14724 P53886 affinity chromatography technology 8895471 physical association X 2 P14724 P53886 affinity chromatography technology 16554755 physical association X 2 Q12440 P53886 affinity chromatography technology 15060174 physical association X 2 Q12440 P53886 affinity chromatography technology 9469814 physical association X 2 Q12440 P53886 biochemical 15060174 colocalization X 2 Q12440 P53886 affinity chromatography technology 16481473 physical association X 2 Q12440 P53886 pull down 16481473 direct interaction X 2 Q12440 P53886 affinity chromatography technology 16554755 physical association X 2 Q12440 P53886 affinity chromatography technology 16429126 physical association X 2 Q12440 P53886 affinity chromatography technology 16481473 physical association X 2 Q12440 P53886 affinity chromatography technology 17200106 physical association X 2 Q12440 P53886 affinity chromatography technology 11805826 physical association X 2 Q05027 P53886 two hybrid 17634282 direct interaction X 2 P0CG63 P53886 affinity chromatography technology 23793018 physical association X 2 P53886 P40577 affinity chromatography technology 12609981 physical association X 2 P53886 P38042 affinity chromatography technology 12609981 physical association X 2 P53886 P40577 affinity chromatography technology 12574115 physical association X 2 P53886 P38042 affinity chromatography technology 8895471 physical association X 2 P53886 P38042 affinity chromatography technology 8895471 physical association X 2 P53886 P40577 affinity chromatography technology 12477395 physical association X 2 P53886 P40577 affinity chromatography technology 12609981 physical association X 2 P53886 P38042 affinity chromatography technology 16481473 physical association X 2 P53886 P38042 pull down 16481473 direct interaction X 2 P53886 P23594 enzymatic study 23751495 direct interaction X 2 P53886 P23595 enzymatic study 23751495 direct interaction X 2 P53886 P00546 enzymatic study 23751495 direct interaction X 2 P53886 Q04964 affinity chromatography technology 16554755 physical association X 2 P53886 Q06604 affinity chromatography technology 16554755 physical association X 2 P53886 P38042 affinity chromatography technology 16554755 physical association X 2 P53886 P38042 affinity chromatography technology 16481473 physical association X 2 P53886 P38042 affinity chromatography technology 17200106 physical association X 2 P53886 P38042 affinity chromatography technology 17459880 physical association X 2 P53886 P50106 two hybrid 17634282 direct interaction X 2 P53886 P47074 two hybrid 17634282 direct interaction X 2 P53886 Q99321 two hybrid 17634282 direct interaction X 2 P53886 P23291 affinity chromatography technology 11805837 physical association X 2 P40568 P53886 affinity chromatography technology 21107429 physical association X 2 P38230 P53886 two hybrid 17634282 direct interaction X 2 P53197 P53886 pull down 16481473 direct interaction X 2 P53279 P53886 two hybrid 17634282 direct interaction X 2 P53068 P53886 affinity chromatography technology 10318877 physical association X 2 P53068 P53886 biochemical 15060174 colocalization X 2 P53068 P53886 affinity chromatography technology 16481473 physical association X 2 P53068 P53886 affinity chromatography technology 16554755 physical association X 2 P53068 P53886 affinity chromatography technology 16481473 physical association X 2 P53068 P53886 two hybrid 17634282 direct interaction X 2 P53068 P53886 pull down 21186364 direct interaction X 2 P53886 anti tag coimmunoprecipitation 9469814 association C 9 P53886 anti tag coimmunoprecipitation 9469814 association C 9 P53886 anti tag coimmunoprecipitation 9469814 association C 9 P53886 anti tag coimmunoprecipitation 9469814 association C 9 P53886 anti tag coimmunoprecipitation 9469814 association C 9 P53886 tandem affinity purification 16429126 association C 22 P53886 tandem affinity purification 16429126 association C 6 P53886 affinity chromatography technology 12609981 association C 11 P53886 affinity chromatography technology 12609981 association C 11 P53886 inferred by author 16554755 association C 12 P53886 tandem affinity purification 12477395 association C 13 P53886 tandem affinity purification 12477395 association C 13 P53886 tandem affinity purification 12477395 association C 13 P53886 affinity chromatography technology 12609981 association C 13 P53886 anti tag coimmunoprecipitation 9469814 association C 7 P53886 anti tag coimmunoprecipitation 9469814 association C 10 P53886 anti tag coimmunoprecipitation 9469814 association C 10 P53886 anti tag coimmunoprecipitation 9469814 association C 10 P53886 anti tag coimmunoprecipitation 9469814 association C 12 P53886 anti tag coimmunoprecipitation 9469814 association C 12 P53886 anti tag coimmunoprecipitation 9469814 association C 12 P53886 anti tag coimmunoprecipitation 9469814 association C 12 P53886 anti tag coimmunoprecipitation 9469814 association C 12 P32589 P53886 tandem affinity purification 19536198 association X 2 P22943 P53886 tandem affinity purification 19536198 association X 2 P40150 P53886 tandem affinity purification 19536198 association X 2 P14724 P53886 tandem affinity purification 16554755 physical association X 2 P53886 tandem affinity purification 19013276 association C 41 P53886 anti tag coimmunoprecipitation 11805837 association C 3 P53886 tandem affinity purification 11805826 association C 6 P53886 tandem affinity purification 16429126 association C 6 P53886 tandem affinity purification 16429126 association C 19 P53886 inferred by author 16429126 physical association C 9 P53886 anti tag coimmunoprecipitation 9469814 association C 8 P53886 anti tag coimmunoprecipitation 9469814 association C 8 P53886 anti tag coimmunoprecipitation 9469814 association C 7 P53886 anti tag coimmunoprecipitation 9469814 association C 7 P10592 P53886 tandem affinity purification 19536198 association X 2 Q12440 P53886 tandem affinity purification 16554755 physical association X 2 Q12440 P53886 tandem affinity purification 16554755 physical association X 2 P53886 P40577 anti tag coimmunoprecipitation 12609981 physical association X 2 P53886 P38042 tandem affinity purification 16554755 physical association X 2 P53886 Q04964 tandem affinity purification 16554755 physical association X 2 P53886 Q06604 tandem affinity purification 16554755 physical association X 2 P53886 P11484 tandem affinity purification 19536198 association X 2 P53886 P38788 tandem affinity purification 19536198 association X 2 P53886 Q04432 tandem affinity purification 19536198 association X 2 P53068 P53886 tandem affinity purification 16554755 physical association X 2 P53068 P53886 tandem affinity purification 16554755 physical association X 2 P53068 P53886 tandem affinity purification 16554755 physical association X 2 P53886 mass spectrometry studies of complexes 11805826 - C 8 Q12157 P53886 coimmunoprecipitation 9469814 - X 2 P53886 P16522 coimmunoprecipitation 8895471,9469814 - X 2 P53886 P16522 coimmunoprecipitation 8895471,9469814 - X 2 P53886 P09798 coimmunoprecipitation 9469814 - X 2 P53886 P09798 coimmunoprecipitation 8895471,9469814 - X 2 Q08683 P53886 coimmunoprecipitation 9469814 - X 2 Q12107 P53886 coimmunoprecipitation 9469814 - X 2 Q04601 P53886 coimmunoprecipitation 9469814 - X 2 P14724 P53886 coimmunoprecipitation 8895471,9469814 - X 2 P14724 P53886 coimmunoprecipitation 8895471,9469814 - X 2 P53886 mass spectrometry studies of complexes 11805837 - C 46 P53886 confirmational text mining - - C 11 Q12440 P53886 coimmunoprecipitation 9469814 - X 2 P53886 P38042 coimmunoprecipitation 8895471,9469814 - X 2 P53068 P53886 coimmunoprecipitation 9469814 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 APC1 23751495 0415 LC CDC16 APC1 9469814,9469814,8895471,8895471,9469814 0004,0019,0019,0004,0007 LC CDC26 APC1 8895471,8895471,9469814,9469814 0019,0004,0019,0007 LC CDC23 APC1 8895471,8895471,9469814,9469814,8895471 0019,0029,0007,0019,0004 LC SPO12 APC1 17634282 0018 HT PPH21 APC1 23751495 0415 LC PPH22 APC1 23751495 0415 LC MCM3 APC1 17634282 0018 HT UGX2 APC1 17634282 0018 HT MRE11 APC1 17634282 0018 HT CDC27 APC1 8895471,8895471,9469814,9469814 0019,0004,0019,0007 LC ZTA1 APC1 17634282 0018 HT IPL1 APC1 17634282 0018 HT PDS1 APC1 16364911 0415 LC MAD3 APC1 17634282 0018 HT RPA14 APC1 17634282 0018 HT DOC1 APC1 15060174,21186364,21186364,17634282,10318877,9469814,10318877,9469814 0401,0030,0096,0018,0004,0019,0019,0007 LC,HT FHN1 APC1 17634282 0018 HT NRM1 APC1 21562221 0415 LC APC1 APC1 8895471,8895471 0019,0004 LC APC1 YHP1 21562221 0415 LC APC1 APC4 9469814,9469814,9469814 0004,0019,0007 LC APC1 TAF9 17634282 0018 HT APC1 SYC1 17634282 0018 HT APC1 APC5 9469814,9469814,9469814 0004,0019,0007 LC APC1 APC9 9469814,9469814 0019,0007 LC APC1 APC11 9469814,9469814,9469814 0019,0004,0007 LC APC1 SWM1 15060174,15060174 0401,0004 LC APC1 APC2 15060174,9469814,15060174,9469814,9469814 0401,0004,0004,0019,0007 LC APC1 SFG1 17634282 0018 HT APC1 DDP1 17634282 0018 HT CDC16 APC1 23751495,17406682,21186364,21107322,16481473,12574115,17200106,9469814,12887895,12402045,9469814,15797379,8895471,21107322,16429126,10318877,15649358,8895471,15060174,16429126,21186364,16275330,16429126,16364911,9469814 0004,0004,0676,0096,0004,0004,0004,0004,0004,0004,0019,0004,0019,0676,0676,0004,0004,0004,0004,0004,0004,0004,0363,0004,0007 LC,HT SSA2 APC1 19536198 0676 HT SSB1 APC1 19536198 0676 HT CDC26 APC1 8895471,16554755,8895471,9469814,9469814,16554755 0019,0004,0004,0019,0007,0676 LC,HT YEF3 APC1 16429126 0363 HT CDC23 APC1 8895471,8895471,16429126,9469814,17200106,16481473,9469814,16429126,8895471,16429126 0019,0029,0676,0007,0004,0004,0019,0004,0004,0363 LC,HT HSP12 APC1 19536198 0676 HT YCK1 APC1 11805837,11805837 0004,0007 HT CDC5 APC1 19013276,19013276 0004,0676 LC SSE1 APC1 19536198 0676 HT CDC27 APC1 8895471,12609981,16554755,17459880,16481473,8895471,16481473,9469814,16429126,17200106,9469814,16554755 0019,0004,0676,0004,0096,0004,0004,0019,0363,0004,0007,0004 LC,HT AIM4 APC1 21386897 0004 LC SSZ1 APC1 19536198 0676 HT SSB2 APC1 19536198 0676 HT DSN1 APC1 21107429 0004 HT MND2 APC1 12477395,12609981,12477395,12574115,12609981 0676,0004,0004,0004,0007 LC DOC1 APC1 15060174,16554755,16554755,21186364,21186364,10318877,16481473,9469814,10318877,9469814,16554755 0401,0363,0676,0030,0096,0004,0004,0019,0019,0007,0004 LC,HT CDH1 APC1 21107322,16481473 0004,0096 LC APC1 APC1 21186364,8895471,21186364,8895471 0004,0019,0007,0004 LC APC1 HSP31 19536198 0676 HT APC1 APC4 12477395,9469814,15060174,12477395,16481473,21186364,9469814,17200106,9469814,16429126 0676,0004,0004,0004,0004,0004,0019,0004,0007,0363 LC,HT APC1 SML1 16554755,16554755 0676,0004 HT APC1 URN1 21386897 0004 LC APC1 BSP1 16554755,16554755 0676,0004 HT APC1 APC5 9469814,16429126,17200106,16481473,9469814,16429126,9469814,16429126 0004,0676,0004,0004,0019,0004,0007,0363 LC,HT APC1 APC9 9469814,9469814,16429126 0019,0007,0363 LC,HT APC1 APC11 9469814,9469814,9469814,16481473 0019,0004,0007,0004 LC APC1 SWM1 15060174,12477395,12609981,12477395,15060174,12574115,9469814 0401,0676,0004,0004,0004,0004,0007 LC APC1 APC2 15060174,16481473,16554755,9469814,16429126,16429126,15060174,11805826,11805826,17200106,16481473,9469814,11805826,16429126,9469814,16554755 0401,0096,0676,0004,0363,0676,0004,0004,0676,0004,0004,0019,0007,0004,0007,0004 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53886 P23291 APC1 YCK1 0.21 11805837 P53886 P23594 APC1 PPH21 0.309 23751495 P53886 P23595 APC1 PPH22 0.309 23751495 P53886 P00546 APC1 CDC28 0.309 23751495 Q12379 P53886 SWM1 APC1 0.416 9469814,15060174,12477395 Q12440 P53886 APC2 APC1 0.832 11805826,16429126,16554755,9469814,16481473,15060174 P53886 P09798 APC1 CDC16 0.899 16275330,17406682,16429126,9469814,16481473,15797379,21186364,8895471,16364911,23751495 P53886 P16522 APC1 CDC23 0.623 8895471,16429126,9469814,16481473 Q12107 P53886 APC9 APC1 0.236 9469814,16429126 P53886 P38305 APC1 AIM4 0.126 21386897 P53886 P32589 APC1 SSE1 0.126 19536198 P53886 P40150 APC1 SSB2 0.126 19536198 P53886 P14724 APC1 CDC26 0.396 16554755,9469814,8895471 Q06525 P53886 URN1 APC1 0.126 21386897 P53886 P10592 APC1 SSA2 0.126 19536198 P53886 P11484 APC1 SSB1 0.126 19536198 P53886 P16521 APC1 YEF3 0.126 16429126 P53886 P17123 APC1 SPO12 0.183 17634282 P53886 P22943 APC1 HSP12 0.126 19536198 P53886 P24279 APC1 MCM3 0.183 17634282 P53886 P32562 APC1 CDC5 0.332 19013276 P53886 P32772 APC1 UGX2 0.183 17634282 P53886 P32829 APC1 MRE11 0.183 17634282 P53886 P38042 APC1 CDC27 0.748 16429126,17459880,16554755,9469814,16481473,8895471 P53886 P38230 APC1 ZTA1 0.183 17634282 P53886 P38788 APC1 SSZ1 0.126 19536198 P53886 P38991 APC1 IPL1 0.183 17634282 P53886 P40577 APC1 MND2 0.396 12609981,12477395 P53886 P47074 APC1 MAD3 0.183 17634282 P53886 P50106 APC1 RPA14 0.183 17634282 P53886 P53068 APC1 DOC1 0.826 17634282,16554755,9469814,16481473,21186364,10318877,15060174 P53886 P53197 APC1 CDH1 0.309 16481473 P53886 P53279 APC1 FHN1 0.183 17634282 P53886 P53886 APC1 APC1 0.236 21186364,8895471 Q04432 P53886 HSP31 APC1 0.126 19536198 Q04601 P53886 APC4 APC1 0.692 16429126,12477395,9469814,21186364,16481473 Q04964 P53886 SML1 APC1 0.236 16554755 Q05027 P53886 TAF9 APC1 0.183 17634282 Q06604 P53886 BSP1 APC1 0.126 16554755 Q08553 P53886 SYC1 APC1 0.183 17634282 Q12157 P53886 APC11 APC1 0.436 9469814,16481473 Q12507 P53886 SFG1 APC1 0.183 17634282 Q99321 P53886 DDP1 APC1 0.183 17634282 Q07807 P53886 PUF3 APC1 0.126 Q08683 P53886 APC5 APC1 0.583 9469814,16481473,16429126