PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus YCK2 MGS1 16319894 biogrid,i2d exp MGS1 PUS9 i2d exp SGS1 MGS1 i2d exp MGS1 PUS6 i2d exp SES1 MGS1 i2d exp MGS1 PCL7 11283351 i2d,mint,intact,dip exp MGS1 PUS5 i2d exp POA1 MGS1 i2d exp POL30 MGS1 21911365 biogrid exp MGS1 SPP382 14690591 intact exp MGS1 UPF0695 membrane protein YOR390W i2d exp SSB2 MGS1 23332755 biogrid exp MGS1 NMA111 i2d exp CMK1 MGS1 16319894 biogrid,i2d exp DIA4 MGS1 i2d exp TEM1 MGS1 10688190 biogrid,i2d,mint,intact,dip exp PCM1 MGS1 11805826,16429126 biogrid,mint,intact,dip exp NAB2 MGS1 19840948 biogrid exp MGS1 MAD2 10688190 biogrid,i2d,mint,intact,dip exp SNF1 MGS1 10688190 biogrid,i2d,mint,intact,dip exp MGS1 RIB2 i2d exp MGS1 WD repeat-containing protein YMR102C 10688190 biogrid,i2d,mint,intact,dip exp MGS1 ACT1 16429126 biogrid,intact exp MGS1 NMA2 11283351 i2d,mint,intact,dip exp MGS1 GIM5 19536198 intact exp MGS1 TRM732 i2d exp MGS1 MGS1 10688190, 23023127 biogrid,i2d,mint,intact,dip exp, ortho, pred MGS1 Uncharacterized bolA-like protein YAL044W-A 18719252, 23023127 biogrid,intact exp, pred CSM1 MGS1 15023545, 23023127 biogrid,intact exp, pred MGS1 POL31 16949354, 23023127 biogrid exp, pred MGS1 ELP2 ortho ESS1 MGS1 ortho SCH9 MGS1 ortho MGS1 ELP3 ortho CDC48 MGS1 ortho CRM1 MGS1 ortho POL3 MGS1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P06782 P40151 - 10688190 - X 2 P40151 Q03177 - 10688190 - X 2 P53204 P40151 - 11283351 - X 2 P38628 P40151 - 11805826 - X 2 P38987 P40151 - 10688190 - X 2 P40958 P40151 - 10688190 - X 2 P40151 P40186 - 11283351 - X 2 P40151 P40151 - 10688190 - X 2 P06782 P40151 two hybrid 10688190 direct interaction X 2 P23292 P40151 enzymatic study 16319894 direct interaction X 2 P40150 P40151 biochemical 23332755 association X 2 P27466 P40151 enzymatic study 16319894 direct interaction X 2 P40151 P25651 two hybrid 15023545 direct interaction X 2 P40151 Q03177 two hybrid 10688190 direct interaction X 2 P46957 P40151 affinity chromatography technology 16949354 physical association X 2 P0CG63 P40151 biochemical 23583075 association X 2 Q3E793 P40151 two hybrid 18719252 direct interaction X 2 P38628 P40151 affinity chromatography technology 17200106 physical association X 2 P38628 P40151 affinity chromatography technology 11805826 physical association X 2 Q12306 P40151 affinity chromatography technology 22285753 physical association X 2 P15873 P40151 two hybrid 21911365 direct interaction X 2 P15873 P40151 pull down 21911365 direct interaction X 2 P15873 P40151 two hybrid 21911365 direct interaction X 2 P38987 P40151 two hybrid 10688190 direct interaction X 2 P40958 P40151 two hybrid 10688190 direct interaction X 2 P40151 P60010 affinity chromatography technology 16429126 physical association X 2 P40151 P40151 two hybrid 10688190 direct interaction X 2 P06782 P40151 two hybrid 10688190 physical association X 2 P40151 Q03177 two hybrid 10688190 physical association X 2 P40151 P40151 two hybrid 10688190 physical association Y 1 P53204 P40151 two hybrid pooling approach 11283351 physical association X 2 P38628 P40151 tandem affinity purification 11805826 physical association X 2 P38628 P40151 inferred by author 11805826 physical association X 2 P38987 P40151 two hybrid 10688190 physical association X 2 P40958 P40151 two hybrid 10688190 physical association X 2 P40151 P40186 two hybrid pooling approach 11283351 physical association X 2 P40151 inferred by author 16429126 physical association C 3 P40151 tandem affinity purification 11805826 association C 3 P06782 P40151 two hybrid 10688190 physical association X 2 P40151 Q03177 two hybrid 10688190 physical association X 2 P40151 P25651 two hybrid 15023545 physical association X 2 P53204 P40151 two hybrid fragment pooling approach 11283351 physical association X 2 Q04493 P40151 tandem affinity purification 19536198 association X 2 Q3E793 P40151 two hybrid 18719252 physical association X 2 P38628 P40151 tandem affinity purification 16429126 physical association X 2 Q06411 P40151 two hybrid array 14690591 physical association X 2 P38987 P40151 two hybrid 10688190 physical association X 2 P40958 P40151 two hybrid 10688190 physical association X 2 P40151 P40151 two hybrid 10688190 physical association X 2 P40151 P40186 two hybrid fragment pooling approach 11283351 physical association X 2 P40151 P60010 tandem affinity purification 16429126 physical association X 2 P40151 P60010 inferred by author 16429126 physical association X 2 P40151 mass spectrometry studies of complexes 11805826 - C 3 P06782 P40151 two hybrid 10688190 - X 2 P35187 P40151 interaction detection method 11743205 - X 2 P35187 P40151 interaction detection method 11743205 - X 2 P40151 Q03177 two hybrid 10688190 - X 2 P53204 P40151 two hybrid 11283351 - X 2 Q06340 P40151 interaction detection method 14764870 - X 2 P38987 P40151 two hybrid 10688190 - X 2 P40958 P40151 two hybrid 10688190 - X 2 P00572 P40151 interaction detection method 14764870 - X 2 P40151 P40186 two hybrid 11283351 - X 2 P40151 P40151 two hybrid 10688190 - X 2

PPI - HINT Gene A Gene B PMID Method Quality SNF1 MGS1 10688190,10688190 0397,0018 HT POL30 MGS1 21911365,21911365 0096,0018 LC YCK2 MGS1 16319894 0415 LC CSM1 MGS1 15023545 0018 LC CMK1 MGS1 16319894 0415 LC TEM1 MGS1 10688190,10688190 0397,0018 HT SSB2 MGS1 23332755 0401 LC MGS1 MGS1 10688190,10688190 0397,0018 HT MGS1 PCL7 11283351,11283351,11283351 0018,0399,0398 HT MGS1 MAD2 10688190,10688190 0397,0018 HT MGS1 NMA2 11283351,11283351,11283351 0018,0399,0398 HT MGS1 Q03177 10688190,10688190 0397,0018 HT MGS1 SPP382 14690591 0397 LC MGS1 Q3E793 18719252 0018 HT POL30 MGS1 21911365,21911365 0096,0018 LC NAB2 MGS1 19840948 0004 LC PCM1 MGS1 16429126,11805826,11805826,11805826,17200106,11805826 0676,0676,0004,0363,0004,0007 HT SSB2 MGS1 23332755 0401 LC MGS1 POL31 16949354 0004 LC MGS1 ACT1 16429126,16429126,16429126 0676,0004,0363 HT MGS1 GIM5 19536198 0676 HT MGS1 SMT3 22285753 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P40151 P15873 MGS1 POL30 0.671 21911365 P40151 P23292 MGS1 YCK2 0.183 16319894 Q04493 P40151 GIM5 MGS1 0.126 19536198 P40151 P25651 MGS1 CSM1 0.309 15023545 P40151 P06782 MGS1 SNF1 0.309 10688190 Q3E793 P40151 Q3E793 MGS1 0.332 18719252 P60010 P40151 ACT1 MGS1 0.416 16429126 P40151 P38628 MGS1 PCM1 0.376 11805826,16429126 P40151 P32505 MGS1 NAB2 0.126 19840948 P40151 P38987 MGS1 TEM1 0.332 10688190 P40151 P27466 MGS1 CMK1 0.183 16319894 P40151 P40150 MGS1 SSB2 0.126 23332755 P40151 O60684 MGS1 KPNA6 0.332 27107014 P40151 P40151 MGS1 MGS1 0.332 10688190 P40958 P40151 MAD2 MGS1 0.332 10688190 P53204 P40151 NMA2 MGS1 0.236 11283351 Q03177 P40151 Q03177 MGS1 0.332 10688190 Q06411 P40151 SPP382 MGS1 0.126 14690591 P40186 P40151 PCL7 MGS1 0.21 11283351 P63279 P40151 UBE2I MGS1 0.332 27107014