PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KAR1 BRR2 11290703 biogrid exp KAR1 NAF1 14690591 intact exp KAR1 HEK2 18805955 biogrid exp KAR1 SPT21 25228766 biogrid exp CDC28 KAR1 17634282 biogrid exp KAR1 SGT1 i2d exp KAR1 LGE1 21179020 intact exp KAR1 SPT10 25228766 biogrid exp KAR1 SPC97 10428957, 23023127 biogrid exp, pred CDC31 KAR1 8188750,8910460,11283351,7876310,21714500,12486115, 23023127 biogrid,i2d,mint,intact,dip exp, pred KAR1 BBP1 10654940, 23023127 biogrid,intact,dip exp, pred KAR1 MLP2 21700874, 23023127 biogrid exp, pred KAR1 SPC24 21179020, 23023127 intact exp, pred KAR1 SPC98 10428957, 23023127 biogrid exp, pred KAR1 SPC72 10428957,21179020, 23023127 biogrid,intact,dip exp, pred KAR1 TUB4 10428957, 23023127 biogrid exp, pred KAR1 SFI1 23023127 pred KAR1 NDC1 23023127 pred KAR1 CIK1 23023127 pred KAR1 SPC29 23023127 pred KAR1 SPC110 23023127 pred CMD1 KAR1 23023127 pred KAR1 KAR5 23023127 pred KAR1 MPS2 23023127 pred HSF1 KAR1 23023127 pred KAR1 SPC42 23023127 pred KAR1 KAR3 23023127 pred BIK1 KAR1 23023127 pred KAR1 NUD1 23023127 pred KAR1 MCD1 23023127 pred KAR1 CBF2 23023127 pred KAR1 NDC80 23023127 pred KAR1 SPC34 23023127 pred KAR1 CNM67 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P06704 P11927 - 7876310 - X 2 P06704 P11927 - 11283351 - X 2 P00546 P11927 two hybrid 17634282 direct interaction X 2 P06704 P11927 pull down 8910460 direct interaction X 2 P06704 P11927 pull down 7876310 direct interaction X 2 P06704 P11927 pull down 8188750 direct interaction X 2 P06704 P11927 imaging technique 8188750 colocalization X 2 P06704 P11927 unspecified method 21714500 direct interaction X 2 P38863 P11927 affinity chromatography technology 10428957 physical association X 2 P35208 P11927 affinity chromatography technology 25228766 physical association X 2 P53378 P11927 affinity chromatography technology 10428957 physical association X 2 P39723 P11927 two hybrid 10428957 direct interaction X 2 P39723 P11927 pull down 10428957 direct interaction X 2 P39723 P11927 imaging technique 10428957 colocalization X 2 P11927 P40457 affinity chromatography technology 21700874 physical association X 2 P53540 P11927 affinity chromatography technology 10428957 physical association X 2 P35209 P11927 affinity chromatography technology 25228766 physical association X 2 Q12365 P11927 two hybrid 10654940 direct interaction X 2 P32639 P11927 two hybrid 11290703 direct interaction X 2 P06704 P11927 two hybrid pooling approach 11283351 physical association X 2 P06704 P11927 affinity chromatography technology 7876310 physical association X 2 P39723 P11927 two hybrid 10428957 physical association X 2 P39723 P11927 affinity chromatography technology 10428957 physical association X 2 Q12365 P11927 two hybrid 10654940 physical association X 2 P11927 tandem affinity purification 21179020 association C 53 P11927 tandem affinity purification 21179020 association C 74 P06704 P11927 two hybrid fragment pooling approach 11283351 physical association X 2 P06704 P11927 far western blotting 12486115 physical association X 2 P11927 tandem affinity purification 21179020 association C 23 P53919 P11927 two hybrid array 14690591 physical association X 2 Q12365 P11927 two hybrid 10654940 physical association X 2 P11927 confirmational text mining - - C 13 P06704 P11927 interaction detection method - - X 2 P06704 P11927 interaction detection method 7876310 - X 2 P06704 P11927 two hybrid 11283351 - X 2

PPI - HINT Gene A Gene B PMID Method Quality CDC28 KAR1 17634282 0018 HT CDC31 KAR1 11283351,11283351,11283351,12486115 0018,0399,0398,0047 HT,LC KAR1 BRR2 11290703 0018 LC KAR1 SPC72 10428957,10428957,10428957,10428957 0018,0004,0428,0096 LC KAR1 NAF1 14690591 0397 LC KAR1 BBP1 10654940 0018 LC CDC31 KAR1 26076691,8188750,8188750,8910460,7876310,7876310 0096,0096,0428,0096,0004,0096 LC KAR1 SPT10 25228766 0004 HT KAR1 SPT21 25228766 0004 HT KAR1 SPC97 10428957 0004 LC KAR1 SPC72 10428957,10428957,21179020,10428957,10428957 0018,0004,0676,0428,0096 LC,HT KAR1 MLP2 21700874 0004 LC KAR1 TUB4 10428957 0004 LC KAR1 SPC98 10428957 0004 LC KAR1 LGE1 21179020 0676 HT KAR1 SPC24 21179020 0676 HT KAR1 SFI1 26076691 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04477 P11927 SPC24 KAR1 0.126 21179020 Q12365 P11927 BBP1 KAR1 0.033 10654940 P38863 P11927 SPC97 KAR1 0.21 10428957 P53378 P11927 TUB4 KAR1 0.21 10428957 P53540 P11927 SPC98 KAR1 0.21 10428957 P53919 P11927 NAF1 KAR1 0.126 14690591 Q12369 P11927 SFI1 KAR1 0.309 26076691 P11927 P00546 KAR1 CDC28 0.183 17634282 P11927 P06704 KAR1 CDC31 0.757 7876310,8188750,26076691,11283351,21714500 P35208 P11927 SPT10 KAR1 0.126 25228766 P38199 P11927 HEK2 KAR1 0.126 18805955 P39723 P11927 SPC72 KAR1 0.636 21179020,10428957 P40457 P11927 MLP2 KAR1 0.21 21700874 Q02796 P11927 LGE1 KAR1 0.126 21179020