PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RPL40A SKP2 11805837 intact,dip exp YDJ1 SKP2 19536198 intact exp SKP2 RVB2 11805837 dip exp KSP1 SKP2 11805837 dip exp SSA1 SKP2 19536198 intact exp HSP82 SKP2 11805837 dip exp SKP2 MET14 10688190,11283351,18719252 biogrid,i2d,mint,intact,dip exp ATP1 SKP2 11805837 dip exp SKP2 SKP2 14747994 biogrid exp RPT2 SKP2 11805837 biogrid,intact,dip exp SKP2 JJJ1 19536198 intact exp ARG3 SKP2 11805837 dip exp SIS1 SKP2 19536198 intact exp RPB2 SKP2 11805837 dip exp GLK1 SKP2 11805837 dip exp SSE1 SKP2 19536198 intact exp CRM1 SKP2 26673895 biogrid exp SKP2 CDC53 14747994 biogrid exp HXK1 SKP2 11805837 dip exp TUB2 SKP2 11805837 dip exp CYC8 SKP2 i2d exp SKP2 ALD6 11805837 dip exp CHC1 SKP2 11805837 dip exp TEF1, TEF2 SKP2 11805837 dip exp UBI4 SKP2 11805837 biogrid exp SKP2 SKP1 23000173,16432255,19882662,11283351,14747994,11805837 biogrid,i2d,mint,intact,dip exp SSC1 SKP2 11805837 dip exp SKP2 HRT1 14747994 biogrid exp XRN1 SKP2 11805837 dip exp SKP2 RPT4 11805837 biogrid,intact,dip exp TUB3 SKP2 11805837 dip exp TUB1 SKP2 11805837 dip exp SKP2 RVB1 11805837 biogrid,intact,dip exp HEK2 SKP2 18805955 biogrid exp SSB1 SKP2 19536198 intact exp STI1 SKP2 11805837 biogrid,mint,intact,dip exp SKP2 DMA2 11805837, 23023127 biogrid,mint,intact,dip exp, pred ERG1 SKP2 11805837, 23023127 biogrid,intact,dip exp, pred SER33 SKP2 10688190,18719252, 23023127 biogrid,i2d,mint,intact,dip exp, pred DMA1 SKP2 11805837, 23023127 biogrid,intact,dip exp, pred CSM1 SKP2 18719252, 23023127 biogrid,intact exp, pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P42843 - 11805837 - C 10 P42843 - 11805837 - C 3 P42843 P38823 - 11805837 - X 2 P42843 Q02196 - 10688190 - X 2 P42843 Q02196 - 11283351 - X 2 P40510 P42843 - 10688190 - X 2 P52286 P42843 - 11283351 - X 2 P53924 P42843 - 11805837 - X 2 P42843 P42843 enzymatic study 14747994 direct interaction X 2 P42843 Q02196 two hybrid 11283351 direct interaction X 2 P42843 P25651 two hybrid 18719252 direct interaction X 2 P42843 Q02196 two hybrid 18719252 direct interaction X 2 P42843 P38823 affinity chromatography technology 11805837 physical association X 2 P42843 P38823 affinity chromatography technology 11805837 physical association X 2 P42843 Q03940 affinity chromatography technology 11805837 physical association X 2 P42843 P32476 affinity chromatography technology 11805837 physical association X 2 P42843 Q02196 two hybrid 10688190 direct interaction X 2 P40510 P42843 two hybrid 18719252 direct interaction X 2 P40510 P42843 two hybrid 10688190 direct interaction X 2 P15705 P42843 affinity chromatography technology 11805837 physical association X 2 P52286 P42843 pull down 23000173 direct interaction X 2 P52286 P42843 pull down 14747994 direct interaction X 2 P52286 P42843 affinity chromatography technology 16432255 physical association X 2 P52286 P42843 affinity chromatography technology 11805837 physical association X 2 P53549 P42843 affinity chromatography technology 11805837 physical association X 2 Q08273 P42843 pull down 14747994 direct interaction X 2 P0CG63 P42843 affinity chromatography technology 11805837 physical association X 2 P42843 Q12018 pull down 14747994 direct interaction X 2 P42843 P40327 affinity chromatography technology 11805837 physical association X 2 P53924 P42843 affinity chromatography technology 11805837 physical association X 2 P53924 P42843 affinity chromatography technology 11805837 physical association X 2 P22137 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 anti tag coimmunoprecipitation 11805837 - C 5 P42843 anti tag coimmunoprecipitation 11805837 - C 26 P22147 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P54115 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P05150 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P07251 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P17709 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P38823 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P38823 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 Q03940 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P05759 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P32476 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 Q02196 two hybrid pooling approach 11283351 physical association X 2 P42843 Q02196 two hybrid 10688190 physical association X 2 P09734 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P40510 P42843 two hybrid 10688190 physical association X 2 P15705 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 P42843 affinity chromatography technology 14747994 physical association X 2 P52286 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P52286 P42843 two hybrid pooling approach 11283351 physical association X 2 P42843 anti tag coimmunoprecipitation 11805837 - C 3 P42843 anti tag coimmunoprecipitation 11805837 - C 7 P42843 anti tag coimmunoprecipitation 11805837 - C 10 P42843 affinity chromatography technology 14747994 - C 4 P08518 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P53549 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P09733 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 Q12464 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P38691 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P02829 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P04806 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P0CS90 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P02994 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P02557 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 P40327 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P53924 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 anti tag coimmunoprecipitation 11805837 association C 3 P42843 Q02196 two hybrid 10688190 physical association X 2 P42843 Q02196 two hybrid fragment pooling approach 11283351 physical association X 2 P42843 P38823 anti tag coimmunoprecipitation 11805837 physical association X 2 P42843 Q02196 two hybrid 18719252 physical association X 2 P42843 P25651 two hybrid 18719252 physical association X 2 P42843 P25294 tandem affinity purification 19536198 association X 2 P40510 P42843 two hybrid 10688190 physical association X 2 P40510 P42843 two hybrid 18719252 physical association X 2 P52286 P42843 two hybrid fragment pooling approach 11283351 physical association X 2 P42843 pull down 19882662 association C 51 P42843 anti tag coimmunoprecipitation 11805837 association C 10 P32589 P42843 tandem affinity purification 19536198 association X 2 P11484 P42843 tandem affinity purification 19536198 association X 2 P42843 P25491 tandem affinity purification 19536198 association X 2 P53924 P42843 anti tag coimmunoprecipitation 11805837 physical association X 2 P53863 P42843 tandem affinity purification 19536198 association X 2 P10591 P42843 tandem affinity purification 19536198 association X 2 P42843 mass spectrometry studies of complexes 11805837 - C 4 P42843 Q02196 two hybrid 10688190 - X 2 P42843 Q02196 two hybrid 11283351 - X 2 P40510 P42843 two hybrid 10688190 - X 2 P52286 P42843 two hybrid 11283351 - X 2 P42843 mass spectrometry studies of complexes 11805837 - C 6 P42843 mass spectrometry studies of complexes 11805837 - C 11 P42843 mass spectrometry studies of complexes 11805837 - C 11

PPI - HINT Gene A Gene B PMID Method Quality CKS1 SKP2 26463131,26463131 0096,0401 LC CSM1 SKP2 18719252 0018 HT SER33 SKP2 18719252,10688190,10688190 0018,0397,0018 HT SKP2 SKP2 14747994 0415 LC SKP2 SKP1 11283351,11283351,11283351 0018,0399,0398 HT SKP2 MET14 18719252,11283351,11283351,11283351,10688190,10688190 0018,0018,0399,0398,0397,0018 HT TUB2 SKP2 11805837 0007 HT HSP82 SKP2 11805837 0007 HT TEF1|TEF2 SKP2 11805837 0007 HT HXK1 SKP2 11805837 0007 HT ARG3 SKP2 11805837 0007 HT RPS31 SKP2 11805837 0007 HT ATP1 SKP2 11805837 0007 HT RPB2 SKP2 11805837 0007 HT TUB1 SKP2 11805837 0007 HT TUB3 SKP2 11805837 0007 HT UBI4 SKP2 11805837 0004 HT RPL40B SKP2 11805837 0007 HT SSC1 SKP2 11805837 0007 HT SSA1 SKP2 19536198 0676 HT SSB1 SKP2 19536198 0676 HT STI1 SKP2 11805837,11805837 0004,0007 HT GLK1 SKP2 11805837 0007 HT CKS1 SKP2 26463131,26463131 0096,0401 LC CHC1 SKP2 11805837 0007 HT XRN1 SKP2 11805837 0007 HT SIS1 SKP2 19536198 0676 HT YDJ1 SKP2 19536198 0676 HT CRM1 SKP2 26673895,26673895 0096,0004 LC ERG1 SKP2 11805837,11805837 0004,0007 HT SSE1 SKP2 19536198 0676 HT KSP1 SKP2 11805837 0007 HT DMA1 SKP2 11805837,11805837 0004,0007 HT RPT2 SKP2 11805837,11805837 0004,0007 HT SKP2 SKP1 11805837,23000173,14747994,19882662,14747994,16432255,11805837 0004,0096,0004,0096,0096,0004,0007 HT,LC SKP2 RPT4 11805837,11805837 0004,0007 HT SKP2 JJJ1 19536198 0676 HT SKP2 DMA2 11805837,11805837 0004,0007 HT SKP2 ALD6 11805837 0007 HT SKP2 RVB1 11805837,11805837 0004,0007 HT SKP2 HRT1 14747994 0096 LC SKP2 CDC53 14747994 0096 LC SKP2 RVB2 11805837 0007 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q12018 P42843 CDC53 SKP2 0.309 14747994 Q12464 P42843 RVB2 SKP2 0.126 11805837 P42843 P25491 SKP2 YDJ1 0.126 19536198 P42843 P09733 SKP2 TUB1 0.126 11805837 P42843 P08518 SKP2 RPB2 0.126 11805837 P42843 P10591 SKP2 SSA1 0.126 19536198 P42843 P02557 SKP2 TUB2 0.126 11805837 P42843 P02829 SKP2 HSP82 0.126 11805837 P42843 P12398 SKP2 SSC1 0.126 11805837 P42843 P20486 SKP2 CKS1 0.454 26463131 Q02196 P42843 MET14 SKP2 0.636 10688190,11283351,18719252 P42843 P30822 SKP2 CRM1 0.236 26673895 P42843 P25651 SKP2 CSM1 0.332 18719252 P52286 P42843 SKP1 SKP2 0.659 14747994,23000173,11805837,11283351,19882662 P42843 P38199 SKP2 HEK2 0.126 18805955 P42843 P32476 SKP2 ERG1 0.236 11805837 P42843 P38823 SKP2 DMA1 0.332 11805837 P42843 P32589 SKP2 SSE1 0.126 19536198 P42843 P40510 SKP2 SER33 0.523 10688190,18719252 P42843 P04806 SKP2 HXK1 0.126 11805837 P42843 P25294 SKP2 SIS1 0.126 19536198 P42843 P02994 SKP2 TEF2 0.126 11805837 P42843 P09734 SKP2 TUB3 0.126 11805837 P42843 P07251 SKP2 ATP1 0.126 11805837 P42843 P05150 SKP2 ARG3 0.126 11805837 P42843 P22137 SKP2 CHC1 0.126 11805837 P42843 P15705 SKP2 STI1 0.236 11805837 P42843 P11484 SKP2 SSB1 0.126 19536198 P42843 P17709 SKP2 GLK1 0.126 11805837 P42843 P40327 SKP2 RPT2 0.21 11805837 P42843 P38691 SKP2 KSP1 0.126 11805837 P42843 P40692 SKP2 MLH1 0.332 27107014 P42843 P42843 SKP2 SKP2 0.332 14747994 P54115 P42843 ALD6 SKP2 0.126 11805837 P53863 P42843 JJJ1 SKP2 0.126 19536198 P53549 P42843 RPT4 SKP2 0.236 11805837 P61864 P42843 RPL40A SKP2 0.21 11805837 Q03940 P42843 RVB1 SKP2 0.236 11805837 P53924 P42843 DMA2 SKP2 0.332 11805837 P42843 P22147 SKP2 XRN1 0.126 11805837