PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CCT6 HUB1 19536198 intact exp SRO9 HUB1 22271760 biogrid exp SSB1 HUB1 19536198 intact exp GIS2 HUB1 21232131 biogrid exp PUF3 HUB1 23409723 biogrid exp SLF1 HUB1 22271760 biogrid exp SSB2 HUB1 19536198 intact exp SPH1 HUB1 11923536 biogrid exp SSE1 HUB1 19536198 intact exp PRP8 HUB1 21614000, 23023127 biogrid exp, ortho, pred SNU66 HUB1 21614000,15620657,18719252, 23023127 biogrid,i2d,intact exp, pred HBT1 HUB1 11923536, 23023127 biogrid exp, pred SNU114 HUB1 ortho TRX3 HUB1 ortho YSC84 HUB1 23023127 pred UBC8 HUB1 23023127 pred UBC4 HUB1 23023127 pred SHP1 HUB1 23023127 pred CDC25 HUB1 23023127 pred LSM2 HUB1 23023127 pred UBX5 HUB1 23023127 pred ULP1 HUB1 23023127 pred CUE2 HUB1 23023127 pred RUP1 HUB1 23023127 pred MYO5 HUB1 23023127 pred UBX6 HUB1 23023127 pred UBC1 HUB1 23023127 pred RAD6 HUB1 23023127 pred SET2 HUB1 23023127 pred MMS2 HUB1 23023127 pred UBC9 HUB1 23023127 pred UBP14 HUB1 23023127 pred UBX3 HUB1 23023127 pred HUB1 HUB1 23023127 pred UBC11 HUB1 23023127 pred CDC42 HUB1 23023127 pred UBP15 HUB1 23023127 pred CUE3 HUB1 23023127 pred GGA1 HUB1 23023127 pred DSK2 HUB1 23023127 pred UBC5 HUB1 23023127 pred VPS9 HUB1 23023127 pred SMT3 HUB1 23023127 pred ATG8 HUB1 23023127 pred YUH1 HUB1 23023127 pred UBC12 HUB1 23023127 pred CDC34 HUB1 23023127 pred EDE1 HUB1 23023127 pred GGA2 HUB1 23023127 pred UBA1 HUB1 23023127 pred UBC13 HUB1 23023127 pred BEM1 HUB1 23023127 pred PAN1 HUB1 23023127 pred CDC24 HUB1 23023127 pred CUE1 HUB1 23023127 pred MDY2 HUB1 23023127 pred UBX7 HUB1 23023127 pred RVS161 HUB1 23023127 pred FUS1 HUB1 23023127 pred RAD23 HUB1 23023127 pred UBC7 HUB1 23023127 pred MYO3 HUB1 23023127 pred PEX4 HUB1 23023127 pred SLA1 HUB1 23023127 pred UBI4 HUB1 23023127 pred OTU1 HUB1 23023127 pred CUE4 HUB1 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q12420 Q6Q546 - 15620657 - X 2 Q6Q546 two hybrid 21614000 direct interaction X 2 Q6Q546 two hybrid 21614000 direct interaction X 2 Q12420 Q6Q546 two hybrid 18719252 direct interaction X 2 Q12420 Q6Q546 affinity chromatography technology 21614000 physical association X 2 Q12420 Q6Q546 affinity chromatography technology 21614000 physical association X 2 Q12420 Q6Q546 two hybrid 21614000 direct interaction X 2 Q12420 Q6Q546 pull down 21614000 direct interaction X 2 Q12420 Q6Q546 pull down 21614000 direct interaction X 2 Q12420 Q6Q546 affinity chromatography technology 21614000 physical association X 2 Q12420 Q6Q546 x-ray crystallography 21614000 association X 2 P33334 Q6Q546 affinity chromatography technology 21614000 physical association X 2 Q07653 Q6Q546 affinity chromatography technology 11923536 physical association X 2 Q6Q546 affinity chromatography technology 11923536 physical association X 2 Q6Q546 O97303 two hybrid 21614000 direct interaction X 2 Q6Q546 P11484 tandem affinity purification 19536198 association X 2 Q6Q546 P40150 tandem affinity purification 19536198 association X 2 P32589 Q6Q546 tandem affinity purification 19536198 association X 2 Q12420 Q6Q546 two hybrid 15620657 physical association X 2 Q12420 Q6Q546 two hybrid 18719252 physical association X 2 Q6Q546 P39079 tandem affinity purification 19536198 association X 2

PPI - HINT Gene A Gene B PMID Method Quality SNU66 HUB1 18719252,15620657,21614000,21614000,21614000,21614000 0018,0018,0018,0096,0114,0004 HT,LC HUB1 HUB1 21614000 0114 LC SSB1 HUB1 19536198 0676 HT SSE1 HUB1 19536198 0676 HT PRP8 HUB1 21614000 0004 LC CCT6 HUB1 19536198 0676 HT SSB2 HUB1 19536198 0676 HT PRP38 HUB1 21614000 0004 LC SPH1 HUB1 11923536 0004 LC HBT1 HUB1 11923536 0004 LC SNU66 HUB1 21614000,21614000,21614000,21614000 0018,0096,0114,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6Q546 Q12034 HUB1 SLF1 0.126 22271760 Q6Q546 P25567 HUB1 SRO9 0.126 22271760 Q6Q546 P33334 HUB1 PRP8 0.126 21614000 Q6Q546 Q06160 HUB1 SPH1 0.21 11923536 Q6Q546 Q07653 HUB1 HBT1 0.21 11923536 Q8LB54 Q6Q546 PRP38 HUB1 0.183 21614000 Q6Q546 P11484 HUB1 SSB1 0.126 19536198 Q6Q546 Q12420 HUB1 SNU66 0.843 21614000,15620657,18719252 Q6Q546 P32589 HUB1 SSE1 0.126 19536198 Q6Q546 P39079 HUB1 CCT6 0.126 19536198 Q6Q546 P40150 HUB1 SSB2 0.126 19536198 Q6Q546 P53849 HUB1 GIS2 0.126 21232131